Alpha,beta-unsaturated aldehydes in cigarette smoke release inflammatory mediators from human macrophages.

abstract：:Acute lung injury (ALI) and its severe form, acute respiratory distress syndrome (ARDS), are major causes of acute respiratory failure with high rates of morbidity and mortality. Although surfactant protein (SP)-D plays a critical role in pulmonary innate immunity and several clinical studies suggest that this protein...

journal_title：American journal of respiratory cell and molecular biology

authors： King BA,Kingma PS

更新日期：2011-05-01 00:00:00

abstract：:Human rhinovirus (HRV) triggers exacerbations of asthma and chronic obstructive pulmonary disease. Cigarette smoking is the primary risk factor for the development of chronic obstructive pulmonary disease, and 25% of individuals with asthma smoke. Smokers experience both longer and more severe colds. We previously sho...

journal_title：American journal of respiratory cell and molecular biology

authors： Hudy MH,Traves SL,Proud D

更新日期：2014-03-01 00:00:00

abstract：:Lung endothelial cell apoptosis and injury occur throughout all stages of acute lung injury/acute respiratory distress syndrome and impact disease progression. Caspases 1, 4, and 5 are essential for completion of the apoptotic program known as pyroptosis that also involves proinflammatory cytokines. Because gasdermin ...

journal_title：American journal of respiratory cell and molecular biology

authors： Mitra S,Exline M,Habyarimana F,Gavrilin MA,Baker PJ,Masters SL,Wewers MD,Sarkar A

更新日期：2018-07-01 00:00:00

abstract：:Infections with bacteria and viruses such as adenovirus are a feature of chronic lung diseases such as chronic obstructive pulmonary diseases (COPD), and may be instrumental in the generation of disease exacerbations. We have previously shown in acute models that elafin (a lung natural chemotactic molecule for macroph...

journal_title：American journal of respiratory cell and molecular biology

authors： Roghanian A,Williams SE,Sheldrake TA,Brown TI,Oberheim K,Xing Z,Howie SE,Sallenave JM

更新日期：2006-05-01 00:00:00

abstract：:The cystic fibrosis transmembrane conductance regulator (CFTR) serves a pivotal role in normal epithelial homeostasis; its absence leads to destruction of exocrine tissues, including those of the gastrointestinal tract and lung. Acute regulation of CFTR protein in response to environmental stimuli occurs at several le...

journal_title：American journal of respiratory cell and molecular biology

authors： Guimbellot JS,Fortenberry JA,Siegal GP,Moore B,Wen H,Venglarik C,Chen YF,Oparil S,Sorscher EJ,Hong JS

更新日期：2008-11-01 00:00:00

abstract：:Chlorine (Cl(2)) gas exposure poses an environmental and occupational hazard that frequently results in acute lung injury. There is no effective treatment. We assessed the efficacy of antioxidants, administered after exposure, in decreasing mortality and lung injury in C57BL/6 mice exposed to 600 ppm of Cl(2) for 45 m...

journal_title：American journal of respiratory cell and molecular biology

authors： Zarogiannis SG,Jurkuvenaite A,Fernandez S,Doran SF,Yadav AK,Squadrito GL,Postlethwait EM,Bowen L,Matalon S

更新日期：2011-08-01 00:00:00

abstract：:Acute lung injury induced by reactive oxygen gases such as ozone (O(3)) is focal and site-selective. To define patterns of acute epithelial injury along intrapulmonary airways, we developed a new analytic approach incorporating labeling of permeable cells, airway microdissection, and laser scanning confocal microscopy...

journal_title：American journal of respiratory cell and molecular biology

authors： Postlethwait EM,Joad JP,Hyde DM,Schelegle ES,Bric JM,Weir AJ,Putney LF,Wong VJ,Velsor LW,Plopper CG

更新日期：2000-02-01 00:00:00

abstract：:Dendritic cells (DCs) play a pivotal role in shaping antiviral immune responses in the respiratory tract. Human metapneumovirus (hMPV) is a recently identified pathogen and like its better known relative, respiratory syncytial virus (RSV), has been increasingly recognized as a major cause of respiratory morbidity in i...

journal_title：American journal of respiratory cell and molecular biology

authors： Guerrero-Plata A,Casola A,Suarez G,Yu X,Spetch L,Peeples ME,Garofalo RP

更新日期：2006-03-01 00:00:00

abstract：:Inflammatory lung disease is associated with increased epithelial permeability, but it is unclear how inflammatory cells alter epithelial permeability. Neutrophils have azurophilic granules containing elastase, cathepsin G, and defensins which are released at sites of inflammation. Experiments using whole animals and ...

journal_title：American journal of respiratory cell and molecular biology

authors： Peterson MW,Walter ME,Nygaard SD

更新日期：1995-12-01 00:00:00

abstract：:We have previously identified two integrins, alpha 9 beta 1 and alpha v beta 6, from guinea pig airway epithelium. The extracellular matrix protein tenascin is a ligand for both of these receptors, and fibronectin is also a ligand for alpha v beta 6. In the present study, we used immunohistochemistry to examine the ex...

journal_title：American journal of respiratory cell and molecular biology

authors： Weinacker A,Ferrando R,Elliott M,Hogg J,Balmes J,Sheppard D

更新日期：1995-05-01 00:00:00

abstract：:The effects of hypoxia on the regulation of inducible nitric oxide synthase (NOS) 2 expression were examined in cultured rat pulmonary microvascular endothelial cells (EC). EC did not express NOS 2 mRNA or protein when exposed to normoxia or hypoxia unless they were pretreated with interleukin (IL)-1beta and/or tumor ...

journal_title：American journal of respiratory cell and molecular biology

authors： Zulueta JJ,Sawhney R,Kayyali U,Fogel M,Donaldson C,Huang H,Lanzillo JJ,Hassoun PM

更新日期：2002-01-01 00:00:00

abstract：:It had been thought that the central molecular event in the malignant transformation of a cell is the mutation of certain oncogenes-and the resultant dysregulated activation of their encoded proteins. During the past decade, however, it has become clear that alteration of the activity of the protein products of tumor ...

journal_title：American journal of respiratory cell and molecular biology

authors： Weintraub SJ

更新日期：1996-08-01 00:00:00

abstract：:To identify mechanisms that allow p185HER2 expression in lung cancer, we performed Western, Southern, and Northern blot analyses of 14 cell lines derived from human non-small cell lung carcinomas and one cell line derived from a human mesothelioma. Human bronchiole epithelial cells and rat type II pneumocytes were fou...

journal_title：American journal of respiratory cell and molecular biology

authors： Kern JA,Robinson RA,Gazdar A,Torney L,Weiner DB

更新日期：1992-04-01 00:00:00

abstract：:We examined the mechanisms underlying tachyphylaxis to beta-adrenergic receptor agonists (beta-agonists) in tracheal smooth muscle. Simultaneous measurements of isometric tension and intracellular Ca2+ concentration ([Ca2+]i) using fura-2-loaded guinea pig tracheas showed that the inhibitory effects of isoproterenol (...

journal_title：American journal of respiratory cell and molecular biology

authors： Kume H,Ishikawa T,Oguma T,Ito S,Shimokata K,Kotlikoff MI

更新日期：2003-09-01 00:00:00

abstract：:Fetal airway smooth muscle contracts to neural stimulation from early gestation. This study aimed to document the development of the nerves and ganglia within the bronchial tree of the fetal pig lung as the structural correlates for this function. The formation of these structures during lung development (pseudoglandu...

journal_title：American journal of respiratory cell and molecular biology

authors： Weichselbaum M,Sparrow MP

更新日期：1999-11-01 00:00:00

abstract：:Interleukin-1 (IL-1) is a proinflammatory cytokine that signals through the Type I IL-1 receptor (IL-1RI). Novel IL-1-like cytokines were recently identified. Their functions in lung disease remain unclear. Interleukin-1 family member-9 (IL-1F9) is one such IL-1-like cytokine, expressed in the lungs of humans and mice...

journal_title：American journal of respiratory cell and molecular biology

authors： Ramadas RA,Ewart SL,Medoff BD,LeVine AM

更新日期：2011-02-01 00:00:00

abstract：:The extracellular matrix in asthmatic lungs contains abundant low-molecular-weight hyaluronan, and this is known to promote antigen presentation and allergic responses. Conversely, high-molecular-weight hyaluronan (HMW-HA), typical of uninflamed tissues, is known to suppress inflammation. We investigated whether HMW-H...

journal_title：American journal of respiratory cell and molecular biology

authors： Gebe JA,Yadava K,Ruppert SM,Marshall P,Hill P,Falk BA,Sweere JM,Han H,Kaber G,Harten IA,Medina C,Mikecz K,Ziegler SF,Balaji S,Keswani SG,Perez VA,Butte MJ,Nadeau K,Altemeier WA,Fanger N,Bollyky PL

更新日期：2017-01-01 00:00:00

abstract：:Type 2 alveolar epithelial cells (AEC2) are regarded as the progenitor population of the alveolus responsible for injury repair and homeostatic maintenance. Depletion of this population is hypothesized to underlie various lung pathologies. Current models of lung injury rely on either uncontrolled, nonspecific destruct...

journal_title：American journal of respiratory cell and molecular biology

authors： Garcia O,Hiatt MJ,Lundin A,Lee J,Reddy R,Navarro S,Kikuchi A,Driscoll B

更新日期：2016-03-01 00:00:00

abstract：:Persistent polyclonal lymphocytosis has been described in a group of female patients who all have the HLA-DR7 antigen in common and who are all heavy cigarette smokers. Immunoglobulin heavy chain gene rearrangement was analyzed by hybridization with specific immunoglobulin heavy chain genes to restriction enzyme-diges...

journal_title：American journal of respiratory cell and molecular biology

authors： Chan MA,Benedict SH,Carstairs KC,Francombe WH,Gelfand EW

更新日期：1990-06-01 00:00:00

abstract：:The reasons for bacterial proliferation in the lungs of mechanically ventilated patients are poorly understood. We hypothesized that prolonged cyclic stretch of lung cells influenced bacterial growth. Human alveolar type II-like A549 cells were submitted in vitro to prolonged cyclic stretch. Bacteria were cultured in ...

journal_title：American journal of respiratory cell and molecular biology

authors： Pugin J,Dunn-Siegrist I,Dufour J,Tissières P,Charles PE,Comte R

更新日期：2008-03-01 00:00:00

abstract：:Over one-third of lung recipients have preexisting antibodies against lung-restricted antigens: collagen (Col) type V and K-α1 tubulin (KAT). Although clinical studies have shown association of these antibodies with primary graft dysfunction (PGD), their biological significance remains unclear. We tested whether preex...

journal_title：American journal of respiratory cell and molecular biology

authors： Bharat A,Chiu S,Zheng Z,Sun H,Yeldandi A,DeCamp MM,Perlman H,Budinger GR,Mohanakumar T

更新日期：2016-10-01 00:00:00

abstract：:PS-341 is a highly selective and potent proteasome inhibitor that is cytotoxic to various types of cancer. However, no objective response was seen in a clinical trial with PS-341 as a single agent in non-small cell lung cancer. Its antitumor activity is limited by the simultaneously activated antiapoptosis pathway. Re...

journal_title：American journal of respiratory cell and molecular biology

authors： Lee KH,Jang AH,Yoo CG

更新日期：2015-09-01 00:00:00

abstract：:A strong correlation exists between smoking and lung cancer; however, susceptibility to lung cancer among smokers is not uniform. Similarly, mice show differential susceptibility to the tobacco carcinogen nitrosamine 4-(methyl-nitrosamino)-1-(3-pyridyl)-1-butanone (NNK), which produces lung tumors in A/J but not in C3...

journal_title：American journal of respiratory cell and molecular biology

authors： Razani-Boroujerdi S,Sopori ML

更新日期：2007-01-01 00:00:00

abstract：:IL-1β is a potent proinflammatory cytokine that is implicated in the pathogenesis of acute respiratory distress syndrome. We hypothesized that LPS and mechanical ventilation (MV) together could lead to IL-1β secretion and the development of acute lung injury (ALI), and that this process would be dependent on caspase-1...

journal_title：American journal of respiratory cell and molecular biology

authors： Jones HD,Crother TR,Gonzalez-Villalobos RA,Jupelli M,Chen S,Dagvadorj J,Arditi M,Shimada K

更新日期：2014-02-01 00:00:00

abstract：:We have developed a method to harvest and culture Clara cells isolated from guinea pig lungs. Their identity was confirmed by the presence of CC16kD protein specific for these cells; we studied their capacity to generate endothelin 1 (ET-1). Using monoclonal antibody and immunofluorescence techniques, ET-1 was localiz...

journal_title：American journal of respiratory cell and molecular biology

authors： Laporte J,D'Orléans-Juste P,Sirois P

更新日期：1996-04-01 00:00:00

abstract：:We studied the relative roles of Duox2-derived reactive oxygen species (ROS) in host defense against influenza A virus (IAV) infection in normal human nasal epithelial cells and mouse nasal mucosa. We found that Duox2 primarily generated ROS rapidly after IAV infection in normal human nasal epithelial cells and that k...

journal_title：American journal of respiratory cell and molecular biology

authors： Kim HJ,Kim CH,Kim MJ,Ryu JH,Seong SY,Kim S,Lim SJ,Holtzman MJ,Yoon JH

更新日期：2015-10-01 00:00:00

abstract：:Glucose moves into airway secretions after a glucose load. Therefore people with diabetes or hyperglycemia spend a significant proportion of each day with glucose in their airways secretions. This study investigated the effects of glucose on isolated human airways and on cultured airway smooth muscle (ASM) cells. Huma...

journal_title：American journal of respiratory cell and molecular biology

authors： Cazzola M,Calzetta L,Rogliani P,Lauro D,Novelli L,Page CP,Kanabar V,Matera MG

更新日期：2012-10-01 00:00:00

abstract：:The doxycycline-inducible, gene regulatory system allows tight control of transgene expression for the study of organ development and disease pathogenesis. Multiple recent reports have employed this model to investigate various lung diseases including emphysema. For our study, we used this transgenic system to test wh...

journal_title：American journal of respiratory cell and molecular biology

authors： Sisson TH,Hansen JM,Shah M,Hanson KE,Du M,Ling T,Simon RH,Christensen PJ

更新日期：2006-05-01 00:00:00

abstract：:Surfactant protein D (SP-D) is believed to contribute to nonimmune host defense within the alveoli and distal airways of the lung. SP-D molecules can bind to specific carbohydrates on the surface of bacterial, fungal, and viral organisms and can also interact with membrane glycoconjugates expressed by alveolar macroph...

journal_title：American journal of respiratory cell and molecular biology

authors： Crouch EC,Persson A,Griffin GL,Chang D,Senior RM

更新日期：1995-04-01 00:00:00

abstract：:Neutrophils were found to demonstrate chemotactic responses to pepsinized human placental type IV collagen and its purified aminoterminal 7S domain. The maximal chemotactic responses occur at approximately 400 ng/ml and approximately 30 ng/ml of type IV collagen and 7S collagen, respectively, and are similar in magnit...

journal_title：American journal of respiratory cell and molecular biology

authors： Senior RM,Hinek A,Griffin GL,Pipoly DJ,Crouch EC,Mecham RP

更新日期：1989-12-01 00:00:00