Cytokines contribute to airway dysfunction in antigen-challenged guinea pigs: inhibition of airway hyperreactivity, pulmonary eosinophil accumulation, and tumor necrosis factor generation by pretreatment with an interleukin-1 receptor antagonist.

abstract：:β(2)-Adrenoceptor (β2AR) agonists are the most effective class of bronchodilators and a mainstay of asthma management. The first potent β2AR agonist discovered and widely used in reversing the airway constriction associated with asthma exacerbation was the endogenous activator of the β2AR, epinephrine. In this study, ...

journal_title：American journal of respiratory cell and molecular biology

authors： Thanawala VJ,Forkuo GS,Al-Sawalha N,Azzegagh Z,Nguyen LP,Eriksen JL,Tuvim MJ,Lowder TW,Dickey BF,Knoll BJ,Walker JK,Bond RA

更新日期：2013-02-01 00:00:00

abstract：:Notch is an ancient cell-signaling system that regulates the specification of cell fate. This study examined the role of Notch in the epithelial-mesenchymal transition (EMT) and myofibroblast differentiation of cultured RLE-6TN cells (i.e., rat alveolar epithelial cells). The activation of Notch, either by ectopic exp...

journal_title：American journal of respiratory cell and molecular biology

authors： Aoyagi-Ikeda K,Maeno T,Matsui H,Ueno M,Hara K,Aoki Y,Aoki F,Shimizu T,Doi H,Kawai-Kowase K,Iso T,Suga T,Arai M,Kurabayashi M

更新日期：2011-07-01 00:00:00

abstract：:The cells/proteases responsible for the development of smoke-induced emphysema is an area of intense investigation. Mice with knockout of macrophage metalloelastase genes (MME(-/-)) do not develop emphysema after smoke exposure, but we also observed that neutrophils (PMN) in lavage appeared to be a requirement for acu...

journal_title：American journal of respiratory cell and molecular biology

authors： Churg A,Zay K,Shay S,Xie C,Shapiro SD,Hendricks R,Wright JL

更新日期：2002-09-01 00:00:00

abstract：:Bronchiolitis obliterans (BO) is an increasingly important lung disease characterized by fibroproliferative airway lesions and decrements in lung function. Occupational exposure to the artificial food flavoring ingredient diacetyl, commonly used to impart a buttery flavor to microwave popcorn, has been associated with...

journal_title：American journal of respiratory cell and molecular biology

authors： Brass DM,Gwinn WM,Valente AM,Kelly FL,Brinkley CD,Nagler AE,Moseley MA,Morgan DL,Palmer SM,Foster MW

更新日期：2017-06-01 00:00:00

abstract：:Prenatal nicotine exposure impairs normal lung development and leads to diminished pulmonary function after birth. Previous work from our laboratory has demonstrated that nicotine alters lung development by affecting a nonneuronal cholinergic autocrine loop that is expressed in lung. Bronchial epithelial cells (BECs) ...

journal_title：American journal of respiratory cell and molecular biology

authors： Fu XW,Lindstrom J,Spindel ER

更新日期：2009-07-01 00:00:00

abstract：:Vitamin A deficiency strongly predicts the risk of developing tuberculosis (TB) in individuals exposed to Mycobacterium tuberculosis (Mtb). The burden of antibiotic-resistant TB is increasing globally; therefore, there is an urgent need to develop host-directed adjunctive therapies to treat TB. Alveolar macrophages, t...

journal_title：American journal of respiratory cell and molecular biology

authors： Coleman MM,Basdeo SA,Coleman AM,Cheallaigh CN,Peral de Castro C,McLaughlin AM,Dunne PJ,Harris J,Keane J

更新日期：2018-11-01 00:00:00

abstract：:Previous studies have shown that polymorphonuclear leukocytes (PMN) are delayed in the pulmonary capillaries by the presence of cigarette smoke. To determine if the PMN delayed by smoking are activated, we estimated the in vivo expression of CD11/CD18 and L-selectin on the surface of PMN in lungs and peripheral blood ...

journal_title：American journal of respiratory cell and molecular biology

authors： Klut ME,Doerschuk CM,Van Eeden SF,Burns AR,Hogg JC

更新日期：1993-07-01 00:00:00

abstract：:Toll-interacting protein (TOLLIP) is an intracellular adaptor protein with diverse actions throughout the body. In a context- and cell type-specific manner, TOLLIP can function as an inhibitor of inflammation and endoplasmic reticulum stress, an activator of autophagy, or a critical regulator of intracellular vacuole ...

journal_title：American journal of respiratory cell and molecular biology

authors： Li X,Goobie GC,Gregory AD,Kass DJ,Zhang Y

更新日期：2020-11-24 00:00:00

abstract：:Normal lung structure is maintained by the presence of mesenchymal cells and their extracellular matrix products. The slow normal turnover of these cells is disrupted in fibrotic disorders, resulting in the in situ accumulation of mesenchymal cells and their extracellular matrix leading to a progressive alveolar wall ...

journal_title：American journal of respiratory cell and molecular biology

authors： Vignaud JM,Allam M,Martinet N,Pech M,Plenat F,Martinet Y

更新日期：1991-12-01 00:00:00

abstract：:Asbestos causes asbestosis and malignancies by mechanisms that are not fully established. Alveolar epithelial cell (AEC) injury and repair are crucial determinants of the fibrogenic potential of noxious agents such as asbestos. We previously showed that mitochondrial reactive oxygen species mediate asbestos-induced AE...

journal_title：American journal of respiratory cell and molecular biology

authors： Cheresh P,Morales-Nebreda L,Kim SJ,Yeldandi A,Williams DB,Cheng Y,Mutlu GM,Budinger GR,Ridge K,Schumacker PT,Bohr VA,Kamp DW

更新日期：2015-01-01 00:00:00

abstract：:The oleic acid (OA) model of acute lung injury in rats is characterized by a massive and rapid influx of polymorphonuclear neutrophils (PMN) within 1 h, with a peak inflammatory response at 4 h and resolution by 72 h. We hypothesized that PMN apoptosis is involved in the resolution of OA-induced acute lung injury. To ...

journal_title：American journal of respiratory cell and molecular biology

authors： Hussain N,Wu F,Zhu L,Thrall RS,Kresch MJ

更新日期：1998-12-01 00:00:00

abstract：:Sox2, a transcription factor critical for the maintenance of embryonic stem cells and induction of pluripotent stem cells, is expressed exclusively in the conducting airway epithelium of the lung, where it is required for differentiation of nonciliated, goblet, and ciliated cells. To determine the role of Sox2 in resp...

journal_title：American journal of respiratory cell and molecular biology

authors： Tompkins DH,Besnard V,Lange AW,Keiser AR,Wert SE,Bruno MD,Whitsett JA

更新日期：2011-07-01 00:00:00

abstract：:Pure nicotine impairs macrophage killing of Mycobacterium tuberculosis (MTB), but it is not known whether the nicotine component in cigarette smoke (CS) plays a role. Moreover, the mechanisms by which nicotine impairs macrophage immunity against MTB have not been explored. To neutralize the effects of nicotine in CS e...

journal_title：American journal of respiratory cell and molecular biology

authors： Bai X,Stitzel JA,Bai A,Zambrano CA,Phillips M,Marrack P,Chan ED

更新日期：2017-09-01 00:00:00

abstract：:Lower respiratory tract infection by respiratory syncytial virus (RSV) is a frequent cause of acute lung injury in young children and infants. Studies in adults and animals suggest that tumor necrosis factor receptor (TNFR) ligands may mediate lung injury by causing apoptosis of epithelial cells. The main goal of the ...

journal_title：American journal of respiratory cell and molecular biology

authors： Bem RA,Bos AP,Wösten-van Asperen RM,Bruijn M,Lutter R,Sprick MR,van Woensel JB

更新日期：2010-06-01 00:00:00

abstract：:The application of conditional reprogramming culture (CRC) methods to nasal airway epithelial cells would allow more wide-spread incorporation of primary airway epithelial culture models into complex lung disease research. In this study, we adapted the CRC method to nasal airway epithelial cells, investigated the grow...

journal_title：American journal of respiratory cell and molecular biology

authors： Reynolds SD,Rios C,Wesolowska-Andersen A,Zhuang Y,Pinter M,Happoldt C,Hill CL,Lallier SW,Cosgrove GP,Solomon GM,Nichols DP,Seibold MA

更新日期：2016-09-01 00:00:00

abstract：:Despite respiratory syncytial virus (RSV) bronchiolitis remaining the most common cause of lower respiratory tract disease in infants worldwide, treatment has progressed little in the past 30 years. The aim of our study was to determine whether post-infection administration of de novo pyrimidine synthesis inhibitors c...

journal_title：American journal of respiratory cell and molecular biology

authors： Davis IC,Lazarowski ER,Chen FP,Hickman-Davis JM,Sullender WM,Matalon S

更新日期：2007-10-01 00:00:00

abstract：:Nontypable Haemophilus influenzae (NTHI) is being increasingly recognized as a cause of both adult pneumonia and acute infectious exacerbations in chronic bronchitis. We used a mouse model to study the immune enhancement of pulmonary clearance of NTHI after a primary immunization. BALB/c mice were immunized with whole...

journal_title：American journal of respiratory cell and molecular biology

authors： McGehee JL,Radolf JD,Toews GB,Hansen EJ

更新日期：1989-09-01 00:00:00

abstract：:Fibroblasts are the major mesenchymal cells present within the interstitium of the lung and are a major source of vascular endothelial growth factor (VEGF), which modulates the maintenance of pulmonary microvasculature. Prostaglandin E(2) (PGE(2)) acts on a set of E-prostanoid (EP) receptors that activate multiple sig...

journal_title：American journal of respiratory cell and molecular biology

authors： Nakanishi M,Sato T,Li Y,Nelson AJ,Farid M,Michalski J,Kanaji N,Wang X,Basma H,Patil A,Goraya J,Liu X,Togo S,L Toews M,Holz O,Muller KC,Magnussen H,Rennard SI

更新日期：2012-02-01 00:00:00

abstract：:Nrf2 is a leucine zipper transcription factor that protects against oxidant-induced injury. Nontypeable Haemophilus influenzae is responsible for frequent disease exacerbations in patients with chronic obstructive pulmonary disease and is responsible for causing otitis media in young children. We hypothesized that Nrf...

journal_title：American journal of respiratory cell and molecular biology

authors： Lugade AA,Vethanayagam RR,Nasirikenari M,Bogner PN,Segal BH,Thanavala Y

更新日期：2011-09-01 00:00:00

abstract：:A murine model was used to assess the role of cytokines in initiating protective T-cell-mediated immunity in the lung. A pulmonary infection was initiated by intratracheal inoculation of Cryptococcus neoformans (Cne). Previously, we had established that Cne lung clearance was mouse-strain-specific: C.B-17 mice were re...

journal_title：American journal of respiratory cell and molecular biology

authors： Hoag KA,Lipscomb MF,Izzo AA,Street NE

更新日期：1997-12-01 00:00:00

abstract：:The gaseous molecule carbon monoxide (CO) is elevated in the breath of individuals with asthma. The physiologic function of CO in asthma is poorly understood. Here we demonstrate that CO (250 ppm) markedly inhibits human airway smooth muscle cell (HASMC) proliferation, arresting cells at the G0/G1 phase. This CO-induc...

journal_title：American journal of respiratory cell and molecular biology

authors： Song R,Mahidhara RS,Liu F,Ning W,Otterbein LE,Choi AM

更新日期：2002-11-01 00:00:00

abstract：:Tissue inhibitors of metalloproteinases (TIMPs) are multifunctional proteins that have the capacity to modify cellular activities and to modulate matrix turnover. We demonstrate that TIMP-1 messenger RNA (mRNA) and protein expression are selectively and markedly increased in a murine model of bleomycin-induced pulmona...

journal_title：American journal of respiratory cell and molecular biology

authors： Madtes DK,Elston AL,Kaback LA,Clark JG

更新日期：2001-05-01 00:00:00

abstract：:Neutrophil elastase (NE) is a major inflammatory mediator in cystic fibrosis (CF) that is a robust predictor of lung disease progression. NE directly causes airway injury via protease activity, and propagates persistent neutrophilic inflammation by up-regulation of neutrophil chemokine expression. Despite its key role...

journal_title：American journal of respiratory cell and molecular biology

authors： Griffin KL,Fischer BM,Kummarapurugu AB,Zheng S,Kennedy TP,Rao NV,Foster WM,Voynow JA

更新日期：2014-04-01 00:00:00

abstract：:Important characteristics of chronic obstructive pulmonary disease (COPD) include airway and vascular remodeling, the molecular mechanisms of which are poorly understood. We assessed the role of fibroblast growth factors (FGF) in pulmonary vascular remodeling by examining the expression pattern of FGF-1, FGF-2, and th...

journal_title：American journal of respiratory cell and molecular biology

authors： Kranenburg AR,De Boer WI,Van Krieken JH,Mooi WJ,Walters JE,Saxena PR,Sterk PJ,Sharma HS

更新日期：2002-11-01 00:00:00

abstract：:Human alveolar macrophages (HAM) express FcalphaR receptors for immunoglobulin (Ig)A which could link humoral and cellular branches of lung immunity. Here, we investigate the effects of polymeric (p-IgA) and secretory (S-IgA) IgA interaction with Fc(alpha)R on lipopolysaccharide (LPS)- and phorbol myristate acetate (P...

journal_title：American journal of respiratory cell and molecular biology

authors： Ouadrhiri Y,Pilette C,Monteiro RC,Vaerman JP,Sibille Y

更新日期：2002-03-01 00:00:00

abstract：:Regulatory T cells (Tregs) play an essential role in maintaining the homeostatic balance of immune responses. Asthma is an inflammatory condition of the airways that is driven by dysregulated immune responses toward normally innocuous antigens. Individuals with asthma have fewer and less functional Tregs, which may le...

journal_title：American journal of respiratory cell and molecular biology

authors： Thorburn AN,Hansbro PM

更新日期：2010-11-01 00:00:00

abstract：:Pulmonary fibrosis is an enigmatic and devastating disease with few treatment options, now thought to result from abnormal wound healing in the lung in response to injury. We have previously noted a role for the chemokine interferon gamma-inducible protein of 10 kD (IP-10)/CXC chemokine ligand 10 in the regulation of ...

journal_title：American journal of respiratory cell and molecular biology

authors： Tager AM,Kradin RL,LaCamera P,Bercury SD,Campanella GS,Leary CP,Polosukhin V,Zhao LH,Sakamoto H,Blackwell TS,Luster AD

更新日期：2004-10-01 00:00:00

abstract：:We recently described overproduction of interferon (IFN)-gamma by lung lymphocytes in mice with silicosis (11% of cells in air-control versus 19% of cells from silica-exposed mice; Davis and colleagues, Am. J. Respir. Cell Mol. Biol. 1999;20:813-824). We hypothesized that the increased IFN-gamma production might be du...

journal_title：American journal of respiratory cell and molecular biology

authors： Davis GS,Pfeiffer LM,Hemenway DR

更新日期：2000-04-01 00:00:00

abstract：:Extensive tissue remodeling occurs in survivors of acute lung injury, leading to nearly normal histology and physiology in the majority of individuals, whereas others suffer significant impairment due to the development of pulmonary fibrosis. Alveolar epithelial cells play a central role in the repair process. They ar...

journal_title：American journal of respiratory cell and molecular biology

authors： Hasegawa T,Sorensen L,Dohi M,Rao NV,Hoidal JR,Marshall BC

更新日期：1997-06-01 00:00:00

abstract：:Using a rat model of acute lung inflammation induced by intratracheal instillation of lipopolysaccharide (LPS), we investigated the kinetics of mRNA expression and the potential cellular sources of tumor necrosis factor-alpha (TNF-alpha), macrophage inflammatory protein-2 (MIP-2), interleukin (IL)-1 beta, IL-6, RANTES...

journal_title：American journal of respiratory cell and molecular biology

authors： Xing Z,Jordana M,Kirpalani H,Driscoll KE,Schall TJ,Gauldie J

更新日期：1994-02-01 00:00:00