Cyclic AMP-mobilizing agents and glucocorticoids modulate human smooth muscle cell migration.

abstract：:The complement system plays a critical role in immune responses against pathogens. However, its identity and regulation in the lung are not fully understood. This study aimed to explore the role of tripartite motif protein (TRIM) 72 in regulating complement receptor (CR) of the Ig superfamily (CRIg) in alveolar macrop...

journal_title：American journal of respiratory cell and molecular biology

authors： Nagre N,Cong X,Terrazas C,Pepper I,Schreiber JM,Fu H,Sill JM,Christman JW,Satoskar AR,Zhao X

更新日期：2018-06-01 00:00:00

abstract：:The mechanisms used by alveolar type I pneumocytes for maintenance of the lipid homeostasis necessary to sustain these large squamous cells are unknown. The processes may involve the ATP-binding cassette transporter A1 (ABCA1), a transport protein shown to be crucial in apolipoprotein A-I (apoA-I)-mediated mobilizatio...

journal_title：American journal of respiratory cell and molecular biology

authors： Bates SR,Tao JQ,Yu KJ,Borok Z,Crandall ED,Collins HL,Rothblat GH

更新日期：2008-03-01 00:00:00

abstract：:The precise role of each nitric oxide (NO) synthase (NOS) isoform in the pathobiology of asthma is not well established. Our objective was to investigate the contribution of constitutive NO synthase (cNOS) and inducible NOS (iNOS) isoforms to lung mechanics and inflammatory and remodeling responses in an experimental ...

journal_title：American journal of respiratory cell and molecular biology

authors： Prado CM,Leick-Maldonado EA,Yano L,Leme AS,Capelozzi VL,Martins MA,Tibério IF

更新日期：2006-10-01 00:00:00

abstract：:Oxidants in cigarette smoke inhibit pathogen recognition receptor function and phagocytosis, but the molecular basis of this inhibition remains obscure. We sought to identify the inhibitory mechanisms that impair alveolar macrophage function. Balb/c mice were acutely exposed to four cigarettes for 4 hours before treat...

journal_title：American journal of respiratory cell and molecular biology

authors： Bozinovski S,Vlahos R,Zhang Y,Lah LC,Seow HJ,Mansell A,Anderson GP

更新日期：2011-08-01 00:00:00

abstract：:The increase of airway smooth muscle (ASM) mass in asthma results from hypertrophic and hyperplastic stimuli, and leads to an increase in cellular contractile proteins. However, little evidence correlates the relative contributions of hypertrophic and hyperplastic muscle with functional effects on airway resistance. W...

journal_title：American journal of respiratory cell and molecular biology

authors： Plant PJ,North ML,Ward A,Ward M,Khanna N,Correa J,Scott JA,Batt J

更新日期：2012-04-01 00:00:00

abstract：:Nontypable Haemophilus influenzae (NTHI) is being increasingly recognized as a cause of both adult pneumonia and acute infectious exacerbations in chronic bronchitis. We used a mouse model to study the immune enhancement of pulmonary clearance of NTHI after a primary immunization. BALB/c mice were immunized with whole...

journal_title：American journal of respiratory cell and molecular biology

authors： McGehee JL,Radolf JD,Toews GB,Hansen EJ

更新日期：1989-09-01 00:00:00

abstract：:T helper 2 (Th2)-like cytokines are thought to play a crucial role in the pathogenesis of airway inflammation in atopic asthma, leading to bronchial hyperresponsiveness. To investigate the role of the principal Th2 cytokine interleukin-4 (IL-4) in asthma, we examined the allergen-induced changes in airway morphology a...

journal_title：American journal of respiratory cell and molecular biology

authors： Brusselle G,Kips J,Joos G,Bluethmann H,Pauwels R

更新日期：1995-03-01 00:00:00

abstract：:Increases in inflammatory-cell progenitors have been demonstrated in the bone marrow (BM) after inhalation of Ascaris suum in dogs at the time of allergen-induced airway hyperresponsiveness (AHR). The aim of this study was to evaluate the effect of allergen challenge on trafficking of inflammatory cells and their prog...

journal_title：American journal of respiratory cell and molecular biology

authors： Wood LJ,Inman MD,Denburg JA,O'Byrne PM

更新日期：1998-06-01 00:00:00

abstract：:Keratinocyte growth factor (KGF) or fibroblast growth factor (FGF)-7, a peptide produced by stromal cells and in particular by lung mesenchyme, has recently been shown to influence early lung morphogenesis and to be a mitogen for fetal and adult alveolar type II cells. Although contradictory findings have been reporte...

journal_title：American journal of respiratory cell and molecular biology

authors： Chelly N,Mouhieddine-Gueddiche OB,Barlier-Mur AM,Chailley-Heu B,Bourbon JR

更新日期：1999-03-01 00:00:00

abstract：:Airway inflammation, hyperreactivity, increased number of goblet cells, and mucus overproduction characterize asthma. Respiratory challenge with ovalbumin (OVA) of sensitized mice has been shown by several laboratories to cause pulmonary pathology similar to that observed in human allergic asthma. Recently, interleuki...

journal_title：American journal of respiratory cell and molecular biology

authors： Zuhdi Alimam M,Piazza FM,Selby DM,Letwin N,Huang L,Rose MC

更新日期：2000-03-01 00:00:00

abstract：:Extracellular signal-regulated kinases (ERKs) phosphorylate and regulate cytoskeletal components of contractile cells and have been implicated in integrin-mediated adhesion. In this study, we examined the contributions of adherence, cell flattening, and cytoskeletal reorganization to adhesion-induced ERK activation in...

journal_title：American journal of respiratory cell and molecular biology

authors： Heuertz RM,Hamann KJ,Hershenson MB,Leff AR

更新日期：1997-10-01 00:00:00

abstract：:The lung epithelium constitutes a selective barrier that separates the airways from the aqueous interstitial compartment. Regulated barrier function controls water and ion transport across the epithelium and is essential for maintaining lung function. Tight junctions (TJs) seal the epithelial barrier and determine the...

journal_title：American journal of respiratory cell and molecular biology

authors： Kielgast F,Schmidt H,Braubach P,Winkelmann VE,Thompson KE,Frick M,Dietl P,Wittekindt OH

更新日期：2016-05-01 00:00:00

abstract：:Specific changes in composition and content of lung extracellular matrix (ECM) proteoglycans (PGs) and hyaluronan (HA) have been observed during the acute response to damage in several forms of injury including infant respiratory distress syndrome (IRDS). These ECM components are thought to modulate the healing respon...

journal_title：American journal of respiratory cell and molecular biology

authors： Juul SE,Krueger RC Jr,Scofield L,Hershenson MB,Schwartz NB

更新日期：1995-12-01 00:00:00

abstract：:Chemokine receptor (CCR) 5 is expressed on dendritic cells, macrophages, CD8 cells, memory CD4 T cells, and stromal cells, and is frequently used as a marker of T helper type 1 cells. Interventions that abrogate CCR5 or interfere with its ligand binding have been shown to alter T helper type 2-induced inflammatory res...

journal_title：American journal of respiratory cell and molecular biology

authors： Fuchimoto Y,Kanehiro A,Miyahara N,Koga H,Ikeda G,Waseda K,Tanimoto Y,Ueha S,Kataoka M,Gelfand EW,Tanimoto M

更新日期：2011-12-01 00:00:00

abstract：:An NADPH-oxidase complex containing at least two protein components (gp91-phox and p22-phox) and a unique low redox potential (-245 mV) cytochrome b-245 is the source of superoxide generated for bacterial killing in neutrophils and has been suggested as the oxygen sensor in the carotid body. In pure cultures of smooth...

journal_title：American journal of respiratory cell and molecular biology

authors： Marshall C,Mamary AJ,Verhoeven AJ,Marshall BE

更新日期：1996-11-01 00:00:00

abstract：:A number of metalloproteinases that degrade the extracellular matrix of connective tissues and two specific tissue inhibitors of metalloproteinases (TIMPs) have now been isolated, characterized, and cloned. Comparison of the enzyme sequences has allowed the delineation of domain structures, and initial studies have be...

journal_title：American journal of respiratory cell and molecular biology

authors： Murphy G,Docherty AJ

更新日期：1992-08-01 00:00:00

abstract：:The cytokine mRNA profiles of primary (arising from inhaled bacilli) and secondary (arising from hematogenous reseeding of the lung) granulomas from the lung lobes of bacillus Calmette-Guérin (BCG)-vaccinated and unimmunized guinea pigs challenged with virulent Mycobacterium tuberculosis by the pulmonary route were as...

journal_title：American journal of respiratory cell and molecular biology

authors： Ly LH,Russell MI,McMurray DN

更新日期：2008-04-01 00:00:00

abstract：:Mechanical ventilation with high tidal volumes has been associated with pulmonary alveolar flooding. Understanding the mechanisms underlying cyclic stretch-induced increases in alveolar epithelial permeability may be important in designing preventive measures for acute lung injury. In this work, we assessed whether cy...

journal_title：American journal of respiratory cell and molecular biology

authors： Davidovich N,DiPaolo BC,Lawrence GG,Chhour P,Yehya N,Margulies SS

更新日期：2013-07-01 00:00:00

abstract：:Idiopathic pulmonary fibrosis (IPF) is a progressive, scarring lung disease characterized by fibroblast accumulation and deposition of collagen. Factors that promote growth and/or survival of fibroblasts are potential therapeutic targets. Methionine aminopeptidase 2 (MetAP2), a member of the aminopeptidase family of p...

journal_title：American journal of respiratory cell and molecular biology

authors： Kass D,Bridges RS,Borczuk A,Greenberg S

更新日期：2007-08-01 00:00:00

abstract：:Airway infections or irritant exposures during early postnatal periods may contribute to the onset of childhood asthma. The purpose of this study was to examine critical periods of postnatal airway development during which ozone (O(3)) exposure leads to heightened neural responses. Rats were exposed to O(3) (2 ppm) or...

journal_title：American journal of respiratory cell and molecular biology

authors： Hunter DD,Wu Z,Dey RD

更新日期：2010-12-01 00:00:00

abstract：:Extensive tissue remodeling occurs in survivors of acute lung injury, leading to nearly normal histology and physiology in the majority of individuals, whereas others suffer significant impairment due to the development of pulmonary fibrosis. Alveolar epithelial cells play a central role in the repair process. They ar...

journal_title：American journal of respiratory cell and molecular biology

authors： Hasegawa T,Sorensen L,Dohi M,Rao NV,Hoidal JR,Marshall BC

更新日期：1997-06-01 00:00:00

abstract：:Stimulated migration of eosinophils out of the bloodstream and into the lung is key in the development of tissue eosinophilia and inflammation in asthma. Platelet-activating factor (PAF) has been implicated as an important inflammatory mediator in asthma pathogenesis in part because of its chemotactic capacity. We the...

journal_title：American journal of respiratory cell and molecular biology

authors： Casale TB,Erger RA,Little MM

更新日期：1993-01-01 00:00:00

abstract：:Monkey Clara cell 10 kDa protein (CC10) was purified from monkey lung lavage. This protein showed an apparent molecular weight of about 10 kDa and 5 kDa under non-reducing and reducing conditions, respectively, as determined by sodium dodecyl sulfate-polyacrylamide gel electrophoresis. From the amino acid sequence dat...

journal_title：American journal of respiratory cell and molecular biology

authors： Hashimoto S,Nakagawa K,Sueishi K

更新日期：1996-09-01 00:00:00

abstract：:Airway epithelial cells produce a number of chemokines, including eotaxins. Among the three known eotaxins, T helper (Th) type 2 cytokines have been observed to induce the expression of eotaxin-3 mRNA. This study investigated the effect of interferon (IFN)-gamma, a Th1 cytokine, on Th2 cytokine-induced eotaxin-3 produ...

journal_title：American journal of respiratory cell and molecular biology

authors： Yamamoto S,Kobayashi I,Tsuji K,Nishi N,Muro E,Miyazaki M,Zaitsu M,Inada S,Ichimaru T,Hamasaki Y

更新日期：2004-10-01 00:00:00

abstract：:Mechanical ventilation with supraphysiological concentrations of oxygen (hyperoxia) is routinely used to treat patients with respiratory distress. However, a significant number of patients on ventilators exhibit enhanced susceptibility to infections and develop ventilator-associated pneumonia (VAP). Pseudomonas aerugi...

journal_title：American journal of respiratory cell and molecular biology

authors： Patel VS,Sitapara RA,Gore A,Phan B,Sharma L,Sampat V,Li JH,Yang H,Chavan SS,Wang H,Tracey KJ,Mantell LL

更新日期：2013-03-01 00:00:00

abstract：:Lung injury is a frequent consequence of oxygen (O2) therapy administered to newborns and adults with respiratory distress. Acute exposure to hyperoxia results in a well-described pathophysiologic response in the lungs. Because inflammation is an important component of pulmonary O2 toxicity, we have an interest in ide...

journal_title：American journal of respiratory cell and molecular biology

authors： Piedboeuf B,Gamache M,Frenette J,Horowitz S,Baldwin HS,Petrov P

更新日期：1998-10-01 00:00:00

abstract：:Airway surface fluids are mainly secreted from submucosal glands, and play important roles in the defense of airways via the up-regulation of mucociliary transport, resulting in an exclusion of many microbes or foreign substances. Although there are many articles concerning the importance of Toll-like receptors (TLRs)...

journal_title：American journal of respiratory cell and molecular biology

authors： Murakami K,Tamada T,Nara M,Muramatsu S,Kikuchi T,Kanehira M,Maruyama Y,Ebina M,Nukiwa T

更新日期：2011-11-01 00:00:00

abstract：:Smoking cigarettes is the major risk factor for chronic obstructive pulmonary disease (COPD). COPD is a condition associated with chronic pulmonary inflammation, characterized by macrophage activation, neutrophil recruitment, and cell injury. Many substances contained in cigarette smoke, including reactive oxygen spec...

journal_title：American journal of respiratory cell and molecular biology

authors： Facchinetti F,Amadei F,Geppetti P,Tarantini F,Di Serio C,Dragotto A,Gigli PM,Catinella S,Civelli M,Patacchini R

更新日期：2007-11-01 00:00:00

abstract：:Patients with severe acute and chronic lung diseases develop derangements in gas exchange that may result in increased levels of CO(2) (hypercapnia), the effects of which on human health are incompletely understood. It has been proposed that hypercapnia may have beneficial effects in patients with acute lung injury, a...

journal_title：American journal of respiratory cell and molecular biology

authors： Vadász I,Hubmayr RD,Nin N,Sporn PH,Sznajder JI

更新日期：2012-04-01 00:00:00

abstract：:Prior studies have demonstrated that human alveolar macrophages (AM) are suppressive of lymphocyte function, through the mechanism of inhibition is unclear. In the current study, human AM inhibited receptor-mediated increases in intracellular calcium concentration ([Ca2+]i) in T cells, natural killer cells, and B cell...

journal_title：American journal of respiratory cell and molecular biology

authors： Yarbrough WC Jr,Wilkes DS,Weissler JC

更新日期：1991-11-01 00:00:00