Requirement for chemokine receptor 5 in the development of allergen-induced airway hyperresponsiveness and inflammation.

abstract：:We have tested the murine macrophagic cell line RAW 264.7 for its ability to undergo activation after exposure to silica particles in vitro. When exposed to silica under controlled conditions (each cell having access to about 10 silica particles), RAW 264.7 cells were able to phagocytose the particles. Concomitantly, ...

journal_title：American journal of respiratory cell and molecular biology

authors： Claudio E,Segade F,Wróbel K,Ramos S,Lazo PS

更新日期：1995-11-01 00:00:00

abstract：:Interleukin (IL)-4 and (IL)-13 induce immunoglobulin (Ig)E synthesis via activation of the transcription factor signal transducer and activator of transcription (Stat)6. The present study describes the identification and characterization of antisense oligonucleotides to Stat6 as an approach to interrupt IL-4 and IL-13...

journal_title：American journal of respiratory cell and molecular biology

authors： Hill S,Herlaar E,Le Cardinal A,van Heeke G,Nicklin P

更新日期：1999-12-01 00:00:00

abstract：:Important characteristics of chronic obstructive pulmonary disease (COPD) include airway and vascular remodeling, the molecular mechanisms of which are poorly understood. We assessed the role of fibroblast growth factors (FGF) in pulmonary vascular remodeling by examining the expression pattern of FGF-1, FGF-2, and th...

journal_title：American journal of respiratory cell and molecular biology

authors： Kranenburg AR,De Boer WI,Van Krieken JH,Mooi WJ,Walters JE,Saxena PR,Sterk PJ,Sharma HS

更新日期：2002-11-01 00:00:00

abstract：:Fibroblasts are the major mesenchymal cells present within the interstitium of the lung and are a major source of vascular endothelial growth factor (VEGF), which modulates the maintenance of pulmonary microvasculature. Prostaglandin E(2) (PGE(2)) acts on a set of E-prostanoid (EP) receptors that activate multiple sig...

journal_title：American journal of respiratory cell and molecular biology

authors： Nakanishi M,Sato T,Li Y,Nelson AJ,Farid M,Michalski J,Kanaji N,Wang X,Basma H,Patil A,Goraya J,Liu X,Togo S,L Toews M,Holz O,Muller KC,Magnussen H,Rennard SI

更新日期：2012-02-01 00:00:00

abstract：:Airway epithelial cell defenses to viral infections are often compromised in disease or injury. Danger molecules, including ATP, are released during infection and contribute to nucleotide receptor-dependent inflammatory responses, largely through P2X(7). Although respiratory epithelium has been shown to express a vari...

journal_title：American journal of respiratory cell and molecular biology

authors： Shi L,Manthei DM,Guadarrama AG,Lenertz LY,Denlinger LC

更新日期：2012-09-01 00:00:00

abstract：:A number of mechanisms participate in virus-induced asthma. Previously, we described enhanced basophil histamine release (HR) during an experimentally induced rhinovirus infection and after in vitro incubation of peripheral blood mononuclear cells (PBMC) with influenza virus. This study extends our previous observatio...

journal_title：American journal of respiratory cell and molecular biology

authors： Huftel MA,Swensen CA,Borcherding WR,Dick EC,Hong R,Kita H,Gleich GJ,Busse WW

更新日期：1992-10-01 00:00:00

abstract：:The extracellular signal-regulated kinases 1 and 2 (ERK1/2) are phosphorylated after inhalation of asbestos. The effect of blocking this signaling pathway in lung epithelium is unclear. Asbestos-exposed transgenic mice expressing a dominant-negative mitogen-activated protein kinase kinase-1 (dnMEK1) (i.e., the upstrea...

journal_title：American journal of respiratory cell and molecular biology

authors： Manning CB,Sabo-Attwood T,Robledo RF,Macpherson MB,Rincón M,Vacek P,Hemenway D,Taatjes DJ,Lee PJ,Mossman BT

更新日期：2008-05-01 00:00:00

abstract：:Primary pulmonary hypertension is characterized by increased pulmonary vascular resistance and smooth muscle proliferation. Stable analogs are increasingly being used to treat this disease, although no data exists comparing their effects on proliferation. We therefore investigated the antiproliferative activity of sev...

journal_title：American journal of respiratory cell and molecular biology

authors： Clapp LH,Finney P,Turcato S,Tran S,Rubin LJ,Tinker A

更新日期：2002-02-01 00:00:00

abstract：:The genetic determinants underlying susceptibility to acute lung injury have not been identified. Recently, we found that the strain distribution pattern for mean survival time (MST) to three irritants-ozone, ultrafine Teflon, and nickel sulfate- was shared between inbred mouse strains. For ozone-induced acute lung in...

journal_title：American journal of respiratory cell and molecular biology

authors： Prows DR,Leikauf GD

更新日期：2001-06-01 00:00:00

abstract：:Oxygen-mediated lung injury can stimulate a fibroproliferative response resulting in the alteration of the pulmonary extracellular matrix and subsequent scarring of parenchymal tissue. Fibronectin (FN), a component of the extracellular matrix, appears in increased quantities in fibrotic lung disease. Alveolar macropha...

journal_title：American journal of respiratory cell and molecular biology

authors： Sinkin RA,LoMonaco MB,Finkelstein JN,Watkins RH,Cox C,Horowitz S

更新日期：1992-11-01 00:00:00

abstract：:Clara cell secretory protein (CCSP), or CC10, is an inhibitor of secretory phospholipase A2 which may be produced by phagocytic cells and by a variety of other cells in the airway. Tumor necrosis factor-alpha (TNF-alpha) is capable of activating phospholipases and inducing the expression of a variety of genes in the a...

journal_title：American journal of respiratory cell and molecular biology

authors： Yao XL,Levine SJ,Cowan MJ,Logun C,Shelhamer JH

更新日期：1998-10-01 00:00:00

abstract：:T helper 2 (Th2)-like cytokines are thought to play a crucial role in the pathogenesis of airway inflammation in atopic asthma, leading to bronchial hyperresponsiveness. To investigate the role of the principal Th2 cytokine interleukin-4 (IL-4) in asthma, we examined the allergen-induced changes in airway morphology a...

journal_title：American journal of respiratory cell and molecular biology

authors： Brusselle G,Kips J,Joos G,Bluethmann H,Pauwels R

更新日期：1995-03-01 00:00:00

abstract：:Tissue factor (TF) is best known as a cellular initiator of coagulation, but it is also a multifunctional protein that has been implicated in multiple pathophysiologic conditions, including asthma. In the lung, airway epithelial cells express TF, but it is unknown how TF expression is regulated by asthma-associated me...

journal_title：American journal of respiratory cell and molecular biology

authors： Mitchel JA,Antoniak S,Lee JH,Kim SH,McGill M,Kasahara DI,Randell SH,Israel E,Shore SA,Mackman N,Park JA

更新日期：2016-04-01 00:00:00

abstract：:A murine model was used to assess the role of cytokines in initiating protective T-cell-mediated immunity in the lung. A pulmonary infection was initiated by intratracheal inoculation of Cryptococcus neoformans (Cne). Previously, we had established that Cne lung clearance was mouse-strain-specific: C.B-17 mice were re...

journal_title：American journal of respiratory cell and molecular biology

authors： Hoag KA,Lipscomb MF,Izzo AA,Street NE

更新日期：1997-12-01 00:00:00

abstract：:Ozone (O3) is the principal oxidant pollutant in photochemical smog. Repeated exposures to O3 induces inflammation and mucous cell metaplasia in the nasal airways of laboratory animals. Our study was designed to determine the efficacy of a topical anti-inflammatory corticosteroid in preventing O3-induced rhinitis and ...

journal_title：American journal of respiratory cell and molecular biology

authors： Hotchkiss JA,Hilaski R,Cho H,Regan K,Spencer P,Slack K,Harkema JR

更新日期：1998-01-01 00:00:00

abstract：:Alveolar macrophages (AM) express gelatinase B, a member of the matrix metalloproteinase family involved in the degradation and remodeling of extracellular matrix components. We evaluated the expression of gelatinase B in the course of idiopathic pulmonary fibrosis (IPF) by studying alveolar macrophages in culture AM ...

journal_title：American journal of respiratory cell and molecular biology

authors： Lemjabbar H,Gosset P,Lechapt-Zalcman E,Franco-Montoya ML,Wallaert B,Harf A,Lafuma C

更新日期：1999-05-01 00:00:00

abstract：:To examine the effects of acid exposure on the adherence of Streptococcus pneumoniae to cultured human tracheal epithelial cells, cells were exposed to acid at various pH levels, and various concentrations of S. pneumoniae were added to the culture medium. The number of S. pneumoniae adhering to cultured human trachea...

journal_title：American journal of respiratory cell and molecular biology

authors： Ishizuka S,Yamaya M,Suzuki T,Nakayama K,Kamanaka M,Ida S,Sekizawa K,Sasaki H

更新日期：2001-04-01 00:00:00

abstract：:Bitter taste receptor (TAS2R) agonists dilate airways by receptor-dependent smooth muscle relaxation. Besides their coupling to relaxation, we have found that human airway smooth muscle (HASM) cell TAS2Rs activate (phosphorylate) extracellular signal-related kinase 1/2 (ERK1/2), but the cellular effects are not known....

journal_title：American journal of respiratory cell and molecular biology

authors： Kim D,Cho S,Castaño MA,Panettieri RA,Woo JA,Liggett SB

更新日期：2019-05-01 00:00:00

abstract：:Lung elastin synthesis is normally confined to periods of development, is maximal during alveolarization, and declines to low levels in mature lung. We have previously described an elastogenic response in the adult rat lung associated with experimental granulomatous disease induced by silica instillation. Reinitiated ...

journal_title：American journal of respiratory cell and molecular biology

authors： Mariani TJ,Arikan MC,Pierce RA

更新日期：1999-08-01 00:00:00

abstract：:Alveolar epithelial cells are directly exposed to acute and chronic fluctuations in alveolar oxygen tension. Previously, we found that the oxygen-binding protein hemoglobin is expressed in alveolar Type II cells (ATII). Here, we report that ATII cells also express a number of highly specific transcription factors and ...

journal_title：American journal of respiratory cell and molecular biology

authors： Grek CL,Newton DA,Spyropoulos DD,Baatz JE

更新日期：2011-04-01 00:00:00

abstract：:Hydrogen sulfide (H2S), a novel signaling gasotransmitter in the respiratory system, may have antiinflammatory properties in the lung. We examined the preventive and therapeutic effects of H2S on ozone-induced features of lung inflammation and emphysema. C57/BL6 mice were exposed to ozone or filtered air over 6 weeks....

journal_title：American journal of respiratory cell and molecular biology

authors： Li F,Zhang P,Zhang M,Liang L,Sun X,Li M,Tang Y,Bao A,Gong J,Zhang J,Adcock I,Chung KF,Zhou X

更新日期：2016-07-01 00:00:00

abstract：:Silicosis is a chronic lung disease induced by the inhalation of crystalline silica. Exposure of cultured macrophages to crystalline silica leads to cell death; however, the mechanism of cell-particle interaction, the fate of particles, and the cause of death are unknown. Time-lapse imaging shows that mouse macrophage...

journal_title：American journal of respiratory cell and molecular biology

authors： Gilberti RM,Joshi GN,Knecht DA

更新日期：2008-11-01 00:00:00

abstract：:IL-1β is a potent proinflammatory cytokine that is implicated in the pathogenesis of acute respiratory distress syndrome. We hypothesized that LPS and mechanical ventilation (MV) together could lead to IL-1β secretion and the development of acute lung injury (ALI), and that this process would be dependent on caspase-1...

journal_title：American journal of respiratory cell and molecular biology

authors： Jones HD,Crother TR,Gonzalez-Villalobos RA,Jupelli M,Chen S,Dagvadorj J,Arditi M,Shimada K

更新日期：2014-02-01 00:00:00

abstract：:Previous studies have shown that a single exposure of animals to ozone (O3) can induce protection or adaptation to the acute injurious effects of a subsequent O3 challenge. Although a number of mechanisms have been proposed to account for this response, none appear to be fully explanatory. We examined the role interle...

journal_title：American journal of respiratory cell and molecular biology

authors： McKinney WJ,Jaskot RH,Richards JH,Costa DL,Dreher KL

更新日期：1998-05-01 00:00:00

abstract：:Airway epithelial cells cultured at the air-liquid interface possess highly differentiated functions and structures compared with the cells cultured under immersion. We examined the oxidative metabolism and glycolysis in cow tracheal epithelial cells on Days 3, 6, 10, and 13, cultured under three different conditions:...

journal_title：American journal of respiratory cell and molecular biology

authors： Kondo M,Tamaoki J,Sakai A,Kameyama S,Kanoh S,Konno K

更新日期：1997-01-01 00:00:00

abstract：:Interleukin-13 (IL-13) is one of the central mediators for development of airway hyperresponsiveness in asthma. However, its effect on bronchial smooth muscle (BSM) is not well known. Recent studies revealed an involvement of RhoA/Rho-kinase in BSM contraction, and this pathway has now been proposed as a new target fo...

journal_title：American journal of respiratory cell and molecular biology

authors： Chiba Y,Nakazawa S,Todoroki M,Shinozaki K,Sakai H,Misawa M

更新日期：2009-02-01 00:00:00

abstract：:Tumor necrosis factor-alpha (TNF-alpha) is thought to be important in the development of pulmonary fibrosis. However, surfactant protein-C/TNF-alpha transgenic mice do not spontaneously develop pulmonary fibrosis but instead develop alveolar enlargement and loss of elastic recoil. We hypothesized that overexpression o...

journal_title：American journal of respiratory cell and molecular biology

authors： Fujita M,Shannon JM,Morikawa O,Gauldie J,Hara N,Mason RJ

更新日期：2003-12-01 00:00:00

abstract：:To reach the sites of inflammation, neutrophils traverse the endothelium, its underlying basement membrane, and other barriers depending on the localization of the insulting agent. Whether neutrophil elastase (NE) plays a role in neutrophil recruitment to inflamed sites is still debatable. By exploiting mice deficient...

journal_title：American journal of respiratory cell and molecular biology

authors： Hirche TO,Atkinson JJ,Bahr S,Belaaouaj A

更新日期：2004-04-01 00:00:00

abstract：:Bronchiolitis obliterans (BO) is an increasingly important lung disease characterized by fibroproliferative airway lesions and decrements in lung function. Occupational exposure to the artificial food flavoring ingredient diacetyl, commonly used to impart a buttery flavor to microwave popcorn, has been associated with...

journal_title：American journal of respiratory cell and molecular biology

authors： Brass DM,Gwinn WM,Valente AM,Kelly FL,Brinkley CD,Nagler AE,Moseley MA,Morgan DL,Palmer SM,Foster MW

更新日期：2017-06-01 00:00:00

abstract：:The time course and nature of the cellular response to left pneumonectomy, with or without prior adrenalectomy, were evaluated in the right lungs of male Sprague-Dawley rats using morphometric techniques. Animals were studied at days 2, 5, and 14 following pneumonectomy, intervals prior to, during the course of, and f...

journal_title：American journal of respiratory cell and molecular biology

authors： Rannels DE,Stockstill B,Mercer RR,Crapo JD

更新日期：1991-10-01 00:00:00