The effect of T-cell depletion on enhanced basophil histamine release after in vitro incubation with live influenza A virus.

abstract：:Despite respiratory syncytial virus (RSV) bronchiolitis remaining the most common cause of lower respiratory tract disease in infants worldwide, treatment has progressed little in the past 30 years. The aim of our study was to determine whether post-infection administration of de novo pyrimidine synthesis inhibitors c...

journal_title：American journal of respiratory cell and molecular biology

authors： Davis IC,Lazarowski ER,Chen FP,Hickman-Davis JM,Sullender WM,Matalon S

更新日期：2007-10-01 00:00:00

abstract：:Bronchiolitis obliterans (BO) is an increasingly important lung disease characterized by fibroproliferative airway lesions and decrements in lung function. Occupational exposure to the artificial food flavoring ingredient diacetyl, commonly used to impart a buttery flavor to microwave popcorn, has been associated with...

journal_title：American journal of respiratory cell and molecular biology

authors： Brass DM,Gwinn WM,Valente AM,Kelly FL,Brinkley CD,Nagler AE,Moseley MA,Morgan DL,Palmer SM,Foster MW

更新日期：2017-06-01 00:00:00

abstract：:Long-term success in lung transplantation is limited by obliterative bronchiolitis, whereas T cell effector mechanisms in this process remain incompletely understood. Using the mouse heterotopic allogeneic airway transplant model, we studied T cell effector responses during obliterative airways disease (OAD). Allospec...

journal_title：American journal of respiratory cell and molecular biology

authors： West EE,Lavoie TL,Orens JB,Chen ES,Ye SQ,Finkelman FD,Garcia JG,McDyer JF

更新日期：2006-01-01 00:00:00

abstract：:Tissue factor (TF) is best known as a cellular initiator of coagulation, but it is also a multifunctional protein that has been implicated in multiple pathophysiologic conditions, including asthma. In the lung, airway epithelial cells express TF, but it is unknown how TF expression is regulated by asthma-associated me...

journal_title：American journal of respiratory cell and molecular biology

authors： Mitchel JA,Antoniak S,Lee JH,Kim SH,McGill M,Kasahara DI,Randell SH,Israel E,Shore SA,Mackman N,Park JA

更新日期：2016-04-01 00:00:00

abstract：:Human rhinovirus (HRV) triggers exacerbations of asthma and chronic obstructive pulmonary disease. Cigarette smoking is the primary risk factor for the development of chronic obstructive pulmonary disease, and 25% of individuals with asthma smoke. Smokers experience both longer and more severe colds. We previously sho...

journal_title：American journal of respiratory cell and molecular biology

authors： Hudy MH,Traves SL,Proud D

更新日期：2014-03-01 00:00:00

abstract：:Transforming growth factor-beta1 (TGF-beta1) has been implicated as a major negative regulator of lung branching morphogenesis. Since connective tissue growth factor (CTGF) is a downstream mediator of TGF-beta1 effects on mesenchymal cells, we hypothesized that TGF-beta1 induces CTGF expression in mouse embryonic lung...

journal_title：American journal of respiratory cell and molecular biology

authors： Wu S,Peng J,Duncan MR,Kasisomayajula K,Grotendorst G,Bancalari E

更新日期：2007-05-01 00:00:00

abstract：:Monkey Clara cell 10 kDa protein (CC10) was purified from monkey lung lavage. This protein showed an apparent molecular weight of about 10 kDa and 5 kDa under non-reducing and reducing conditions, respectively, as determined by sodium dodecyl sulfate-polyacrylamide gel electrophoresis. From the amino acid sequence dat...

journal_title：American journal of respiratory cell and molecular biology

authors： Hashimoto S,Nakagawa K,Sueishi K

更新日期：1996-09-01 00:00:00

abstract：:We compared the chemical composition of salivary mucin glycopeptides from cystic fibrosis (CF) and from non-CF subjects and the adhesion of Pseudomonas aeruginosa to these different salivary glycopeptides. Three pools of CF saliva, four pools of non-CF saliva, one individual CF saliva, and one individual non-CF saliva...

journal_title：American journal of respiratory cell and molecular biology

authors： Carnoy C,Ramphal R,Scharfman A,Lo-Guidice JM,Houdret N,Klein A,Galabert C,Lamblin G,Roussel P

更新日期：1993-09-01 00:00:00

abstract：:Tumor necrosis factor alpha (TNF-alpha), a major product of alveolar macrophages (AM), has been implicated in many pulmonary diseases. Histamine, a mediator important in pulmonary inflammation, has been demonstrated to regulate the production of TNF-alpha by monocytes. In this study, we show that human AM and monocyte...

journal_title：American journal of respiratory cell and molecular biology

authors： Rowe J,Finlay-Jones JJ,Nicholas TE,Bowden J,Morton S,Hart PH

更新日期：1997-08-01 00:00:00

abstract：:To examine the effects of acid exposure with moderate acidity (pH 3.0-5.0) on bactericidal activity of airway surface liquid (ASL), ASL was collected by washing the surface of primary cultures of human tracheal epithelial cells 24 h after treatment with phosphate-buffered saline (PBS) adjusted to a pH of 3.0, 4.0, or ...

journal_title：American journal of respiratory cell and molecular biology

authors： Nakayama K,Jia YX,Hirai H,Shinkawa M,Yamaya M,Sekizawa K,Sasaki H

更新日期：2002-01-01 00:00:00

abstract：:Human rhinovirus (HRV) infections are associated with exacerbations of lower-airway diseases. HRV-induced production of proinflammatory chemokines, such as CXCL10, from infected airway epithelial cells may play a role in the pathogenesis of exacerbations. We have previously shown that the MAP/ERK kinase (MEK) pathway ...

journal_title：American journal of respiratory cell and molecular biology

authors： Zaheer RS,Proud D

更新日期：2010-10-01 00:00:00

abstract：:Single-cell RNA sequencing (scRNASeq) has advanced our understanding of lung biology, but its utility is limited by the need for fresh samples, loss of cell types by death or inadequate dissociation, and transcriptional stress responses induced during tissue digestion. Single-nucleus RNA sequencing (snRNASeq) has addr...

journal_title：American journal of respiratory cell and molecular biology

authors： Koenitzer JR,Wu H,Atkinson JJ,Brody SL,Humphreys BD

更新日期：2020-12-01 00:00:00

abstract：:Development of gene transfer vectors with regulated, lung-specific expression will be a useful tool for studying lung biology and developing gene therapies. In this study we constructed a series of lentiviral vectors with regulatory elements predicted to produce lung-specific transgene expression: the surfactant prote...

journal_title：American journal of respiratory cell and molecular biology

authors： Hendrickson B,Senadheera D,Mishra S,Bui KC,Wang X,Chan B,Petersen D,Pepper K,Lutzko C

更新日期：2007-10-01 00:00:00

abstract：:Previous observations by our laboratory indicate that the presence of anti-IL-8 autoantibody:IL-8 immune complexes in lung fluids from patients with acute lung injury/acute respiratory distress syndrome (ALI/ARDS) comprises an important prognostic indicator in the development and ultimate outcome of ALI/ARDS. We also ...

journal_title：American journal of respiratory cell and molecular biology

authors： Krupa A,Fudala R,Florence JM,Tucker T,Allen TC,Standiford TJ,Luchowski R,Fol M,Rahman M,Gryczynski Z,Gryczynski I,Kurdowska AK

更新日期：2013-02-01 00:00:00

abstract：:Tumor necrosis factor-alpha (TNF), interleukin-1 beta (IL-1), interleukin-6 (IL-6), and interleukin-8 (IL-8) are inflammatory cytokines produced by alveolar macrophages (AMs) and implicated in sepsis-related adult respiratory distress syndrome (ARDS). Preliminary findings from clinical trials suggest that aerosolized ...

journal_title：American journal of respiratory cell and molecular biology

authors： Thomassen MJ,Meeker DP,Antal JM,Connors MJ,Wiedemann HP

更新日期：1992-09-01 00:00:00

abstract：:Hydrogen peroxide (H(2)O(2)) is found in exhaled breath and is produced by airway epithelia. In addition, H(2)O(2) is a necessary substrate for the airway lactoperoxidase (LPO) anti-infection system. To investigate the source of H(2)O(2) produced by airway epithelia, PCR was used to screen nicotinamide adenine dinucle...

journal_title：American journal of respiratory cell and molecular biology

authors： Forteza R,Salathe M,Miot F,Forteza R,Conner GE

更新日期：2005-05-01 00:00:00

abstract：:Successful phagolysosomal maturation is an important innate immune response to intracellular infection. However, Mycobacterium tuberculosis (Mtb) can manipulate and inhibit this host response to ensure survival within its niche cell. We investigate the role of the anti-inflammatory cytokine IL-10 on Mtb-phagosome matu...

journal_title：American journal of respiratory cell and molecular biology

authors： O'Leary S,O'Sullivan MP,Keane J

更新日期：2011-07-01 00:00:00

abstract：:Protein kinase C (PKC) is known to regulate ryanodine receptor (RyR)-mediated local Ca(2+) signaling (Ca(2+) spark) in airway and vascular smooth muscle cells (SMCs), but its specific molecular mechanisms and functions still remain elusive. In this study, we reveal that, in airway SMCs, specific PKCepsilon peptide inh...

journal_title：American journal of respiratory cell and molecular biology

authors： Liu QH,Zheng YM,Korde AS,Li XQ,Ma J,Takeshima H,Wang YX

更新日期：2009-06-01 00:00:00

abstract：:Acute lung injury (ALI) is characterized by pulmonary inflammation and edema. Innate immune cells (e.g., neutrophils and macrophages) are major contributors to inflammation in ALI. Less is known regarding the role of T cells. We examined the effects of rapamycin on inflammation in a LPS-induced murine model of ALI. Ra...

journal_title：American journal of respiratory cell and molecular biology

authors： Nakajima T,Lin KW,Li J,McGee HS,Kwan JM,Perkins DL,Finn PW

更新日期：2014-08-01 00:00:00

abstract：:Alveolar macrophages (AM) express gelatinase B, a member of the matrix metalloproteinase family involved in the degradation and remodeling of extracellular matrix components. We evaluated the expression of gelatinase B in the course of idiopathic pulmonary fibrosis (IPF) by studying alveolar macrophages in culture AM ...

journal_title：American journal of respiratory cell and molecular biology

authors： Lemjabbar H,Gosset P,Lechapt-Zalcman E,Franco-Montoya ML,Wallaert B,Harf A,Lafuma C

更新日期：1999-05-01 00:00:00

abstract：:Neutrophil elastase (NE) is a major inflammatory mediator in cystic fibrosis (CF) that is a robust predictor of lung disease progression. NE directly causes airway injury via protease activity, and propagates persistent neutrophilic inflammation by up-regulation of neutrophil chemokine expression. Despite its key role...

journal_title：American journal of respiratory cell and molecular biology

authors： Griffin KL,Fischer BM,Kummarapurugu AB,Zheng S,Kennedy TP,Rao NV,Foster WM,Voynow JA

更新日期：2014-04-01 00:00:00

abstract：:After localized lung immunization and challenge, antigen-specific antibody continues to be produced in the immunized lung lobes of dogs for years after the last antigen exposure. Lavage fluid from immunized lung lobes contains significantly more antigen-specific antibody than lavage fluid from control lung lobes, and ...

journal_title：American journal of respiratory cell and molecular biology

authors： Bice DE,Jones SE,Muggenburg BA

更新日期：1993-06-01 00:00:00

abstract：:Transforming growth factor-beta (TGF-beta) is a cytokine implicated in wound healing and in the pathogenesis of pulmonary fibrosis. TGF-beta stimulates myofibroblast differentiation characterized by expression of contractile smooth muscle (SM)-specific proteins such as SM-alpha-actin. In the present study, we examined...

journal_title：American journal of respiratory cell and molecular biology

authors： Sandbo N,Kregel S,Taurin S,Bhorade S,Dulin NO

更新日期：2009-09-01 00:00:00

abstract：:Vascular endothelial growth factor (VEGF) is a potent peptide growth factor specific for vascular endothelial cells, which promotes neovascularization and increases vascular permeability in vivo. Enhanced microvascular permeability and edema are common characteristics of inflammatory and neoplastic disorders. Two proi...

journal_title：American journal of respiratory cell and molecular biology

authors： Nauck M,Roth M,Tamm M,Eickelberg O,Wieland H,Stulz P,Perruchoud AP

更新日期：1997-04-01 00:00:00

abstract：:Airway epithelial cell defenses to viral infections are often compromised in disease or injury. Danger molecules, including ATP, are released during infection and contribute to nucleotide receptor-dependent inflammatory responses, largely through P2X(7). Although respiratory epithelium has been shown to express a vari...

journal_title：American journal of respiratory cell and molecular biology

authors： Shi L,Manthei DM,Guadarrama AG,Lenertz LY,Denlinger LC

更新日期：2012-09-01 00:00:00

abstract：:Aging is associated with metabolic diseases such as type 2 diabetes mellitus, cardiovascular disease, cancer, and neurodegeneration. Aging contributes to common processes including metabolic dysfunction, DNA damage, and reactive oxygen species generation. Although glycolysis has been linked to cell growth and prolifer...

journal_title：American journal of respiratory cell and molecular biology

authors： Cho SJ,Moon JS,Lee CM,Choi AM,Stout-Delgado HW

更新日期：2017-04-01 00:00:00

abstract：:Although hemolytic anemia-associated pulmonary hypertension (PH) and pulmonary arterial hypertension (PAH) are more common than the prevalence of idiopathic PAH alone, the role of hemolysis in the development of PAH is poorly characterized. We hypothesized that hemolysis independently contributes to PAH pathogenesis v...

journal_title：American journal of respiratory cell and molecular biology

authors： Rafikova O,Williams ER,McBride ML,Zemskova M,Srivastava A,Nair V,Desai AA,Langlais PR,Zemskov E,Simon M,Mandarino LJ,Rafikov R

更新日期：2018-09-01 00:00:00

abstract：:Antenatal corticosteroids enhance lung maturation. However, the importance of glucocorticoid genes on early lung development, asthma susceptibility, and treatment response remains unknown. We investigated whether glucocorticoid genes are important during lung development and their role in asthma susceptibility and tre...

journal_title：American journal of respiratory cell and molecular biology

authors： Sharma S,Kho AT,Chhabra D,Qiu W,Gaedigk R,Vyhlidal CA,Leeder JS,Barraza-Villarreal A,London SJ,Gilliland F,Raby BA,Weiss ST,Tantisira KG

更新日期：2015-05-01 00:00:00

abstract：:Mucin glycoproteins play a key role in the normal function of the airway epithelium. We examined the expression of mucin genes, MUC3, 4, 5AC, 5B, 6, 7, and 8 in human fetal tissues to establish the localization and age of onset of expression of each mucin gene during human development. We detected expression of MUC4, ...

journal_title：American journal of respiratory cell and molecular biology

authors： Reid CJ,Gould S,Harris A

更新日期：1997-11-01 00:00:00

abstract：:Cystic fibrosis (CF) is characterized by a dramatic neutrophil recruitment and repeated Pseudomonas infections in the lungs. To evaluate cytokine releasibility by airway epithelial cells in the context of CF, we studied primary nasal epithelial cells isolated from the upper airways and continuous epithelial cell lines...

journal_title：American journal of respiratory cell and molecular biology

authors： Bédard M,McClure CD,Schiller NL,Francoeur C,Cantin A,Denis M

更新日期：1993-10-01 00:00:00