Critical role of serum response factor in pulmonary myofibroblast differentiation induced by TGF-beta.

abstract：:While elastin degradation is a hallmark of pulmonary emphysema, it is likely that elastin synthesis also occurs. However, the supramolecular structure and function of the newly synthesized elastin are abnormal. Very little is known about the regulation of elastin synthesis during the development of emphysema when prom...

journal_title：American journal of respiratory cell and molecular biology

authors： McGowan SE,McNamer R

更新日期：1990-10-01 00:00:00

abstract：:Fibronectin (FN) is an extracellular matrix protein that acts as a substrate for cell migration and adhesion during development. FN adheres to cells through a dimeric membrane protein, the FN receptor. Antibodies to FN and synthetic peptides that inhibit FN-receptor interaction inhibit gastrulation, block neural crest...

journal_title：American journal of respiratory cell and molecular biology

authors： Dean DC

更新日期：1989-07-01 00:00:00

abstract：:Prenatal nicotine exposure impairs normal lung development and leads to diminished pulmonary function after birth. Previous work from our laboratory has demonstrated that nicotine alters lung development by affecting a nonneuronal cholinergic autocrine loop that is expressed in lung. Bronchial epithelial cells (BECs) ...

journal_title：American journal of respiratory cell and molecular biology

authors： Fu XW,Lindstrom J,Spindel ER

更新日期：2009-07-01 00:00:00

abstract：:After localized lung immunization and challenge, antigen-specific antibody continues to be produced in the immunized lung lobes of dogs for years after the last antigen exposure. Lavage fluid from immunized lung lobes contains significantly more antigen-specific antibody than lavage fluid from control lung lobes, and ...

journal_title：American journal of respiratory cell and molecular biology

authors： Bice DE,Jones SE,Muggenburg BA

更新日期：1993-06-01 00:00:00

abstract：:Inhaled nitric oxide (NO) is an important new therapeutic agent used to treat pulmonary arterial hypertension in a variety of disease states. However, the effects of NO on cells in the lung are uncertain. Previously, we have shown that NO gas depresses neutrophil oxidative cell function and increases neutrophil cell d...

journal_title：American journal of respiratory cell and molecular biology

authors： Fortenberry JD,Owens ML,Brown MR,Atkinson D,Brown LA

更新日期：1998-03-01 00:00:00

abstract：:Airway surface fluids are mainly secreted from submucosal glands, and play important roles in the defense of airways via the up-regulation of mucociliary transport, resulting in an exclusion of many microbes or foreign substances. Although there are many articles concerning the importance of Toll-like receptors (TLRs)...

journal_title：American journal of respiratory cell and molecular biology

authors： Murakami K,Tamada T,Nara M,Muramatsu S,Kikuchi T,Kanehira M,Maruyama Y,Ebina M,Nukiwa T

更新日期：2011-11-01 00:00:00

abstract：:Hydrogen sulfide (H2S), a novel signaling gasotransmitter in the respiratory system, may have antiinflammatory properties in the lung. We examined the preventive and therapeutic effects of H2S on ozone-induced features of lung inflammation and emphysema. C57/BL6 mice were exposed to ozone or filtered air over 6 weeks....

journal_title：American journal of respiratory cell and molecular biology

authors： Li F,Zhang P,Zhang M,Liang L,Sun X,Li M,Tang Y,Bao A,Gong J,Zhang J,Adcock I,Chung KF,Zhou X

更新日期：2016-07-01 00:00:00

abstract：:Macrolides have been shown to be effective in treating diffuse panbronchiolitis (DPB), although the precise modes of action remain unclear. At sites of airway inflammation, respiratory epithelium is considered an active participant in regulating neutrophil survival. We therefore examined the effect of erythromycin, cl...

journal_title：American journal of respiratory cell and molecular biology

authors： Yamasawa H,Oshikawa K,Ohno S,Sugiyama Y

更新日期：2004-04-01 00:00:00

abstract：:Tissue inhibitors of metalloproteinases (TIMPs) are multifunctional proteins that have the capacity to modify cellular activities and to modulate matrix turnover. We demonstrate that TIMP-1 messenger RNA (mRNA) and protein expression are selectively and markedly increased in a murine model of bleomycin-induced pulmona...

journal_title：American journal of respiratory cell and molecular biology

authors： Madtes DK,Elston AL,Kaback LA,Clark JG

更新日期：2001-05-01 00:00:00

abstract：:To identify mechanisms that allow p185HER2 expression in lung cancer, we performed Western, Southern, and Northern blot analyses of 14 cell lines derived from human non-small cell lung carcinomas and one cell line derived from a human mesothelioma. Human bronchiole epithelial cells and rat type II pneumocytes were fou...

journal_title：American journal of respiratory cell and molecular biology

authors： Kern JA,Robinson RA,Gazdar A,Torney L,Weiner DB

更新日期：1992-04-01 00:00:00

abstract：:NFU1 is a mitochondrial protein that is involved in the biosynthesis of iron-sulfur clusters, and its genetic modification is associated with disorders of mitochondrial energy metabolism. Patients with autosomal-recessive inheritance of the NFU1 mutation G208C have reduced activity of the respiratory chain Complex II ...

journal_title：American journal of respiratory cell and molecular biology

authors： Niihori M,Eccles CA,Kurdyukov S,Zemskova M,Varghese MV,Stepanova AA,Galkin A,Rafikov R,Rafikova O

更新日期：2020-02-01 00:00:00

abstract：:Increased airway responsiveness is linked to lung function decline and mortality in subjects with chronic obstructive pulmonary disease (COPD); however, the genetic contribution to airway responsiveness remains largely unknown. A genome-wide association study (GWAS) was performed using the Illumina (San Diego, CA) Hum...

journal_title：American journal of respiratory cell and molecular biology

authors： Hansel NN,Paré PD,Rafaels N,Sin DD,Sandford A,Daley D,Vergara C,Huang L,Elliott WM,Pascoe CD,Arsenault BA,Postma DS,Boezen HM,Bossé Y,van den Berge M,Hiemstra PS,Cho MH,Litonjua AA,Sparrow D,Ober C,Wise RA,Conne

更新日期：2015-08-01 00:00:00

abstract：:Previous studies by our group as well as others have shown that acute adenosine exposure enhances lung vascular endothelial barrier integrity and protects against increased permeability lung edema. In contrast, there is growing evidence that sustained adenosine exposure has detrimental effects on the lungs, including ...

journal_title：American journal of respiratory cell and molecular biology

authors： Lu Q,Newton J,Hsiao V,Shamirian P,Blackburn MR,Pedroza M

更新日期：2012-11-01 00:00:00

abstract：:Increased activity of lung epithelial sodium channels (ENaCs) contributes to the pathophysiology of cystic fibrosis (CF) by increasing the rate of epithelial lining fluid reabsorption. Inter-α-inhibitor (IαI), a serum protease inhibitor, may decrease ENaC activity by preventing its cleavage by serine proteases. High c...

journal_title：American journal of respiratory cell and molecular biology

authors： Lazrak A,Jurkuvenaite A,Ness EC,Zhang S,Woodworth BA,Muhlebach MS,Stober VP,Lim YP,Garantziotis S,Matalon S

更新日期：2014-05-01 00:00:00

abstract：:Humans and rodents exposed to an aerosol of asbestos fibers develop lung injury that can lead to a fibroproliferative response culminating in excessive scarring and impaired lung function. To define the early events that precede asbestos-induced fibrotic lung disease, rats were exposed to an aerosol of chrysotile asbe...

journal_title：American journal of respiratory cell and molecular biology

authors： Mishra A,Liu JY,Brody AR,Morris GF

更新日期：1997-04-01 00:00:00

abstract：:Redox imbalance has been implicated in the pathogenesis of many acute and chronic lung diseases. The b-Zip transcription factor Nrf2 acts via an antioxidant/electrophilic response element to regulate antioxidants and maintain cellular redox homeostasis. Our previous studies have shown that Nrf2-deficient mice (Nrf2(-/...

journal_title：American journal of respiratory cell and molecular biology

authors： Reddy NM,Kleeberger SR,Cho HY,Yamamoto M,Kensler TW,Biswal S,Reddy SP

更新日期：2007-07-01 00:00:00

abstract：:The insulin-like growth factor (IGF)-II/mannose-6-phosphate (M6P) receptor, which targets acid hydrolases to lysosomes, is a multifunctional protein with separate binding sites for IGF-II and M6P. The purpose of this study was to determine if alveolar macrophages (AM) and their precursor cells, blood monocytes, expres...

journal_title：American journal of respiratory cell and molecular biology

authors： Rom WN

更新日期：1991-06-01 00:00:00

abstract：:Mucus hypersecretion is characteristic of chronic airway diseases. However, regulatory mechanisms are poorly understood. Human airway epithelial cells grown on permeable supports at the air-liquid interface (ALI) develop a mucociliary morphology resembling that found in vivo. Such cultures provide a model for studying...

journal_title：American journal of respiratory cell and molecular biology

authors： Bernacki SH,Nelson AL,Abdullah L,Sheehan JK,Harris A,Davis CW,Randell SH

更新日期：1999-04-01 00:00:00

abstract：:Aging is associated with metabolic diseases such as type 2 diabetes mellitus, cardiovascular disease, cancer, and neurodegeneration. Aging contributes to common processes including metabolic dysfunction, DNA damage, and reactive oxygen species generation. Although glycolysis has been linked to cell growth and prolifer...

journal_title：American journal of respiratory cell and molecular biology

authors： Cho SJ,Moon JS,Lee CM,Choi AM,Stout-Delgado HW

更新日期：2017-04-01 00:00:00

abstract：:Clara-cell populations show a high degree of variation in susceptibility to injury by bioactivated cytotoxicants. Because glutathione (GSH) is critical for detoxification of electrophilic metabolites, heterogeneity in Clara cell GSH levels may lead to a wide range of cytotoxic responses. This study was designed to def...

journal_title：American journal of respiratory cell and molecular biology

authors： West JA,Chichester CH,Buckpitt AR,Tyler NK,Brennan P,Helton C,Plopper CG

更新日期：2000-07-01 00:00:00

abstract：:Receptors for advanced glycation end-products (RAGEs) are multiligand cell surface receptors highly expressed in the lung that contribute to alveolar epithelial cell differentiation during embryogenesis and the modulation of pulmonary inflammation during disease. When RAGEs are overexpressed throughout embryogenesis, ...

journal_title：American journal of respiratory cell and molecular biology

authors： Stogsdill JA,Stogsdill MP,Porter JL,Hancock JM,Robinson AB,Reynolds PR

更新日期：2012-07-01 00:00:00

abstract：:Accumulating evidence has demonstrated that up-regulation of the angiotensin (Ang)-converting enzyme (ACE)/AngII/AngII type 1 receptor (AT1R) axis aggravates pulmonary fibrosis. The recently discovered ACE2/Ang-(1-7)/Mas axis, which counteracts the activity of the ACE/AngII/AT1R axis, has been shown to protect against...

journal_title：American journal of respiratory cell and molecular biology

authors： Meng Y,Yu CH,Li W,Li T,Luo W,Huang S,Wu PS,Cai SX,Li X

更新日期：2014-04-01 00:00:00

abstract：:The matrix glycoprotein, fibronectin, stimulates the proliferation of non-small cell lung carcinoma in vitro through α5β1 integrin receptor-mediated signals. However, the true role of fibronectin and its receptor in lung carcinogenesis in vivo remains unclear. To test this, we generated mouse Lewis lung carcinoma cell...

journal_title：American journal of respiratory cell and molecular biology

authors： Roman J,Ritzenthaler JD,Roser-Page S,Sun X,Han S

更新日期：2010-12-01 00:00:00

abstract：:T1alpha is a protein of unknown function that is expressed at the plasma membrane in epithelia involved in fluid transport, including type I alveolar epithelial cells, choroid plexus, and ciliary epithelium. The purpose of this study was to test the hypothesis that T1alpha functions as a water channel or a regulator o...

journal_title：American journal of respiratory cell and molecular biology

authors： Ma T,Yang B,Matthay MA,Verkman AS

更新日期：1998-07-01 00:00:00

abstract：:Interleukin-6 (IL-6) is known to be involved in the pathogenesis of various inflammatory diseases, but its role in bleomycin (BLM)-induced lung injury and subsequent fibrotic changes remains to be determined. We evaluated the role of IL-6 in the lung inflammatory changes induced by BLM using wild-type (WT) and IL-6-de...

journal_title：American journal of respiratory cell and molecular biology

authors： Saito F,Tasaka S,Inoue K,Miyamoto K,Nakano Y,Ogawa Y,Yamada W,Shiraishi Y,Hasegawa N,Fujishima S,Takano H,Ishizaka A

更新日期：2008-05-01 00:00:00

abstract：:Protein kinase C (PKC) is known to regulate ryanodine receptor (RyR)-mediated local Ca(2+) signaling (Ca(2+) spark) in airway and vascular smooth muscle cells (SMCs), but its specific molecular mechanisms and functions still remain elusive. In this study, we reveal that, in airway SMCs, specific PKCepsilon peptide inh...

journal_title：American journal of respiratory cell and molecular biology

authors： Liu QH,Zheng YM,Korde AS,Li XQ,Ma J,Takeshima H,Wang YX

更新日期：2009-06-01 00:00:00

abstract：:Polymorphonuclear neutrophil (PMN) migration across basement membrane is thought to be dependent on the degradation of membrane constituents. PMN gelatinase B, a metalloproteinase able to degrade type IV collagen, may be involved in this phenomenon. PMN gelatinase B is released in the extracellular medium as a latent ...

journal_title：American journal of respiratory cell and molecular biology

authors： Delclaux C,Delacourt C,D'Ortho MP,Boyer V,Lafuma C,Harf A

更新日期：1996-03-01 00:00:00

abstract：:To evaluate the response of an epithelial barrier to a moderate but sustained oxidative stress, we cultured monolayers of Madin Darby canine kidney cells on microporous filters and exposed them to the hypoxanthine-xanthine oxidase (HX-XO) reaction. The transepithelial permeability coefficient for mannitol (Pm) was ass...

journal_title：American journal of respiratory cell and molecular biology

authors： Rochat T,Burkhard C,Finci-Cerkez V,Meda P

更新日期：1993-11-01 00:00:00

abstract：:Although neuroanatomical and neurophysiological features of neurons in the ferret trachea have been studied, the neural mediators associated with this plexus have not been completely characterized. The purpose of this study was to examine the occurrence of choline acetyltransferase (ChAT), nitric oxide synthase (NOS),...

journal_title：American journal of respiratory cell and molecular biology

authors： Dey RD,Altemus JB,Rodd A,Mayer B,Said SI,Coburn RF

更新日期：1996-03-01 00:00:00

abstract：:High mobility group box 1 (HMGB1) is an alarmin released from macrophages after infection or inflammation and is a biomarker of lung disease progression in patients with cystic fibrosis. We reported that 2-O, 3-O desulfated heparin (ODSH) inhibits the release of HMGB1 from murine macrophages triggered by neutrophil el...

journal_title：American journal of respiratory cell and molecular biology

authors： Zheng S,Kummarapurugu AB,Afosah DK,Sankaranarayanan NV,Boothello RS,Desai UR,Kennedy T,Voynow JA

更新日期：2017-01-01 00:00:00