Allergen-induced airway inflammation and bronchial responsiveness in wild-type and interleukin-4-deficient mice.

abstract：:The extracellular signal-regulated kinases 1 and 2 (ERK1/2) are phosphorylated after inhalation of asbestos. The effect of blocking this signaling pathway in lung epithelium is unclear. Asbestos-exposed transgenic mice expressing a dominant-negative mitogen-activated protein kinase kinase-1 (dnMEK1) (i.e., the upstrea...

journal_title：American journal of respiratory cell and molecular biology

authors： Manning CB,Sabo-Attwood T,Robledo RF,Macpherson MB,Rincón M,Vacek P,Hemenway D,Taatjes DJ,Lee PJ,Mossman BT

更新日期：2008-05-01 00:00:00

abstract：:Combustion-generated radicals interact to form polynuclear aromatic hydrocarbons (PAHs), including carcinogens. PAHs aggregate into 20- to 50-nm particles, which extend into branched-chain structures (soots). Incomplete combustion yields black soot particles and black smoke. Many PAHs, including those in soots, fluore...

journal_title：American journal of respiratory cell and molecular biology

authors： Murphy G Jr,Rouse RL,Polk WW,Henk WG,Barker SA,Boudreaux MJ,Floyd ZE,Penn AL

更新日期：2008-05-01 00:00:00

abstract：:Tissue inhibitors of metalloproteinases (TIMPs) are multifunctional proteins that have the capacity to modify cellular activities and to modulate matrix turnover. We demonstrate that TIMP-1 messenger RNA (mRNA) and protein expression are selectively and markedly increased in a murine model of bleomycin-induced pulmona...

journal_title：American journal of respiratory cell and molecular biology

authors： Madtes DK,Elston AL,Kaback LA,Clark JG

更新日期：2001-05-01 00:00:00

abstract：:Emphasis has recently been placed on the roles of chemotactic cytokines called chemokines to explain the accumulation of inflammatory cells in the lung that may precede or accompany pulmonary fibrosis in interstitial lung diseases. We hypothesized that RANTES, a member of the C-C chemokines, is one such chemokine. Bro...

journal_title：American journal of respiratory cell and molecular biology

authors： Kodama N,Yamaguchi E,Hizawa N,Furuya K,Kojima J,Oguri M,Takahashi T,Kawakami Y

更新日期：1998-04-01 00:00:00

abstract：:Skeletal muscle dysfunction in patients with chronic obstructive pulmonary disease negatively impacts quality of life and survival. Cigarette smoking (CS) is the major risk factor for chronic obstructive pulmonary disease and skeletal muscle dysfunction; however, how CS affects skeletal muscle function remains enigmat...

journal_title：American journal of respiratory cell and molecular biology

authors： Chan SMH,Cerni C,Passey S,Seow HJ,Bernardo I,van der Poel C,Dobric A,Brassington K,Selemidis S,Bozinovski S,Vlahos R

更新日期：2020-02-01 00:00:00

abstract：:The cellular events involved in generating the hypoxic pulmonary vasoconstriction response are not clearly understood, in part because of the multitude of factors that alter pulmonary vascular tone. The goal of the present studies was to determine if a cell culture preparation containing vascular smooth muscle (VSM) c...

journal_title：American journal of respiratory cell and molecular biology

authors： Murray TR,Chen L,Marshall BE,Macarak EJ

更新日期：1990-11-01 00:00:00

abstract：:Chronic airway infections with Pseudomonas aeruginosa determine morbidity in most individuals with cystic fibrosis (CF). P. aeruginosa may persist for decades in CF lungs, which provides a rare opportunity to study the long-term within-host evolution of a bacterial airway pathogen. In this work, we sought to resolve t...

journal_title：American journal of respiratory cell and molecular biology

authors： Klockgether J,Cramer N,Fischer S,Wiehlmann L,Tümmler B

更新日期：2018-08-01 00:00:00

abstract：:Infants born to heroin- and cocaine-addicted mothers have been reported to have a lower incidence of respiratory distress syndrome (RDS) compared with nonaddicted infants. However, it is not known whether these are direct drug-mediated effects or secondary phenomena. We therefore investigated the effect of opioids and...

journal_title：American journal of respiratory cell and molecular biology

authors： Gewolb IH,O'Brien J,Slavin RE

更新日期：1999-03-01 00:00:00

abstract：:Activin A is a homodimeric protein structurally and functionally related to transforming growth factor beta (TGF-beta), and the expression of activin A is modulated by TGF-beta. Here, we demonstrate the expression of activin A in normal and bleomycin (BLM)-treated murine lungs. ICR mice were treated with BLM intraperi...

journal_title：American journal of respiratory cell and molecular biology

authors： Matsuse T,Fukuchi Y,Eto Y,Matsui H,Hosoi T,Oka T,Ohga E,Nagase T,Orimo H

更新日期：1995-07-01 00:00:00

abstract：:Primary hamster tracheal surface epithelial (HTSE) cells carry mucin-like glycoproteins on the apical surface which are releasable by neutrophil elastase. In some cancer cells, mucins are localized on the cell surface and have been shown to be encoded by the MUC1 mucin gene. The objectives of the present experiments w...

journal_title：American journal of respiratory cell and molecular biology

authors： Park H,Hyun SW,Kim KC

更新日期：1996-08-01 00:00:00

abstract：:Acute lung injury (ALI) and its severe form, acute respiratory distress syndrome (ARDS), are major causes of acute respiratory failure with high rates of morbidity and mortality. Although surfactant protein (SP)-D plays a critical role in pulmonary innate immunity and several clinical studies suggest that this protein...

journal_title：American journal of respiratory cell and molecular biology

authors： King BA,Kingma PS

更新日期：2011-05-01 00:00:00

abstract：:CTP:phosphocholine cytidylyltransferase (CT) is the rate-limiting enzyme in the biosynthesis by type II pneumocytes of phosphatidylcholine (PC), the predominant phospholipid in lung surfactant. Augmentation of endogenous CT activity might therefore result in enhanced surfactant PC production. To test this hypothesis, ...

journal_title：American journal of respiratory cell and molecular biology

authors： Li J,Marsh JJ,Spragg RG

更新日期：2002-06-01 00:00:00

abstract：:Alveolar macrophages (AM) and interstitial macrophages (IM) from rat lungs were characterized with respect to morphology, phagocytosis, adhesion properties, and phenotype. AM were recovered by lung lavage and IM by treatment of the lung tissue with DNAse and collagenase. The AM were enzyme treated in the same way as t...

journal_title：American journal of respiratory cell and molecular biology

authors： Johansson A,Lundborg M,Sköld CM,Lundahl J,Tornling G,Eklund A,Camner P

更新日期：1997-05-01 00:00:00

abstract：:Macrophages are key orchestrators of the inflammatory and repair responses in the lung, and the diversity of their function is indicated by their polarized states and distinct subpopulations and localization in the lung. Here, we characterized the pulmonary macrophage populations in the interstitial and alveolar compa...

journal_title：American journal of respiratory cell and molecular biology

authors： Johnston LK,Rims CR,Gill SE,McGuire JK,Manicone AM

更新日期：2012-10-01 00:00:00

abstract：:Although neuroanatomical and neurophysiological features of neurons in the ferret trachea have been studied, the neural mediators associated with this plexus have not been completely characterized. The purpose of this study was to examine the occurrence of choline acetyltransferase (ChAT), nitric oxide synthase (NOS),...

journal_title：American journal of respiratory cell and molecular biology

authors： Dey RD,Altemus JB,Rodd A,Mayer B,Said SI,Coburn RF

更新日期：1996-03-01 00:00:00

abstract：:Wheeze is a common symptom in infants, but not all wheezers develop asthma. Indeed, up to 50% of wheezing children outgrow their symptoms by school age. How to predict if early wheeze will become asthma is still a matter of vivid debate. In this work, we sought to assess the clinical and pathological factors that migh...

journal_title：American journal of respiratory cell and molecular biology

authors： Bonato M,Bazzan E,Snijders D,Tinè M,Biondini D,Turato G,Balestro E,Papi A,Cosio MG,Barbato A,Baraldo S,Saetta M

更新日期：2018-10-01 00:00:00

abstract：:Tumor necrosis factor (TNF) is an inflammatory cytokine produced by many cell types which may contribute to the pathophysiology of a variety of lung diseases. In this study we have used Ro 45-2081 (a soluble receptor composed of the human p55 TNF receptor and human heavy-chain immunoglobulin G) to explore the role of ...

journal_title：American journal of respiratory cell and molecular biology

authors： Gater PR,Wasserman MA,Paciorek PM,Renzetti LM

更新日期：1996-05-01 00:00:00

abstract：:Bleomycin-induced lung injury causes increased fibroblast numbers in the lung and pulmonary fibrosis. Studies of fibroblasts isolated from such injured lungs have revealed evidence of increased intrinsic proliferative capacity, but the mechanism is unknown. Telomerase catalyzes the addition of telomeric DNA repeats on...

journal_title：American journal of respiratory cell and molecular biology

authors： Nozaki Y,Liu T,Hatano K,Gharaee-Kermani M,Phan SH

更新日期：2000-10-01 00:00:00

abstract：:In the present study, splenic dendritic cells (DC) and alveolar macrophages (AM) were pulsed with antigen in vitro and subsequently intratracheally instilled to test whether these cells have the capacity to sensitize T cells in the draining lymph nodes of the lung. The data demonstrate that antigen-pulsed DC, instille...

journal_title：American journal of respiratory cell and molecular biology

authors： Havenith CE,Breedijk AJ,Betjes MG,Calame W,Beelen RH,Hoefsmit EC

更新日期：1993-03-01 00:00:00

abstract：:Pulmonary carbonic anhydrase (CA) activity plays important roles in carbon dioxide exchange, fluid secretion, and pH regulation. This study reports the use of molecular and immunologic techniques to characterize expression of the high-activity cytosolic isoenzyme CA II in rat lung tissue. Northern blot analysis of RNA...

journal_title：American journal of respiratory cell and molecular biology

authors： Fleming RE,Moxley MA,Waheed A,Crouch EC,Sly WS,Longmore WJ

更新日期：1994-05-01 00:00:00

abstract：:Endothelin-1 (ET-1) exerts many biological effects in airways, including bronchoconstriction, airway mucus secretion, cell proliferation, and inflammation. We investigated the effect of ET-1 on Na absorption and Cl secretion in human bronchial epithelial cells. Addition of 10(-7) M ET-1 had no effect on the inhibition...

journal_title：American journal of respiratory cell and molecular biology

authors： Blouquit S,Sari A,Lombet A,D'herbomez M,Naline E,Matran R,Chinet T

更新日期：2003-08-01 00:00:00

abstract：:Tumor necrosis factor-alpha (TNF-alpha) is an important inflammatory mediator produced by activated monocytes and macrophages. We have previously shown that porcine alveolar macrophages (PAM) mediate bystander cytotoxicity through hydrogen peroxide production following activation with immobilized IgG immune complex (I...

journal_title：American journal of respiratory cell and molecular biology

authors： Kim JW,Wierda WG,Kim YB

更新日期：1991-09-01 00:00:00

abstract：:The biologic activity of substance P has been demonstrated to be limited both in in vivo and in vitro by a membrane-bound protease, neutral endopeptidase (EC 3.4.24.11). The interaction of substance P with its receptor on guinea pig lung tissues was studied in the presence of an inhibitor of neutral endopeptidase unde...

journal_title：American journal of respiratory cell and molecular biology

authors： Coats SR,Gerard NP

更新日期：1989-10-01 00:00:00

abstract：:The mTOR pathway is one of the key signal cascades in the pathogenesis of idiopathic pulmonary fibrosis. Previous studies have mainly focused on this pathway in the fibroblasts and/or myofibroblasts, but not in the epithelial cells. In this study, we sought to investigate the role of the mTOR pathway in lung epithelia...

journal_title：American journal of respiratory cell and molecular biology

authors： Saito M,Mitani A,Ishimori T,Miyashita N,Isago H,Mikami Y,Noguchi S,Tarui M,Nagase T

更新日期：2020-06-01 00:00:00

abstract：:Inhalation of the pulmonary irritant ozone is associated with an accumulation of macrophages in the lung. These cells, along with type II epithelial cells, are activated to release increased quantities of hydrogen peroxide and nitric oxide, two reactive mediators that have been implicated in tissue injury. In the pres...

journal_title：American journal of respiratory cell and molecular biology

authors： Pendino KJ,Gardner CR,Shuler RL,Laskin JD,Durham SK,Barton DS,Ohnishi ST,Ohnishi T,Laskin DL

更新日期：1996-06-01 00:00:00

abstract：:Two isoforms of the human glucocorticoid receptor (hGR) have been described, hGRalpha and hGRbeta. We analyzed the expression and regulation of both hGR isoforms in human respiratory epithelial cells (BEAS-2B, A549, and primary nasal epithelial cells). In BEAS-2B cells, the expression of hGRalpha messenger RNA (mRNA) ...

journal_title：American journal of respiratory cell and molecular biology

authors： Pujols L,Mullol J,Pérez M,Roca-Ferrer J,Juan M,Xaubet A,Cidlowski JA,Picado C

更新日期：2001-01-01 00:00:00

abstract：:The human lung accumulates iron with senescence. Smoking escalates the accumulation of iron, and we have demonstrated regional variability in the accumulation of iron in smokers' lungs. Iron has been reported to influence the production of a number of proinflammatory mediators, including human interleukin (IL)-1beta. ...

journal_title：American journal of respiratory cell and molecular biology

authors： O'Brien-Ladner AR,Nelson SR,Murphy WJ,Blumer BM,Wesselius LJ

更新日期：2000-07-01 00:00:00

abstract：:A strong correlation exists between smoking and lung cancer; however, susceptibility to lung cancer among smokers is not uniform. Similarly, mice show differential susceptibility to the tobacco carcinogen nitrosamine 4-(methyl-nitrosamino)-1-(3-pyridyl)-1-butanone (NNK), which produces lung tumors in A/J but not in C3...

journal_title：American journal of respiratory cell and molecular biology

authors： Razani-Boroujerdi S,Sopori ML

更新日期：2007-01-01 00:00:00

abstract：:The role of guanine nucleotide-binding proteins in the induction of prostacyclin synthesis by stimulated endothelial cells is incompletely understood. We report that sodium fluoride (NaF), a potent activator of cellular guanine nucleotide-binding proteins, affected time- and concentration-dependent generation of prost...

journal_title：American journal of respiratory cell and molecular biology

authors： Garcia JG,Dominguez J,English D

更新日期：1991-08-01 00:00:00

abstract：:Hyperplasia of airway smooth muscle cells is present in the airways of asthmatic patients and may contribute to the development of the bronchial hyperresponsiveness that occurs in these patients. Because tryptase is an abundant component of mast cell granules and has demonstrated growth-stimulatory effects in other me...

journal_title：American journal of respiratory cell and molecular biology

authors： Brown JK,Tyler CL,Jones CA,Ruoss SJ,Hartmann T,Caughey GH

更新日期：1995-08-01 00:00:00