Endogenous arachidonic acid metabolism by calcium ionophore A23187-stimulated lamb lungs: effect of hypoxia.

abstract：:Nrf2 is a leucine zipper transcription factor that protects against oxidant-induced injury. Nontypeable Haemophilus influenzae is responsible for frequent disease exacerbations in patients with chronic obstructive pulmonary disease and is responsible for causing otitis media in young children. We hypothesized that Nrf...

journal_title：American journal of respiratory cell and molecular biology

authors： Lugade AA,Vethanayagam RR,Nasirikenari M,Bogner PN,Segal BH,Thanavala Y

更新日期：2011-09-01 00:00:00

abstract：:The purpose of this study was to characterize basolateral anion channels in Calu-3 and normal human bronchial epithelial cells, and their role in anion secretion. Patch clamp studies identified an outwardly rectifying Cl- channel (ORCC), which could be activated by the adenosine receptor agonist 5'-(N-ethylcarboxamido...

journal_title：American journal of respiratory cell and molecular biology

authors： Szkotak AJ,Man SF,Duszyk M

更新日期：2003-12-01 00:00:00

abstract：:Previous studies have shown that polymorphonuclear leukocytes (PMN) are delayed in the pulmonary capillaries by the presence of cigarette smoke. To determine if the PMN delayed by smoking are activated, we estimated the in vivo expression of CD11/CD18 and L-selectin on the surface of PMN in lungs and peripheral blood ...

journal_title：American journal of respiratory cell and molecular biology

authors： Klut ME,Doerschuk CM,Van Eeden SF,Burns AR,Hogg JC

更新日期：1993-07-01 00:00:00

abstract：:Smoking cigarettes is the major risk factor for chronic obstructive pulmonary disease (COPD). COPD is a condition associated with chronic pulmonary inflammation, characterized by macrophage activation, neutrophil recruitment, and cell injury. Many substances contained in cigarette smoke, including reactive oxygen spec...

journal_title：American journal of respiratory cell and molecular biology

authors： Facchinetti F,Amadei F,Geppetti P,Tarantini F,Di Serio C,Dragotto A,Gigli PM,Catinella S,Civelli M,Patacchini R

更新日期：2007-11-01 00:00:00

abstract：:It is generally important to elucidate airway epithelial cell lineages and to identify multipotent progenitors as targets for gene therapy. Stem (S) cells are typically present in specialized compartments spatially proximal to their differentiated progeny, but an equivalent paradigm has not been demonstrated in the ai...

journal_title：American journal of respiratory cell and molecular biology

authors： Borthwick DW,Shahbazian M,Krantz QT,Dorin JR,Randell SH

更新日期：2001-06-01 00:00:00

abstract：:Although neutrophil migration from the systemic circulation involves the beta2- (or CD18) integrin family, the existence of an alternative, CD18-independent route of neutrophil extravasation to tissues has been demonstrated in animal models. The molecular interactions involved in this alternative migratory route have ...

journal_title：American journal of respiratory cell and molecular biology

authors： Mackarel AJ,Russell KJ,Brady CS,FitzGerald MX,O'Connor CM

更新日期：2000-08-01 00:00:00

abstract：:Surfactant protein D (SP-D) is a collagenous, surfactant-associated, carbohydrate-binding protein that is synthesized by pulmonary epithelial cells. In the present studies, we examined the expression of SP-D and SP-D mRNA during late fetal (day 17, 19, 21) and early postnatal (day 5) rat lung development using immunoc...

journal_title：American journal of respiratory cell and molecular biology

authors： Crouch E,Rust K,Marienchek W,Parghi D,Chang D,Persson A

更新日期：1991-07-01 00:00:00

abstract：:Chloride (Cl(-)) movement across fetal lung epithelia is thought to be mediated by the sodium-potassium-2-Cl(-) cotransporter NKCC1. We studied the role of NKCC1 in Cl(-) and liquid secretion in late-gestation NKCC-null (-/-) and littermate control fetal mouse lung. NKCC -/- mice had decreased lung water compared with...

journal_title：American journal of respiratory cell and molecular biology

authors： Gillie DJ,Pace AJ,Coakley RJ,Koller BH,Barker PM

更新日期：2001-07-01 00:00:00

abstract：:We have previously reported that medium conditioned by hypoxic pulmonary artery endothelial cells (ECCM) contains a factor of small molecular weight that inhibits the growth of pulmonary artery smooth muscle cells (SMC). We postulated that this factor might be a breakdown product of ATP and, therefore, measured the le...

journal_title：American journal of respiratory cell and molecular biology

authors： Hassoun PM,Shedd AL,Lanzillo JJ,Thappa V,Landman MJ,Fanburg BL

更新日期：1992-06-01 00:00:00

abstract：:Pneumocystis is an important fungal pathogen that causes life-threatening pneumonia in patients with AIDS and malignancy. Lung fungal pathogens are recognized by C-type lectin receptors (CLRs), which bind specific ligands and stimulate innate immune responses. The CLR Dectin-1 was previously shown to mediate immune re...

journal_title：American journal of respiratory cell and molecular biology

authors： Kottom TJ,Hebrink DM,Jenson PE,Marsolek PL,Wüthrich M,Wang H,Klein B,Yamasaki S,Limper AH

更新日期：2018-02-01 00:00:00

abstract：:Morphologic changes are reported to occur in rat lung vasculature after 3 days of hypoxia. We have previously shown that immunoreactivity for the vasodilator calcitonin gene-related peptide (CGRP) is increased in pulmonary endocrine cells by 7 days of hypoxia. Because these cells may be among the earliest mediators of...

journal_title：American journal of respiratory cell and molecular biology

authors： Roncalli M,Springall DR,Maggioni M,Moradoghli-Haftvani A,Winter RJ,Zhao L,Coggi G,Polak JM

更新日期：1993-11-01 00:00:00

abstract：:Recent evidence from genetic experiments in yeast and from studies using guanosine triphosphate (GTP) analogues in mammalian cells suggests a key role for low-molecular-mass GTP-binding proteins (LMM-GBPs) (Mr 19 to 28 kD) in processes of intracellular vesicular sorting and secretion. Assembly and exocytosis of the la...

journal_title：American journal of respiratory cell and molecular biology

authors： Rubins JB,Panchenko M,Shannon TM,Dickey BF

更新日期：1992-03-01 00:00:00

abstract：:Tumor necrosis factor alpha (TNF alpha) is a potentially important cytokine in allergic respiratory reactions since it is released by mast cells and eosinophils, and it can promote mediator and cytokine release, adhesion molecule expression, and granulocyte migration. Therefore, we induced an IgE-mediated response in ...

journal_title：American journal of respiratory cell and molecular biology

authors： Casale TB,Costa JJ,Galli SJ

更新日期：1996-07-01 00:00:00

abstract：:Impaired sphingolipid synthesis is linked genetically to childhood asthma and functionally to airway hyperreactivity (AHR). The objective was to investigate whether sphingolipid synthesis could be a target for asthma therapeutics. The effects of GlyH-101 and fenretinide via modulation of de novo sphingolipid synthesis...

journal_title：American journal of respiratory cell and molecular biology

authors： Heras AF,Veerappan A,Silver RB,Emala CW,Worgall TS,Perez-Zoghbi J,Worgall S

更新日期：2020-11-01 00:00:00

abstract：:Regulatory T cells (Tregs) play an essential role in maintaining the homeostatic balance of immune responses. Asthma is an inflammatory condition of the airways that is driven by dysregulated immune responses toward normally innocuous antigens. Individuals with asthma have fewer and less functional Tregs, which may le...

journal_title：American journal of respiratory cell and molecular biology

authors： Thorburn AN,Hansbro PM

更新日期：2010-11-01 00:00:00

abstract：:The protease-antiprotease imbalance that is characteristic of most inflammatory lung disorders depends on the spatial-temporal regulation of active inhibitor and protease concentrations in lung secretions. We have studied the competition between the three main serine proteases from human neutrophil primary granules in...

journal_title：American journal of respiratory cell and molecular biology

authors： Korkmaz B,Poutrain P,Hazouard E,de Monte M,Attucci S,Gauthier FL

更新日期：2005-06-01 00:00:00

abstract：:In rat models of Gram-negative pneumonia, pulmonary emigration of neutrophils (polymorphonuclear leukocytes [PMNs]) is blocked when rats are made endotoxemic by an intravenous administration of endotoxin (lipopolysaccharide [LPS]). To test whether dysfunctional PMN migratory responses in the endotoxemic rat are specif...

journal_title：American journal of respiratory cell and molecular biology

authors： Wagner JG,Driscoll KE,Roth RA

更新日期：1999-04-01 00:00:00

abstract：:Macrolides have been shown to be effective in treating diffuse panbronchiolitis (DPB), although the precise modes of action remain unclear. At sites of airway inflammation, respiratory epithelium is considered an active participant in regulating neutrophil survival. We therefore examined the effect of erythromycin, cl...

journal_title：American journal of respiratory cell and molecular biology

authors： Yamasawa H,Oshikawa K,Ohno S,Sugiyama Y

更新日期：2004-04-01 00:00:00

abstract：:Thy-1 is a glycosylphosphytidylinositol-linked cell-surface glycoprotein present on a subset of lung fibroblasts, which plays an important role in postnatal alveolarization. In the present study, we define the role of Thy-1 in pulmonary lipofibroblast differentiation and in the regulation of lipid homeostasis via pero...

journal_title：American journal of respiratory cell and molecular biology

authors： Varisco BM,Ambalavanan N,Whitsett JA,Hagood JS

更新日期：2012-06-01 00:00:00

abstract：:To identify mechanisms that allow p185HER2 expression in lung cancer, we performed Western, Southern, and Northern blot analyses of 14 cell lines derived from human non-small cell lung carcinomas and one cell line derived from a human mesothelioma. Human bronchiole epithelial cells and rat type II pneumocytes were fou...

journal_title：American journal of respiratory cell and molecular biology

authors： Kern JA,Robinson RA,Gazdar A,Torney L,Weiner DB

更新日期：1992-04-01 00:00:00

abstract：:Pulmonary infection with an exaggerated inflammatory response is the major cause of morbidity and mortality in cystic fibrosis (CF). The objective of this study was to determine whether differences in the innate immune system underlie the exaggerated immune response in CF. We established a model that recapitulates the...

journal_title：American journal of respiratory cell and molecular biology

authors： Bruscia EM,Zhang PX,Ferreira E,Caputo C,Emerson JW,Tuck D,Krause DS,Egan ME

更新日期：2009-03-01 00:00:00

abstract：:MyD88 is an adapter protein required for the induction of proinflammatory cytokines by most Toll-like receptors (TLR), and Pseudomonas aeruginosa expresses ligands for multiple TLRs. MyD88(-/-) (KO) mice are highly susceptible to aerosolized P. aeruginosa, failing to elicit an early inflammatory response and permittin...

journal_title：American journal of respiratory cell and molecular biology

authors： Hajjar AM,Harowicz H,Liggitt HD,Fink PJ,Wilson CB,Skerrett SJ

更新日期：2005-11-01 00:00:00

abstract：:The lung epithelium constitutes a selective barrier that separates the airways from the aqueous interstitial compartment. Regulated barrier function controls water and ion transport across the epithelium and is essential for maintaining lung function. Tight junctions (TJs) seal the epithelial barrier and determine the...

journal_title：American journal of respiratory cell and molecular biology

authors： Kielgast F,Schmidt H,Braubach P,Winkelmann VE,Thompson KE,Frick M,Dietl P,Wittekindt OH

更新日期：2016-05-01 00:00:00

abstract：:It is known that interleukin (IL)-23, an IL-12-family cytokine, can be released by certain antigen-presenting cells in response to bacterial pathogens. Recent in vitro studies indicate that this cytokine stimulates a unique subset of CD4 cells, the T helper cell (Th)17 subset, to produce and release the proinflammator...

journal_title：American journal of respiratory cell and molecular biology

authors： Ivanov S,Bozinovski S,Bossios A,Valadi H,Vlahos R,Malmhäll C,Sjöstrand M,Kolls JK,Anderson GP,Lindén A

更新日期：2007-04-01 00:00:00

abstract：:The differentiated phenotype of the alveolar type II cell is rapidly altered in vitro. To evaluate factors that might influence this process, we isolated and plated rat type II cells in serum-supplemented media to promote adherence and then maintained the cells in a simple nutrient medium in the absence (S- cells) or ...

journal_title：American journal of respiratory cell and molecular biology

authors： Paine R 3rd,Joyce-Brady M,Clement A,Brody JS

更新日期：1990-10-01 00:00:00

abstract：:Pleural organization may occur after empyema or complicated parapneumonic effusion and can result in restrictive lung disease with pleural fibrosis (PF). Pleural mesothelial cells; PMCs, may contribute to PF through acquisition of a profibrotic phenotype; meso-mesenchymal transition (MesoMT), which is characterized by...

journal_title：American journal of respiratory cell and molecular biology

authors： Qin W,Jeffers A,Owens S,Chauhan P,Komatsu S,Qian G,Guo X,Ikebe M,Idell S,Tucker TA

更新日期：2021-01-29 00:00:00

abstract：:FGFs (fibroblast growth factors) are major factors associated with the pathogenesis of pulmonary fibrosis. On the one hand, nintedanib, a tyrosine kinase inhibitor targeting several growth factor receptors, including the FGF receptor (FGFR), has been approved for the treatment of idiopathic pulmonary fibrosis. On the ...

journal_title：American journal of respiratory cell and molecular biology

authors： Morizumi S,Sato S,Koyama K,Okazaki H,Chen Y,Goto H,Kagawa K,Ogawa H,Nishimura H,Kawano H,Toyoda Y,Uehara H,Nishioka Y

更新日期：2020-09-01 00:00:00

abstract：:Idiopathic pulmonary fibrosis (IPF) is a progressive, scarring lung disease characterized by fibroblast accumulation and deposition of collagen. Factors that promote growth and/or survival of fibroblasts are potential therapeutic targets. Methionine aminopeptidase 2 (MetAP2), a member of the aminopeptidase family of p...

journal_title：American journal of respiratory cell and molecular biology

authors： Kass D,Bridges RS,Borczuk A,Greenberg S

更新日期：2007-08-01 00:00:00

abstract：:Stimulated migration of eosinophils out of the bloodstream and into the lung is key in the development of tissue eosinophilia and inflammation in asthma. Platelet-activating factor (PAF) has been implicated as an important inflammatory mediator in asthma pathogenesis in part because of its chemotactic capacity. We the...

journal_title：American journal of respiratory cell and molecular biology

authors： Casale TB,Erger RA,Little MM

更新日期：1993-01-01 00:00:00

abstract：:Quantitative measurement of [3H]thymidine [( 3H]TdR) incorporation into cultured cells is widely used as an indicator of cell proliferation. The observation that adult type II cells are able to incorporate large amounts of [3H]TdR despite the fact that they are not proliferating raised the question of the meaning of [...

journal_title：American journal of respiratory cell and molecular biology

authors： Clement A,Riedel N,Brody JS

更新日期：1990-08-01 00:00:00