Harnessing regulatory T cells to suppress asthma: from potential to therapy.

abstract：:In the present study, we sought to elucidate the mechanisms by which monocytes migrate into the pleural space in the presence of anaphylatoxins in tuberculous pleural effusion (TPE). Monocytes in both pleural effusion and blood were counted, and their phenotypic characteristics were analyzed. Activation of the complem...

journal_title：American journal of respiratory cell and molecular biology

authors： Luo L,Li X,Hu X,Hu C,Tang W,Deng S,Feng J

更新日期：2019-04-01 00:00:00

abstract：:Airway epithelial cell defenses to viral infections are often compromised in disease or injury. Danger molecules, including ATP, are released during infection and contribute to nucleotide receptor-dependent inflammatory responses, largely through P2X(7). Although respiratory epithelium has been shown to express a vari...

journal_title：American journal of respiratory cell and molecular biology

authors： Shi L,Manthei DM,Guadarrama AG,Lenertz LY,Denlinger LC

更新日期：2012-09-01 00:00:00

abstract：:Clara cell secretory protein (CCSP), or CC10, is an inhibitor of secretory phospholipase A2 which may be produced by phagocytic cells and by a variety of other cells in the airway. Tumor necrosis factor-alpha (TNF-alpha) is capable of activating phospholipases and inducing the expression of a variety of genes in the a...

journal_title：American journal of respiratory cell and molecular biology

authors： Yao XL,Levine SJ,Cowan MJ,Logun C,Shelhamer JH

更新日期：1998-10-01 00:00:00

abstract：:Heme oxygenase-1 (HO-1) is a stress-response protein, the expression of which is transcriptionally regulated by agents that cause oxidative stress. We have previously shown that lipopolysaccharide (LPS)-induced HO-1 gene transcription in RAW 264.7 macrophage cells is mediated by a distal enhancer called SX2, located 4...

journal_title：American journal of respiratory cell and molecular biology

authors： Camhi SL,Alam J,Wiegand GW,Chin BY,Choi AM

更新日期：1998-02-01 00:00:00

abstract：:Humans and rodents exposed to an aerosol of asbestos fibers develop lung injury that can lead to a fibroproliferative response culminating in excessive scarring and impaired lung function. To define the early events that precede asbestos-induced fibrotic lung disease, rats were exposed to an aerosol of chrysotile asbe...

journal_title：American journal of respiratory cell and molecular biology

authors： Mishra A,Liu JY,Brody AR,Morris GF

更新日期：1997-04-01 00:00:00

abstract：:Pseudomonas aeruginosa colonizes the lower respiratory tracts of patients with severe bronchiectasis, including cystic fibrosis, a condition associated with increased airway mucus output. We have shown that an extract containing chloroform-soluble extracellular products of P. aeruginosa releases glycoconjugates into t...

journal_title：American journal of respiratory cell and molecular biology

authors： Somerville M,Taylor GW,Watson D,Rendell NB,Rutman A,Todd H,Davies JR,Wilson R,Cole P,Richardson PS

更新日期：1992-01-01 00:00:00

abstract：:Pleural infection is common. Evacuation of infected pleural fluid is essential for successful treatment, but it is often difficult because of adhesions/loculations within the effusion and the viscosity of the fluid. Intrapleural delivery of tissue plasminogen activator (tPA) (to break the adhesions) and deoxyribonucle...

journal_title：American journal of respiratory cell and molecular biology

authors： Lansley SM,Cheah HM,Varano Della Vergiliana JF,Chakera A,Lee YC

更新日期：2015-07-01 00:00:00

abstract：:Extracellular signal-regulated kinases (ERKs) phosphorylate and regulate cytoskeletal components of contractile cells and have been implicated in integrin-mediated adhesion. In this study, we examined the contributions of adherence, cell flattening, and cytoskeletal reorganization to adhesion-induced ERK activation in...

journal_title：American journal of respiratory cell and molecular biology

authors： Heuertz RM,Hamann KJ,Hershenson MB,Leff AR

更新日期：1997-10-01 00:00:00

abstract：:To identify relationships amongst tracheal and alveolar epithelial cells during lung development, we used conditional systems controlled by the rat CCSP and human SFTPC gene promoters to express Cre-recombinase in the developing mouse lung, thereby permanently labeling cells by expression of alkaline phosphatase or gr...

journal_title：American journal of respiratory cell and molecular biology

authors： Perl AK,Wert SE,Loudy DE,Shan Z,Blair PA,Whitsett JA

更新日期：2005-11-01 00:00:00

abstract：:T helper 2 (Th2)-like cytokines are thought to play a crucial role in the pathogenesis of airway inflammation in atopic asthma, leading to bronchial hyperresponsiveness. To investigate the role of the principal Th2 cytokine interleukin-4 (IL-4) in asthma, we examined the allergen-induced changes in airway morphology a...

journal_title：American journal of respiratory cell and molecular biology

authors： Brusselle G,Kips J,Joos G,Bluethmann H,Pauwels R

更新日期：1995-03-01 00:00:00

abstract：:Integrins are heterodimeric cell-surface glycoproteins that mediate cell-cell and cell-matrix adhesion. We previously identified cDNA encoding a novel integrin beta subunit, beta 7, from bronchoalveolar lavage fluid (BALF) leukocytes. The beta 7 subunit protein is now known to associate with at least two integrin alph...

journal_title：American journal of respiratory cell and molecular biology

authors： Erle DJ,Brown T,Christian D,Aris R

更新日期：1994-03-01 00:00:00

abstract：:Although several studies have demonstrated that the pulmonary collectins surfactant protein (SP)-A and SP-D contribute to innate immunity by enhancing pathogen phagocytosis, the role of SP-A and SP-D in regulating production of free radicals and cytokines is controversial. We hypothesized that the state and mechanism ...

journal_title：American journal of respiratory cell and molecular biology

authors： Stamme C,Walsh E,Wright JR

更新日期：2000-12-01 00:00:00

abstract：:The oleic acid (OA) model of acute lung injury in rats is characterized by a massive and rapid influx of polymorphonuclear neutrophils (PMN) within 1 h, with a peak inflammatory response at 4 h and resolution by 72 h. We hypothesized that PMN apoptosis is involved in the resolution of OA-induced acute lung injury. To ...

journal_title：American journal of respiratory cell and molecular biology

authors： Hussain N,Wu F,Zhu L,Thrall RS,Kresch MJ

更新日期：1998-12-01 00:00:00

abstract：:The reasons for bacterial proliferation in the lungs of mechanically ventilated patients are poorly understood. We hypothesized that prolonged cyclic stretch of lung cells influenced bacterial growth. Human alveolar type II-like A549 cells were submitted in vitro to prolonged cyclic stretch. Bacteria were cultured in ...

journal_title：American journal of respiratory cell and molecular biology

authors： Pugin J,Dunn-Siegrist I,Dufour J,Tissières P,Charles PE,Comte R

更新日期：2008-03-01 00:00:00

abstract：:Hexavalent chromium (Cr[VI]) is classified by the International Agency for Research on Cancer as a group I carcinogen. Although the U.S. Occupational Safety and Health Administration was obliged to reduce the permissible exposure limit (PEL), it was reported that U.S. workers continue to be exposed to dangerously high...

journal_title：American journal of respiratory cell and molecular biology

authors： Russo P,Catassi A,Cesario A,Imperatori A,Rotolo N,Fini M,Granone P,Dominioni L

更新日期：2005-12-01 00:00:00

abstract：:Profound impairment in cellular oxygen consumption, referred to as cytopathic dysoxia, is one of the pathological hallmarks in the lungs of patients with pathogen-induced acute lung injury (ALI). However, the underlying mechanism for this functional defect remains largely unexplored. In this study, we found that prima...

journal_title：American journal of respiratory cell and molecular biology

authors： Cui H,Xie N,Banerjee S,Ge J,Guo S,Liu G

更新日期：2019-02-01 00:00:00

abstract：:Polymorphonuclear leukocytes (PMN) release gelatinase B in response to variable stimuli. Gelatinase B degrades basement membrane components in vitro, and inhibition of matrix metalloproteinase activity blunts PMN migration through a prototype basement membrane (Matrigel) and amnionic membranes. Accordingly, it has bee...

journal_title：American journal of respiratory cell and molecular biology

authors： Betsuyaku T,Shipley JM,Liu Z,Senior RM

更新日期：1999-06-01 00:00:00

abstract：:Pseudomonas aeruginosa, which may cause severe lung infections, secretes a metalloelastase that may interfere with the assay of neutrophil elastase and cathepsin G in lung secretions. Using nuclear magnetic resonance spectroscopy, we have shown that P. aeruginosa elastase (PsE) cleaves succinyl-Ala3-p-nitroanilide bet...

journal_title：American journal of respiratory cell and molecular biology

authors： Pelletier A,Dimicoli JL,Boudier C,Bieth JG

更新日期：1989-07-01 00:00:00

abstract：:Pulmonary lymphangioleiomyomatosis (LAM), a disease of young women, is characterized by proliferation of immature-appearing smooth-muscle cells (LAM cells) in the lungs and abdomen. LAM cells react with monoclonal antibody HMB45, which recognizes a 100-kD glycoprotein (gp100) originally found in human melanoma cells. ...

journal_title：American journal of respiratory cell and molecular biology

authors： Matsumoto Y,Horiba K,Usuki J,Chu SC,Ferrans VJ,Moss J

更新日期：1999-09-01 00:00:00

abstract：:Semaphorins are a large family of proteins originally identified as axon guidance cues that play a crucial role in neural development. They are also ubiquitously expressed beyond the nervous system and contribute to regulation of essential cell functions, such as cell migration, proliferation, and adhesion. Binding of...

journal_title：American journal of respiratory cell and molecular biology

authors： Movassagh H,Khadem F,Gounni AS

更新日期：2018-01-01 00:00:00

abstract：:Using a rat model of acute lung inflammation induced by intratracheal instillation of lipopolysaccharide (LPS), we investigated the kinetics of mRNA expression and the potential cellular sources of tumor necrosis factor-alpha (TNF-alpha), macrophage inflammatory protein-2 (MIP-2), interleukin (IL)-1 beta, IL-6, RANTES...

journal_title：American journal of respiratory cell and molecular biology

authors： Xing Z,Jordana M,Kirpalani H,Driscoll KE,Schall TJ,Gauldie J

更新日期：1994-02-01 00:00:00

abstract：:Epithelial-mesenchymal cell interactions and factors that control normal lung development are key players in lung injury, repair, and fibrosis. A number of studies have investigated the roles and sources of epithelial progenitors during lung regeneration; such information, however, is limited in lung fibroblasts. Thus...

journal_title：American journal of respiratory cell and molecular biology

authors： Green J,Endale M,Auer H,Perl AK

更新日期：2016-04-01 00:00:00

abstract：:Airway inflammation, hyperreactivity, increased number of goblet cells, and mucus overproduction characterize asthma. Respiratory challenge with ovalbumin (OVA) of sensitized mice has been shown by several laboratories to cause pulmonary pathology similar to that observed in human allergic asthma. Recently, interleuki...

journal_title：American journal of respiratory cell and molecular biology

authors： Zuhdi Alimam M,Piazza FM,Selby DM,Letwin N,Huang L,Rose MC

更新日期：2000-03-01 00:00:00

abstract：:Lung morphometry was introduced over 50 years ago to provide quantitative evaluation of the lung structure. The existing parameters, such as mean linear intercept and destructive index, suffer from simplistic data interpretation and a subjective data acquisition process. To overcome these existing shortcomings, parenc...

journal_title：American journal of respiratory cell and molecular biology

authors： Xiao R,Goldklang MP,D'Armiento JM

更新日期：2016-11-01 00:00:00

abstract：:Adenosine triphosphate (ATP) acting through epithelial nucleotide receptors exerts multiple physiologic actions on airway mucociliary clearance and caliber. However, the effect of ATP on arachidonate metabolism in the airway remains unknown. In this study, the ability of ATP to regulate eicosanoid production was studi...

journal_title：American journal of respiratory cell and molecular biology

authors： Aksoy MO,Borenstein M,Li XX,Kelsen SG

更新日期：1995-10-01 00:00:00

abstract：:We examined the ability of the human surfactant protein B (SP-B) promoter to confer cell specificity of transgene expression in an adenoviral vector. Using similar replication-deficient adenoviruses (rAd), we compared lacZ reporter gene expression driven by the human SP-B promoter (rAd.SPBlacZ) with the ubiquitously e...

journal_title：American journal of respiratory cell and molecular biology

authors： Strayer MS,Guttentag SH,Ballard PL

更新日期：1998-01-01 00:00:00

abstract：:Pulmonary fibrosis is an enigmatic and devastating disease with few treatment options, now thought to result from abnormal wound healing in the lung in response to injury. We have previously noted a role for the chemokine interferon gamma-inducible protein of 10 kD (IP-10)/CXC chemokine ligand 10 in the regulation of ...

journal_title：American journal of respiratory cell and molecular biology

authors： Tager AM,Kradin RL,LaCamera P,Bercury SD,Campanella GS,Leary CP,Polosukhin V,Zhao LH,Sakamoto H,Blackwell TS,Luster AD

更新日期：2004-10-01 00:00:00

abstract：:Enhanced protein tyrosine phosphorylation is associated with changes in vascular permeability through formation and dissolution of adherens junctions and regulation of stress fiber formation. Inhibition of the protein tyrosine phosphorylase SH2 domain-containing protein tyrosine phosphatase 2 (SHP2) increases tyrosine...

journal_title：American journal of respiratory cell and molecular biology

authors： Chichger H,Braza J,Duong H,Harrington EO

更新日期：2015-06-01 00:00:00

abstract：:Although neutrophil migration from the systemic circulation involves the beta2- (or CD18) integrin family, the existence of an alternative, CD18-independent route of neutrophil extravasation to tissues has been demonstrated in animal models. The molecular interactions involved in this alternative migratory route have ...

journal_title：American journal of respiratory cell and molecular biology

authors： Mackarel AJ,Russell KJ,Brady CS,FitzGerald MX,O'Connor CM

更新日期：2000-08-01 00:00:00

abstract：:Bombesin-like peptides within neuroepithelial cells elicit proliferation of normal and malignant airway epithelial cells. It is not clear that these peptides also elicit epithelial cell migration, a necessary component of airway repair after injury. We studied the effects of the bombesin analogues, gastrin releasing p...

journal_title：American journal of respiratory cell and molecular biology

authors： Kim JS,McKinnis VS,White SR

更新日期：1997-03-01 00:00:00