Inhibition of pulmonary fibrosis by the chemokine IP-10/CXCL10.

abstract：:Inhaled nitric oxide (NO) is an important new therapeutic agent used to treat pulmonary arterial hypertension in a variety of disease states. However, the effects of NO on cells in the lung are uncertain. Previously, we have shown that NO gas depresses neutrophil oxidative cell function and increases neutrophil cell d...

journal_title：American journal of respiratory cell and molecular biology

authors： Fortenberry JD,Owens ML,Brown MR,Atkinson D,Brown LA

更新日期：1998-03-01 00:00:00

abstract：:The increase of airway smooth muscle (ASM) mass in asthma results from hypertrophic and hyperplastic stimuli, and leads to an increase in cellular contractile proteins. However, little evidence correlates the relative contributions of hypertrophic and hyperplastic muscle with functional effects on airway resistance. W...

journal_title：American journal of respiratory cell and molecular biology

authors： Plant PJ,North ML,Ward A,Ward M,Khanna N,Correa J,Scott JA,Batt J

更新日期：2012-04-01 00:00:00

abstract：:To better understand asthma pathogenesis, we characterized airway responsiveness, lung inflammation, and mediator production of alveolar macrophages (AM) after allergen sensitization and challenge in two strains of rats showing different susceptibilities in developing airway allergic reactions. Airway responsiveness t...

journal_title：American journal of respiratory cell and molecular biology

authors： Careau E,Sirois J,Bissonnette EY

更新日期：2002-05-01 00:00:00

abstract：:MyD88 is an adapter protein required for the induction of proinflammatory cytokines by most Toll-like receptors (TLR), and Pseudomonas aeruginosa expresses ligands for multiple TLRs. MyD88(-/-) (KO) mice are highly susceptible to aerosolized P. aeruginosa, failing to elicit an early inflammatory response and permittin...

journal_title：American journal of respiratory cell and molecular biology

authors： Hajjar AM,Harowicz H,Liggitt HD,Fink PJ,Wilson CB,Skerrett SJ

更新日期：2005-11-01 00:00:00

abstract：:The present study utilized the monocrotaline (MCT) model of pulmonary hypertension in rats to examine temporal alterations in steady-state levels of basement membrane (BM) component mRNA and deposition of protein using Northern analysis and immunohistochemistry, respectively. MCT (60 mg/kg, subcutaneous) produced sust...

journal_title：American journal of respiratory cell and molecular biology

authors： Lipke DW,Arcot SS,Gillespie MN,Olson JW

更新日期：1993-10-01 00:00:00

abstract：:FGFs (fibroblast growth factors) are major factors associated with the pathogenesis of pulmonary fibrosis. On the one hand, nintedanib, a tyrosine kinase inhibitor targeting several growth factor receptors, including the FGF receptor (FGFR), has been approved for the treatment of idiopathic pulmonary fibrosis. On the ...

journal_title：American journal of respiratory cell and molecular biology

authors： Morizumi S,Sato S,Koyama K,Okazaki H,Chen Y,Goto H,Kagawa K,Ogawa H,Nishimura H,Kawano H,Toyoda Y,Uehara H,Nishioka Y

更新日期：2020-09-01 00:00:00

abstract：:Receptors for advanced glycation end-products (RAGEs) are multiligand cell surface receptors highly expressed in the lung that contribute to alveolar epithelial cell differentiation during embryogenesis and the modulation of pulmonary inflammation during disease. When RAGEs are overexpressed throughout embryogenesis, ...

journal_title：American journal of respiratory cell and molecular biology

authors： Stogsdill JA,Stogsdill MP,Porter JL,Hancock JM,Robinson AB,Reynolds PR

更新日期：2012-07-01 00:00:00

abstract：:The mammalian alveolar epithelium is composed of alveolar type I (AT1) and alveolar type II (AT2) cells that together coordinate tissue function. We used a heterocellular culture model of AT1 and AT2 cells to determine pathways for intercellular signaling between these two phenotypes. Gap junction protein (connexin) p...

journal_title：American journal of respiratory cell and molecular biology

authors： Isakson BE,Seedorf GJ,Lubman RL,Evans WH,Boitano S

更新日期：2003-11-01 00:00:00

abstract：:T lymphocytes and alveolar macrophages accumulating in the lower respiratory tract of patients with pulmonary sarcoidosis are known to be activated to produce several cytokines, presumably leading to granuloma formation within the lung. We hypothesized that these cells produce colony-stimulating factors (CSFs), which ...

journal_title：American journal of respiratory cell and molecular biology

authors： Itoh A,Yamaguchi E,Kuzumaki N,Okazaki N,Furuya K,Abe S,Kawakami Y

更新日期：1990-09-01 00:00:00

abstract：:Airway inflammation, hyperreactivity, increased number of goblet cells, and mucus overproduction characterize asthma. Respiratory challenge with ovalbumin (OVA) of sensitized mice has been shown by several laboratories to cause pulmonary pathology similar to that observed in human allergic asthma. Recently, interleuki...

journal_title：American journal of respiratory cell and molecular biology

authors： Zuhdi Alimam M,Piazza FM,Selby DM,Letwin N,Huang L,Rose MC

更新日期：2000-03-01 00:00:00

abstract：:Alveolar epithelial type II cells secrete lung surfactant via exocytosis. Soluble N-ethylmaleimide-sensitive factor attachment protein receptors (SNARE) are implicated in this process. Lipid rafts, the cholesterol- and sphingolipid-rich microdomains, may offer a platform for protein organization on the cell membrane. ...

journal_title：American journal of respiratory cell and molecular biology

authors： Chintagari NR,Jin N,Wang P,Narasaraju TA,Chen J,Liu L

更新日期：2006-06-01 00:00:00

abstract：:Bleomycin-induced lung injury causes increased fibroblast numbers in the lung and pulmonary fibrosis. Studies of fibroblasts isolated from such injured lungs have revealed evidence of increased intrinsic proliferative capacity, but the mechanism is unknown. Telomerase catalyzes the addition of telomeric DNA repeats on...

journal_title：American journal of respiratory cell and molecular biology

authors： Nozaki Y,Liu T,Hatano K,Gharaee-Kermani M,Phan SH

更新日期：2000-10-01 00:00:00

abstract：:Myosin light chain phosphorylation results in cellular contraction and is a critical component of agonist-mediated endothelial cell (EC) junctional gap formation and permeability. We have shown that this reaction is catalyzed by a novel high molecular-weight Ca2+/calmodulin-dependent nonmuscle myosin light chain kinas...

journal_title：American journal of respiratory cell and molecular biology

authors： Verin AD,Lazar V,Torry RJ,Labarrere CA,Patterson CE,Garcia JG

更新日期：1998-11-01 00:00:00

abstract：:Na(+) absorption and Cl(-) secretion are in equilibrium to maintain an appropriate airway surface fluid volume and ensure appropriate mucociliary clearance. In cystic fibrosis, this equilibrium is disrupted by mutations in the cystic fibrosis transmembrane conductance regulator (CFTR) gene resulting in the absence of ...

journal_title：American journal of respiratory cell and molecular biology

authors： Caci E,Melani R,Pedemonte N,Yueksekdag G,Ravazzolo R,Rosenecker J,Galietta LJ,Zegarra-Moran O

更新日期：2009-02-01 00:00:00

abstract：:Approximately 3 billion people-half the worldwide population-are exposed to extremely high concentrations of household air pollution due to the burning of biomass fuels on inefficient cookstoves, accounting for 4 million annual deaths globally. Yet, our understanding of the pulmonary responses to household air polluti...

journal_title：American journal of respiratory cell and molecular biology

authors： Sussan TE,Ingole V,Kim JH,McCormick S,Negherbon J,Fallica J,Akulian J,Yarmus L,Feller-Kopman D,Wills-Karp M,Horton MR,Breysse PN,Agrawal A,Juvekar S,Salvi S,Biswal S

更新日期：2014-03-01 00:00:00

abstract：:Lung endothelial cell apoptosis and injury occur throughout all stages of acute lung injury/acute respiratory distress syndrome and impact disease progression. Caspases 1, 4, and 5 are essential for completion of the apoptotic program known as pyroptosis that also involves proinflammatory cytokines. Because gasdermin ...

journal_title：American journal of respiratory cell and molecular biology

authors： Mitra S,Exline M,Habyarimana F,Gavrilin MA,Baker PJ,Masters SL,Wewers MD,Sarkar A

更新日期：2018-07-01 00:00:00

abstract：:To assess the temporal and spatial expression of the matrix-associated proteoglycan, biglycan, in a model of chronic hyperoxia-induced lung injury, changes in mRNA and protein were examined using Northern blot analyses and immunohistochemistry. Newborn rats were exposed to 85% or 100% oxygen for 6 and 4 wk, respective...

journal_title：American journal of respiratory cell and molecular biology

authors： Veness-Meehan KA,Rhodes DN,Stiles AD

更新日期：1994-11-01 00:00:00

abstract：:Specific changes in composition and content of lung extracellular matrix (ECM) proteoglycans (PGs) and hyaluronan (HA) have been observed during the acute response to damage in several forms of injury including infant respiratory distress syndrome (IRDS). These ECM components are thought to modulate the healing respon...

journal_title：American journal of respiratory cell and molecular biology

authors： Juul SE,Krueger RC Jr,Scofield L,Hershenson MB,Schwartz NB

更新日期：1995-12-01 00:00:00

abstract：:Bacterial lung diseases are a major cause of morbidity and mortality both in immunocompromised and in immunocompetent individuals. Neutrophil accumulation, a pathological hallmark of bacterial diseases, is critical to host defense, but may also cause acute lung injury/acute respiratory distress syndrome. Toll-like rec...

journal_title：American journal of respiratory cell and molecular biology

authors： Balamayooran G,Batra S,Fessler MB,Happel KI,Jeyaseelan S

更新日期：2010-07-01 00:00:00

abstract：:Tissue inhibitor of metalloproteinases-3 (TIMP-3) has emerged as a key mediator of inflammation. Recently, we reported that the resolution of inflammation is impaired in Timp3(-/-) mice after bleomycin-induced lung injury. Here, we demonstrate that after LPS instillation (another model of acute lung injury), Timp3(-/-...

journal_title：American journal of respiratory cell and molecular biology

authors： Gill SE,Gharib SA,Bench EM,Sussman SW,Wang RT,Rims C,Birkland TP,Wang Y,Manicone AM,McGuire JK,Parks WC

更新日期：2013-11-01 00:00:00

abstract：:Primary hamster tracheal surface epithelial (HTSE) cells carry mucin-like glycoproteins on the apical surface which are releasable by neutrophil elastase. In some cancer cells, mucins are localized on the cell surface and have been shown to be encoded by the MUC1 mucin gene. The objectives of the present experiments w...

journal_title：American journal of respiratory cell and molecular biology

authors： Park H,Hyun SW,Kim KC

更新日期：1996-08-01 00:00:00

abstract：:The mammalian airways are sensitive to inhaled stimuli, and airway diseases are characterized by hypersensitivity to volatile stimuli, such as perfumes, industrial solvents, and others. However, the identity and function of the cells in the airway that can sense volatile chemicals remain uncertain, particularly in hum...

journal_title：American journal of respiratory cell and molecular biology

authors： Gu X,Karp PH,Brody SL,Pierce RA,Welsh MJ,Holtzman MJ,Ben-Shahar Y

更新日期：2014-03-01 00:00:00

abstract：:Recent in vitro studies have suggested that interleukin-4 (IL-4) may be involved in the preferential migration of eosinophils into the airways in allergic asthma through its capacity to selectively increase vascular cell adhesion molecule-1 (VCAM-1) expression on vessels. To test this hypothesis, we studied the expres...

journal_title：American journal of respiratory cell and molecular biology

authors： Fukuda T,Fukushima Y,Numao T,Ando N,Arima M,Nakajima H,Sagara H,Adachi T,Motojima S,Makino S

更新日期：1996-01-01 00:00:00

abstract：:Tumor necrosis factor alpha (TNF alpha) is a potentially important cytokine in allergic respiratory reactions since it is released by mast cells and eosinophils, and it can promote mediator and cytokine release, adhesion molecule expression, and granulocyte migration. Therefore, we induced an IgE-mediated response in ...

journal_title：American journal of respiratory cell and molecular biology

authors： Casale TB,Costa JJ,Galli SJ

更新日期：1996-07-01 00:00:00

abstract：:Alveolar macrophages (AM) express gelatinase B, a member of the matrix metalloproteinase family involved in the degradation and remodeling of extracellular matrix components. We evaluated the expression of gelatinase B in the course of idiopathic pulmonary fibrosis (IPF) by studying alveolar macrophages in culture AM ...

journal_title：American journal of respiratory cell and molecular biology

authors： Lemjabbar H,Gosset P,Lechapt-Zalcman E,Franco-Montoya ML,Wallaert B,Harf A,Lafuma C

更新日期：1999-05-01 00:00:00

abstract：:Nitric oxide (NO) is produced in lung epithelial cells by nitric oxide synthases (NOSs), which can enhance inflammation and edema formation. The inducible NOS (iNOS, type II NOS) has been shown to be increased in lung disorders such as asthma. Therapy for asthma includes antiinflammatory agents such as corticosteroids...

journal_title：American journal of respiratory cell and molecular biology

authors： Robbins RA,Jinkins PA,Bryan TW,Prado SC,Milligan SA

更新日期：1998-06-01 00:00:00

abstract：:Despite respiratory syncytial virus (RSV) bronchiolitis remaining the most common cause of lower respiratory tract disease in infants worldwide, treatment has progressed little in the past 30 years. The aim of our study was to determine whether post-infection administration of de novo pyrimidine synthesis inhibitors c...

journal_title：American journal of respiratory cell and molecular biology

authors： Davis IC,Lazarowski ER,Chen FP,Hickman-Davis JM,Sullender WM,Matalon S

更新日期：2007-10-01 00:00:00

abstract：:The expression of bombesin-like peptides (BLPs) by pulmonary neuroendocrine cells is transiently upregulated during lung development. A functional role for BLPs is supported by their ability to stimulate lung growth and maturation both in vitro and in vivo during the late stages of lung development. In addition, the c...

journal_title：American journal of respiratory cell and molecular biology

authors： Aguayo SM,Schuyler WE,Murtagh JJ Jr,Roman J

更新日期：1994-06-01 00:00:00

abstract：:The prevalence of asthma has increased in recent years, and is characterized by airway hyperresponsiveness and inflammation. Many patients report using alternative therapies to self-treat asthma symptoms as adjuncts to short-acting and long-acting β-agonists and inhaled corticosteroids (ICS). As many as 40% of patient...

journal_title：American journal of respiratory cell and molecular biology

authors： Townsend EA,Siviski ME,Zhang Y,Xu C,Hoonjan B,Emala CW

更新日期：2013-02-01 00:00:00

abstract：:Amiodarone interferes with the endocytic pathway, inhibits proteolysis, and causes the formation of vacuoles, but uptake and intracellular distribution of the drug, origin of vacuoles, and functional consequences of amiodarone accumulation remain unclear. Our objective was to study amiodarone uptake, clarify the origi...

journal_title：American journal of respiratory cell and molecular biology

authors： Stadler K,Ha HR,Ciminale V,Spirli C,Saletti G,Schiavon M,Bruttomesso D,Bigler L,Follath F,Pettenazzo A,Baritussio A

更新日期：2008-08-01 00:00:00