Characterization of lung hyperresponsiveness, inflammation, and alveolar macrophage mediator production in allergy resistant and susceptible rats.

abstract：:Macrophage elastase (MMP12) is a key mediator of cigarette smoke (CS)-induced emphysema, yet its role in other smoking related pathologies remains unclear. The weight suppressing effects of smoking are a major hindrance to cessation efforts, and MMP12 is known to suppress the vascularization on which adipose tissue gr...

journal_title：American journal of respiratory cell and molecular biology

authors： Tsuji T,Kelly NJ,Takahashi S,Leme AS,Houghton AM,Shapiro SD

更新日期：2014-12-01 00:00:00

abstract：:The etiology of acute lung injury is complex and associated with numerous, chemically diverse precipitating factors. During acute lung injury in mice, one key event is epithelial cell injury that leads to reduced surfactant biosynthesis. We have previously reported that transgenic mice that express transforming growth...

journal_title：American journal of respiratory cell and molecular biology

authors： Bein K,Wesselkamper SC,Liu X,Dietsch M,Majumder N,Concel VJ,Medvedovic M,Sartor MA,Henning LN,Venditto C,Borchers MT,Barchowsky A,Weaver TE,Tichelaar JW,Prows DR,Korfhagen TR,Hardie WD,Bachurski CJ,Leikauf GD

更新日期：2009-08-01 00:00:00

abstract：:Preclinical models of human conditions including asthma showed the therapeutic potential of Compound A (CpdA), a dissociated glucocorticoid (GC) receptor (GRα) ligand. Whether CpdA inhibits GC resistance, a central feature of severe asthma, has not been addressed. We investigated whether CpdA modulates cytokine-induce...

journal_title：American journal of respiratory cell and molecular biology

authors： Gavrila A,Chachi L,Tliba O,Brightling C,Amrani Y

更新日期：2015-11-01 00:00:00

abstract：:Surfactant protein D (SP-D) is believed to contribute to nonimmune host defense within the alveoli and distal airways of the lung. SP-D molecules can bind to specific carbohydrates on the surface of bacterial, fungal, and viral organisms and can also interact with membrane glycoconjugates expressed by alveolar macroph...

journal_title：American journal of respiratory cell and molecular biology

authors： Crouch EC,Persson A,Griffin GL,Chang D,Senior RM

更新日期：1995-04-01 00:00:00

abstract：:Proteinase-activated receptor (PAR)-2 is cleaved within its aminoterminal extracellular domain by serine proteinases such as trypsin, unmasking a new aminoterminus starting with the sequence SLIGKV, which binds intramolecularly and activates the receptor. PAR-2 has been reported to be involved in inflammation within t...

journal_title：American journal of respiratory cell and molecular biology

authors： Dulon S,Candé C,Bunnett NW,Hollenberg MD,Chignard M,Pidard D

更新日期：2003-03-01 00:00:00

abstract：:The cytokine mRNA profiles of primary (arising from inhaled bacilli) and secondary (arising from hematogenous reseeding of the lung) granulomas from the lung lobes of bacillus Calmette-Guérin (BCG)-vaccinated and unimmunized guinea pigs challenged with virulent Mycobacterium tuberculosis by the pulmonary route were as...

journal_title：American journal of respiratory cell and molecular biology

authors： Ly LH,Russell MI,McMurray DN

更新日期：2008-04-01 00:00:00

abstract：:Macrolides have been shown to be effective in treating diffuse panbronchiolitis (DPB), although the precise modes of action remain unclear. At sites of airway inflammation, respiratory epithelium is considered an active participant in regulating neutrophil survival. We therefore examined the effect of erythromycin, cl...

journal_title：American journal of respiratory cell and molecular biology

authors： Yamasawa H,Oshikawa K,Ohno S,Sugiyama Y

更新日期：2004-04-01 00:00:00

abstract：:Silicosis is a chronic lung disease induced by the inhalation of crystalline silica. Exposure of cultured macrophages to crystalline silica leads to cell death; however, the mechanism of cell-particle interaction, the fate of particles, and the cause of death are unknown. Time-lapse imaging shows that mouse macrophage...

journal_title：American journal of respiratory cell and molecular biology

authors： Gilberti RM,Joshi GN,Knecht DA

更新日期：2008-11-01 00:00:00

abstract：:Receptors for advanced glycation end-products (RAGEs) are multiligand cell surface receptors highly expressed in the lung that contribute to alveolar epithelial cell differentiation during embryogenesis and the modulation of pulmonary inflammation during disease. When RAGEs are overexpressed throughout embryogenesis, ...

journal_title：American journal of respiratory cell and molecular biology

authors： Stogsdill JA,Stogsdill MP,Porter JL,Hancock JM,Robinson AB,Reynolds PR

更新日期：2012-07-01 00:00:00

abstract：:Airway epithelial cells can respond to infection by activating several signaling pathways. We examined the induction of apoptosis in response to Pseudomonas aeruginosa PAO1 in normal cells and several cystic fibrosis (CF) and corrected cell lines. Epithelial cells in monolayers with tight junctions, confirmed by apica...

journal_title：American journal of respiratory cell and molecular biology

authors： Rajan S,Cacalano G,Bryan R,Ratner AJ,Sontich CU,van Heerckeren A,Davis P,Prince A

更新日期：2000-09-01 00:00:00

abstract：:Patients with acute lung injury or respiratory distress syndrome often require supplemental oxygen to maintain tissue oxygenation; however, this treatment can cause or worsen lung inflammation. CD44 is a transmembrane adhesion molecule that is present on a wide variety of cell types, including leukocytes and parenchym...

journal_title：American journal of respiratory cell and molecular biology

authors： van der Windt GJ,Schouten M,Zeerleder S,Florquin S,van der Poll T

更新日期：2011-03-01 00:00:00

abstract：:Although neutrophils play critical roles in innate immunity, in excess these cells cause severe tissue damage. Thus, neutrophil activation must be tightly regulated to prevent indiscriminant damage. Previously, we reported that mice lacking matrix metalloproteinase (MMP) 7 are protected from lung injury owing to marke...

journal_title：American journal of respiratory cell and molecular biology

authors： Gill SE,Nadler ST,Li Q,Frevert CW,Park PW,Chen P,Parks WC

更新日期：2016-08-01 00:00:00

abstract：:Lung injury is a frequent consequence of oxygen (O2) therapy administered to newborns and adults with respiratory distress. Acute exposure to hyperoxia results in a well-described pathophysiologic response in the lungs. Because inflammation is an important component of pulmonary O2 toxicity, we have an interest in ide...

journal_title：American journal of respiratory cell and molecular biology

authors： Piedboeuf B,Gamache M,Frenette J,Horowitz S,Baldwin HS,Petrov P

更新日期：1998-10-01 00:00:00

abstract：:Tumor necrosis factor-related apoptosis-inducing ligand (TRAIL/APO-2L) is a member of the tumor necrosis factor family that induces apoptosis in a variety of transformed cell lines and in normal human hepatocytes and brain cells. Soluble TRAIL at high concentrations was found to induce apoptotic death in normal human ...

journal_title：American journal of respiratory cell and molecular biology

authors： Yurovsky VV

更新日期：2003-02-01 00:00:00

abstract：:Clara cell secretory protein (CCSP), or CC10, is an inhibitor of secretory phospholipase A2 which may be produced by phagocytic cells and by a variety of other cells in the airway. Tumor necrosis factor-alpha (TNF-alpha) is capable of activating phospholipases and inducing the expression of a variety of genes in the a...

journal_title：American journal of respiratory cell and molecular biology

authors： Yao XL,Levine SJ,Cowan MJ,Logun C,Shelhamer JH

更新日期：1998-10-01 00:00:00

abstract：:The expression of bombesin-like peptides (BLPs) by pulmonary neuroendocrine cells is transiently upregulated during lung development. A functional role for BLPs is supported by their ability to stimulate lung growth and maturation both in vitro and in vivo during the late stages of lung development. In addition, the c...

journal_title：American journal of respiratory cell and molecular biology

authors： Aguayo SM,Schuyler WE,Murtagh JJ Jr,Roman J

更新日期：1994-06-01 00:00:00

abstract：:Recently, investigators demonstrated associations between fine particulate matter (PM)-associated metals and adverse health effects. Residual oil fly ash (ROFA), a waste product of fossil fuel combustion from boilers, is rich in the transition metals Fe, Ni, and V, and when released as a fugitive particle, is an impor...

journal_title：American journal of respiratory cell and molecular biology

authors： Farraj AK,Hazari MS,Haykal-Coates N,Lamb C,Winsett DW,Ge Y,Ledbetter AD,Carll AP,Bruno M,Ghio A,Costa DL

更新日期：2011-02-01 00:00:00

abstract：:Pulmonary fibrosis is an enigmatic and devastating disease with few treatment options, now thought to result from abnormal wound healing in the lung in response to injury. We have previously noted a role for the chemokine interferon gamma-inducible protein of 10 kD (IP-10)/CXC chemokine ligand 10 in the regulation of ...

journal_title：American journal of respiratory cell and molecular biology

authors： Tager AM,Kradin RL,LaCamera P,Bercury SD,Campanella GS,Leary CP,Polosukhin V,Zhao LH,Sakamoto H,Blackwell TS,Luster AD

更新日期：2004-10-01 00:00:00

abstract：:The capacity of Mycobacterium tuberculosis (MTB) to induce production of chemokines with known chemotactic activity for monocytes and lymphocytes, the cellular building blocks of granulomas, was investigated. These chemokines included regulated upon activation, normal T cell expressed and secreted (RANTES), monocyte c...

journal_title：American journal of respiratory cell and molecular biology

authors： Sadek MI,Sada E,Toossi Z,Schwander SK,Rich EA

更新日期：1998-09-01 00:00:00

abstract：:Platelet-activating factor (PAF), a proinflammatory lipid mediator, is a potent airway mucin secretagogue. This study assessed the role of protein kinase C (PKC) in PAF-induced mucin release from primary cultures of feline tracheal epithelial cells (FTEC). Mucin secretion was quantitated by enzyme-linked immunosorbent...

journal_title：American journal of respiratory cell and molecular biology

authors： Larivée P,Levine SJ,Martinez A,Wu T,Logun C,Shelhamer JH

更新日期：1994-08-01 00:00:00

abstract：:Recently, we described the isolation through fluorescent-activated cell sorting (FACS) of low autofluorescent (LAF) cells from human bronchoalveolar lavage (BAL). These LAF cells displayed an immunophenotype comparable with that of dendritic cells (DC), and showed a high potency to stimulate naive T cells. In the stud...

journal_title：American journal of respiratory cell and molecular biology

authors： van Haarst JM,Verhoeven GT,de Wit HJ,Hoogsteden HC,Debets R,Drexhage HA

更新日期：1996-12-01 00:00:00

abstract：:Tumor necrosis factor (TNF) is an inflammatory cytokine produced by many cell types which may contribute to the pathophysiology of a variety of lung diseases. In this study we have used Ro 45-2081 (a soluble receptor composed of the human p55 TNF receptor and human heavy-chain immunoglobulin G) to explore the role of ...

journal_title：American journal of respiratory cell and molecular biology

authors： Gater PR,Wasserman MA,Paciorek PM,Renzetti LM

更新日期：1996-05-01 00:00:00

abstract：:We investigated mechanically induced cell-to-cell Ca2+ signaling in a preparation of rabbit tracheal epithelium close to its in vivo condition. We used confocal microscopy to analyze changes in intracellular free calcium concentration ([Ca2+]i) in intact ciliated tracheal mucosal explants loaded with the Ca2+-indicato...

journal_title：American journal of respiratory cell and molecular biology

authors： Felix JA,Chaban VV,Woodruff ML,Dirksen ER

更新日期：1998-05-01 00:00:00

abstract：:Tumor necrosis factor-alpha (TNF-alpha) is thought to be important in the development of pulmonary fibrosis. However, surfactant protein-C/TNF-alpha transgenic mice do not spontaneously develop pulmonary fibrosis but instead develop alveolar enlargement and loss of elastic recoil. We hypothesized that overexpression o...

journal_title：American journal of respiratory cell and molecular biology

authors： Fujita M,Shannon JM,Morikawa O,Gauldie J,Hara N,Mason RJ

更新日期：2003-12-01 00:00:00

abstract：:SLC6A14-mediated l-arginine transport has been shown to augment the residual anion channel activity of the major mutant, F508del-CFTR, in the murine gastrointestinal tract. It is not yet known if this transporter augments residual and pharmacological corrected F508del-CFTR in primary airway epithelia. We sought to det...

journal_title：American journal of respiratory cell and molecular biology

authors： Ahmadi S,Wu YS,Li M,Ip W,Lloyd-Kuzik A,Di Paola M,Du K,Xia S,Lew A,Bozoky Z,Forman-Kay J,Bear CE,Gonska T

更新日期：2019-12-01 00:00:00

abstract：:Mucus hypersecretion is characteristic of chronic airway diseases. However, regulatory mechanisms are poorly understood. Human airway epithelial cells grown on permeable supports at the air-liquid interface (ALI) develop a mucociliary morphology resembling that found in vivo. Such cultures provide a model for studying...

journal_title：American journal of respiratory cell and molecular biology

authors： Bernacki SH,Nelson AL,Abdullah L,Sheehan JK,Harris A,Davis CW,Randell SH

更新日期：1999-04-01 00:00:00

abstract：:Recent in vitro studies have suggested that interleukin-4 (IL-4) may be involved in the preferential migration of eosinophils into the airways in allergic asthma through its capacity to selectively increase vascular cell adhesion molecule-1 (VCAM-1) expression on vessels. To test this hypothesis, we studied the expres...

journal_title：American journal of respiratory cell and molecular biology

authors： Fukuda T,Fukushima Y,Numao T,Ando N,Arima M,Nakajima H,Sagara H,Adachi T,Motojima S,Makino S

更新日期：1996-01-01 00:00:00

abstract：:Cytochrome P4501A1 (CYP1A1) metabolizes polycyclic aromatic hydrocarbons in cigarette smoke to DNA-binding reactive intermediates associated with carcinogenesis. Epidemiologic studies indicate that the majority of coal miners are smokers but have a lower risk of lung cancer than other smokers. We hypothesized that coa...

journal_title：American journal of respiratory cell and molecular biology

authors： Ghanem MM,Porter D,Battelli LA,Vallyathan V,Kashon ML,Ma JY,Barger MW,Nath J,Castranova V,Hubbs AF

更新日期：2004-08-01 00:00:00

abstract：:Acute lung injury (ALI) and its severe form, acute respiratory distress syndrome (ARDS), are major causes of acute respiratory failure with high rates of morbidity and mortality. Although surfactant protein (SP)-D plays a critical role in pulmonary innate immunity and several clinical studies suggest that this protein...

journal_title：American journal of respiratory cell and molecular biology

authors： King BA,Kingma PS

更新日期：2011-05-01 00:00:00

abstract：:Rat alveolar type II pneumocytes, in situ, label with Maclura pomifera agglutinin (MPA), a plant lectin that recognizes alpha-galactosyl oligosaccharide residues of glycoproteins and glycolipids. To study the glycoproteins recognized by the lectin, MPA lectin affinity chromatography was used to isolate a novel glycopr...

journal_title：American journal of respiratory cell and molecular biology

authors： Lwebuga-Mukasa JS

更新日期：1991-06-01 00:00:00