Amiodarone alters late endosomes and inhibits SARS coronavirus infection at a post-endosomal level.

abstract：:Genome-wide association studies (GWAS) have identified multiple associations with emphysema apicobasal distribution (EABD), but the biological functions of these variants are unknown. To characterize the functions of EABD-associated variants, we integrated GWAS results with 1) expression quantitative trait loci (eQTL)...

journal_title：American journal of respiratory cell and molecular biology

authors： Boueiz A,Pham B,Chase R,Lamb A,Lee S,Naing ZZC,Cho MH,Parker MM,Sakornsakolpat P,Hersh CP,Crapo JD,Stergachis AB,Tal-Singer R,DeMeo DL,Silverman EK,Zhou X,Castaldi PJ,COPDGene investigators, by Core Units:, ECLIPSE Inve

更新日期：2019-04-01 00:00:00

abstract：:Previous studies have shown that a single exposure of animals to ozone (O3) can induce protection or adaptation to the acute injurious effects of a subsequent O3 challenge. Although a number of mechanisms have been proposed to account for this response, none appear to be fully explanatory. We examined the role interle...

journal_title：American journal of respiratory cell and molecular biology

authors： McKinney WJ,Jaskot RH,Richards JH,Costa DL,Dreher KL

更新日期：1998-05-01 00:00:00

abstract：:Genetic epidemiology studies of end-stage lung disease are potentially hindered by low numbers of participants due to early death of patients from the underlying disease, or due to exclusion from studies after patients have had lung transplants, because of concern about bias of genotype data due to chimerism. The numb...

journal_title：American journal of respiratory cell and molecular biology

authors： DeMeo DL,Reilly JJ,Ginns LC,Sylvia JS,Silverman EK

更新日期：2005-10-01 00:00:00

abstract：:The objective of this study was to define phenotypic changes of antigen-presenting cells (APCs) and T cells in a murine model of antigen-induced airways inflammation that involves intraperitoneal sensitization with ovalbumin (OVA)/adjuvant followed by antigen aerosolization. We investigated the APC and T-cell compartm...

journal_title：American journal of respiratory cell and molecular biology

authors： Gajewska BU,Swirski FK,Alvarez D,Ritz SA,Goncharova S,Cundall M,Snider DP,Coyle AJ,Gutierrez-Ramos JC,Stämpfli MR,Jordana M

更新日期：2001-09-01 00:00:00

abstract：:T lymphocytes and alveolar macrophages accumulating in the lower respiratory tract of patients with pulmonary sarcoidosis are known to be activated to produce several cytokines, presumably leading to granuloma formation within the lung. We hypothesized that these cells produce colony-stimulating factors (CSFs), which ...

journal_title：American journal of respiratory cell and molecular biology

authors： Itoh A,Yamaguchi E,Kuzumaki N,Okazaki N,Furuya K,Abe S,Kawakami Y

更新日期：1990-09-01 00:00:00

abstract：:While elastin degradation is a hallmark of pulmonary emphysema, it is likely that elastin synthesis also occurs. However, the supramolecular structure and function of the newly synthesized elastin are abnormal. Very little is known about the regulation of elastin synthesis during the development of emphysema when prom...

journal_title：American journal of respiratory cell and molecular biology

authors： McGowan SE,McNamer R

更新日期：1990-10-01 00:00:00

abstract：:We previously described a reduction of silica-induced lung fibrosis in interleukin-10-deficient mice (IL-10-/-) (Huaux and colleagues; Am. J. Respir. Cell Mol. Biol. 1998;18:51-59). In the present study, we further dissect the exact functions of IL-10 in experimental silicosis. The reduced lung fibrotic response to si...

journal_title：American journal of respiratory cell and molecular biology

authors： Barbarin V,Arras M,Misson P,Delos M,McGarry B,Phan SH,Lison D,Huaux F

更新日期：2004-07-01 00:00:00

abstract：:Pleural organization may occur after empyema or complicated parapneumonic effusion and can result in restrictive lung disease with pleural fibrosis (PF). Pleural mesothelial cells; PMCs, may contribute to PF through acquisition of a profibrotic phenotype; meso-mesenchymal transition (MesoMT), which is characterized by...

journal_title：American journal of respiratory cell and molecular biology

authors： Qin W,Jeffers A,Owens S,Chauhan P,Komatsu S,Qian G,Guo X,Ikebe M,Idell S,Tucker TA

更新日期：2021-01-29 00:00:00

abstract：:Airway epithelial cells produce a number of chemokines, including eotaxins. Among the three known eotaxins, T helper (Th) type 2 cytokines have been observed to induce the expression of eotaxin-3 mRNA. This study investigated the effect of interferon (IFN)-gamma, a Th1 cytokine, on Th2 cytokine-induced eotaxin-3 produ...

journal_title：American journal of respiratory cell and molecular biology

authors： Yamamoto S,Kobayashi I,Tsuji K,Nishi N,Muro E,Miyazaki M,Zaitsu M,Inada S,Ichimaru T,Hamasaki Y

更新日期：2004-10-01 00:00:00

abstract：:The glucocorticoids (GC) and retinoids (RA) modulate branching morphogenesis and cytodifferentiation in the developing lung. We investigated downstream target genes that link glucocorticoid stimulation to the achievement of a mature lung in glucocorticoid receptor (GR) knockout mice. All GR(null) mice and approximatel...

journal_title：American journal of respiratory cell and molecular biology

authors： Kaplan F,Comber J,Sladek R,Hudson TJ,Muglia LJ,Macrae T,Gagnon S,Asada M,Brewer JA,Sweezey NB

更新日期：2003-01-01 00:00:00

abstract：:Interleukin (IL)-9 has recently been shown to play an important role in allergic disease because its expression is strongly associated with the degree of airway responsiveness and the asthmatic-like phenotype. IL-9 is a pleiotropic cytokine that is active on many cell types involved in the allergic immune response. Mu...

journal_title：American journal of respiratory cell and molecular biology

authors： Louahed J,Toda M,Jen J,Hamid Q,Renauld JC,Levitt RC,Nicolaides NC

更新日期：2000-06-01 00:00:00

abstract：:The increase of airway smooth muscle (ASM) mass in asthma results from hypertrophic and hyperplastic stimuli, and leads to an increase in cellular contractile proteins. However, little evidence correlates the relative contributions of hypertrophic and hyperplastic muscle with functional effects on airway resistance. W...

journal_title：American journal of respiratory cell and molecular biology

authors： Plant PJ,North ML,Ward A,Ward M,Khanna N,Correa J,Scott JA,Batt J

更新日期：2012-04-01 00:00:00

abstract：:Morphologic changes are reported to occur in rat lung vasculature after 3 days of hypoxia. We have previously shown that immunoreactivity for the vasodilator calcitonin gene-related peptide (CGRP) is increased in pulmonary endocrine cells by 7 days of hypoxia. Because these cells may be among the earliest mediators of...

journal_title：American journal of respiratory cell and molecular biology

authors： Roncalli M,Springall DR,Maggioni M,Moradoghli-Haftvani A,Winter RJ,Zhao L,Coggi G,Polak JM

更新日期：1993-11-01 00:00:00

abstract：:It had been thought that the central molecular event in the malignant transformation of a cell is the mutation of certain oncogenes-and the resultant dysregulated activation of their encoded proteins. During the past decade, however, it has become clear that alteration of the activity of the protein products of tumor ...

journal_title：American journal of respiratory cell and molecular biology

authors： Weintraub SJ

更新日期：1996-08-01 00:00:00

abstract：:Exposure to particulate air pollution is associated with increased cardiopulmonary morbidity and mortality, although the pathogenic mechanisms are poorly understood. We previously demonstrated that particulate matter (PM) exposure triggers massive oxidative stress in vascular endothelial cells (ECs), resulting in the ...

journal_title：American journal of respiratory cell and molecular biology

authors： Wang T,Wang L,Zaidi SR,Sammani S,Siegler J,Moreno-Vinasco L,Mathew B,Natarajan V,Garcia JG

更新日期：2012-10-01 00:00:00

abstract：:Geldanamycin is a benzoquinone ansamycin with multiple pharmacologic properties. Recent data demonstrated that geldanamycin conferred protection in an animal model of inflammation-associated acute lung injury. In the current study, we investigated the effects of geldanamycin on interleukin (IL)-8 gene expression and n...

journal_title：American journal of respiratory cell and molecular biology

authors： Malhotra V,Shanley TP,Pittet JF,Welch WJ,Wong HR

更新日期：2001-07-01 00:00:00

abstract：:The double-stranded RNA (dsRNA)-activated serine/threonine kinase R (PKR) is well characterized as an essential component of the innate antiviral response. Recently, PKR has been implicated in Toll-like receptor (TLR) signal transduction in response to bacterial cell wall components. Its contribution to pulmonary immu...

journal_title：American journal of respiratory cell and molecular biology

authors： Cabanski M,Steinmüller M,Marsh LM,Surdziel E,Seeger W,Lohmeyer J

更新日期：2008-01-01 00:00:00

abstract：:Bombesin-like peptides within neuroepithelial cells elicit proliferation of normal and malignant airway epithelial cells. It is not clear that these peptides also elicit epithelial cell migration, a necessary component of airway repair after injury. We studied the effects of the bombesin analogues, gastrin releasing p...

journal_title：American journal of respiratory cell and molecular biology

authors： Kim JS,McKinnis VS,White SR

更新日期：1997-03-01 00:00:00

abstract：:Neutrophil-associated inflammation during Pseudomonas aeruginosa lung infection is a determinant of morbidity in cystic fibrosis (CF). Neutrophil apoptosis is a key factor in inflammation resolution and is controlled by cytosolic proliferating cell nuclear antigen (PCNA). p21/Waf1, a cyclin-dependent kinase inhibitor,...

journal_title：American journal of respiratory cell and molecular biology

authors： Martin C,Ohayon D,Alkan M,Mocek J,Pederzoli-Ribeil M,Candalh C,Thevenot G,Millet A,Tamassia N,Cassatella MA,Thieblemont N,Burgel PR,Witko-Sarsat V

更新日期：2016-05-01 00:00:00

abstract：:Chronic airway infections with Pseudomonas aeruginosa determine morbidity in most individuals with cystic fibrosis (CF). P. aeruginosa may persist for decades in CF lungs, which provides a rare opportunity to study the long-term within-host evolution of a bacterial airway pathogen. In this work, we sought to resolve t...

journal_title：American journal of respiratory cell and molecular biology

authors： Klockgether J,Cramer N,Fischer S,Wiehlmann L,Tümmler B

更新日期：2018-08-01 00:00:00

abstract：:Although it is known that surfactant lipids and proteins are altered in patients with Pseudomonas aeruginosa infections, the mechanisms and implications of these alterations are not clear. In this study, the effects of P. aeruginosa on the surfactant large aggregate fraction were examined using an in vitro surface are...

journal_title：American journal of respiratory cell and molecular biology

authors： Beatty AL,Malloy JL,Wright JR

更新日期：2005-02-01 00:00:00

abstract：:Polymorphonuclear neutrophil (PMN) migration across basement membrane is thought to be dependent on the degradation of membrane constituents. PMN gelatinase B, a metalloproteinase able to degrade type IV collagen, may be involved in this phenomenon. PMN gelatinase B is released in the extracellular medium as a latent ...

journal_title：American journal of respiratory cell and molecular biology

authors： Delclaux C,Delacourt C,D'Ortho MP,Boyer V,Lafuma C,Harf A

更新日期：1996-03-01 00:00:00

abstract：:Quantitative measurement of [3H]thymidine [( 3H]TdR) incorporation into cultured cells is widely used as an indicator of cell proliferation. The observation that adult type II cells are able to incorporate large amounts of [3H]TdR despite the fact that they are not proliferating raised the question of the meaning of [...

journal_title：American journal of respiratory cell and molecular biology

authors： Clement A,Riedel N,Brody JS

更新日期：1990-08-01 00:00:00

abstract：:In this study we examined the effect of oral antigen (Ag) administration on the development of experimental asthma in different mouse strains. We selected BALB/c, BP2, CBA/Ca interleukin (IL)-5 transgenic, and BALB/c T-cell receptor-delta-deficient mouse strains because they exhibit different aspects of the asthma syn...

journal_title：American journal of respiratory cell and molecular biology

authors： Russo M,Nahori MA,Lefort J,Gomes E,de Castro Keller A,Rodriguez D,Ribeiro OG,Adriouch S,Gallois V,de Faria AM,Vargaftig BB

更新日期：2001-05-01 00:00:00

abstract：:Impaired sphingolipid synthesis is linked genetically to childhood asthma and functionally to airway hyperreactivity (AHR). The objective was to investigate whether sphingolipid synthesis could be a target for asthma therapeutics. The effects of GlyH-101 and fenretinide via modulation of de novo sphingolipid synthesis...

journal_title：American journal of respiratory cell and molecular biology

authors： Heras AF,Veerappan A,Silver RB,Emala CW,Worgall TS,Perez-Zoghbi J,Worgall S

更新日期：2020-11-01 00:00:00

abstract：:Isoprostanes are prostaglandin-like molecules that accumulate in oxidative stress and also exert powerful biological effects on a wide variety of tissues. We investigated the effects of several different isoprostanes on contractions evoked by electrical field stimulation (EFS) in bovine trachealis, finding only 15-E2t...

journal_title：American journal of respiratory cell and molecular biology

authors： Paredes C,Tazzeo T,Janssen LJ

更新日期：2007-12-01 00:00:00

abstract：:In the current study, we describe cytokine and Escherichia coli lipopolysaccharide (LPS) induction of nitric oxide (NO) synthase mRNA levels in cultured smooth muscle from rat pulmonary artery (RPASM). Exposure of RPASM to interleukin-1 beta, interferon-gamma, or LPS alone did not significantly affect NO synthesis, as...

journal_title：American journal of respiratory cell and molecular biology

authors： Nakayama DK,Geller DA,Lowenstein CJ,Chern HD,Davies P,Pitt BR,Simmons RL,Billiar TR

更新日期：1992-11-01 00:00:00

abstract：:Distribution of actin and fodrin, a nonerythroid analogue of spectrin, was studied in cytocentrifuge preparations and in tissue sections of normal and pathologic respiratory epithelium by using immunofluorescence and immunoelectron microscopy. In ciliated epithelial cells and in goblet cells of normal bronchial epithe...

journal_title：American journal of respiratory cell and molecular biology

authors： Sormunen R,Pääkkö P,Palovuori R,Soini Y,Lehto VP

更新日期：1994-07-01 00:00:00

abstract：:Tumor necrosis factor-alpha (TNF-alpha) is an important inflammatory mediator produced by activated monocytes and macrophages. We have previously shown that porcine alveolar macrophages (PAM) mediate bystander cytotoxicity through hydrogen peroxide production following activation with immobilized IgG immune complex (I...

journal_title：American journal of respiratory cell and molecular biology

authors： Kim JW,Wierda WG,Kim YB

更新日期：1991-09-01 00:00:00

abstract：:Inhalation of the pulmonary irritant ozone is associated with an accumulation of macrophages in the lung. These cells, along with type II epithelial cells, are activated to release increased quantities of hydrogen peroxide and nitric oxide, two reactive mediators that have been implicated in tissue injury. In the pres...

journal_title：American journal of respiratory cell and molecular biology

authors： Pendino KJ,Gardner CR,Shuler RL,Laskin JD,Durham SK,Barton DS,Ohnishi ST,Ohnishi T,Laskin DL

更新日期：1996-06-01 00:00:00