Priming of allergic immune responses by repeated ozone exposure in mice.

abstract：:In the current study, we describe cytokine and Escherichia coli lipopolysaccharide (LPS) induction of nitric oxide (NO) synthase mRNA levels in cultured smooth muscle from rat pulmonary artery (RPASM). Exposure of RPASM to interleukin-1 beta, interferon-gamma, or LPS alone did not significantly affect NO synthesis, as...

journal_title：American journal of respiratory cell and molecular biology

authors： Nakayama DK,Geller DA,Lowenstein CJ,Chern HD,Davies P,Pitt BR,Simmons RL,Billiar TR

更新日期：1992-11-01 00:00:00

abstract：:Endothelin, an endothelium-derived vasoconstrictor peptide, has recently been reported to exist in airway epithelial cells. To elucidate a possible role of endothelin on epithelial functions, we studied the effects of this peptide on ciliary beat frequency (CBF) and electrical properties of canine cultured tracheal ep...

journal_title：American journal of respiratory cell and molecular biology

authors： Tamaoki J,Kanemura T,Sakai N,Isono K,Kobayashi K,Takizawa T

更新日期：1991-05-01 00:00:00

abstract：:The purpose of this study was to characterize basolateral anion channels in Calu-3 and normal human bronchial epithelial cells, and their role in anion secretion. Patch clamp studies identified an outwardly rectifying Cl- channel (ORCC), which could be activated by the adenosine receptor agonist 5'-(N-ethylcarboxamido...

journal_title：American journal of respiratory cell and molecular biology

authors： Szkotak AJ,Man SF,Duszyk M

更新日期：2003-12-01 00:00:00

abstract：:Over one-third of lung recipients have preexisting antibodies against lung-restricted antigens: collagen (Col) type V and K-α1 tubulin (KAT). Although clinical studies have shown association of these antibodies with primary graft dysfunction (PGD), their biological significance remains unclear. We tested whether preex...

journal_title：American journal of respiratory cell and molecular biology

authors： Bharat A,Chiu S,Zheng Z,Sun H,Yeldandi A,DeCamp MM,Perlman H,Budinger GR,Mohanakumar T

更新日期：2016-10-01 00:00:00

abstract：:The objective of this study was to define phenotypic changes of antigen-presenting cells (APCs) and T cells in a murine model of antigen-induced airways inflammation that involves intraperitoneal sensitization with ovalbumin (OVA)/adjuvant followed by antigen aerosolization. We investigated the APC and T-cell compartm...

journal_title：American journal of respiratory cell and molecular biology

authors： Gajewska BU,Swirski FK,Alvarez D,Ritz SA,Goncharova S,Cundall M,Snider DP,Coyle AJ,Gutierrez-Ramos JC,Stämpfli MR,Jordana M

更新日期：2001-09-01 00:00:00

abstract：:Neutrophil-associated inflammation during Pseudomonas aeruginosa lung infection is a determinant of morbidity in cystic fibrosis (CF). Neutrophil apoptosis is a key factor in inflammation resolution and is controlled by cytosolic proliferating cell nuclear antigen (PCNA). p21/Waf1, a cyclin-dependent kinase inhibitor,...

journal_title：American journal of respiratory cell and molecular biology

authors： Martin C,Ohayon D,Alkan M,Mocek J,Pederzoli-Ribeil M,Candalh C,Thevenot G,Millet A,Tamassia N,Cassatella MA,Thieblemont N,Burgel PR,Witko-Sarsat V

更新日期：2016-05-01 00:00:00

abstract：:To evaluate the response of an epithelial barrier to a moderate but sustained oxidative stress, we cultured monolayers of Madin Darby canine kidney cells on microporous filters and exposed them to the hypoxanthine-xanthine oxidase (HX-XO) reaction. The transepithelial permeability coefficient for mannitol (Pm) was ass...

journal_title：American journal of respiratory cell and molecular biology

authors： Rochat T,Burkhard C,Finci-Cerkez V,Meda P

更新日期：1993-11-01 00:00:00

abstract：:Gene therapy is the treatment of any disorder or pathophysiologic state based upon the transfer of genetic information. The lung represents a major target of gene therapy for the treatment of genetic disorders such as cystic fibrosis and alpha 1-antitrypsin deficiency. Other diseases are also being targeted, including...

journal_title：American journal of respiratory cell and molecular biology

authors： Curiel DT,Pilewski JM,Albelda SM

更新日期：1996-01-01 00:00:00

abstract：:A subset of workers in swine confinement facilities develops chronic respiratory disease. An aqueous extract of dust from these facilities (hogbarn dust extract [HDE]) induces IL-6 and IL-8 release and several other responses in isolated airway epithelial cells. The cell membrane receptors by which HDE initiates these...

journal_title：American journal of respiratory cell and molecular biology

authors： Dodmane PR,Schulte NA,Heires AJ,Band H,Romberger DJ,Toews ML

更新日期：2011-10-01 00:00:00

abstract：:Type 2 alveolar epithelial cells (AEC2) are regarded as the progenitor population of the alveolus responsible for injury repair and homeostatic maintenance. Depletion of this population is hypothesized to underlie various lung pathologies. Current models of lung injury rely on either uncontrolled, nonspecific destruct...

journal_title：American journal of respiratory cell and molecular biology

authors： Garcia O,Hiatt MJ,Lundin A,Lee J,Reddy R,Navarro S,Kikuchi A,Driscoll B

更新日期：2016-03-01 00:00:00

abstract：:IL-11 and IL-11 receptor (R)alpha are induced by Th2 cytokines. However, the role(s) of endogenous IL-11 in antigen-induced Th2 inflammation has not been fully defined. We hypothesized that IL-11, signaling via IL-11Ralpha, plays an important role in aeroallergen-induced Th2 inflammation and mucus metaplasia. To test ...

journal_title：American journal of respiratory cell and molecular biology

authors： Lee CG,Hartl D,Matsuura H,Dunlop FM,Scotney PD,Fabri LJ,Nash AD,Chen NY,Tang CY,Chen Q,Homer RJ,Baca M,Elias JA

更新日期：2008-12-01 00:00:00

abstract：:Pneumocystis is an important fungal pathogen that causes life-threatening pneumonia in patients with AIDS and malignancy. Lung fungal pathogens are recognized by C-type lectin receptors (CLRs), which bind specific ligands and stimulate innate immune responses. The CLR Dectin-1 was previously shown to mediate immune re...

journal_title：American journal of respiratory cell and molecular biology

authors： Kottom TJ,Hebrink DM,Jenson PE,Marsolek PL,Wüthrich M,Wang H,Klein B,Yamasaki S,Limper AH

更新日期：2018-02-01 00:00:00

abstract：:Muc1 is a heterodimeric mucin that is expressed on the apical surface of airway epithelial cells as well as hematopoietic cells. Both in vivo and in vitro studies revealed that Muc1 suppresses inflammatory responses induced by Pseudomonas aeruginosa (PA). In this study, we sought to determine, using intact animals (C5...

journal_title：American journal of respiratory cell and molecular biology

authors： Choi S,Park YS,Koga T,Treloar A,Kim KC

更新日期：2011-02-01 00:00:00

abstract：:Pleural infection is common. Evacuation of infected pleural fluid is essential for successful treatment, but it is often difficult because of adhesions/loculations within the effusion and the viscosity of the fluid. Intrapleural delivery of tissue plasminogen activator (tPA) (to break the adhesions) and deoxyribonucle...

journal_title：American journal of respiratory cell and molecular biology

authors： Lansley SM,Cheah HM,Varano Della Vergiliana JF,Chakera A,Lee YC

更新日期：2015-07-01 00:00:00

abstract：:We examined the ability of conditioned medium (CM) generated by human upper airway epithelial (Ep) cells from normal (NN) and inflamed, allergic rhinitis (AR) and nasal polyp (NP) tissues to induce monocytic differentiation of hemopoietic progenitors of the HL-60 myeloid leukemia cell line in vitro. In HL-60 cells cul...

journal_title：American journal of respiratory cell and molecular biology

authors： Ohtoshi T,Vancheri C,Cox G,Gauldie J,Dolovich J,Denburg JA,Jordana M

更新日期：1991-03-01 00:00:00

abstract：:The development of multiple organ failure in patients with hemorrhagic shock is significantly influenced by patient age. Adenosine monophosphate-activated protein kinase (AMPK) is a crucial regulator of energy homeostasis, which coordinates metabolic repair during cellular stress. We investigated whether AMPK-regulate...

journal_title：American journal of respiratory cell and molecular biology

authors： Klingbeil LR,Kim P,Piraino G,O'Connor M,Hake PW,Wolfe V,Zingarelli B

更新日期：2017-05-01 00:00:00

abstract：:Polymorphonuclear leukocytes (PMN) and eosinophils (Eos) are important cellular participants in a variety of acute and chronic inflammatory reactions in the airway. Histologic evidence has implicated direct interactions between these two subsets of leukocytes and airway epithelial cells during inflammation. A comprehe...

journal_title：American journal of respiratory cell and molecular biology

authors： Jagels MA,Daffern PJ,Zuraw BL,Hugli TE

更新日期：1999-09-01 00:00:00

abstract：:Pneumocystis carinii causes severe pneumonia in immunocompromised patients. Recent studies indicate that P. carinii uses a Cdc2 cyclin-dependent kinase to control its proliferation. To further study the regulation of the life cycle of P. carinii, we characterized the P. carinii B-type cyclin termed Cdc13, whose bindin...

journal_title：American journal of respiratory cell and molecular biology

authors： Kottom TJ,Thomas CF Jr,Mubarak KK,Leof EB,Limper AH

更新日期：2000-06-01 00:00:00

abstract：:Although mast cell secretion has been intensively studied because of its pivotal role in allergic reactions and its advantages as a physiologic model, the molecular composition of the secretory machine is virtually unknown. In view of the guanine-nucleotide dependency of mast cell exocytosis and the participation of R...

journal_title：American journal of respiratory cell and molecular biology

authors： Tuvim MJ,Adachi R,Chocano JF,Moore RH,Lampert RM,Zera E,Romero E,Knoll BJ,Dickey BF

更新日期：1999-01-01 00:00:00

abstract：:Nontypable Haemophilus influenzae (NTHI) is being increasingly recognized as a cause of both adult pneumonia and acute infectious exacerbations in chronic bronchitis. We used a mouse model to study the immune enhancement of pulmonary clearance of NTHI after a primary immunization. BALB/c mice were immunized with whole...

journal_title：American journal of respiratory cell and molecular biology

authors： McGehee JL,Radolf JD,Toews GB,Hansen EJ

更新日期：1989-09-01 00:00:00

abstract：:Laminins are heterotrimeric proteins that are secreted by the alveolar epithelium into the basement membrane, and their expression is altered in extracellular matrices from patients with pulmonary fibrosis. In a small number of patients with pulmonary fibrosis, we found that the normal basement membrane distribution o...

journal_title：American journal of respiratory cell and molecular biology

authors： Morales-Nebreda LI,Rogel MR,Eisenberg JL,Hamill KJ,Soberanes S,Nigdelioglu R,Chi M,Cho T,Radigan KA,Ridge KM,Misharin AV,Woychek A,Hopkinson S,Perlman H,Mutlu GM,Pardo A,Selman M,Jones JC,Budinger GR

更新日期：2015-04-01 00:00:00

abstract：:Patients with severe acute and chronic lung diseases develop derangements in gas exchange that may result in increased levels of CO(2) (hypercapnia), the effects of which on human health are incompletely understood. It has been proposed that hypercapnia may have beneficial effects in patients with acute lung injury, a...

journal_title：American journal of respiratory cell and molecular biology

authors： Vadász I,Hubmayr RD,Nin N,Sporn PH,Sznajder JI

更新日期：2012-04-01 00:00:00

abstract：:Mechanical stimulation of the airway epithelium, as would occur during bronchoconstriction, is a potent stimulus and can activate profibrotic pathways. We used DNA microarray technology to examine gene expression in compressed normal human bronchial epithelial cells (NHBE). Compressive stress applied continuously over...

journal_title：American journal of respiratory cell and molecular biology

authors： Chu EK,Cheng J,Foley JS,Mecham BH,Owen CA,Haley KJ,Mariani TJ,Kohane IS,Tschumperlin DJ,Drazen JM

更新日期：2006-12-01 00:00:00

abstract：:Infants born to heroin- and cocaine-addicted mothers have been reported to have a lower incidence of respiratory distress syndrome (RDS) compared with nonaddicted infants. However, it is not known whether these are direct drug-mediated effects or secondary phenomena. We therefore investigated the effect of opioids and...

journal_title：American journal of respiratory cell and molecular biology

authors： Gewolb IH,O'Brien J,Slavin RE

更新日期：1999-03-01 00:00:00

abstract：:Chronic pulmonary inflammation in patients affected by cystic fibrosis (CF) is characterized by massive bronchial infiltrates of neutrophils, which is sustained by the interaction of pathogens (e.g., Pseudomonas aeruginosa) with surface bronchial cells. To explore new treatment options focused on the reduction of neut...

journal_title：American journal of respiratory cell and molecular biology

authors： Bezzerri V,Borgatti M,Nicolis E,Lampronti I,Dechecchi MC,Mancini I,Rizzotti P,Gambari R,Cabrini G

更新日期：2008-07-01 00:00:00

abstract：:Platelet-activating factor (PAF), a proinflammatory lipid mediator, is a potent airway mucin secretagogue. This study assessed the role of protein kinase C (PKC) in PAF-induced mucin release from primary cultures of feline tracheal epithelial cells (FTEC). Mucin secretion was quantitated by enzyme-linked immunosorbent...

journal_title：American journal of respiratory cell and molecular biology

authors： Larivée P,Levine SJ,Martinez A,Wu T,Logun C,Shelhamer JH

更新日期：1994-08-01 00:00:00

abstract：:The transcription factor (TF) Foxp2 has been shown to partially repress surfactant protein C (SP-C) transcription, presumably through interaction of an independent repressor domain with a conserved Foxp2 consensus site in the SP-C promoter. We explored the role of interactions between Foxp2 and the homeodomain TF Nkx2...

journal_title：American journal of respiratory cell and molecular biology

authors： Zhou B,Zhong Q,Minoo P,Li C,Ann DK,Frenkel B,Morrisey EE,Crandall ED,Borok Z

更新日期：2008-06-01 00:00:00

abstract：:IL-1β is a potent proinflammatory cytokine that is implicated in the pathogenesis of acute respiratory distress syndrome. We hypothesized that LPS and mechanical ventilation (MV) together could lead to IL-1β secretion and the development of acute lung injury (ALI), and that this process would be dependent on caspase-1...

journal_title：American journal of respiratory cell and molecular biology

authors： Jones HD,Crother TR,Gonzalez-Villalobos RA,Jupelli M,Chen S,Dagvadorj J,Arditi M,Shimada K

更新日期：2014-02-01 00:00:00

abstract：:The cytokine mRNA profiles of primary (arising from inhaled bacilli) and secondary (arising from hematogenous reseeding of the lung) granulomas from the lung lobes of bacillus Calmette-Guérin (BCG)-vaccinated and unimmunized guinea pigs challenged with virulent Mycobacterium tuberculosis by the pulmonary route were as...

journal_title：American journal of respiratory cell and molecular biology

authors： Ly LH,Russell MI,McMurray DN

更新日期：2008-04-01 00:00:00

abstract：:Cigarette smoke (CS) is the main causative factor of chronic obstructive pulmonary disease (COPD). Current research supports the concept that airway inflammation is central to the development and progression of the disease. Studies have demonstrated that neutrophils are increased in COPD lungs and that neutrophil-asso...

journal_title：American journal of respiratory cell and molecular biology

authors： Cardini S,Dalli J,Fineschi S,Perretti M,Lungarella G,Lucattelli M

更新日期：2012-09-01 00:00:00