Genetic ablation of the fpr1 gene confers protection from smoking-induced lung emphysema in mice.

abstract：:In surgically excised nasal polyps, most epithelial mast cells were formalin sensitive, chloroacetate esterase (CAE) negative, and chymase negative. Thus, this represents a population of mast cells not identified by staining for CAE. On the other hand, most stromal mast cells were formalin resistant and CAE positive, ...

journal_title：American journal of respiratory cell and molecular biology

authors： Kawabori S,Denburg JA,Schwartz LB,Irani AA,Wong D,Jordana G,Evans S,Dolovich J

更新日期：1992-01-01 00:00:00

abstract：:Eotaxins-1, -2, and -3 mediate the recruitment of blood-borne eosinophils to allergically inflamed tissues by binding CC chemokine receptor (CCR) 3. Mast cells (MCs) are resident tissue cells that also express CCR3. In the present study, we demonstrate that human (h) MCs in nasal polyps and cultured cord blood-derived...

journal_title：American journal of respiratory cell and molecular biology

authors： Price KS,Friend DS,Mellor EA,De Jesus N,Watts GF,Boyce JA

更新日期：2003-04-01 00:00:00

abstract：:Inhalation of the pulmonary irritant ozone is associated with an accumulation of macrophages in the lung. These cells, along with type II epithelial cells, are activated to release increased quantities of hydrogen peroxide and nitric oxide, two reactive mediators that have been implicated in tissue injury. In the pres...

journal_title：American journal of respiratory cell and molecular biology

authors： Pendino KJ,Gardner CR,Shuler RL,Laskin JD,Durham SK,Barton DS,Ohnishi ST,Ohnishi T,Laskin DL

更新日期：1996-06-01 00:00:00

abstract：:Bleomycin-induced lung injury causes increased fibroblast numbers in the lung and pulmonary fibrosis. Studies of fibroblasts isolated from such injured lungs have revealed evidence of increased intrinsic proliferative capacity, but the mechanism is unknown. Telomerase catalyzes the addition of telomeric DNA repeats on...

journal_title：American journal of respiratory cell and molecular biology

authors： Nozaki Y,Liu T,Hatano K,Gharaee-Kermani M,Phan SH

更新日期：2000-10-01 00:00:00

abstract：:Lung morphometry was introduced over 50 years ago to provide quantitative evaluation of the lung structure. The existing parameters, such as mean linear intercept and destructive index, suffer from simplistic data interpretation and a subjective data acquisition process. To overcome these existing shortcomings, parenc...

journal_title：American journal of respiratory cell and molecular biology

authors： Xiao R,Goldklang MP,D'Armiento JM

更新日期：2016-11-01 00:00:00

abstract：:Human tracheal gland serous (HTGS) cells are now considered one principal pulmonary target for the gene therapy of cystic fibrosis (CF). We developed a CF tracheal gland serous cell line, CF-KM4, obtained by the transformation of primary cultures of CF tracheal gland serous cells homozygous for the DeltaF508 mutation ...

journal_title：American journal of respiratory cell and molecular biology

authors： Kammouni W,Moreau B,Becq F,Saleh A,Pavirani A,Figarella C,Merten MD

更新日期：1999-04-01 00:00:00

abstract：:Increased susceptibility to infections, including tuberculosis (TB), is a major cause of morbidity and mortality in patients with diabetes. Despite the clinical importance of this problem, little is known about how diabetes impairs protective immunity. We modeled this phenomenon by infecting acute (< or = 1 mo) or chr...

journal_title：American journal of respiratory cell and molecular biology

authors： Martens GW,Arikan MC,Lee J,Ren F,Greiner D,Kornfeld H

更新日期：2007-11-01 00:00:00

abstract：:Tissue inhibitors of metalloproteinases (TIMPs) are multifunctional proteins that have the capacity to modify cellular activities and to modulate matrix turnover. We demonstrate that TIMP-1 messenger RNA (mRNA) and protein expression are selectively and markedly increased in a murine model of bleomycin-induced pulmona...

journal_title：American journal of respiratory cell and molecular biology

authors： Madtes DK,Elston AL,Kaback LA,Clark JG

更新日期：2001-05-01 00:00:00

abstract：:β-Arrestin-2 (βarr2) is a ubiquitously expressed cytosolic protein that terminates G protein-coupled receptor signaling and transduces G protein-independent signaling. We previously showed that mice lacking βarr2 do not develop an asthma phenotype when sensitized to, and challenged with, allergens. The current study e...

journal_title：American journal of respiratory cell and molecular biology

authors： Chen M,Hegde A,Choi YH,Theriot BS,Premont RT,Chen W,Walker JK

更新日期：2015-09-01 00:00:00

abstract：:Protein kinase C (PKC) is known to regulate ryanodine receptor (RyR)-mediated local Ca(2+) signaling (Ca(2+) spark) in airway and vascular smooth muscle cells (SMCs), but its specific molecular mechanisms and functions still remain elusive. In this study, we reveal that, in airway SMCs, specific PKCepsilon peptide inh...

journal_title：American journal of respiratory cell and molecular biology

authors： Liu QH,Zheng YM,Korde AS,Li XQ,Ma J,Takeshima H,Wang YX

更新日期：2009-06-01 00:00:00

abstract：:Neutrophils were found to demonstrate chemotactic responses to pepsinized human placental type IV collagen and its purified aminoterminal 7S domain. The maximal chemotactic responses occur at approximately 400 ng/ml and approximately 30 ng/ml of type IV collagen and 7S collagen, respectively, and are similar in magnit...

journal_title：American journal of respiratory cell and molecular biology

authors： Senior RM,Hinek A,Griffin GL,Pipoly DJ,Crouch EC,Mecham RP

更新日期：1989-12-01 00:00:00

abstract：:Since the lung is repeatedly subjected to injury by pathogens and toxicants, maintenance of pulmonary homeostasis requires rapid repair of its epithelial surfaces. Ciliated bronchiolar epithelial cells, previously considered as terminally differentiated, underwent squamous cell metaplasia within hours after bronchiola...

journal_title：American journal of respiratory cell and molecular biology

authors： Park KS,Wells JM,Zorn AM,Wert SE,Laubach VE,Fernandez LG,Whitsett JA

更新日期：2006-02-01 00:00:00

abstract：:Increased airway responsiveness is linked to lung function decline and mortality in subjects with chronic obstructive pulmonary disease (COPD); however, the genetic contribution to airway responsiveness remains largely unknown. A genome-wide association study (GWAS) was performed using the Illumina (San Diego, CA) Hum...

journal_title：American journal of respiratory cell and molecular biology

authors： Hansel NN,Paré PD,Rafaels N,Sin DD,Sandford A,Daley D,Vergara C,Huang L,Elliott WM,Pascoe CD,Arsenault BA,Postma DS,Boezen HM,Bossé Y,van den Berge M,Hiemstra PS,Cho MH,Litonjua AA,Sparrow D,Ober C,Wise RA,Conne

更新日期：2015-08-01 00:00:00

abstract：:Cyclooxygenase-2 (COX-2) expression and PGE2 secretion from human airway smooth muscle cells (hASMCs) may contribute to β2-adrenoceptor hyporesponsiveness, a clinical feature observed in some patients with asthma. hASMCs from patients with asthma exhibit elevated expression of cytokine-responsive genes, and in some in...

journal_title：American journal of respiratory cell and molecular biology

authors： Comer BS,Camoretti-Mercado B,Kogut PC,Halayko AJ,Solway J,Gerthoffer WT

更新日期：2015-04-01 00:00:00

abstract：:We examined the effects of extracellular ATP on the proliferation and synthesis of DNA by guinea pig alveolar macrophages (AM). AM proliferated spontaneously in vitro, their number doubling in 72 h. Such proliferation was completely inhibited by adding 1 mM ATP to the culture. The inhibition was dose dependent. ATP al...

journal_title：American journal of respiratory cell and molecular biology

authors： Nakanishi M,Kawasaki M,Ogino H,Yoshida M,Yagawa K

更新日期：1994-05-01 00:00:00

abstract：:Keratinocyte growth factor (KGF) or fibroblast growth factor (FGF)-7, a peptide produced by stromal cells and in particular by lung mesenchyme, has recently been shown to influence early lung morphogenesis and to be a mitogen for fetal and adult alveolar type II cells. Although contradictory findings have been reporte...

journal_title：American journal of respiratory cell and molecular biology

authors： Chelly N,Mouhieddine-Gueddiche OB,Barlier-Mur AM,Chailley-Heu B,Bourbon JR

更新日期：1999-03-01 00:00:00

abstract：:Endotoxin lipopolysaccharide and the cytokines, tumor necrosis factor (TNF) and interleukin-1 (IL-1), are known to protect adult rats against O2 toxicity. However, whether the effect of endotoxin is mediated by these cytokines is not clear. We have previously demonstrated that depletion of 84% rat alveolar macrophages...

journal_title：American journal of respiratory cell and molecular biology

authors： Tang G,White JE,Lumb PD,Lawrence DA,Tsan MF

更新日期：1995-03-01 00:00:00

abstract：:Pleural infection is common. Evacuation of infected pleural fluid is essential for successful treatment, but it is often difficult because of adhesions/loculations within the effusion and the viscosity of the fluid. Intrapleural delivery of tissue plasminogen activator (tPA) (to break the adhesions) and deoxyribonucle...

journal_title：American journal of respiratory cell and molecular biology

authors： Lansley SM,Cheah HM,Varano Della Vergiliana JF,Chakera A,Lee YC

更新日期：2015-07-01 00:00:00

abstract：:The alveolar epithelium is a critical target for pulmonary viruses and can produce proinflammatory cytokines and chemokines upon viral infection. However, the molecular interactions between virus-infected alveolar epithelial cells and inflammatory cells, including polymorphonuclear leukocytes (PMNs), have not been tho...

journal_title：American journal of respiratory cell and molecular biology

authors： Rzepka JP,Haick AK,Miura TA

更新日期：2012-06-01 00:00:00

abstract：:Morphologic changes are reported to occur in rat lung vasculature after 3 days of hypoxia. We have previously shown that immunoreactivity for the vasodilator calcitonin gene-related peptide (CGRP) is increased in pulmonary endocrine cells by 7 days of hypoxia. Because these cells may be among the earliest mediators of...

journal_title：American journal of respiratory cell and molecular biology

authors： Roncalli M,Springall DR,Maggioni M,Moradoghli-Haftvani A,Winter RJ,Zhao L,Coggi G,Polak JM

更新日期：1993-11-01 00:00:00

abstract：:Humans and rodents exposed to an aerosol of asbestos fibers develop lung injury that can lead to a fibroproliferative response culminating in excessive scarring and impaired lung function. To define the early events that precede asbestos-induced fibrotic lung disease, rats were exposed to an aerosol of chrysotile asbe...

journal_title：American journal of respiratory cell and molecular biology

authors： Mishra A,Liu JY,Brody AR,Morris GF

更新日期：1997-04-01 00:00:00

abstract：:Airway allergen exposure induces inflammation among individuals with atopy that is characterized by altered airway gene expression, elevated levels of T helper type 2 cytokines, mucus hypersecretion, and airflow obstruction. To identify the genetic determinants of the airway allergen response, we employed a systems ge...

journal_title：American journal of respiratory cell and molecular biology

authors： Kelada SN,Carpenter DE,Aylor DL,Chines P,Rutledge H,Chesler EJ,Churchill GA,Pardo-Manuel de Villena F,Schwartz DA,Collins FS

更新日期：2014-09-01 00:00:00

abstract：:PS-341 is a highly selective and potent proteasome inhibitor that is cytotoxic to various types of cancer. However, no objective response was seen in a clinical trial with PS-341 as a single agent in non-small cell lung cancer. Its antitumor activity is limited by the simultaneously activated antiapoptosis pathway. Re...

journal_title：American journal of respiratory cell and molecular biology

authors： Lee KH,Jang AH,Yoo CG

更新日期：2015-09-01 00:00:00

abstract：:The doxycycline-inducible, gene regulatory system allows tight control of transgene expression for the study of organ development and disease pathogenesis. Multiple recent reports have employed this model to investigate various lung diseases including emphysema. For our study, we used this transgenic system to test wh...

journal_title：American journal of respiratory cell and molecular biology

authors： Sisson TH,Hansen JM,Shah M,Hanson KE,Du M,Ling T,Simon RH,Christensen PJ

更新日期：2006-05-01 00:00:00

abstract：:Species in the genus Pneumocystis can cause severe pneumonia in immune-compromised hosts. The identification of specific targets present in Pneumocystis species, but lacking in mammalian hosts, is paramount to developing new means to treat this infection. One such potential protein is Rtt109, which is a type of histon...

journal_title：American journal of respiratory cell and molecular biology

authors： Kottom TJ,Han J,Zhang Z,Limper AH

更新日期：2011-06-01 00:00:00

abstract：:We sought to determine whether an intact bone marrow is essential to lung repair following bleomycin-induced lung injury in mice, and the mechanisms of any protective effects conferred by bone marrow-derived mesenchymal stem cell (BMDMSC) transfer. We found that myelosupression increased susceptibility to bleomycin in...

journal_title：American journal of respiratory cell and molecular biology

authors： Rojas M,Xu J,Woods CR,Mora AL,Spears W,Roman J,Brigham KL

更新日期：2005-08-01 00:00:00

abstract：:Cytochrome P4501A1 (CYP1A1) metabolizes polycyclic aromatic hydrocarbons in cigarette smoke to DNA-binding reactive intermediates associated with carcinogenesis. Epidemiologic studies indicate that the majority of coal miners are smokers but have a lower risk of lung cancer than other smokers. We hypothesized that coa...

journal_title：American journal of respiratory cell and molecular biology

authors： Ghanem MM,Porter D,Battelli LA,Vallyathan V,Kashon ML,Ma JY,Barger MW,Nath J,Castranova V,Hubbs AF

更新日期：2004-08-01 00:00:00

abstract：:IL-13 is a T-helper class 2 cytokine that induces goblet cell hyperplasia and mucus production in airway epithelial cells. Because macrolide antibiotics are known to have immunomodulatory and mucoregulatory properties, the aim of this study was to examine the effect of clarithromycin on IL-13-induced goblet cell hyper...

journal_title：American journal of respiratory cell and molecular biology

authors： Tanabe T,Kanoh S,Tsushima K,Yamazaki Y,Kubo K,Rubin BK

更新日期：2011-11-01 00:00:00

abstract：:Gamma-aminobutyric acid (GABA) is the major inhibitory neurotransmitter in the mammalian central nervous system and exerts its actions via both ionotropic (GABA(A)) and metabotropic (GABA(B)) receptors. The GABA(B) receptor is a dimer composed of R1 and R2 components and classically couples to the heterotrimeric G(i) ...

journal_title：American journal of respiratory cell and molecular biology

authors： Mizuta K,Osawa Y,Mizuta F,Xu D,Emala CW

更新日期：2008-09-01 00:00:00

abstract：:It had been thought that the central molecular event in the malignant transformation of a cell is the mutation of certain oncogenes-and the resultant dysregulated activation of their encoded proteins. During the past decade, however, it has become clear that alteration of the activity of the protein products of tumor ...

journal_title：American journal of respiratory cell and molecular biology

authors： Weintraub SJ

更新日期：1996-08-01 00:00:00