Role of endogenous cytokines in endotoxin- and interleukin-1-induced pulmonary inflammatory response and oxygen tolerance.

abstract：:Oxidants in cigarette smoke inhibit pathogen recognition receptor function and phagocytosis, but the molecular basis of this inhibition remains obscure. We sought to identify the inhibitory mechanisms that impair alveolar macrophage function. Balb/c mice were acutely exposed to four cigarettes for 4 hours before treat...

journal_title：American journal of respiratory cell and molecular biology

authors： Bozinovski S,Vlahos R,Zhang Y,Lah LC,Seow HJ,Mansell A,Anderson GP

更新日期：2011-08-01 00:00:00

abstract：:A number of metalloproteinases that degrade the extracellular matrix of connective tissues and two specific tissue inhibitors of metalloproteinases (TIMPs) have now been isolated, characterized, and cloned. Comparison of the enzyme sequences has allowed the delineation of domain structures, and initial studies have be...

journal_title：American journal of respiratory cell and molecular biology

authors： Murphy G,Docherty AJ

更新日期：1992-08-01 00:00:00

abstract：:Combustion-generated radicals interact to form polynuclear aromatic hydrocarbons (PAHs), including carcinogens. PAHs aggregate into 20- to 50-nm particles, which extend into branched-chain structures (soots). Incomplete combustion yields black soot particles and black smoke. Many PAHs, including those in soots, fluore...

journal_title：American journal of respiratory cell and molecular biology

authors： Murphy G Jr,Rouse RL,Polk WW,Henk WG,Barker SA,Boudreaux MJ,Floyd ZE,Penn AL

更新日期：2008-05-01 00:00:00

abstract：:Epidemiologic studies have linked gestational vitamin D deficiency to respiratory diseases, although mechanisms have not been defined. We hypothesized that antenatal vitamin D deficiency would impair airway development and alveolarization in a mouse model. We studied the effect of antenatal vitamin D deficiency by ind...

journal_title：American journal of respiratory cell and molecular biology

authors： Saadoon A,Ambalavanan N,Zinn K,Ashraf AP,MacEwen M,Nicola T,Fanucchi MV,Harris WT

更新日期：2017-03-01 00:00:00

abstract：:It is known that interleukin (IL)-23, an IL-12-family cytokine, can be released by certain antigen-presenting cells in response to bacterial pathogens. Recent in vitro studies indicate that this cytokine stimulates a unique subset of CD4 cells, the T helper cell (Th)17 subset, to produce and release the proinflammator...

journal_title：American journal of respiratory cell and molecular biology

authors： Ivanov S,Bozinovski S,Bossios A,Valadi H,Vlahos R,Malmhäll C,Sjöstrand M,Kolls JK,Anderson GP,Lindén A

更新日期：2007-04-01 00:00:00

abstract：:Patients with acute lung injury or respiratory distress syndrome often require supplemental oxygen to maintain tissue oxygenation; however, this treatment can cause or worsen lung inflammation. CD44 is a transmembrane adhesion molecule that is present on a wide variety of cell types, including leukocytes and parenchym...

journal_title：American journal of respiratory cell and molecular biology

authors： van der Windt GJ,Schouten M,Zeerleder S,Florquin S,van der Poll T

更新日期：2011-03-01 00:00:00

abstract：:Obesity affects the incidence and severity of asthma in at least two major phenotypes: an early-onset allergic (EOA) form that is complicated by obesity and a late-onset nonallergic (LONA) form that occurs only in the setting of obesity. Both groups exhibit airway hyperresponsiveness to methacholine challenge but exhi...

journal_title：American journal of respiratory cell and molecular biology

authors： Bates JH

更新日期：2016-05-01 00:00:00

abstract：:Clara-cell populations show a high degree of variation in susceptibility to injury by bioactivated cytotoxicants. Because glutathione (GSH) is critical for detoxification of electrophilic metabolites, heterogeneity in Clara cell GSH levels may lead to a wide range of cytotoxic responses. This study was designed to def...

journal_title：American journal of respiratory cell and molecular biology

authors： West JA,Chichester CH,Buckpitt AR,Tyler NK,Brennan P,Helton C,Plopper CG

更新日期：2000-07-01 00:00:00

abstract：:Endogenous hydrogen peroxide (H2O2) release from aortic endothelial cells was studied in the presence of antioxidant enzyme inhibitors, mitochondrial inhibitors, a microsomal cytochrome P-450 inhibitor, and after oxidative stress induced with H2O2 or menadione. Extracellular H2O2 generation was determined spectrofluor...

journal_title：American journal of respiratory cell and molecular biology

authors： Kinnula VL,Whorton AR,Chang LY,Crapo JD

更新日期：1992-02-01 00:00:00

abstract：:This study investigated whether hypoxia-inducible factor (HIF)-1 influences postnatal vascularization and alveologenesis in mice and whether stable (constitutive-active) HIF could prevent hyperoxia-induced lung injury. We assessed postnatal vessel and alveolar formation in transgenic mice, expressing a stable, constit...

journal_title：American journal of respiratory cell and molecular biology

authors： Tibboel J,Groenman FA,Selvaratnam J,Wang J,Tseu I,Huang Z,Caniggia I,Luo D,van Tuyl M,Ackerley C,de Jongste JC,Tibboel D,Post M

更新日期：2015-04-01 00:00:00

abstract：:T helper 2 (Th2)-like cytokines are thought to play a crucial role in the pathogenesis of airway inflammation in atopic asthma, leading to bronchial hyperresponsiveness. To investigate the role of the principal Th2 cytokine interleukin-4 (IL-4) in asthma, we examined the allergen-induced changes in airway morphology a...

journal_title：American journal of respiratory cell and molecular biology

authors： Brusselle G,Kips J,Joos G,Bluethmann H,Pauwels R

更新日期：1995-03-01 00:00:00

abstract：:Hydrogen sulfide (H(2)S) is synthesized intracellularly by the enzymes cystathionine-γ-lyase and cystathionine-β-synthase (CBS), and is proposed to be a gasotransmitter with effects in modulating inflammation and cellular proliferation. We determined a role of H(2)S in airway smooth muscle (ASM) function. ASM were rem...

journal_title：American journal of respiratory cell and molecular biology

authors： Perry MM,Hui CK,Whiteman M,Wood ME,Adcock I,Kirkham P,Michaeloudes C,Chung KF

更新日期：2011-10-01 00:00:00

abstract：:Human rhinovirus (HRV) triggers exacerbations of asthma and chronic obstructive pulmonary disease. Cigarette smoking is the primary risk factor for the development of chronic obstructive pulmonary disease, and 25% of individuals with asthma smoke. Smokers experience both longer and more severe colds. We previously sho...

journal_title：American journal of respiratory cell and molecular biology

authors： Hudy MH,Traves SL,Proud D

更新日期：2014-03-01 00:00:00

abstract：:Silicosis is a chronic lung disease induced by the inhalation of crystalline silica. Exposure of cultured macrophages to crystalline silica leads to cell death; however, the mechanism of cell-particle interaction, the fate of particles, and the cause of death are unknown. Time-lapse imaging shows that mouse macrophage...

journal_title：American journal of respiratory cell and molecular biology

authors： Gilberti RM,Joshi GN,Knecht DA

更新日期：2008-11-01 00:00:00

abstract：:We report that S100 proteins were reduced in patients with chronic rhinosinusitis (CRS). S100A8/9, which is important in epithelial barrier function, was particularly decreased in elderly patients with CRS. Epithelial expression of S100A8/9 is partly regulated by the IL-6 trans-signaling pathway. The goal of this stud...

journal_title：American journal of respiratory cell and molecular biology

authors： Cho SH,Kim DW,Lee SH,Kolliputi N,Hong SJ,Suh L,Norton J,Hulse KE,Seshadri S,Conley DB,Kern RC,Tan BK,Peters A,Grammer LC,Schleimer RP

更新日期：2015-11-01 00:00:00

abstract：:Interleukin-6 (IL-6) is known to be involved in the pathogenesis of various inflammatory diseases, but its role in bleomycin (BLM)-induced lung injury and subsequent fibrotic changes remains to be determined. We evaluated the role of IL-6 in the lung inflammatory changes induced by BLM using wild-type (WT) and IL-6-de...

journal_title：American journal of respiratory cell and molecular biology

authors： Saito F,Tasaka S,Inoue K,Miyamoto K,Nakano Y,Ogawa Y,Yamada W,Shiraishi Y,Hasegawa N,Fujishima S,Takano H,Ishizaka A

更新日期：2008-05-01 00:00:00

abstract：:Chronic hypoxia induces proliferation of human pulmonary artery smooth muscle cells (hPASMCs), leading to remodeling and pulmonary hypertension, but the mechanism remains unclear. The present study tested the roles of mitochondrial ATP-sensitive potassium channel (mitoK(ATP)) and mitochondrial membrane potential (Delt...

journal_title：American journal of respiratory cell and molecular biology

authors： Hu HL,Zhang ZX,Chen CS,Cai C,Zhao JP,Wang X

更新日期：2010-06-01 00:00:00

abstract：:Cystic fibrosis (CF) is characterized by a dramatic neutrophil recruitment and repeated Pseudomonas infections in the lungs. To evaluate cytokine releasibility by airway epithelial cells in the context of CF, we studied primary nasal epithelial cells isolated from the upper airways and continuous epithelial cell lines...

journal_title：American journal of respiratory cell and molecular biology

authors： Bédard M,McClure CD,Schiller NL,Francoeur C,Cantin A,Denis M

更新日期：1993-10-01 00:00:00

abstract：:In this study, we investigated the effect of the novel retinoid 6-[3-(1-adamantyl)-4-hydroxyphenyl]-2-naphthalene carboxylic acid (AHPN/CD437) on the growth of human lung carcinoma cell lines. AHPN inhibits the proliferation of all cell lines tested, irrespective of the lung tumor type, in a concentration- and time-de...

journal_title：American journal of respiratory cell and molecular biology

authors： Adachi H,Preston G,Harvat B,Dawson MI,Jetten AM

更新日期：1998-03-01 00:00:00

abstract：:The increase of airway smooth muscle (ASM) mass in asthma results from hypertrophic and hyperplastic stimuli, and leads to an increase in cellular contractile proteins. However, little evidence correlates the relative contributions of hypertrophic and hyperplastic muscle with functional effects on airway resistance. W...

journal_title：American journal of respiratory cell and molecular biology

authors： Plant PJ,North ML,Ward A,Ward M,Khanna N,Correa J,Scott JA,Batt J

更新日期：2012-04-01 00:00:00

abstract：:Keratinocyte growth factor (KGF) or fibroblast growth factor (FGF)-7, a peptide produced by stromal cells and in particular by lung mesenchyme, has recently been shown to influence early lung morphogenesis and to be a mitogen for fetal and adult alveolar type II cells. Although contradictory findings have been reporte...

journal_title：American journal of respiratory cell and molecular biology

authors： Chelly N,Mouhieddine-Gueddiche OB,Barlier-Mur AM,Chailley-Heu B,Bourbon JR

更新日期：1999-03-01 00:00:00

abstract：:Lung transplantation remains the only therapeutic option for many patients suffering from end-stage pulmonary disease. Long-term success after lung transplantation is severely limited by the development of bronchiolitis obliterans. The murine heterotopic tracheal transplantation model has been widely used for studies ...

journal_title：American journal of respiratory cell and molecular biology

authors： Okazaki M,Gelman AE,Tietjens JR,Ibricevic A,Kornfeld CG,Huang HJ,Richardson SB,Lai J,Garbow JR,Patterson GA,Krupnick AS,Brody SL,Kreisel D

更新日期：2007-12-01 00:00:00

abstract：:Sphingosine 1-phosphate (S1P) is a bioactive sphingolipid that plays an important proinflammatory role in asthmatic airways. Corticosteroids are first-line antiinflammatories in asthma; however, their repressive effects on S1P-induced cytokine secretion have not been investigated. To address this, our in vitro study r...

journal_title：American journal of respiratory cell and molecular biology

authors： Che W,Parmentier J,Seidel P,Manetsch M,Ramsay EE,Alkhouri H,Ge Q,Armour CL,Ammit AJ

更新日期：2014-02-01 00:00:00

abstract：:Proteinase-activated receptor (PAR)-2 is cleaved within its aminoterminal extracellular domain by serine proteinases such as trypsin, unmasking a new aminoterminus starting with the sequence SLIGKV, which binds intramolecularly and activates the receptor. PAR-2 has been reported to be involved in inflammation within t...

journal_title：American journal of respiratory cell and molecular biology

authors： Dulon S,Candé C,Bunnett NW,Hollenberg MD,Chignard M,Pidard D

更新日期：2003-03-01 00:00:00

abstract：:A murine model was used to assess the role of cytokines in initiating protective T-cell-mediated immunity in the lung. A pulmonary infection was initiated by intratracheal inoculation of Cryptococcus neoformans (Cne). Previously, we had established that Cne lung clearance was mouse-strain-specific: C.B-17 mice were re...

journal_title：American journal of respiratory cell and molecular biology

authors： Hoag KA,Lipscomb MF,Izzo AA,Street NE

更新日期：1997-12-01 00:00:00

abstract：:A subset of workers in swine confinement facilities develops chronic respiratory disease. An aqueous extract of dust from these facilities (hogbarn dust extract [HDE]) induces IL-6 and IL-8 release and several other responses in isolated airway epithelial cells. The cell membrane receptors by which HDE initiates these...

journal_title：American journal of respiratory cell and molecular biology

authors： Dodmane PR,Schulte NA,Heires AJ,Band H,Romberger DJ,Toews ML

更新日期：2011-10-01 00:00:00

abstract：:Species in the genus Pneumocystis can cause severe pneumonia in immune-compromised hosts. The identification of specific targets present in Pneumocystis species, but lacking in mammalian hosts, is paramount to developing new means to treat this infection. One such potential protein is Rtt109, which is a type of histon...

journal_title：American journal of respiratory cell and molecular biology

authors： Kottom TJ,Han J,Zhang Z,Limper AH

更新日期：2011-06-01 00:00:00

abstract：:The asthmatic lung is prone to respiratory viral infections that exacerbate the symptoms of the underlying disease. Recent work has suggested that a deficient T-helper cell type 1 response in early life may lead to these aberrant antiviral responses. To study the development of long-term dysregulation of innate respon...

journal_title：American journal of respiratory cell and molecular biology

authors： Spalluto CM,Singhania A,Cellura D,Woelk CH,Sanchez-Elsner T,Staples KJ,Wilkinson TMA

更新日期：2017-10-01 00:00:00

abstract：:Increases in inflammatory-cell progenitors have been demonstrated in the bone marrow (BM) after inhalation of Ascaris suum in dogs at the time of allergen-induced airway hyperresponsiveness (AHR). The aim of this study was to evaluate the effect of allergen challenge on trafficking of inflammatory cells and their prog...

journal_title：American journal of respiratory cell and molecular biology

authors： Wood LJ,Inman MD,Denburg JA,O'Byrne PM

更新日期：1998-06-01 00:00:00

abstract：:Tumor necrosis factor-alpha (TNF-alpha) is an important inflammatory mediator produced by activated monocytes and macrophages. We have previously shown that porcine alveolar macrophages (PAM) mediate bystander cytotoxicity through hydrogen peroxide production following activation with immobilized IgG immune complex (I...

journal_title：American journal of respiratory cell and molecular biology

authors： Kim JW,Wierda WG,Kim YB

更新日期：1991-09-01 00:00:00