Lung-specific loss of α3 laminin worsens bleomycin-induced pulmonary fibrosis.

abstract：:Hydrogen sulfide (H(2)S) is synthesized intracellularly by the enzymes cystathionine-γ-lyase and cystathionine-β-synthase (CBS), and is proposed to be a gasotransmitter with effects in modulating inflammation and cellular proliferation. We determined a role of H(2)S in airway smooth muscle (ASM) function. ASM were rem...

journal_title：American journal of respiratory cell and molecular biology

authors： Perry MM,Hui CK,Whiteman M,Wood ME,Adcock I,Kirkham P,Michaeloudes C,Chung KF

更新日期：2011-10-01 00:00:00

abstract：:Silicosis is a chronic lung disease induced by the inhalation of crystalline silica. Exposure of cultured macrophages to crystalline silica leads to cell death; however, the mechanism of cell-particle interaction, the fate of particles, and the cause of death are unknown. Time-lapse imaging shows that mouse macrophage...

journal_title：American journal of respiratory cell and molecular biology

authors： Gilberti RM,Joshi GN,Knecht DA

更新日期：2008-11-01 00:00:00

abstract：:Previous studies have demonstrated that high tidal volumes can cause interstitial and alveolar edema, with degradation of pulmonary epithelial barrier integrity. Separate studies have shown that F-actin disruption and decreased intracellular ATP (ATP(i)) levels in the nonpulmonary epithelium can increase tight junctio...

journal_title：American journal of respiratory cell and molecular biology

authors： Cavanaugh KJ Jr,Oswari J,Margulies SS

更新日期：2001-11-01 00:00:00

abstract：:Accumulating evidence has demonstrated that up-regulation of the angiotensin (Ang)-converting enzyme (ACE)/AngII/AngII type 1 receptor (AT1R) axis aggravates pulmonary fibrosis. The recently discovered ACE2/Ang-(1-7)/Mas axis, which counteracts the activity of the ACE/AngII/AT1R axis, has been shown to protect against...

journal_title：American journal of respiratory cell and molecular biology

authors： Meng Y,Yu CH,Li W,Li T,Luo W,Huang S,Wu PS,Cai SX,Li X

更新日期：2014-04-01 00:00:00

abstract：:Degradation of preexisting and newly synthesized extracellular matrix is thought to play an important role in tissue remodeling. The current study evaluated whether thrombin and TNF-alpha/IL-1beta could collaboratively induce collagen degradation by human fetal lung fibroblasts (HFL-1) and adult bronchial fibroblasts ...

journal_title：American journal of respiratory cell and molecular biology

authors： Fang Q,Liu X,Al-Mugotir M,Kobayashi T,Abe S,Kohyama T,Rennard SI

更新日期：2006-12-01 00:00:00

abstract：:Pulmonary lymphangioleiomyomatosis (LAM), a disease of young women, is characterized by proliferation of immature-appearing smooth-muscle cells (LAM cells) in the lungs and abdomen. LAM cells react with monoclonal antibody HMB45, which recognizes a 100-kD glycoprotein (gp100) originally found in human melanoma cells. ...

journal_title：American journal of respiratory cell and molecular biology

authors： Matsumoto Y,Horiba K,Usuki J,Chu SC,Ferrans VJ,Moss J

更新日期：1999-09-01 00:00:00

abstract：:Pneumocystis is an important fungal pathogen that causes life-threatening pneumonia in patients with AIDS and malignancy. Lung fungal pathogens are recognized by C-type lectin receptors (CLRs), which bind specific ligands and stimulate innate immune responses. The CLR Dectin-1 was previously shown to mediate immune re...

journal_title：American journal of respiratory cell and molecular biology

authors： Kottom TJ,Hebrink DM,Jenson PE,Marsolek PL,Wüthrich M,Wang H,Klein B,Yamasaki S,Limper AH

更新日期：2018-02-01 00:00:00

abstract：:Idiopathic pulmonary fibrosis (IPF) is characterized by excessive deposition of extracellular matrix, in particular, collagens. Two IPF therapeutics, nintedanib and pirfenidone, decelerate lung function decline, but their underlying mechanisms of action are poorly understood. In this study, we sought to analyze their ...

journal_title：American journal of respiratory cell and molecular biology

authors： Knüppel L,Ishikawa Y,Aichler M,Heinzelmann K,Hatz R,Behr J,Walch A,Bächinger HP,Eickelberg O,Staab-Weijnitz CA

更新日期：2017-07-01 00:00:00

abstract：:Oxygen-mediated lung injury can stimulate a fibroproliferative response resulting in the alteration of the pulmonary extracellular matrix and subsequent scarring of parenchymal tissue. Fibronectin (FN), a component of the extracellular matrix, appears in increased quantities in fibrotic lung disease. Alveolar macropha...

journal_title：American journal of respiratory cell and molecular biology

authors： Sinkin RA,LoMonaco MB,Finkelstein JN,Watkins RH,Cox C,Horowitz S

更新日期：1992-11-01 00:00:00

abstract：:We have previously reported that medium conditioned by hypoxic pulmonary artery endothelial cells (ECCM) contains a factor of small molecular weight that inhibits the growth of pulmonary artery smooth muscle cells (SMC). We postulated that this factor might be a breakdown product of ATP and, therefore, measured the le...

journal_title：American journal of respiratory cell and molecular biology

authors： Hassoun PM,Shedd AL,Lanzillo JJ,Thappa V,Landman MJ,Fanburg BL

更新日期：1992-06-01 00:00:00

abstract：:The human lung accumulates iron with senescence. Smoking escalates the accumulation of iron, and we have demonstrated regional variability in the accumulation of iron in smokers' lungs. Iron has been reported to influence the production of a number of proinflammatory mediators, including human interleukin (IL)-1beta. ...

journal_title：American journal of respiratory cell and molecular biology

authors： O'Brien-Ladner AR,Nelson SR,Murphy WJ,Blumer BM,Wesselius LJ

更新日期：2000-07-01 00:00:00

abstract：:It is generally important to elucidate airway epithelial cell lineages and to identify multipotent progenitors as targets for gene therapy. Stem (S) cells are typically present in specialized compartments spatially proximal to their differentiated progeny, but an equivalent paradigm has not been demonstrated in the ai...

journal_title：American journal of respiratory cell and molecular biology

authors： Borthwick DW,Shahbazian M,Krantz QT,Dorin JR,Randell SH

更新日期：2001-06-01 00:00:00

abstract：:We have tested the murine macrophagic cell line RAW 264.7 for its ability to undergo activation after exposure to silica particles in vitro. When exposed to silica under controlled conditions (each cell having access to about 10 silica particles), RAW 264.7 cells were able to phagocytose the particles. Concomitantly, ...

journal_title：American journal of respiratory cell and molecular biology

authors： Claudio E,Segade F,Wróbel K,Ramos S,Lazo PS

更新日期：1995-11-01 00:00:00

abstract：:A greater understanding of the regulatory processes contributing to lung development could help ameliorate morbidity and mortality in premature infants and identify individuals at risk for congenital and/or chronic lung diseases. Genomics technologies have provided rich gene expression datasets for the developing lung...

journal_title：American journal of respiratory cell and molecular biology

authors： Kho AT,Bhattacharya S,Mecham BH,Hong J,Kohane IS,Mariani TJ

更新日期：2009-01-01 00:00:00

abstract：:Vascular endothelial growth factor (VEGF) is necessary for normal postnatal lung development and may underlie the structural lung damage that follows hyperoxic exposure. To determine the individual roles of VEGF receptors (VEGFR) 2 and 1 on postnatal lung growth, neonatal mice were treated with neutralizing antibodies...

journal_title：American journal of respiratory cell and molecular biology

authors： McGrath-Morrow SA,Cho C,Cho C,Zhen L,Hicklin DJ,Tuder RM

更新日期：2005-05-01 00:00:00

abstract：:Neutrophils were found to demonstrate chemotactic responses to pepsinized human placental type IV collagen and its purified aminoterminal 7S domain. The maximal chemotactic responses occur at approximately 400 ng/ml and approximately 30 ng/ml of type IV collagen and 7S collagen, respectively, and are similar in magnit...

journal_title：American journal of respiratory cell and molecular biology

authors： Senior RM,Hinek A,Griffin GL,Pipoly DJ,Crouch EC,Mecham RP

更新日期：1989-12-01 00:00:00

abstract：:The genetic basis for the underlying individual susceptibility to chlorine-induced acute lung injury is unknown. To uncover the genetic basis and pathophysiological processes that could provide additional homeostatic capacities during lung injury, 40 inbred murine strains were exposed to chlorine, and haplotype associ...

journal_title：American journal of respiratory cell and molecular biology

authors： Leikauf GD,Pope-Varsalona H,Concel VJ,Liu P,Bein K,Berndt A,Martin TM,Ganguly K,Jang AS,Brant KA,Dopico RA Jr,Upadhyay S,Di YP,Li Q,Hu Z,Vuga LJ,Medvedovic M,Kaminski N,You M,Alexander DC,McDunn JE,Prows DR,Kn

更新日期：2012-08-01 00:00:00

abstract：:Although mast cell secretion has been intensively studied because of its pivotal role in allergic reactions and its advantages as a physiologic model, the molecular composition of the secretory machine is virtually unknown. In view of the guanine-nucleotide dependency of mast cell exocytosis and the participation of R...

journal_title：American journal of respiratory cell and molecular biology

authors： Tuvim MJ,Adachi R,Chocano JF,Moore RH,Lampert RM,Zera E,Romero E,Knoll BJ,Dickey BF

更新日期：1999-01-01 00:00:00

abstract：:Pulmonary carbonic anhydrase (CA) activity plays important roles in carbon dioxide exchange, fluid secretion, and pH regulation. This study reports the use of molecular and immunologic techniques to characterize expression of the high-activity cytosolic isoenzyme CA II in rat lung tissue. Northern blot analysis of RNA...

journal_title：American journal of respiratory cell and molecular biology

authors： Fleming RE,Moxley MA,Waheed A,Crouch EC,Sly WS,Longmore WJ

更新日期：1994-05-01 00:00:00

abstract：:Primary ciliary dyskinesia (PCD) is a genetically heterogeneous chronic destructive airway disease. PCD is traditionally diagnosed by nasal nitric oxide measurement, analysis of ciliary beating, transmission electron microscopy (TEM), and/or genetic testing. In most genetic PCD variants, laterality defects can occur. ...

journal_title：American journal of respiratory cell and molecular biology

authors： Cindrić S,Dougherty GW,Olbrich H,Hjeij R,Loges NT,Amirav I,Philipsen MC,Marthin JK,Nielsen KG,Sutharsan S,Raidt J,Werner C,Pennekamp P,Dworniczak B,Omran H

更新日期：2020-03-01 00:00:00

abstract：:Although it is known that surfactant lipids and proteins are altered in patients with Pseudomonas aeruginosa infections, the mechanisms and implications of these alterations are not clear. In this study, the effects of P. aeruginosa on the surfactant large aggregate fraction were examined using an in vitro surface are...

journal_title：American journal of respiratory cell and molecular biology

authors： Beatty AL,Malloy JL,Wright JR

更新日期：2005-02-01 00:00:00

abstract：:Enhanced protein tyrosine phosphorylation is associated with changes in vascular permeability through formation and dissolution of adherens junctions and regulation of stress fiber formation. Inhibition of the protein tyrosine phosphorylase SH2 domain-containing protein tyrosine phosphatase 2 (SHP2) increases tyrosine...

journal_title：American journal of respiratory cell and molecular biology

authors： Chichger H,Braza J,Duong H,Harrington EO

更新日期：2015-06-01 00:00:00

abstract：:Tert-butylhydroquinone (TBHQ) is a monofunctional Phase II enzyme inducer, which produces reactive oxygen species. Incubation with a sublethal concentration of TBHQ increased the activities of both gamma-glutamyl transpeptidase (GGT) and gamma-glutamylcysteine synthetase (GCS), although the mechanisms are different (L...

journal_title：American journal of respiratory cell and molecular biology

authors： Liu RM,Hu H,Robison TW,Forman HJ

更新日期：1996-02-01 00:00:00

abstract：:Remodeling of the airways, as occurs in asthmatic patients, is associated with the continual presence of inflammatory mediators and Th2 cytokines, especially interleukin (IL)-13, during cycles of epithelial injury and repair. In this study, we examined the effect of IL-13 on well-differentiated normal human bronchial ...

journal_title：American journal of respiratory cell and molecular biology

authors： Booth BW,Adler KB,Bonner JC,Tournier F,Martin LD

更新日期：2001-12-01 00:00:00

abstract：:Mechanical ventilation with high tidal volumes has been associated with pulmonary alveolar flooding. Understanding the mechanisms underlying cyclic stretch-induced increases in alveolar epithelial permeability may be important in designing preventive measures for acute lung injury. In this work, we assessed whether cy...

journal_title：American journal of respiratory cell and molecular biology

authors： Davidovich N,DiPaolo BC,Lawrence GG,Chhour P,Yehya N,Margulies SS

更新日期：2013-07-01 00:00:00

abstract：:We examined the contribution of the leukocyte function-associated antigen (LFA-1) in a murine model of lung inflammation determined by exposure to the thermophilic actinomycete Faeni rectivirgula. The exposure generated a large influx of cells in the bronchoalveolar space and in the lung parenchyma, as seen from enhan...

journal_title：American journal of respiratory cell and molecular biology

authors： Denis M,Bisson D

更新日期：1994-05-01 00:00:00

abstract：:The expression of bombesin-like peptides (BLPs) by pulmonary neuroendocrine cells is transiently upregulated during lung development. A functional role for BLPs is supported by their ability to stimulate lung growth and maturation both in vitro and in vivo during the late stages of lung development. In addition, the c...

journal_title：American journal of respiratory cell and molecular biology

authors： Aguayo SM,Schuyler WE,Murtagh JJ Jr,Roman J

更新日期：1994-06-01 00:00:00

abstract：:Little is known about whether maternal immune status during pregnancy influences asthma development in the child. We measured cytokine production in supernatants from mitogen-stimulated peripheral blood immune cells collected during and after pregnancy from the mothers of children enrolled in the Tucson Infant Immune ...

journal_title：American journal of respiratory cell and molecular biology

authors： Rothers J,Stern DA,Lohman IC,Spangenberg A,Wright AL,DeVries A,Vercelli D,Halonen M

更新日期：2018-11-01 00:00:00

abstract：:Amiodarone interferes with the endocytic pathway, inhibits proteolysis, and causes the formation of vacuoles, but uptake and intracellular distribution of the drug, origin of vacuoles, and functional consequences of amiodarone accumulation remain unclear. Our objective was to study amiodarone uptake, clarify the origi...

journal_title：American journal of respiratory cell and molecular biology

authors： Stadler K,Ha HR,Ciminale V,Spirli C,Saletti G,Schiavon M,Bruttomesso D,Bigler L,Follath F,Pettenazzo A,Baritussio A

更新日期：2008-08-01 00:00:00

abstract：:Congenital diaphragmatic hernia (CDH) is associated with high neonatal mortality from lung hypoplasia and persistent pulmonary hypertension. Pulmonary neuroendocrine cells (PNEC) produce calcitonin gene-related peptide (CGRP), a potent vasodilator. We previously reported altered distribution of CGRP-positive PNEC in f...

journal_title：American journal of respiratory cell and molecular biology

authors： IJsselstijn H,Hung N,de Jongste JC,Tibboel D,Cutz E

更新日期：1998-08-01 00:00:00