Vascular endothelial growth factor receptor 2 blockade disrupts postnatal lung development.

abstract：:Prenatal nicotine exposure impairs normal lung development and leads to diminished pulmonary function after birth. Previous work from our laboratory has demonstrated that nicotine alters lung development by affecting a nonneuronal cholinergic autocrine loop that is expressed in lung. Bronchial epithelial cells (BECs) ...

journal_title：American journal of respiratory cell and molecular biology

authors： Fu XW,Lindstrom J,Spindel ER

更新日期：2009-07-01 00:00:00

abstract：:Prior studies have demonstrated that human alveolar macrophages (AM) are suppressive of lymphocyte function, through the mechanism of inhibition is unclear. In the current study, human AM inhibited receptor-mediated increases in intracellular calcium concentration ([Ca2+]i) in T cells, natural killer cells, and B cell...

journal_title：American journal of respiratory cell and molecular biology

authors： Yarbrough WC Jr,Wilkes DS,Weissler JC

更新日期：1991-11-01 00:00:00

abstract：:Eosinophils are an important source of leukotriene (LT)C(4), which can be synthesized within lipid bodies-cytoplasmic organelles where eicosanoid formation may take place. Allergy-driven lipid body formation and function have never been investigated. Here, we studied the in vivo induction and role of lipid bodies with...

journal_title：American journal of respiratory cell and molecular biology

authors： Vieira-de-Abreu A,Assis EF,Gomes GS,Castro-Faria-Neto HC,Weller PF,Bandeira-Melo C,Bozza PT

更新日期：2005-09-01 00:00:00

abstract：:A defining feature of acute lung injury (ALI) is the increased lung vascular permeability and alveolar flooding, which leads to associated morbidity and mortality. Specific therapies to alleviate the unremitting vascular leak in ALI are not currently clinically available; however, our prior studies indicate a protecti...

journal_title：American journal of respiratory cell and molecular biology

authors： Zhao Y,Gorshkova IA,Berdyshev E,He D,Fu P,Ma W,Su Y,Usatyuk PV,Pendyala S,Oskouian B,Saba JD,Garcia JG,Natarajan V

更新日期：2011-08-01 00:00:00

abstract：:Inflammatory lung diseases are associated with increased production of matrix metalloproteinase-9 (MMP-9) from infiltrating granulocytes or from the respiratory epithelium, and inappropriate expression and activation of MMP-9 may be associated with tissue injury and airway remodeling. Inflammatory conditions also resu...

journal_title：American journal of respiratory cell and molecular biology

authors： Okamoto T,Valacchi G,Gohil K,Akaike T,van der Vliet A

更新日期：2002-10-01 00:00:00

abstract：:In this study, we have used the rat model of hyperoxia to examine the molecular responses to oxidative stress in lung. We show that in addition to the antioxidant enzyme manganese superoxide dismutase, expression of a variety of stress-responsive genes including heme oxygenase-1, c-fos, c-jun, CAAT-enhancer binding pr...

journal_title：American journal of respiratory cell and molecular biology

authors： Choi AM,Sylvester S,Otterbein L,Holbrook NJ

更新日期：1995-07-01 00:00:00

abstract：:Surfactant protein D (SP-D) is a collagenous, surfactant-associated, carbohydrate-binding protein that is synthesized by pulmonary epithelial cells. In the present studies, we examined the expression of SP-D and SP-D mRNA during late fetal (day 17, 19, 21) and early postnatal (day 5) rat lung development using immunoc...

journal_title：American journal of respiratory cell and molecular biology

authors： Crouch E,Rust K,Marienchek W,Parghi D,Chang D,Persson A

更新日期：1991-07-01 00:00:00

abstract：:Bacterial lung diseases are a major cause of morbidity and mortality both in immunocompromised and in immunocompetent individuals. Neutrophil accumulation, a pathological hallmark of bacterial diseases, is critical to host defense, but may also cause acute lung injury/acute respiratory distress syndrome. Toll-like rec...

journal_title：American journal of respiratory cell and molecular biology

authors： Balamayooran G,Batra S,Fessler MB,Happel KI,Jeyaseelan S

更新日期：2010-07-01 00:00:00

abstract：:Patients with acute lung injury or respiratory distress syndrome often require supplemental oxygen to maintain tissue oxygenation; however, this treatment can cause or worsen lung inflammation. CD44 is a transmembrane adhesion molecule that is present on a wide variety of cell types, including leukocytes and parenchym...

journal_title：American journal of respiratory cell and molecular biology

authors： van der Windt GJ,Schouten M,Zeerleder S,Florquin S,van der Poll T

更新日期：2011-03-01 00:00:00

abstract：:The double-stranded RNA (dsRNA)-activated serine/threonine kinase R (PKR) is well characterized as an essential component of the innate antiviral response. Recently, PKR has been implicated in Toll-like receptor (TLR) signal transduction in response to bacterial cell wall components. Its contribution to pulmonary immu...

journal_title：American journal of respiratory cell and molecular biology

authors： Cabanski M,Steinmüller M,Marsh LM,Surdziel E,Seeger W,Lohmeyer J

更新日期：2008-01-01 00:00:00

abstract：:Macrolides have been shown to be effective in treating diffuse panbronchiolitis (DPB), although the precise modes of action remain unclear. At sites of airway inflammation, respiratory epithelium is considered an active participant in regulating neutrophil survival. We therefore examined the effect of erythromycin, cl...

journal_title：American journal of respiratory cell and molecular biology

authors： Yamasawa H,Oshikawa K,Ohno S,Sugiyama Y

更新日期：2004-04-01 00:00:00

abstract：:Lower respiratory tract infection by respiratory syncytial virus (RSV) is a frequent cause of acute lung injury in young children and infants. Studies in adults and animals suggest that tumor necrosis factor receptor (TNFR) ligands may mediate lung injury by causing apoptosis of epithelial cells. The main goal of the ...

journal_title：American journal of respiratory cell and molecular biology

authors： Bem RA,Bos AP,Wösten-van Asperen RM,Bruijn M,Lutter R,Sprick MR,van Woensel JB

更新日期：2010-06-01 00:00:00

abstract：:Asthma arises from the complex interplay of inflammatory pathways in diverse cell types and tissues. We sought to undertake a comprehensive transcriptomic assessment of the epithelium and airway T cells that remain understudied in asthma and investigate interactions between multiple cells and tissues. Epithelial brush...

journal_title：American journal of respiratory cell and molecular biology

authors： Singhania A,Wallington JC,Smith CG,Horowitz D,Staples KJ,Howarth PH,Gadola SD,Djukanović R,Woelk CH,Hinks TSC

更新日期：2018-02-01 00:00:00

abstract：:Acute lung injury induced by reactive oxygen gases such as ozone (O(3)) is focal and site-selective. To define patterns of acute epithelial injury along intrapulmonary airways, we developed a new analytic approach incorporating labeling of permeable cells, airway microdissection, and laser scanning confocal microscopy...

journal_title：American journal of respiratory cell and molecular biology

authors： Postlethwait EM,Joad JP,Hyde DM,Schelegle ES,Bric JM,Weir AJ,Putney LF,Wong VJ,Velsor LW,Plopper CG

更新日期：2000-02-01 00:00:00

abstract：:Glucocorticoids increase surfactant phosphatidylcholine synthesis, in part, by stimulating the rate regulatory enzyme CTP:cholinephosphate cytidylyltransferase. This enzyme exists in mammalian lung cytosol as an active lipoprotein form (H-form) and an inactive apoprotein (L-form) species. We administered betamethasone...

journal_title：American journal of respiratory cell and molecular biology

authors： Mallampalli RK,Walter ME,Peterson MW,Hunninghake GW

更新日期：1994-01-01 00:00:00

abstract：:Pulmonary carbonic anhydrase (CA) activity plays important roles in carbon dioxide exchange, fluid secretion, and pH regulation. This study reports the use of molecular and immunologic techniques to characterize expression of the high-activity cytosolic isoenzyme CA II in rat lung tissue. Northern blot analysis of RNA...

journal_title：American journal of respiratory cell and molecular biology

authors： Fleming RE,Moxley MA,Waheed A,Crouch EC,Sly WS,Longmore WJ

更新日期：1994-05-01 00:00:00

abstract：:Previous studies have shown that polymorphonuclear leukocytes (PMN) are delayed in the pulmonary capillaries by the presence of cigarette smoke. To determine if the PMN delayed by smoking are activated, we estimated the in vivo expression of CD11/CD18 and L-selectin on the surface of PMN in lungs and peripheral blood ...

journal_title：American journal of respiratory cell and molecular biology

authors： Klut ME,Doerschuk CM,Van Eeden SF,Burns AR,Hogg JC

更新日期：1993-07-01 00:00:00

abstract：:Species in the genus Pneumocystis can cause severe pneumonia in immune-compromised hosts. The identification of specific targets present in Pneumocystis species, but lacking in mammalian hosts, is paramount to developing new means to treat this infection. One such potential protein is Rtt109, which is a type of histon...

journal_title：American journal of respiratory cell and molecular biology

authors： Kottom TJ,Han J,Zhang Z,Limper AH

更新日期：2011-06-01 00:00:00

abstract：:The application of conditional reprogramming culture (CRC) methods to nasal airway epithelial cells would allow more wide-spread incorporation of primary airway epithelial culture models into complex lung disease research. In this study, we adapted the CRC method to nasal airway epithelial cells, investigated the grow...

journal_title：American journal of respiratory cell and molecular biology

authors： Reynolds SD,Rios C,Wesolowska-Andersen A,Zhuang Y,Pinter M,Happoldt C,Hill CL,Lallier SW,Cosgrove GP,Solomon GM,Nichols DP,Seibold MA

更新日期：2016-09-01 00:00:00

abstract：:Previous observations by our laboratory indicate that the presence of anti-IL-8 autoantibody:IL-8 immune complexes in lung fluids from patients with acute lung injury/acute respiratory distress syndrome (ALI/ARDS) comprises an important prognostic indicator in the development and ultimate outcome of ALI/ARDS. We also ...

journal_title：American journal of respiratory cell and molecular biology

authors： Krupa A,Fudala R,Florence JM,Tucker T,Allen TC,Standiford TJ,Luchowski R,Fol M,Rahman M,Gryczynski Z,Gryczynski I,Kurdowska AK

更新日期：2013-02-01 00:00:00

abstract：:Adenosine concentrations are elevated in the lungs of patients with asthma and chronic obstructive pulmonary disease, where it balances between tissue repair and excessive airway remodeling. We previously demonstrated that the activation of the adenosine A2A receptor promotes epithelial wound closure. However, the mec...

journal_title：American journal of respiratory cell and molecular biology

authors： Allen-Gipson DS,Zimmerman MC,Zhang H,Castellanos G,O'Malley JK,Alvarez-Ramirez H,Kharbanda K,Sisson JH,Wyatt TA

更新日期：2013-05-01 00:00:00

abstract：:Ventilator-induced lung injury (VILI) is a severe complication of mechanical ventilation that can lead to acute respiratory distress syndrome. VILI is characterized by damage to the epithelial barrier with subsequent pulmonary edema and profound hypoxia. Available lung-protective ventilator strategies offer only a mod...

journal_title：American journal of respiratory cell and molecular biology

authors： Dolinay T,Himes BE,Shumyatcher M,Lawrence GG,Margulies SS

更新日期：2017-08-01 00:00:00

abstract：:Tumor necrosis factor-alpha (TNF), interleukin-1 beta (IL-1), interleukin-6 (IL-6), and interleukin-8 (IL-8) are inflammatory cytokines produced by alveolar macrophages (AMs) and implicated in sepsis-related adult respiratory distress syndrome (ARDS). Preliminary findings from clinical trials suggest that aerosolized ...

journal_title：American journal of respiratory cell and molecular biology

authors： Thomassen MJ,Meeker DP,Antal JM,Connors MJ,Wiedemann HP

更新日期：1992-09-01 00:00:00

abstract：:Polymorphonuclear leukocytes (PMN) and eosinophils (Eos) are important cellular participants in a variety of acute and chronic inflammatory reactions in the airway. Histologic evidence has implicated direct interactions between these two subsets of leukocytes and airway epithelial cells during inflammation. A comprehe...

journal_title：American journal of respiratory cell and molecular biology

authors： Jagels MA,Daffern PJ,Zuraw BL,Hugli TE

更新日期：1999-09-01 00:00:00

abstract：:Idiopathic pulmonary fibrosis is a lethal parenchymal lung disease characterized by denudation of the lung epithelium, fibroblast proliferation, and collagen deposition. Cellular changes underlying disease progression involve injury to alveolar epithelial cells, epithelial to mesenchymal transition, proliferation of a...

journal_title：American journal of respiratory cell and molecular biology

authors： Shukla MN,Rose JL,Ray R,Lathrop KL,Ray A,Ray P

更新日期：2009-06-01 00:00:00

abstract：:Stachybotrys chartarum is a fungal contaminant within the built environment and a respiratory health concern in the United States. The objective of this study was to characterize the mechanisms influencing pulmonary immune responses to repeatedly inhaled S. chartarum. Groups of B6C3F1/N mice repeatedly inhaled viable ...

journal_title：American journal of respiratory cell and molecular biology

authors： Croston TL,Lemons AR,Barnes MA,Goldsmith WT,Orandle MS,Nayak AP,Germolec DR,Green BJ,Beezhold DH

更新日期：2020-05-01 00:00:00

abstract：:Skeletal muscle atrophy in individuals with advanced chronic obstructive pulmonary disease (COPD) is associated with diminished quality of life, increased health resource use, and worsened survival. Muscle wasting results from an imbalance between protein degradation and synthesis, and is enhanced by decreased regener...

journal_title：American journal of respiratory cell and molecular biology

authors： Plant PJ,Brooks D,Faughnan M,Bayley T,Bain J,Singer L,Correa J,Pearce D,Binnie M,Batt J

更新日期：2010-04-01 00:00:00

abstract：:Although nitric oxide (NO) is known to inhibit vascular smooth muscle cell proliferation, the subcellular molecular mechanisms involved with the inhibitory signal transduction pathways are uncertain. We investigated the effect of exogenous NO on cell proliferation and the expression of p53, p21, and phosphorylated p42...

journal_title：American journal of respiratory cell and molecular biology

authors： Mizuno S,Kadowaki M,Demura Y,Ameshima S,Miyamori I,Ishizaki T

更新日期：2004-08-01 00:00:00

abstract：:PS-341 is a highly selective and potent proteasome inhibitor that is cytotoxic to various types of cancer. However, no objective response was seen in a clinical trial with PS-341 as a single agent in non-small cell lung cancer. Its antitumor activity is limited by the simultaneously activated antiapoptosis pathway. Re...

journal_title：American journal of respiratory cell and molecular biology

authors： Lee KH,Jang AH,Yoo CG

更新日期：2015-09-01 00:00:00

abstract：:Apoptosis of fibroblasts/myofibroblasts is a critical event in the resolution of tissue repair responses; however, mechanisms for the regulation of (myo)fibroblast apoptosis/survival remain unclear. In this study, we demonstrate counter-regulatory interactions between the plasminogen activation system and transforming...

journal_title：American journal of respiratory cell and molecular biology

authors： Horowitz JC,Rogers DS,Simon RH,Sisson TH,Thannickal VJ

更新日期：2008-01-01 00:00:00