Potential role of soluble TRAIL in epithelial injury in children with severe RSV infection.

abstract：:Enzymes which exhibit core 2 beta1,6 N-acetylglucosaminyltransferase (C2GnT) activity play important roles in physiologic processes including the inflammatory response and immune system function, and C2GnT activity is regulated during processes, such as T cell activation and cellular differentiation. In this study, we...

journal_title：American journal of respiratory cell and molecular biology

authors： Beum PV,Bastola DR,Cheng PW

更新日期：2003-07-01 00:00:00

abstract：:The ability of Pseudomonas aeruginosa to form antibiotic-resistant biofilms is thought to account for the inability of current therapies to resolve bacterial infections in the lungs of patients with cystic fibrosis (CF). We recently described a system in which highly antibiotic-resistant P. aeruginosa biofilms grow on...

journal_title：American journal of respiratory cell and molecular biology

authors： Moreau-Marquis S,O'Toole GA,Stanton BA

更新日期：2009-09-01 00:00:00

abstract：:Redox imbalance has been implicated in the pathogenesis of many acute and chronic lung diseases. The b-Zip transcription factor Nrf2 acts via an antioxidant/electrophilic response element to regulate antioxidants and maintain cellular redox homeostasis. Our previous studies have shown that Nrf2-deficient mice (Nrf2(-/...

journal_title：American journal of respiratory cell and molecular biology

authors： Reddy NM,Kleeberger SR,Cho HY,Yamamoto M,Kensler TW,Biswal S,Reddy SP

更新日期：2007-07-01 00:00:00

abstract：:Myosin light chain kinase (MLCK; gene code, MYLK) is a multifunctional enzyme involved in isoform-specific nonmuscle (nm) and smooth muscle contraction, inflammation, and vascular permeability, processes directly relevant to asthma pathobiology. In this report, we highlight the contribution of the nm isoform (nmMLCK) ...

journal_title：American journal of respiratory cell and molecular biology

authors： Wang T,Moreno-Vinasco L,Ma SF,Zhou T,Shimizu Y,Sammani S,Epshtein Y,Watterson DM,Dudek SM,Garcia JG

更新日期：2014-06-01 00:00:00

abstract：:Hypervascularity is known as an important element of airway remodeling in bronchial asthma. However, it remains obscure how allergic inflammation relates to angiogenesis in the lung. In this study, we examined the in vitro effects of inflammatory cytokines on endothelial cell functions, particularly angiogenesis. Huma...

journal_title：American journal of respiratory cell and molecular biology

authors： Matsuda A,Fukuda S,Matsumoto K,Saito H

更新日期：2008-02-01 00:00:00

abstract：:Asthma is characterized by appearance of eosinophils in the airway. Eosinophils purified from the airway 48 h after segmental antigen challenge are described as exhibiting greater adhesion to albumin-coated surfaces via an unidentified beta2 integrin and increased expression of alphaMbeta2 (CD11b/18) compared with pur...

journal_title：American journal of respiratory cell and molecular biology

authors： Barthel SR,Jarjour NN,Mosher DF,Johansson MW

更新日期：2006-09-01 00:00:00

abstract：:It has long been speculated that neutrophils deploy proteases to digest subendothelial matrix as they migrate from the bloodstream. Direct evidence for the involvement of proteases in neutrophil transendothelial migration is, however, lacking. To address this issue we used transmission electron microscopy to verify th...

journal_title：American journal of respiratory cell and molecular biology

authors： Mackarel AJ,Cottell DC,Russell KJ,FitzGerald MX,O'Connor CM

更新日期：1999-06-01 00:00:00

abstract：:Idiopathic pulmonary fibrosis (IPF) is a fatal disorder resulting from the progressive remodeling of lungs, with no known effective treatment. Although transforming growth factor (TGF)-β has a well-established role in lung fibrosis, clinical experience with neutralizing antibodies to TGF-β has been disappointing, and ...

journal_title：American journal of respiratory cell and molecular biology

authors： Das S,Kumar M,Negi V,Pattnaik B,Prakash YS,Agrawal A,Ghosh B

更新日期：2014-05-01 00:00:00

abstract：:Isoprostanes are prostaglandin-like molecules that accumulate in oxidative stress and also exert powerful biological effects on a wide variety of tissues. We investigated the effects of several different isoprostanes on contractions evoked by electrical field stimulation (EFS) in bovine trachealis, finding only 15-E2t...

journal_title：American journal of respiratory cell and molecular biology

authors： Paredes C,Tazzeo T,Janssen LJ

更新日期：2007-12-01 00:00:00

abstract：:Bombesin-like peptides within neuroepithelial cells elicit proliferation of normal and malignant airway epithelial cells. It is not clear that these peptides also elicit epithelial cell migration, a necessary component of airway repair after injury. We studied the effects of the bombesin analogues, gastrin releasing p...

journal_title：American journal of respiratory cell and molecular biology

authors： Kim JS,McKinnis VS,White SR

更新日期：1997-03-01 00:00:00

abstract：:Heritable pulmonary arterial hypertension (HPAH) is a serious lung vascular disease caused by heterozygous mutations in the bone morphogenetic protein (BMP) pathway genes, BMPR2 and SMAD9. One noncanonical function of BMP signaling regulates biogenesis of a subset of microRNAs. We have previously shown that this funct...

journal_title：American journal of respiratory cell and molecular biology

authors： Drake KM,Dunmore BJ,McNelly LN,Morrell NW,Aldred MA

更新日期：2013-09-01 00:00:00

abstract：:Mutations in the p53 gene have been implicated to play an important role in the development of various human cancers. To evaluate the importance of p53 in lung cancer, a transgenic mouse model was established by utilizing the Clara cell secretory protein (CCSP) promoter to target the expression of a dominant-negative ...

journal_title：American journal of respiratory cell and molecular biology

authors： Tchou-Wong KM,Jiang Y,Yee H,LaRosa J,Lee TC,Pellicer A,Jagirdar J,Gordon T,Goldberg JD,Rom WN

更新日期：2002-08-01 00:00:00

abstract：:A subset of workers in swine confinement facilities develops chronic respiratory disease. An aqueous extract of dust from these facilities (hogbarn dust extract [HDE]) induces IL-6 and IL-8 release and several other responses in isolated airway epithelial cells. The cell membrane receptors by which HDE initiates these...

journal_title：American journal of respiratory cell and molecular biology

authors： Dodmane PR,Schulte NA,Heires AJ,Band H,Romberger DJ,Toews ML

更新日期：2011-10-01 00:00:00

abstract：:DNA double-strand breaks (DSBs) can result in cell death or genetic alterations when cells are subjected to radiation, exposure to toxins, or other environmental stresses. A complex DNA-damage-response pathway is activated to repair the damage, and the inability to repair these breaks can lead to carcinogenesis. One o...

journal_title：American journal of respiratory cell and molecular biology

authors： Msiska Z,Pacurari M,Mishra A,Leonard SS,Castranova V,Vallyathan V

更新日期：2010-08-01 00:00:00

abstract：:We examined the ability of the human surfactant protein B (SP-B) promoter to confer cell specificity of transgene expression in an adenoviral vector. Using similar replication-deficient adenoviruses (rAd), we compared lacZ reporter gene expression driven by the human SP-B promoter (rAd.SPBlacZ) with the ubiquitously e...

journal_title：American journal of respiratory cell and molecular biology

authors： Strayer MS,Guttentag SH,Ballard PL

更新日期：1998-01-01 00:00:00

abstract：:The cells/proteases responsible for the development of smoke-induced emphysema is an area of intense investigation. Mice with knockout of macrophage metalloelastase genes (MME(-/-)) do not develop emphysema after smoke exposure, but we also observed that neutrophils (PMN) in lavage appeared to be a requirement for acu...

journal_title：American journal of respiratory cell and molecular biology

authors： Churg A,Zay K,Shay S,Xie C,Shapiro SD,Hendricks R,Wright JL

更新日期：2002-09-01 00:00:00

abstract：:The mechanisms used by alveolar type I pneumocytes for maintenance of the lipid homeostasis necessary to sustain these large squamous cells are unknown. The processes may involve the ATP-binding cassette transporter A1 (ABCA1), a transport protein shown to be crucial in apolipoprotein A-I (apoA-I)-mediated mobilizatio...

journal_title：American journal of respiratory cell and molecular biology

authors： Bates SR,Tao JQ,Yu KJ,Borok Z,Crandall ED,Collins HL,Rothblat GH

更新日期：2008-03-01 00:00:00

abstract：:Idiopathic pulmonary fibrosis (IPF) is a progressive, scarring lung disease characterized by fibroblast accumulation and deposition of collagen. Factors that promote growth and/or survival of fibroblasts are potential therapeutic targets. Methionine aminopeptidase 2 (MetAP2), a member of the aminopeptidase family of p...

journal_title：American journal of respiratory cell and molecular biology

authors： Kass D,Bridges RS,Borczuk A,Greenberg S

更新日期：2007-08-01 00:00:00

abstract：:Prenatal nicotine exposure impairs normal lung development and leads to diminished pulmonary function after birth. Previous work from our laboratory has demonstrated that nicotine alters lung development by affecting a nonneuronal cholinergic autocrine loop that is expressed in lung. Bronchial epithelial cells (BECs) ...

journal_title：American journal of respiratory cell and molecular biology

authors： Fu XW,Lindstrom J,Spindel ER

更新日期：2009-07-01 00:00:00

abstract：:Although nitric oxide (NO) is known to inhibit vascular smooth muscle cell proliferation, the subcellular molecular mechanisms involved with the inhibitory signal transduction pathways are uncertain. We investigated the effect of exogenous NO on cell proliferation and the expression of p53, p21, and phosphorylated p42...

journal_title：American journal of respiratory cell and molecular biology

authors： Mizuno S,Kadowaki M,Demura Y,Ameshima S,Miyamori I,Ishizaki T

更新日期：2004-08-01 00:00:00

abstract：:Pseudomonas aeruginosa, which may cause severe lung infections, secretes a metalloelastase that may interfere with the assay of neutrophil elastase and cathepsin G in lung secretions. Using nuclear magnetic resonance spectroscopy, we have shown that P. aeruginosa elastase (PsE) cleaves succinyl-Ala3-p-nitroanilide bet...

journal_title：American journal of respiratory cell and molecular biology

authors： Pelletier A,Dimicoli JL,Boudier C,Bieth JG

更新日期：1989-07-01 00:00:00

abstract：:In the present study, splenic dendritic cells (DC) and alveolar macrophages (AM) were pulsed with antigen in vitro and subsequently intratracheally instilled to test whether these cells have the capacity to sensitize T cells in the draining lymph nodes of the lung. The data demonstrate that antigen-pulsed DC, instille...

journal_title：American journal of respiratory cell and molecular biology

authors： Havenith CE,Breedijk AJ,Betjes MG,Calame W,Beelen RH,Hoefsmit EC

更新日期：1993-03-01 00:00:00

abstract：:The purpose of this review is to give a comprehensive overview of transgenic mouse lines suitable for studying gene function and cellular lineage relationships in lung development, homeostasis, injury, and repair. Many of the mouse strains reviewed in this Perspective have been widely shared within the lung research c...

journal_title：American journal of respiratory cell and molecular biology

authors： Rawlins EL,Perl AK

更新日期：2012-03-01 00:00:00

abstract：:The role of guanine nucleotide-binding proteins in the induction of prostacyclin synthesis by stimulated endothelial cells is incompletely understood. We report that sodium fluoride (NaF), a potent activator of cellular guanine nucleotide-binding proteins, affected time- and concentration-dependent generation of prost...

journal_title：American journal of respiratory cell and molecular biology

authors： Garcia JG,Dominguez J,English D

更新日期：1991-08-01 00:00:00

abstract：:Activin A is a homodimeric protein structurally and functionally related to transforming growth factor beta (TGF-beta), and the expression of activin A is modulated by TGF-beta. Here, we demonstrate the expression of activin A in normal and bleomycin (BLM)-treated murine lungs. ICR mice were treated with BLM intraperi...

journal_title：American journal of respiratory cell and molecular biology

authors： Matsuse T,Fukuchi Y,Eto Y,Matsui H,Hosoi T,Oka T,Ohga E,Nagase T,Orimo H

更新日期：1995-07-01 00:00:00

abstract：:Opiate-like peptides can regulate many cellular functions. We now map [D-Ala(2)]deltorphin I (DADTI)-like immunoreactivity (DADTI-LI) in developing mouse lung and analyze potential functional roles. Most DADTI-LI-positive cells were alveolar cells negative for prosurfactant protein (proSP)-C immunoreactivity. Peak num...

journal_title：American journal of respiratory cell and molecular biology

authors： Sunday ME,Haley KJ,Emanuel RL,Torday JS,Asokananthan N,Sikorski KA,Tooyama I,Kimura H,Renda T,Erspamer V

更新日期：2001-10-01 00:00:00

abstract：:The lung is richly supplied with peptidergic nerves that store and secrete substance P (SP), vasoactive intestinal peptide (VIP), and other neuropeptides known to potently modulate leukocyte function in vitro and airway inflammation in vivo. To investigate and characterize neuromodulation of immune responses compartme...

journal_title：American journal of respiratory cell and molecular biology

authors： Kaltreider HB,Ichikawa S,Byrd PK,Ingram DA,Kishiyama JL,Sreedharan SP,Warnock ML,Beck JM,Goetzl EJ

更新日期：1997-02-01 00:00:00

abstract：:Heme oxygenase (HO)-1, an inducible, low-molecular-weight stress protein, confers cellular and tissue protection in multiple models of injury and disease, including oxidative or inflammatory lung injury, ischemia/reperfusion (I/R) injuries, and vascular injury/disease. The tissue protection provided by HO-1 potentiall...

journal_title：American journal of respiratory cell and molecular biology

authors： Ryter SW,Morse D,Choi AM

更新日期：2007-02-01 00:00:00

abstract：:In these studies, we examined signaling through the transcription factor STAT5 in human peripheral blood eosinophils after treatment with granulocyte macrophage colony-stimulating factor (GM-CSF) or interleukin (IL)-5. In response to either cytokine, STAT5 was rapidly tyrosine phosphorylated and acquired interferon ga...

journal_title：American journal of respiratory cell and molecular biology

authors： Bhattacharya S,Stout BA,Bates ME,Bertics PJ,Malter JS

更新日期：2001-03-01 00:00:00

abstract：:Idiopathic pulmonary fibrosis (IPF) is a progressive disease characterized by excessive deposition of extracellular matrix (ECM) in the lung parenchyma. The abnormal ECM deposition slowly overtakes normal lung tissue, disturbing gas exchange and leading to respiratory failure and death. ECM cross-linking and subsequen...

journal_title：American journal of respiratory cell and molecular biology

authors： Bellaye PS,Shimbori C,Upagupta C,Sato S,Shi W,Gauldie J,Ask K,Kolb M

更新日期：2018-04-01 00:00:00