Abstract:
:Gene therapy is the treatment of any disorder or pathophysiologic state based upon the transfer of genetic information. The lung represents a major target of gene therapy for the treatment of genetic disorders such as cystic fibrosis and alpha 1-antitrypsin deficiency. Other diseases are also being targeted, including pulmonary inflammation, surfactant deficiency, pulmonary hypertension, lung cancer, and malignant mesothelioma. This review will examine some general concepts regarding gene transfer and gene therapy, provide an overview of the current vectors being developed to achieve safe and efficient gene transfer, and summarize the ongoing work to apply this new technology to the treatment of both inherited and acquired pulmonary diseases. Although tremendous progress has been made in the ability to successfully transfer genes to cells, there are several unresolved problems limiting the clinical application of this technology to human pulmonary disease. However, as vector technology evolves, gene therapy may become a reality for a number of lung diseases.
journal_name
Am J Respir Cell Mol Biolauthors
Curiel DT,Pilewski JM,Albelda SMdoi
10.1165/ajrcmb.14.1.8534480subject
Has Abstractpub_date
1996-01-01 00:00:00pages
1-18issue
1eissn
1044-1549issn
1535-4989journal_volume
14pub_type
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journal_title:American journal of respiratory cell and molecular biology
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journal_title:American journal of respiratory cell and molecular biology
pub_type: 杂志文章
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更新日期:2016-01-01 00:00:00
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journal_title:American journal of respiratory cell and molecular biology
pub_type: 杂志文章
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更新日期:2004-08-01 00:00:00
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journal_title:American journal of respiratory cell and molecular biology
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更新日期:2001-08-01 00:00:00
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pub_type: 杂志文章,评审
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journal_title:American journal of respiratory cell and molecular biology
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更新日期:2006-02-01 00:00:00
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journal_title:American journal of respiratory cell and molecular biology
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journal_title:American journal of respiratory cell and molecular biology
pub_type: 杂志文章
doi:10.1165/ajrcmb.23.1.3907
更新日期:2000-07-01 00:00:00
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journal_title:American journal of respiratory cell and molecular biology
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更新日期:2016-08-01 00:00:00
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doi:10.1165/ajrcmb/3.3.245
更新日期:1990-09-01 00:00:00
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pub_type: 杂志文章
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更新日期:2005-03-01 00:00:00
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pub_type: 杂志文章
doi:10.1165/rcmb.2009-0203OC
更新日期:2010-10-01 00:00:00
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journal_title:American journal of respiratory cell and molecular biology
pub_type: 杂志文章
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更新日期:2007-04-01 00:00:00
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journal_title:American journal of respiratory cell and molecular biology
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更新日期:2006-05-01 00:00:00
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journal_title:American journal of respiratory cell and molecular biology
pub_type: 杂志文章
doi:10.1165/rcmb.2017-0436OC
更新日期:2018-10-01 00:00:00