Oxidation of Z α1-antitrypsin by cigarette smoke induces polymerization: a novel mechanism of early-onset emphysema.

abstract：:Airway remodeling is strongly correlated with the progression of chronic obstructive pulmonary disease (COPD). In this study, our goal was to characterize progressive structural changes in site-specific airways, along with the temporal and spatial expression of transforming growth factor (TGF)-β in the lungs of male s...

journal_title：American journal of respiratory cell and molecular biology

authors： Hoang LL,Nguyen YP,Aspeé R,Bolton SJ,Shen YH,Wang L,Kenyon NJ,Smiley-Jewell S,Pinkerton KE

更新日期：2016-06-01 00:00:00

abstract：:After localized lung immunization and challenge, antigen-specific antibody continues to be produced in the immunized lung lobes of dogs for years after the last antigen exposure. Lavage fluid from immunized lung lobes contains significantly more antigen-specific antibody than lavage fluid from control lung lobes, and ...

journal_title：American journal of respiratory cell and molecular biology

authors： Bice DE,Jones SE,Muggenburg BA

更新日期：1993-06-01 00:00:00

abstract：:The reasons for bacterial proliferation in the lungs of mechanically ventilated patients are poorly understood. We hypothesized that prolonged cyclic stretch of lung cells influenced bacterial growth. Human alveolar type II-like A549 cells were submitted in vitro to prolonged cyclic stretch. Bacteria were cultured in ...

journal_title：American journal of respiratory cell and molecular biology

authors： Pugin J,Dunn-Siegrist I,Dufour J,Tissières P,Charles PE,Comte R

更新日期：2008-03-01 00:00:00

abstract：:Lung fibrosis has been postulated to be mediated by the production of macrophage-derived growth factors that are both mitogenic and chemotactic for fibroblasts. In vitro studies from our laboratory demonstrated that alveolar and interstitial macrophages treated with iron and asbestos release platelet-derived growth fa...

journal_title：American journal of respiratory cell and molecular biology

authors： Osornio-Vargas AR,Kalter VG,Badgett A,Hernández-Rodríguez N,Aguilar-Delfín I,Brody AR

更新日期：1993-05-01 00:00:00

abstract：:Nitric oxide (NO) is an important regulator of Na(+) reabsorption by pulmonary epithelial cells and therefore of alveolar fluid clearance. The mechanisms by which NO affects epithelial ion transport are poorly understood and vary from model to model. In this study, the effects of NO on sodium reabsorption by H441 cell...

journal_title：American journal of respiratory cell and molecular biology

authors： Althaus M,Pichl A,Clauss WG,Seeger W,Fronius M,Morty RE

更新日期：2011-01-01 00:00:00

abstract：:The protease-antiprotease imbalance that is characteristic of most inflammatory lung disorders depends on the spatial-temporal regulation of active inhibitor and protease concentrations in lung secretions. We have studied the competition between the three main serine proteases from human neutrophil primary granules in...

journal_title：American journal of respiratory cell and molecular biology

authors： Korkmaz B,Poutrain P,Hazouard E,de Monte M,Attucci S,Gauthier FL

更新日期：2005-06-01 00:00:00

abstract：:Heme oxygenase-1 (HO-1) is a stress-response protein, the expression of which is transcriptionally regulated by agents that cause oxidative stress. We have previously shown that lipopolysaccharide (LPS)-induced HO-1 gene transcription in RAW 264.7 macrophage cells is mediated by a distal enhancer called SX2, located 4...

journal_title：American journal of respiratory cell and molecular biology

authors： Camhi SL,Alam J,Wiegand GW,Chin BY,Choi AM

更新日期：1998-02-01 00:00:00

abstract：:Nicotinamide phosphoribosyltransferase (NAMPT) exists as both intracellular NAMPT and extracellular NAMPT (eNAMPT) proteins. eNAMPT is secreted into the blood and functions as a cytokine/enzyme (cytozyme) that activates NF-κB signaling via ligation of Toll-like receptor 4 (TLR4), further serving as a biomarker for inf...

journal_title：American journal of respiratory cell and molecular biology

authors： Oita RC,Camp SM,Ma W,Ceco E,Harbeck M,Singleton P,Messana J,Sun X,Wang T,Garcia JGN

更新日期：2018-07-01 00:00:00

abstract：:To reach the sites of inflammation, neutrophils traverse the endothelium, its underlying basement membrane, and other barriers depending on the localization of the insulting agent. Whether neutrophil elastase (NE) plays a role in neutrophil recruitment to inflamed sites is still debatable. By exploiting mice deficient...

journal_title：American journal of respiratory cell and molecular biology

authors： Hirche TO,Atkinson JJ,Bahr S,Belaaouaj A

更新日期：2004-04-01 00:00:00

abstract：:Congenital diaphragmatic hernia (CDH) is associated with high neonatal mortality from lung hypoplasia and persistent pulmonary hypertension. Pulmonary neuroendocrine cells (PNEC) produce calcitonin gene-related peptide (CGRP), a potent vasodilator. We previously reported altered distribution of CGRP-positive PNEC in f...

journal_title：American journal of respiratory cell and molecular biology

authors： IJsselstijn H,Hung N,de Jongste JC,Tibboel D,Cutz E

更新日期：1998-08-01 00:00:00

abstract：:The human lung is constantly exposed to the environment and potential pathogens. As the interface between host and environment, the respiratory epithelium has evolved sophisticated sensing mechanisms as part of its defense against pathogens. In this review, we examine how the respiratory epithelium senses and responds...

journal_title：American journal of respiratory cell and molecular biology

authors： Benam KH,Denney L,Ho LP

更新日期：2019-03-01 00:00:00

abstract：:Although neutrophils play critical roles in innate immunity, in excess these cells cause severe tissue damage. Thus, neutrophil activation must be tightly regulated to prevent indiscriminant damage. Previously, we reported that mice lacking matrix metalloproteinase (MMP) 7 are protected from lung injury owing to marke...

journal_title：American journal of respiratory cell and molecular biology

authors： Gill SE,Nadler ST,Li Q,Frevert CW,Park PW,Chen P,Parks WC

更新日期：2016-08-01 00:00:00

abstract：:Previously it was reported that hyperoxia induced death of the human lung adenocarcinoma cell line (A549 cells) by necrosis, not by apoptosis. This study examined proliferation and death of untransformed human small airway epithelial (SAE) cells in normoxia or hyperoxia in comparison with A549 cells. We tested the hyp...

journal_title：American journal of respiratory cell and molecular biology

authors： Jyonouchi H,Sun S,Abiru T,Chareancholvanich S,Ingbar DH

更新日期：1998-09-01 00:00:00

abstract：:A defining feature of acute lung injury (ALI) is the increased lung vascular permeability and alveolar flooding, which leads to associated morbidity and mortality. Specific therapies to alleviate the unremitting vascular leak in ALI are not currently clinically available; however, our prior studies indicate a protecti...

journal_title：American journal of respiratory cell and molecular biology

authors： Zhao Y,Gorshkova IA,Berdyshev E,He D,Fu P,Ma W,Su Y,Usatyuk PV,Pendyala S,Oskouian B,Saba JD,Garcia JG,Natarajan V

更新日期：2011-08-01 00:00:00

abstract：:Bronchopulmonary dysplasia (BPD) is the most common and serious chronic lung disease of preterm infants. The development of pulmonary hypertension (PH) significantly increases the mortality and morbidity of this disease. β-Catenin signaling plays an important role in tissue development and remodeling. Aberrant β-caten...

journal_title：American journal of respiratory cell and molecular biology

authors： Alapati D,Rong M,Chen S,Hehre D,Hummler SC,Wu S

更新日期：2014-07-01 00:00:00

abstract：:Regulatory T cells (Tregs) play an essential role in maintaining the homeostatic balance of immune responses. Asthma is an inflammatory condition of the airways that is driven by dysregulated immune responses toward normally innocuous antigens. Individuals with asthma have fewer and less functional Tregs, which may le...

journal_title：American journal of respiratory cell and molecular biology

authors： Thorburn AN,Hansbro PM

更新日期：2010-11-01 00:00:00

abstract：:Adenosine is a signaling nucleoside that has been proposed to contribute to the pathogenesis of asthma and chronic obstructive pulmonary disease. Previous studies suggest that adenosine might play an important role in modulating levels of inflammatory mediators in the lung. Because airway epithelium is an important ce...

journal_title：American journal of respiratory cell and molecular biology

authors： Zhong H,Wu Y,Belardinelli L,Zeng D

更新日期：2006-11-01 00:00:00

abstract：:The role of pro-inflammatory cytokines in an animal model of allergic lung disease was examined by use of an interleukin-1 receptor antagonist (IL-1ra) and a specific bioassay for tumor necrosis factor (TNF). Ovalbumin-sensitized guinea pigs exhibit a marked bronchial hyperreactivity (assessed by airway responsiveness...

journal_title：American journal of respiratory cell and molecular biology

authors： Watson ML,Smith D,Bourne AD,Thompson RC,Westwick J

更新日期：1993-04-01 00:00:00

abstract：:Neutrophil apoptosis is essential for the resolution of inflammation but is delayed by several inflammatory mediators. In such terminally differentiated cells it has been uncertain whether these agents can inhibit apoptosis through transcriptional regulation of anti-death (Bcl-X(L), Mcl-1, Bcl2A1) or BH3-only (Bim, Bi...

journal_title：American journal of respiratory cell and molecular biology

authors： Cowburn AS,Summers C,Dunmore BJ,Farahi N,Hayhoe RP,Print CG,Cook SJ,Chilvers ER

更新日期：2011-06-01 00:00:00

abstract：:The present study utilized the monocrotaline (MCT) model of pulmonary hypertension in rats to examine temporal alterations in steady-state levels of basement membrane (BM) component mRNA and deposition of protein using Northern analysis and immunohistochemistry, respectively. MCT (60 mg/kg, subcutaneous) produced sust...

journal_title：American journal of respiratory cell and molecular biology

authors： Lipke DW,Arcot SS,Gillespie MN,Olson JW

更新日期：1993-10-01 00:00:00

abstract：:Oxygen-mediated lung injury can stimulate a fibroproliferative response resulting in the alteration of the pulmonary extracellular matrix and subsequent scarring of parenchymal tissue. Fibronectin (FN), a component of the extracellular matrix, appears in increased quantities in fibrotic lung disease. Alveolar macropha...

journal_title：American journal of respiratory cell and molecular biology

authors： Sinkin RA,LoMonaco MB,Finkelstein JN,Watkins RH,Cox C,Horowitz S

更新日期：1992-11-01 00:00:00

abstract：:Acute lung injury (ALI) is characterized by pulmonary inflammation and edema. Innate immune cells (e.g., neutrophils and macrophages) are major contributors to inflammation in ALI. Less is known regarding the role of T cells. We examined the effects of rapamycin on inflammation in a LPS-induced murine model of ALI. Ra...

journal_title：American journal of respiratory cell and molecular biology

authors： Nakajima T,Lin KW,Li J,McGee HS,Kwan JM,Perkins DL,Finn PW

更新日期：2014-08-01 00:00:00

abstract：:The investigation of novel targets for the treatment of cystic fibrosis (CF) lung inflammation is a major priority, considering that no effective therapy is available for this purpose. Consistent with the evidence that the sphingolipid (SL) ceramide regulates airway inflammation and infection in mice and patients with...

journal_title：American journal of respiratory cell and molecular biology

authors： Dechecchi MC,Nicolis E,Mazzi P,Cioffi F,Bezzerri V,Lampronti I,Huang S,Wiszniewski L,Gambari R,Scupoli MT,Berton G,Cabrini G

更新日期：2011-10-01 00:00:00

abstract：:Accumulating evidence has demonstrated that up-regulation of the angiotensin (Ang)-converting enzyme (ACE)/AngII/AngII type 1 receptor (AT1R) axis aggravates pulmonary fibrosis. The recently discovered ACE2/Ang-(1-7)/Mas axis, which counteracts the activity of the ACE/AngII/AT1R axis, has been shown to protect against...

journal_title：American journal of respiratory cell and molecular biology

authors： Meng Y,Yu CH,Li W,Li T,Luo W,Huang S,Wu PS,Cai SX,Li X

更新日期：2014-04-01 00:00:00

abstract：:Since the lung is repeatedly subjected to injury by pathogens and toxicants, maintenance of pulmonary homeostasis requires rapid repair of its epithelial surfaces. Ciliated bronchiolar epithelial cells, previously considered as terminally differentiated, underwent squamous cell metaplasia within hours after bronchiola...

journal_title：American journal of respiratory cell and molecular biology

authors： Park KS,Wells JM,Zorn AM,Wert SE,Laubach VE,Fernandez LG,Whitsett JA

更新日期：2006-02-01 00:00:00

abstract：:Substantial challenges remain in our understanding of fibrotic lung diseases. Nowhere is this more true than in the elucidation and verification of the pathogenetic basis upon which they develop. Scientific progress, most recently in the field of experimental therapy, has relied closely on interpreting data derived fr...

journal_title：American journal of respiratory cell and molecular biology

authors： Chua F,Gauldie J,Laurent GJ

更新日期：2005-07-01 00:00:00

abstract：:Mucin glycoproteins play a key role in the normal function of the airway epithelium. We examined the expression of mucin genes, MUC3, 4, 5AC, 5B, 6, 7, and 8 in human fetal tissues to establish the localization and age of onset of expression of each mucin gene during human development. We detected expression of MUC4, ...

journal_title：American journal of respiratory cell and molecular biology

authors： Reid CJ,Gould S,Harris A

更新日期：1997-11-01 00:00:00

abstract：:Profound impairment in cellular oxygen consumption, referred to as cytopathic dysoxia, is one of the pathological hallmarks in the lungs of patients with pathogen-induced acute lung injury (ALI). However, the underlying mechanism for this functional defect remains largely unexplored. In this study, we found that prima...

journal_title：American journal of respiratory cell and molecular biology

authors： Cui H,Xie N,Banerjee S,Ge J,Guo S,Liu G

更新日期：2019-02-01 00:00:00

abstract：:The capacity of Mycobacterium tuberculosis (MTB) to induce production of chemokines with known chemotactic activity for monocytes and lymphocytes, the cellular building blocks of granulomas, was investigated. These chemokines included regulated upon activation, normal T cell expressed and secreted (RANTES), monocyte c...

journal_title：American journal of respiratory cell and molecular biology

authors： Sadek MI,Sada E,Toossi Z,Schwander SK,Rich EA

更新日期：1998-09-01 00:00:00

abstract：:Patients with acute lung injury or respiratory distress syndrome often require supplemental oxygen to maintain tissue oxygenation; however, this treatment can cause or worsen lung inflammation. CD44 is a transmembrane adhesion molecule that is present on a wide variety of cell types, including leukocytes and parenchym...

journal_title：American journal of respiratory cell and molecular biology

authors： van der Windt GJ,Schouten M,Zeerleder S,Florquin S,van der Poll T

更新日期：2011-03-01 00:00:00