Effects of nitrogen dioxide exposure on bronchoalveolar lavage proteins in humans.

abstract：:Peroxisome proliferator-activated receptor (PPAR) γ is critical for alveolar macrophage (AM) function. Chronic alcohol abuse causes AM phagocytic dysfunction and susceptibility to respiratory infections by stimulating nicotinamide adenine dinucleotide oxidases (Nox), transforming growth factor-β1, and oxidative stress...

journal_title：American journal of respiratory cell and molecular biology

authors： Yeligar SM,Mehta AJ,Harris FL,Brown LA,Hart CM

更新日期：2016-07-01 00:00:00

abstract：:Tissue inhibitors of metalloproteinases (TIMPs) are multifunctional proteins that have the capacity to modify cellular activities and to modulate matrix turnover. We demonstrate that TIMP-1 messenger RNA (mRNA) and protein expression are selectively and markedly increased in a murine model of bleomycin-induced pulmona...

journal_title：American journal of respiratory cell and molecular biology

authors： Madtes DK,Elston AL,Kaback LA,Clark JG

更新日期：2001-05-01 00:00:00

abstract：:Cigarette smoke-induced apoptosis and necrosis contribute to the pathogenesis of chronic obstructive pulmonary disease. The induction of heme oxygenase-1 provides cytoprotection against oxidative stress, and may protect in smoking-related disease. Since mitochondria regulate cellular death, we examined the functional ...

journal_title：American journal of respiratory cell and molecular biology

authors： Slebos DJ,Ryter SW,van der Toorn M,Liu F,Guo F,Baty CJ,Karlsson JM,Watkins SC,Kim HP,Wang X,Lee JS,Postma DS,Kauffman HF,Choi AM

更新日期：2007-04-01 00:00:00

abstract：:In rat models of Gram-negative pneumonia, pulmonary emigration of neutrophils (polymorphonuclear leukocytes [PMNs]) is blocked when rats are made endotoxemic by an intravenous administration of endotoxin (lipopolysaccharide [LPS]). To test whether dysfunctional PMN migratory responses in the endotoxemic rat are specif...

journal_title：American journal of respiratory cell and molecular biology

authors： Wagner JG,Driscoll KE,Roth RA

更新日期：1999-04-01 00:00:00

abstract：:Lung development is associated with a surge in surfactant phosphatidylcholine (PC) production to prepare the newborn for extrauterine breathing. This process is associated with a marked increase in the activity of the rate-regulatory surfactant enzyme, CTP:phosphocholine cytidylyltransferase (CCTalpha). To investigate...

journal_title：American journal of respiratory cell and molecular biology

authors： McCoy DM,Fisher K,Robichaud J,Ryan AJ,Mallampalli RK

更新日期：2006-09-01 00:00:00

abstract：:Bronchiolitis obliterans (BO) is an increasingly important lung disease characterized by fibroproliferative airway lesions and decrements in lung function. Occupational exposure to the artificial food flavoring ingredient diacetyl, commonly used to impart a buttery flavor to microwave popcorn, has been associated with...

journal_title：American journal of respiratory cell and molecular biology

authors： Brass DM,Gwinn WM,Valente AM,Kelly FL,Brinkley CD,Nagler AE,Moseley MA,Morgan DL,Palmer SM,Foster MW

更新日期：2017-06-01 00:00:00

abstract：:Recent studies have indicated that, during the development of pulmonary hypertension (PH), there is a switch from oxidative phosphorylation to glycolysis in the pulmonary endothelium. However, the mechanisms underlying this phenomenon have not been elucidated. Endothelin (ET)-1, an endothelial-derived vasoconstrictor ...

journal_title：American journal of respiratory cell and molecular biology

authors： Sun X,Kumar S,Sharma S,Aggarwal S,Lu Q,Gross C,Rafikova O,Lee SG,Dasarathy S,Hou Y,Meadows ML,Han W,Su Y,Fineman JR,Black SM

更新日期：2014-06-01 00:00:00

abstract：:Polymorphonuclear leukocytes (PMN) and eosinophils (Eos) are important cellular participants in a variety of acute and chronic inflammatory reactions in the airway. Histologic evidence has implicated direct interactions between these two subsets of leukocytes and airway epithelial cells during inflammation. A comprehe...

journal_title：American journal of respiratory cell and molecular biology

authors： Jagels MA,Daffern PJ,Zuraw BL,Hugli TE

更新日期：1999-09-01 00:00:00

abstract：:In allergic airway diseases, intermediate progenitor cells (IPCs) increase in number in the surface epithelium. IPCs arise from basal cells, the origin of hallmark pathological changes, including goblet cell hyperplasia and mucus hypersecretion. Thus, targeting IPCs will benefit future treatment of allergic airway dis...

journal_title：American journal of respiratory cell and molecular biology

authors： Lee SN,Kim SJ,Yoon SA,Song JM,Ahn JS,Kim HC,Choi AMK,Yoon JH

更新日期：2020-12-02 00:00:00

abstract：:We investigated the effects of cultured epithelial cells and supernatants on resting membrane potential and excitatory neuroeffector transmission in smooth muscle cells of dog trachea and bronchioles. The mean resting membrane potential of the mucosa-free tracheal smooth muscle cells was -59.5 +/- 1.5 mV (+/- SD). App...

journal_title：American journal of respiratory cell and molecular biology

authors： Matsumoto K,Aizawa H,Inoue R,Hamano S,Ikeda S,Xie Z,Hirata M,Hara N,Ito Y

更新日期：1994-03-01 00:00:00

abstract：:The purpose of this study was to examine the relationship between hyperpnea-induced mucosal injury, bronchovascular hyperpermeability, and airway reactivity. Hyperpnea-induced bronchoconstriction was assessed by measuring peripheral airway resistance (Rp) in anesthetized mechanically ventilated male mongrel dogs. Eith...

journal_title：American journal of respiratory cell and molecular biology

authors： Freed AN,Omori C,Schofield BH,Mitzner W

更新日期：1994-12-01 00:00:00

abstract：:Alveolar type (AT)I and ATII cells are central to maintaining normal alveolar fluid homeostasis. When disrupted, they contribute to the pathogenesis of acute lung injury (ALI) and acute respiratory distress syndrome. Research on ATII cells has been limited by the inability to propagate primary cells in vitro to study ...

journal_title：American journal of respiratory cell and molecular biology

authors： Bove PF,Dang H,Cheluvaraju C,Jones LC,Liu X,O'Neal WK,Randell SH,Schlegel R,Boucher RC

更新日期：2014-04-01 00:00:00

abstract：:Alveolar hypoxia produces widespread systemic inflammation in rats. The inflammation appears to be triggered by activation of mast cells by a mediator released from alveolar macrophages, not by the reduced systemic partial pressure of oxygen (PO2). If this is correct, the following should apply: (1) neither mast cells...

journal_title：American journal of respiratory cell and molecular biology

authors： Chao J,Wood JG,Blanco VG,Gonzalez NC

更新日期：2009-11-01 00:00:00

abstract：:New approaches for improving tuberculosis (TB) control using adjunct host-directed cellular and repurposed drug therapies are needed. Autophagy plays a crucial role in the response to TB, and a variety of autophagy-inducing drugs that are currently available for various medical conditions may serve as an adjunct treat...

journal_title：American journal of respiratory cell and molecular biology

authors： Juárez E,Carranza C,Sánchez G,González M,Chávez J,Sarabia C,Torres M,Sada E

更新日期：2016-12-01 00:00:00

abstract：:Previous studies have demonstrated that high tidal volumes can cause interstitial and alveolar edema, with degradation of pulmonary epithelial barrier integrity. Separate studies have shown that F-actin disruption and decreased intracellular ATP (ATP(i)) levels in the nonpulmonary epithelium can increase tight junctio...

journal_title：American journal of respiratory cell and molecular biology

authors： Cavanaugh KJ Jr,Oswari J,Margulies SS

更新日期：2001-11-01 00:00:00

abstract：:To examine the effects of acid exposure on the adherence of Streptococcus pneumoniae to cultured human tracheal epithelial cells, cells were exposed to acid at various pH levels, and various concentrations of S. pneumoniae were added to the culture medium. The number of S. pneumoniae adhering to cultured human trachea...

journal_title：American journal of respiratory cell and molecular biology

authors： Ishizuka S,Yamaya M,Suzuki T,Nakayama K,Kamanaka M,Ida S,Sekizawa K,Sasaki H

更新日期：2001-04-01 00:00:00

abstract：:We have determined eicosanoid production from endogenous arachidonic acid by neonatal lamb lungs stimulated with calcium ionophore A23187 during normoxia and hypoxia. Lungs of lambs 19 to 25 d of age were isolated and perfused with cell-free Krebs' bicarbonate buffer at a flow rate of 15 to 20 ml/kg/min. After 30 min ...

journal_title：American journal of respiratory cell and molecular biology

authors： Ibe BO,Isenberg WB,Raj JU

更新日期：1991-04-01 00:00:00

abstract：:Transforming growth factor-beta1 (TGF-beta1) has been implicated as a major negative regulator of lung branching morphogenesis. Since connective tissue growth factor (CTGF) is a downstream mediator of TGF-beta1 effects on mesenchymal cells, we hypothesized that TGF-beta1 induces CTGF expression in mouse embryonic lung...

journal_title：American journal of respiratory cell and molecular biology

authors： Wu S,Peng J,Duncan MR,Kasisomayajula K,Grotendorst G,Bancalari E

更新日期：2007-05-01 00:00:00

abstract：:A defining feature of acute lung injury (ALI) is the increased lung vascular permeability and alveolar flooding, which leads to associated morbidity and mortality. Specific therapies to alleviate the unremitting vascular leak in ALI are not currently clinically available; however, our prior studies indicate a protecti...

journal_title：American journal of respiratory cell and molecular biology

authors： Zhao Y,Gorshkova IA,Berdyshev E,He D,Fu P,Ma W,Su Y,Usatyuk PV,Pendyala S,Oskouian B,Saba JD,Garcia JG,Natarajan V

更新日期：2011-08-01 00:00:00

abstract：:Airway epithelial cells cultured at the air-liquid interface possess highly differentiated functions and structures compared with the cells cultured under immersion. We examined the oxidative metabolism and glycolysis in cow tracheal epithelial cells on Days 3, 6, 10, and 13, cultured under three different conditions:...

journal_title：American journal of respiratory cell and molecular biology

authors： Kondo M,Tamaoki J,Sakai A,Kameyama S,Kanoh S,Konno K

更新日期：1997-01-01 00:00:00

abstract：:Macrophages are the primary lung phagocyte and are instrumental in maintenance of a sterile, noninflamed microenvironment. IFNs are produced in response to bacterial and viral infection, and activate the macrophage to efficiently counteract and remove pathogenic invaders. Respiratory syncytial virus (RSV) inhibits IFN...

journal_title：American journal of respiratory cell and molecular biology

authors： Senft AP,Taylor RH,Lei W,Campbell SA,Tipper JL,Martinez MJ,Witt TL,Clay CC,Harrod KS

更新日期：2010-04-01 00:00:00

abstract：:Surfactant protein D (SP-D) is believed to contribute to nonimmune host defense within the alveoli and distal airways of the lung. SP-D molecules can bind to specific carbohydrates on the surface of bacterial, fungal, and viral organisms and can also interact with membrane glycoconjugates expressed by alveolar macroph...

journal_title：American journal of respiratory cell and molecular biology

authors： Crouch EC,Persson A,Griffin GL,Chang D,Senior RM

更新日期：1995-04-01 00:00:00

abstract：:Fetal airway smooth muscle contracts to neural stimulation from early gestation. This study aimed to document the development of the nerves and ganglia within the bronchial tree of the fetal pig lung as the structural correlates for this function. The formation of these structures during lung development (pseudoglandu...

journal_title：American journal of respiratory cell and molecular biology

authors： Weichselbaum M,Sparrow MP

更新日期：1999-11-01 00:00:00

abstract：:Polymorphonuclear leukocytes (PMN) release gelatinase B in response to variable stimuli. Gelatinase B degrades basement membrane components in vitro, and inhibition of matrix metalloproteinase activity blunts PMN migration through a prototype basement membrane (Matrigel) and amnionic membranes. Accordingly, it has bee...

journal_title：American journal of respiratory cell and molecular biology

authors： Betsuyaku T,Shipley JM,Liu Z,Senior RM

更新日期：1999-06-01 00:00:00

abstract：:The effects of concomitant P1-receptor stimulation on peak intracellular Ca2+ release by extracellular adenosine 5'-triphosphate (ATP) and 5-hydroxytryptamine (5-HT) were investigated in cultured airway smooth-muscle (ASM) cells. The results show that peak Ca2+ release to ATP is enhanced by preincubation with adenosin...

journal_title：American journal of respiratory cell and molecular biology

authors： Michoud MC,Tao FC,Pradhan AA,Martin JG

更新日期：1999-07-01 00:00:00

abstract：:Infants born to heroin- and cocaine-addicted mothers have been reported to have a lower incidence of respiratory distress syndrome (RDS) compared with nonaddicted infants. However, it is not known whether these are direct drug-mediated effects or secondary phenomena. We therefore investigated the effect of opioids and...

journal_title：American journal of respiratory cell and molecular biology

authors： Gewolb IH,O'Brien J,Slavin RE

更新日期：1999-03-01 00:00:00

abstract：:Patients with systemic hypertension of various etiologies maintain their pulmonary artery pressures within normal limits. We have reported in isolated perfused rat lungs that low basal tone appears to be regulated by nitric oxide (NO)-dependent and -independent mechanisms of soluble guanylate cyclase activation, and s...

journal_title：American journal of respiratory cell and molecular biology

authors： Itani MM,Talerico MG,Pino PA,Burke-Wolin T

更新日期：1996-10-01 00:00:00

abstract：:Congenital diaphragmatic hernia (CDH) is associated with high neonatal mortality from lung hypoplasia and persistent pulmonary hypertension. Pulmonary neuroendocrine cells (PNEC) produce calcitonin gene-related peptide (CGRP), a potent vasodilator. We previously reported altered distribution of CGRP-positive PNEC in f...

journal_title：American journal of respiratory cell and molecular biology

authors： IJsselstijn H,Hung N,de Jongste JC,Tibboel D,Cutz E

更新日期：1998-08-01 00:00:00

abstract：:To better understand asthma pathogenesis, we characterized airway responsiveness, lung inflammation, and mediator production of alveolar macrophages (AM) after allergen sensitization and challenge in two strains of rats showing different susceptibilities in developing airway allergic reactions. Airway responsiveness t...

journal_title：American journal of respiratory cell and molecular biology

authors： Careau E,Sirois J,Bissonnette EY

更新日期：2002-05-01 00:00:00

abstract：:The role of guanine nucleotide-binding proteins in the induction of prostacyclin synthesis by stimulated endothelial cells is incompletely understood. We report that sodium fluoride (NaF), a potent activator of cellular guanine nucleotide-binding proteins, affected time- and concentration-dependent generation of prost...

journal_title：American journal of respiratory cell and molecular biology

authors： Garcia JG,Dominguez J,English D

更新日期：1991-08-01 00:00:00