Mycobacterium abscessus and M. avium trigger Toll-like receptor 2 and distinct cytokine response in human cells.

abstract：:Multiple cytokines play a role in the orchestration of inflammation in inflammatory airway diseases, such as chronic obstructive pulmonary disease, through the recruitment, activation and survival of inflammatory cells. Lymphokines secreted from T cells regulate the pattern of inflammation, whereas proinflammatory cyt...

journal_title：American journal of respiratory cell and molecular biology

authors： Barnes PJ

更新日期：2009-12-01 00:00:00

abstract：:The role of pro-inflammatory cytokines in an animal model of allergic lung disease was examined by use of an interleukin-1 receptor antagonist (IL-1ra) and a specific bioassay for tumor necrosis factor (TNF). Ovalbumin-sensitized guinea pigs exhibit a marked bronchial hyperreactivity (assessed by airway responsiveness...

journal_title：American journal of respiratory cell and molecular biology

authors： Watson ML,Smith D,Bourne AD,Thompson RC,Westwick J

更新日期：1993-04-01 00:00:00

abstract：:Since the lung is repeatedly subjected to injury by pathogens and toxicants, maintenance of pulmonary homeostasis requires rapid repair of its epithelial surfaces. Ciliated bronchiolar epithelial cells, previously considered as terminally differentiated, underwent squamous cell metaplasia within hours after bronchiola...

journal_title：American journal of respiratory cell and molecular biology

authors： Park KS,Wells JM,Zorn AM,Wert SE,Laubach VE,Fernandez LG,Whitsett JA

更新日期：2006-02-01 00:00:00

abstract：:IL-27 is involved in inflammatory reactions. CXCL10 is an important chemokine contributing to airway inflammatory disease. In this study, we investigated whether IL-27 modulated the synthesis of CXCL10 in primary human lung fibroblasts (HLFs). HLFs were activated by IL-27 alone, or in combination with other cytokines....

journal_title：American journal of respiratory cell and molecular biology

authors： Dong S,Zhang X,He Y,Xu F,Li D,Xu W,Wang H,Yin Y,Cao J

更新日期：2013-04-01 00:00:00

abstract：:The present study investigated mechanisms underlying apical and basolateral P2Y(1)-mediated Cl(-) secretion in human airway epithelial cells. Apical and basolateral ATP induced short-circuit currents (I(sc)) with different properties via P2Y(1) receptors. The former comprised an immediate rise followed by a slow atten...

journal_title：American journal of respiratory cell and molecular biology

authors： Son M,Ito Y,Sato S,Ishikawa T,Kondo M,Nakayama S,Shimokata K,Kume H

更新日期：2004-03-01 00:00:00

abstract：:The gaseous molecule carbon monoxide (CO) is elevated in the breath of individuals with asthma. The physiologic function of CO in asthma is poorly understood. Here we demonstrate that CO (250 ppm) markedly inhibits human airway smooth muscle cell (HASMC) proliferation, arresting cells at the G0/G1 phase. This CO-induc...

journal_title：American journal of respiratory cell and molecular biology

authors： Song R,Mahidhara RS,Liu F,Ning W,Otterbein LE,Choi AM

更新日期：2002-11-01 00:00:00

abstract：:Endotoxin lipopolysaccharide and the cytokines, tumor necrosis factor (TNF) and interleukin-1 (IL-1), are known to protect adult rats against O2 toxicity. However, whether the effect of endotoxin is mediated by these cytokines is not clear. We have previously demonstrated that depletion of 84% rat alveolar macrophages...

journal_title：American journal of respiratory cell and molecular biology

authors： Tang G,White JE,Lumb PD,Lawrence DA,Tsan MF

更新日期：1995-03-01 00:00:00

abstract：:Over 70% of patients with cystic fibrosis have the DeltaF508 mutation. This protein is a partially functional chloride (Cl-) channel that is prematurely degraded in the endoplasmic reticulum. Specific members of the flavonoid class of compounds have been shown to increase Cl- conductance of wild-type and DeltaF508 cys...

journal_title：American journal of respiratory cell and molecular biology

authors： Lim M,McKenzie K,Floyd AD,Kwon E,Zeitlin PL

更新日期：2004-09-01 00:00:00

abstract：:Alveolar macrophages (AMs) play an important role in the regulation of the local immune reactivity in the lung. It was previously shown that exposure of rats to mild inescapable electrical footshock stress (20 min, 4 shocks/min, 5 s/shock, 0.8 mAmp) leads to apparent changes in the activity of AMs upon stimulation, re...

journal_title：American journal of respiratory cell and molecular biology

authors： Broug-Holub E,Persoons JH,Schornagel K,Mastbergen SC,Kraal G

更新日期：1998-11-01 00:00:00

abstract：:Preclinical models of human conditions including asthma showed the therapeutic potential of Compound A (CpdA), a dissociated glucocorticoid (GC) receptor (GRα) ligand. Whether CpdA inhibits GC resistance, a central feature of severe asthma, has not been addressed. We investigated whether CpdA modulates cytokine-induce...

journal_title：American journal of respiratory cell and molecular biology

authors： Gavrila A,Chachi L,Tliba O,Brightling C,Amrani Y

更新日期：2015-11-01 00:00:00

abstract：:PS-341 is a highly selective and potent proteasome inhibitor that is cytotoxic to various types of cancer. However, no objective response was seen in a clinical trial with PS-341 as a single agent in non-small cell lung cancer. Its antitumor activity is limited by the simultaneously activated antiapoptosis pathway. Re...

journal_title：American journal of respiratory cell and molecular biology

authors： Lee KH,Jang AH,Yoo CG

更新日期：2015-09-01 00:00:00

abstract：:Tumor necrosis factor-alpha (TNF-alpha) is an important inflammatory mediator produced by activated monocytes and macrophages. We have previously shown that porcine alveolar macrophages (PAM) mediate bystander cytotoxicity through hydrogen peroxide production following activation with immobilized IgG immune complex (I...

journal_title：American journal of respiratory cell and molecular biology

authors： Kim JW,Wierda WG,Kim YB

更新日期：1991-09-01 00:00:00

abstract：:Lung morphometry was introduced over 50 years ago to provide quantitative evaluation of the lung structure. The existing parameters, such as mean linear intercept and destructive index, suffer from simplistic data interpretation and a subjective data acquisition process. To overcome these existing shortcomings, parenc...

journal_title：American journal of respiratory cell and molecular biology

authors： Xiao R,Goldklang MP,D'Armiento JM

更新日期：2016-11-01 00:00:00

abstract：:Influenza A virus (IAV) infection is known to induce endoplasmic reticulum (ER) stress, Fas-dependent apoptosis, and TGF-β production in a variety of cells. However, the relationship between these events in murine primary tracheal epithelial cells (MTECS), which are considered one of the primary sites of IAV infection...

journal_title：American journal of respiratory cell and molecular biology

authors： Roberson EC,Tully JE,Guala AS,Reiss JN,Godburn KE,Pociask DA,Alcorn JF,Riches DW,Dienz O,Janssen-Heininger YM,Anathy V

更新日期：2012-05-01 00:00:00

abstract：:Tumor necrosis factor-alpha (TNF-alpha) is thought to be important in the development of pulmonary fibrosis. However, surfactant protein-C/TNF-alpha transgenic mice do not spontaneously develop pulmonary fibrosis but instead develop alveolar enlargement and loss of elastic recoil. We hypothesized that overexpression o...

journal_title：American journal of respiratory cell and molecular biology

authors： Fujita M,Shannon JM,Morikawa O,Gauldie J,Hara N,Mason RJ

更新日期：2003-12-01 00:00:00

abstract：:Laminins are heterotrimeric proteins that are secreted by the alveolar epithelium into the basement membrane, and their expression is altered in extracellular matrices from patients with pulmonary fibrosis. In a small number of patients with pulmonary fibrosis, we found that the normal basement membrane distribution o...

journal_title：American journal of respiratory cell and molecular biology

authors： Morales-Nebreda LI,Rogel MR,Eisenberg JL,Hamill KJ,Soberanes S,Nigdelioglu R,Chi M,Cho T,Radigan KA,Ridge KM,Misharin AV,Woychek A,Hopkinson S,Perlman H,Mutlu GM,Pardo A,Selman M,Jones JC,Budinger GR

更新日期：2015-04-01 00:00:00

abstract：:Quantitative measurement of [3H]thymidine [( 3H]TdR) incorporation into cultured cells is widely used as an indicator of cell proliferation. The observation that adult type II cells are able to incorporate large amounts of [3H]TdR despite the fact that they are not proliferating raised the question of the meaning of [...

journal_title：American journal of respiratory cell and molecular biology

authors： Clement A,Riedel N,Brody JS

更新日期：1990-08-01 00:00:00

abstract：:Acute lung injury (ALI) and its severe form, acute respiratory distress syndrome (ARDS), are major causes of acute respiratory failure with high rates of morbidity and mortality. Although surfactant protein (SP)-D plays a critical role in pulmonary innate immunity and several clinical studies suggest that this protein...

journal_title：American journal of respiratory cell and molecular biology

authors： King BA,Kingma PS

更新日期：2011-05-01 00:00:00

abstract：:Tumor necrosis factor (TNF) is an inflammatory cytokine produced by many cell types which may contribute to the pathophysiology of a variety of lung diseases. In this study we have used Ro 45-2081 (a soluble receptor composed of the human p55 TNF receptor and human heavy-chain immunoglobulin G) to explore the role of ...

journal_title：American journal of respiratory cell and molecular biology

authors： Gater PR,Wasserman MA,Paciorek PM,Renzetti LM

更新日期：1996-05-01 00:00:00

abstract：:Metformin has been used as first-line treatment in patients with type 2 diabetes, and is reported to reduce cancer risk and progression by activating the liver kinase B1 (LKB1)-AMP-activated protein kinase (AMPK) pathway. Cisplatin remains the main drug for treating advanced non-small-cell lung cancer. However, drug r...

journal_title：American journal of respiratory cell and molecular biology

authors： Lin CC,Yeh HH,Huang WL,Yan JJ,Lai WW,Su WP,Chen HH,Su WC

更新日期：2013-08-01 00:00:00

abstract：:Dendritic cells (DCs) are essential for innate and adaptive immunity, but are purported to exhibit variable radiosensitivity in response to irradiation in various bone marrow transplantation (BMT) protocols. To address this controversy, we analyzed the magnitude of depletion and repopulation of both lung CD11b(pos) DC...

journal_title：American journal of respiratory cell and molecular biology

authors： Hahn I,Klaus A,Maus R,Christman JW,Welte T,Maus UA

更新日期：2011-09-01 00:00:00

abstract：:Two isoforms of the human glucocorticoid receptor (hGR) have been described, hGRalpha and hGRbeta. We analyzed the expression and regulation of both hGR isoforms in human respiratory epithelial cells (BEAS-2B, A549, and primary nasal epithelial cells). In BEAS-2B cells, the expression of hGRalpha messenger RNA (mRNA) ...

journal_title：American journal of respiratory cell and molecular biology

authors： Pujols L,Mullol J,Pérez M,Roca-Ferrer J,Juan M,Xaubet A,Cidlowski JA,Picado C

更新日期：2001-01-01 00:00:00

abstract：:The mechanisms used by alveolar type I pneumocytes for maintenance of the lipid homeostasis necessary to sustain these large squamous cells are unknown. The processes may involve the ATP-binding cassette transporter A1 (ABCA1), a transport protein shown to be crucial in apolipoprotein A-I (apoA-I)-mediated mobilizatio...

journal_title：American journal of respiratory cell and molecular biology

authors： Bates SR,Tao JQ,Yu KJ,Borok Z,Crandall ED,Collins HL,Rothblat GH

更新日期：2008-03-01 00:00:00

abstract：:The capacity of Mycobacterium tuberculosis (MTB) to induce production of chemokines with known chemotactic activity for monocytes and lymphocytes, the cellular building blocks of granulomas, was investigated. These chemokines included regulated upon activation, normal T cell expressed and secreted (RANTES), monocyte c...

journal_title：American journal of respiratory cell and molecular biology

authors： Sadek MI,Sada E,Toossi Z,Schwander SK,Rich EA

更新日期：1998-09-01 00:00:00

abstract：:Bacterial pneumonia is a common public health problem associated with significant mortality, morbidity, and cost. Neutrophils are usually the earliest leukocytes to respond to bacteria in the lungs. Neutrophils rapidly sequester in the pulmonary microvasculature and migrate into the lung parenchyma and alveolar spaces...

journal_title：American journal of respiratory cell and molecular biology

authors： Gomez JC,Yamada M,Martin JR,Dang H,Brickey WJ,Bergmeier W,Dinauer MC,Doerschuk CM

更新日期：2015-03-01 00:00:00

abstract：:We hypothesized that, as in animal models, localized deposition of antigen into the human lung would induce local inflammatory and immune responses in antigen-exposed sites. To test this hypothesis, segmental instillation of a well-characterized, highly immunogenic, soluble antigen, keyhole limpet hemocyanin (KLH) was...

journal_title：American journal of respiratory cell and molecular biology

authors： Weissman DN,Bice DE,Crowell RE,Schuyler MR

更新日期：1994-11-01 00:00:00

abstract：:Patients with severe acute and chronic lung diseases develop derangements in gas exchange that may result in increased levels of CO(2) (hypercapnia), the effects of which on human health are incompletely understood. It has been proposed that hypercapnia may have beneficial effects in patients with acute lung injury, a...

journal_title：American journal of respiratory cell and molecular biology

authors： Vadász I,Hubmayr RD,Nin N,Sporn PH,Sznajder JI

更新日期：2012-04-01 00:00:00

abstract：:Humans and rodents exposed to an aerosol of asbestos fibers develop lung injury that can lead to a fibroproliferative response culminating in excessive scarring and impaired lung function. To define the early events that precede asbestos-induced fibrotic lung disease, rats were exposed to an aerosol of chrysotile asbe...

journal_title：American journal of respiratory cell and molecular biology

authors： Mishra A,Liu JY,Brody AR,Morris GF

更新日期：1997-04-01 00:00:00

abstract：:Impaired sphingolipid synthesis is linked genetically to childhood asthma and functionally to airway hyperreactivity (AHR). The objective was to investigate whether sphingolipid synthesis could be a target for asthma therapeutics. The effects of GlyH-101 and fenretinide via modulation of de novo sphingolipid synthesis...

journal_title：American journal of respiratory cell and molecular biology

authors： Heras AF,Veerappan A,Silver RB,Emala CW,Worgall TS,Perez-Zoghbi J,Worgall S

更新日期：2020-11-01 00:00:00

abstract：:Bacterial lung diseases are a major cause of morbidity and mortality both in immunocompromised and in immunocompetent individuals. Neutrophil accumulation, a pathological hallmark of bacterial diseases, is critical to host defense, but may also cause acute lung injury/acute respiratory distress syndrome. Toll-like rec...

journal_title：American journal of respiratory cell and molecular biology

authors： Balamayooran G,Batra S,Fessler MB,Happel KI,Jeyaseelan S

更新日期：2010-07-01 00:00:00