当前位置： SCI文献检索 > International Journal of Laboratory Hematology期刊下所有文献 > Inappropriate use of protein C, protein S, and antithrombin testing for hereditary thrombophilia screening: an experience from a large university hospital.

Inappropriate use of protein C, protein S, and antithrombin testing for hereditary thrombophilia screening: an experience from a large university hospital.

Abstract：

INTRODUCTION:Deficiencies of protein C, protein S, and antithrombin are the main inherited risk factors in Thai patients with venous thromboembolism, although the prevalence is not high. METHODS:To evaluate the appropriate use of the testing for these proteins, the test orders of 503 patients were retrospectively reviewed using the proposed guidelines. Inter-rater reliability between two investigators was also calculated. RESULTS:Of 503, 459 (91%; 95% confidence interval 88-93%) of the test orders were inappropriate. The most common cause of inappropriateness was testing during acute thrombosis (42.5%). Results were inconclusive in 105 (20.9%) patients who had isolated decrease in one of the proteins, mostly owing to lack of confirmation of the abnormal results. Kappa index for the reliability of two investigators was 0.79. CONCLUSION:To enhance the appropriate use of hereditary thrombophilia screening tests, physician education concerning the patient selection, suitable timing for testing and repetition of the tests with abnormal results should be emphasized.

journal_name

Int J Lab Hematol

journal_title

International journal of laboratory hematology

authors

Tientadakul P,Chinthammitr Y,Sanpakit K,Wongwanit C,Nilanont Y

doi

10.1111/j.1751-553X.2011.01332.x

subject

Has Abstract

pub_date

2011-12-01 00:00:00

pages

593-600

issue

6

eissn

1751-5521

issn

1751-553X

journal_volume

33

pub_type

杂志文章

相关文献

International Journal of Laboratory Hematology文献大全
  • Hematopoietic stem cell lodgment in the adult bone marrow stem cell niche.

    abstract：:Treatment of malignant blood disorders, such as leukemia, that can provide a better chance of long-term remission involves myeloablation followed by transplantation of matched donor hematopoietic stem cells (HSCs). For successful engraftment and re-establishment of hematopoiesis to occur in the recipient, the transpla...

    journal_title：International journal of laboratory hematology

    pub_type： 杂志文章,评审

    doi：10.1111/j.1751-553X.2010.01250.x

    authors： Lam BS,Adams GB

    更新日期：2010-12-01 00:00:00

  • ADAMTS13 activity to von Willebrand factor antigen ratio predicts acute kidney injury in patients with COVID-19: Evidence of SARS-CoV-2 induced secondary thrombotic microangiopathy.

    abstract：INTRODUCTION:Severe COVID-19 is often compounded by a prothrombotic state that is associated with poor outcomes. In this investigation, we aimed to evaluate ADAMTS13 activity, von Willebrand factor level (VWF:Ag), and the corresponding ADAMTS13 activity/VWF:Ag ratio, in patients with COVID-19 and for associations with ...

    journal_title：International journal of laboratory hematology

    pub_type： 杂志文章

    doi：10.1111/ijlh.13415

    authors： Henry BM,Benoit SW,de Oliveira MHS,Lippi G,Favaloro EJ,Benoit JL

    更新日期：2020-12-03 00:00:00

  • International Council for Standardization in Haematology (ICSH) laboratory guidance for the evaluation of haemostasis analyser-reagent test systems. Part 1: Instrument-specific issues and commonly used coagulation screening tests.

    abstract：:Before a new method is used for clinical testing, it is essential that it is evaluated for suitability for its intended purpose. This document gives guidance for the performance of verification, validation and implementation processes required by regulatory and accreditation bodies. It covers the planning and executio...

    journal_title：International journal of laboratory hematology

    pub_type： 杂志文章,评审

    doi：10.1111/ijlh.13411

    authors： Gardiner C,Coleman R,de Maat MPM,Dorgalaleh A,Echenagucia M,Gosselin RC,Ieko M,Kitchen S

    更新日期：2020-11-29 00:00:00

  • Three novel alternative splicing mutations in BCR-ABL1 detected in CML patients with resistance to kinase inhibitors.

    abstract：INTRODUCTION:Multiple types of mutations in the BCR-ABL1 kinase domain have been reported. We previously reported a common alternatively spliced BCR-ABL mRNA with a 35-nucleotide insertion (35INS). We report three novel alternative splicing mutants expressed as the dominant transcripts in patient with chronic myelogeno...

    journal_title：International journal of laboratory hematology

    pub_type： 杂志文章

    doi：10.1111/j.1751-553X.2010.01291.x

    authors： Ma W,Giles F,Zhang X,Wang X,Zhang Z,Lee TS,Yeh CH,Albitar M

    更新日期：2011-06-01 00:00:00

  • Direct international normalized ratio determination using multicalibrators is more responsive than the conventional method for measuring prothrombin time.

    abstract：:Direct international normalized ratio (INR) determination using certified INR plasmas was shown to improve precision and accuracy. We evaluated the utility of a multicalibrator in determining INR. INR values were measured in 493 blood samples from patients subjected to anticoagulation therapy (320) and control subject...

    journal_title：International journal of laboratory hematology

    pub_type： 杂志文章

    doi：10.1111/j.1751-553X.2009.01195.x

    authors： Cha CH,Park CJ,Kim DH,Kim MJ,Cho YU,Jang S,Chi HS

    更新日期：2010-08-01 00:00:00

  • The role of automated measurement of red cell subpopulations on the Sysmex XE 5000 analyzer in the differential diagnosis of microcytic anemia.

    abstract：:Cell counter-based formulae have been used in the differential diagnosis of microcytic anemia. The measurement of new red cell parameters is now available on the Sysmex XE 5000 analyzer. Derived from the percentages of microcytic and hypochromic red cells, the authors describe the new formula %microcytic-%hypochromic,...

    journal_title：International journal of laboratory hematology

    pub_type： 杂志文章

    doi：10.1111/j.1751-553X.2010.01237.x

    authors： Urrechaga E,Borque L,Escanero JF

    更新日期：2011-02-01 00:00:00

  • How I investigate Eosinophilia.

    abstract：:Eosinophilia is typically secondary, that is, reactive, in nature and is associated with a wide variety of neoplastic and non-neoplastic disorders. Clonal eosinophilia is also seen in a wide variety of hematopoietic neoplasms, and sub-classification can be diagnostically challenging. A proper evaluation of persistent ...

    journal_title：International journal of laboratory hematology

    pub_type： 杂志文章,评审

    doi：10.1111/ijlh.12955

    authors： Larsen RL,Savage NM

    更新日期：2019-04-01 00:00:00

  • Factor XIII-A subunit Val34Leu polymorphism in fatal hemorrhagic stroke.

    abstract：:Blood coagulation factor XIII (FXIII) plays a key role in the protection of fibrin clot against fibrinolysis, in the cross-linking of fibrin and its mechanical strength. The role of the FXIII-A subunit Val34Leu polymorphism with fatal primary intracerebral hemorrhages (PICH) has not been studied. We evaluated retrospe...

    journal_title：International journal of laboratory hematology

    pub_type： 杂志文章

    doi：10.1111/j.1751-553X.2012.01465.x

    authors： Antalfi B,Pongrácz E,Csiki Z,Mezei ZA,Shemirani AH

    更新日期：2013-02-01 00:00:00

  • Expression of CD4 is correlated with an unfavorable prognosis in wild-type NPM1, FLT3-ITD-negative cytogenetically normal adult acute myeloid leukemia.

    abstract：INTRODUCTION:In the cytogenetically normal population of AML (CN-AML), FLT3-ITD-positive and wild-type NPM1 is correlated with a worse outcome, and FLT3-ITD-negative with NPM1-mut is correlated with a better outcome. This leaves a large subpopulation of CN-AML patients without NPM1 or FLT3-ITD mutations with heterogene...

    journal_title：International journal of laboratory hematology

    pub_type： 杂志文章

    doi：10.1111/ijlh.12649

    authors： Guo RJ,Atenafu EG,Schimmer AD,Minden MD,Chang H

    更新日期：2017-08-01 00:00:00

  • Guidance for storing blood samples in laboratories performing complete blood count with differential.

    abstract：INTRODUCTION:The complete blood count (CBC) with differential leukocyte count (DIFF) is an important part of clinical laboratory analyses and provides crucial data for clinicians. Delivery time after blood collection and conditions of storage is known to affect the reliability of results of some hematologic parameters....

    journal_title：International journal of laboratory hematology

    pub_type： 杂志文章

    doi：10.1111/j.1751-553X.2012.01452.x

    authors： Cornet E,Behier C,Troussard X

    更新日期：2012-12-01 00:00:00

  • Toward routine detection of extracellular vesicles in clinical samples.

    abstract：:The majority, if not all, of human cell types secrete extracellular vesicles (EVs) into their environment, at least partly as a means of intercellular communication. These secreted vesicles can be detected in most bodily fluids including blood, urine, and saliva. The number of secreted vesicles and their composition i...

    journal_title：International journal of laboratory hematology

    pub_type： 杂志文章,评审

    doi：10.1111/ijlh.12247

    authors： van der Meel R,Krawczyk-Durka M,van Solinge WW,Schiffelers RM

    更新日期：2014-06-01 00:00:00

  • The biological characteristics of dendritic cells derived in vitro from myelogeneous leukemia cells and healthy donor cells.

    abstract：:Successful adoptive immunotherapy for leukemia depends on the generation of T cells that can specifically react with malignant cells. Dendritic cells (DCs) are important antigen-presenting cells in the development of antileukemia T-cell responses. Mononuclear cells (MNC) were isolated from peripheral blood or bone mar...

    journal_title：International journal of laboratory hematology

    pub_type： 杂志文章

    doi：10.1111/j.1751-553X.2007.00986.x

    authors： Tong XM,Yao HP,Qian WB,Zhu LF,Fu ZH,Huang ZL,Jin J

    更新日期：2008-10-01 00:00:00

  • Osmotic gradient ektacytometry: A valuable screening test for hereditary spherocytosis and other red blood cell membrane disorders.

    abstract：INTRODUCTION:New generation osmotic gradient ektacytometry has become a powerful procedure for measuring red blood cell deformability and therefore for the diagnosis of red blood cell membrane disorders. In this study, we aim to provide further support to the usefulness of osmotic gradient ektacytometry for the differe...

    journal_title：International journal of laboratory hematology

    pub_type： 临床试验,杂志文章

    doi：10.1111/ijlh.12746

    authors： Llaudet-Planas E,Vives-Corrons JL,Rizzuto V,Gómez-Ramírez P,Sevilla Navarro J,Coll Sibina MT,García-Bernal M,Ruiz Llobet A,Badell I,Velasco-Puyó P,Dapena JL,Mañú-Pereira MM

    更新日期：2018-02-01 00:00:00

  • Utility of new mature erythrocyte and reticulocyte indices in screening for iron-deficiency anemia in a pediatric population.

    abstract：INTRODUCTION:Iron-deficient erythropoiesis attributable to nutritional deficiency is the most common cause of anemia in early childhood. Beckman Coulter has proposed new parameters: red blood cell size factor (RSf) and low hemoglobin density (LHD%). [Formula: see text] The aims of the present communication were to esta...

    journal_title：International journal of laboratory hematology

    pub_type： 杂志文章

    doi：10.1111/ijlh.12030

    authors： Osta V,Caldirola MS,Fernandez M,Marcone MI,Tissera G,Pennesi S,Ayuso C

    更新日期：2013-08-01 00:00:00

  • The hematology laboratory's response to the COVID-19 pandemic: A scoping review.

    abstract：:The ongoing COVID-19 pandemic has had a profound worldwide impact on the laboratory hematology community. Nevertheless, the pace of COVID-19 hematology-related research has continued to accelerate and has established the role of laboratory hematology data for many purposes including disease prognosis and outcome. The ...

    journal_title：International journal of laboratory hematology

    pub_type： 杂志文章,评审

    doi：10.1111/ijlh.13381

    authors： Bell R,Zini G,d'Onofrio G,Rogers HJ,Lee YS,Frater JL

    更新日期：2020-11-12 00:00:00

  • Assessing maternal clotting function with novel global coagulation assays: A prospective pilot study.

    abstract：INTRODUCTION:Women are at higher risk of venous thromboembolism (VTE) during pregnancy and the puerperium. Global coagulation assays (GCAs), including thromboelastography (TEG), thrombin generation using the calibrated automated thrombogram (CAT) and fibrin generation using the overall haemostatic potential assay (OHP)...

    journal_title：International journal of laboratory hematology

    pub_type： 杂志文章

    doi：10.1111/ijlh.13389

    authors： O'Keefe D,Lim HY,Tham J,Ho P,Hui L

    更新日期：2020-11-10 00:00:00

  • Performance evaluation of a new Stago® automated haemostasis analyser: The STA R Max® 2.

    abstract：INTRODUCTION:The STA R Max® 2 is a new coagulation analyser developed by Diagnostica Stago, able to perform clotting, chromogenic and immuno-turbidimetric tests. A pre-analytical module build into the cap-piercing needle performs the sample integrity verification (sample tube filling and measurement of haemolysis, icte...

    journal_title：International journal of laboratory hematology

    pub_type： 杂志文章

    doi：10.1111/ijlh.13100

    authors： Cupaiolo R,Govaerts D,Blauwaert M,Cauchie P

    更新日期：2019-12-01 00:00:00

  • Signal transducer and activator of transcription 3 (STAT3) gene polymorphisms are associated with treatment outcomes in acute myeloid leukemia.

    abstract：INTRODUCTION:In the Janus kinase/signal transducer and activator of transcription (JAK/STAT) signaling pathway, STAT3 is one of the most prominent prognosis factors for cancer and leukemia. STAT3 activation might promote cellular transformation and therefore have an important role in human tumors. This study aimed to i...

    journal_title：International journal of laboratory hematology

    pub_type： 杂志文章

    doi：10.1111/j.1751-553X.2012.01406.x

    authors： Zhong Y,Feng J,Chen B,Cheng L,Li Y,Qian J,Ding J,Gao F,Xia G

    更新日期：2012-08-01 00:00:00

  • Usefulness of automated fragmented red blood cell percentage in the diagnosis of paediatric haemolytic uraemic syndrome.

    abstract：INTRODUCTION:Presence of schistocytes in peripheral blood smear supporting haemolysis is important for diagnosis and decision-making in paediatric haemolytic uraemic syndrome (HUS). High observer dependency and requirement of expertise for peripheral smear evaluation propels us to think of other modalities to overcome ...

    journal_title：International journal of laboratory hematology

    pub_type： 杂志文章

    doi：10.1111/ijlh.13324

    authors： Govindarajan S,Bhatia P,Dawman L,Tiewsoh K

    更新日期：2021-02-01 00:00:00

  • Comparison of five point-of-care D-dimer assays with the standard laboratory method.

    abstract：INTRODUCTION:D-dimer (DD) assays are effective for the exclusion of deep-vein thrombosis (DVT), but point-of-care (POC) DD assays have not been fully evaluated. METHODS:We have compared five POC DD assays (Pathfast, Cardiac, Vidas, Stratus and NycoCard) with our routine DD method (Tinaquant), testing 60 samples from p...

    journal_title：International journal of laboratory hematology

    pub_type： 杂志文章

    doi：10.1111/j.1751-553X.2012.01421.x

    authors： Antovic JP,Höög Hammarström K,Forslund G,Eintrei J,Sten-Linder M

    更新日期：2012-10-01 00:00:00

  • Optimal wavelength for the clot waveform analysis: Determination of the best resolution with minimal interference of the reagents.

    abstract：INTRODUCTION:Clot waveform analysis (CWA), a new methodology to assess coagulation process, can be usefully applied in various clinical settings. However, its clinical use is limited mainly because of the absence of standardization. No consensus exists regarding the wavelengths at which CWA has to be performed what is ...

    journal_title：International journal of laboratory hematology

    pub_type： 杂志文章

    doi：10.1111/ijlh.12975

    authors： Evrard J,Siriez R,Morimont L,Thémans P,Laloy J,Bouvy C,Gheldof D,Mullier F,Dogné JM,Douxfils J

    更新日期：2019-06-01 00:00:00

  • IgG subclasses of FVIII inhibitors in an argentine cohort of severe hemophilia A patients: Analysis by flow cytometry.

    abstract：INTRODUCTION:FVIII inhibitors consist of a polyclonal population of antibodies. Previous studies have demonstrated different distribution of IgG subclasses. IgG4 was associated to high level of FVIII inhibitors and failure of immune tolerance induction (ITI) treatment. This study monitored the relative distribution of ...

    journal_title：International journal of laboratory hematology

    pub_type： 杂志文章

    doi：10.1111/ijlh.12696

    authors： Irigoyen MB,Primiani L,Felippo M,Candela M,de Bracco MME,Galassi NV

    更新日期：2017-12-01 00:00:00

  • CD34, RAB20, PU.1 and GFI1 mRNA expression in myelodysplastic syndrome.

    abstract：:Myelodysplastic syndrome (MDS) with hypocellular bone marrow (BM) is often difficult to distinguish from aplastic anemia (AA). Furthermore, the diagnosis of MDS with low blast counts and normal karyotype may be problematic. These issues highlight the need for a reliable marker for the diagnosis of MDS. This study was ...

    journal_title：International journal of laboratory hematology

    pub_type： 杂志文章

    doi：10.1111/j.1751-553X.2008.01056.x

    authors： Huh HJ,Chae SL,Lee M,Hong KS,Mun YC,Seong CM,Chung WS,Huh JW

    更新日期：2009-06-01 00:00:00

  • Multicentric evaluation of the new HemosIL Acustar® chemiluminescence ADAMTS13 activity assay.

    abstract：INTRODUCTION:Thrombotic thrombocytopenic purpura (TTP) is a rare life-threatening thrombotic microangiopathy (TMA) characterized by the severe deficiency of ADAMTS13 activity (<10%). Rapid ADAMTS13 testing is crucial for early diagnosis and optimal management of TTP patients and other TMAs. The objective of this study ...

    journal_title：International journal of laboratory hematology

    pub_type： 杂志文章

    doi：10.1111/ijlh.13414

    authors： Pascual C,Nieto JM,Fidalgo T,Seguí IG,Díaz-Ricart M,Docampo MF,Del Rio J,Salinas R

    更新日期：2020-12-02 00:00:00

  • Evaluation of amotosalem treated platelets over 7 days of storage with an automated cytometry assay panel.

    abstract：INTRODUCTION:Pathogen Inactivation allows to overcome microbial contamination and growth related to storage of platelets concentrates (PC) at room temperature. The aim of our study was to evaluate the platelet storage lesion extending the storage period of pathogen inactivated platelet concentrates over 7 days using an...

    journal_title：International journal of laboratory hematology

    pub_type： 杂志文章

    doi：10.1111/ijlh.12102

    authors： Diquattro M,De Francisci G,Bonaccorso R,Tagliavia AM,Marcatti M,Palma B,Agliastro R

    更新日期：2013-12-01 00:00:00

  • Acute myeloid leukaemia: How to combine multiple tools.

    abstract：:The pathogenesis of acute myeloid leukaemias (AML) frequently requires at least 3 mutations in different cellular pathways. In many cases, mutations in proliferation/survival mechanisms and differentiation pathways are involved. Genetic aberrations explain the pathogenesis of AML, provide prognostic criteria and guide...

    journal_title：International journal of laboratory hematology

    pub_type： 杂志文章

    doi：10.1111/ijlh.12831

    authors： Merino A,Boldú L,Ermens A

    更新日期：2018-05-01 00:00:00

  • A rare case of Lennert's type peripheral T-cell lymphoma with t(14;19)(q11.2;q13.3).

    abstract：:Although most patients with peripheral T-cell lymphoma (PTCL) show clonal rearrangement of T-cell receptor genes, few PTCLs show recurrent chromosomal abnormalities. We describe here a rare chromosomal rearrangement, t(14;19)(q11.2;q13.3), in a Lennert's lymphoma, a variant of PTCL, not otherwise specified. Sequential...

    journal_title：International journal of laboratory hematology

    pub_type： 杂志文章

    doi：10.1111/j.1751-553X.2011.01385.x

    authors： Shin SY,Jang S,Park CJ,Chi HS,Lee KH,Huh J,Seo EJ

    更新日期：2012-06-01 00:00:00

  • Evaluation of automated capillary complete blood counts for routine clinical decision making in a large cohort of hematological patients, using Mindray BC-3000 Plus Auto and Sysmex XE-5000 hematology analyzers.

    abstract：INTRODUCTION:Venous blood (VB) sampling for complete blood count (CBC) via venipuncture is the basic method for the daily evaluation of hematological patients. However, several issues during this process, such as venipuncture difficulty and repetitive attempts, may cause pain, phlebitis, hematomas, inadequate sampling,...

    journal_title：International journal of laboratory hematology

    pub_type： 杂志文章

    doi：10.1111/ijlh.13237

    authors： Oudatzis G,Tsagarakis NJ,Paterakis G,Vasileiou P,Xenou E,Maraki P,Pangrati T,Angelopoulou MK,Vassilakopoulos TP,Konstantopoulos K

    更新日期：2020-10-01 00:00:00

  • Gene expression risk signatures maintain prognostic power in multiple myeloma despite microarray probe set translation.

    abstract：INTRODUCTION:Gene expression profiling (GEP) risk models in multiple myeloma are based on 3'-end microarrays. We hypothesized that GEP risk signatures could retain prognostic power despite being translated and applied to whole-transcript microarray data. METHODS:We studied CD138-positive bone marrow plasma cells in a ...

    journal_title：International journal of laboratory hematology

    pub_type： 临床试验,杂志文章,多中心研究

    doi：10.1111/ijlh.12486

    authors： Hermansen NE,Borup R,Andersen MK,Vangsted AJ,Clausen NT,Kristensen DL,Nielsen FC,Gimsing P

    更新日期：2016-06-01 00:00:00

  • Clinical and hematological characteristics of 88 patients with COVID-19.

    abstract：INTRODUCTION:To retrospectively analyze epidemiological, clinical and hematological characteristics of COVID-19 patients. METHODS:The demographic, symptoms, and physiological parameters of 88 patients were collected and analyzed. The performance of complete blood count (CBC) indexes for monitoring and predicting the s...

    journal_title：International journal of laboratory hematology

    pub_type： 杂志文章

    doi：10.1111/ijlh.13291

    authors： Zhang H,Cao X,Kong M,Mao X,Huang L,He P,Pan S,Li J,Lu Z

    更新日期：2020-12-01 00:00:00