Why so impulsive? White matter alterations are associated with impulsivity in chronic marijuana smokers.

abstract：:Prevalence of heavy alcohol use remain high, and daily marijuana use is at an all-time high in young adults. As perceptions of drug effects may guide risky decision making, understanding subjective feelings for alcohol and marijuana use is critical. Existing laboratory-based and diary metrics (0-100 rating of "how dru...

journal_title：Experimental and clinical psychopharmacology

authors： Linden-Carmichael AN,Masters LD,Lanza ST

更新日期：2020-12-01 00:00:00

abstract：:Alcohol and cannabis couse is highly prevalent and associated with various negative consequences. The likelihood of same day couse is high, especially among men, however, underlying mechanisms to their couse and its sex-dependent nature remain poorly understood. This study aims to elucidate the effects of controlled a...

journal_title：Experimental and clinical psychopharmacology

authors： Venegas A,Meredith LR,Green R,Cooper ZD,Ray LA

更新日期：2020-07-13 00:00:00

abstract：:This report describes a novel procedure for computer-controlled drug-dose determination for IV drug self-administration studies. By modifying the duration of each infusion of a single concentration of a drug solution, five or more unit doses (mg/kg/inj) can be dispensed from the same syringe. The advantages of this pr...

journal_title：Experimental and clinical psychopharmacology

authors： Fivel PA

更新日期：2011-04-01 00:00:00

abstract：:Varenicline reduces drinking in people with alcohol use disorder, but little is known about the mechanisms underlying this effect. Varenicline targets α4β2 and α7 nicotinic acetylcholine receptors, which are associated with several cognitive functions such as working memory. Varenicline may improve drinking outcomes b...

journal_title：Experimental and clinical psychopharmacology

authors： Roberts W,McKee SA

更新日期：2018-02-01 00:00:00

abstract：:The effects of methylphenidate (MPH) on performance of a time-production task were studied in 17 children with attention-deficit/hyperactivity disorder who participated in 1 test session on and 1 off MPH. Participants held a response lever down for at least 10 but no longer than 14 s. Administration of MPH had no effe...

journal_title：Experimental and clinical psychopharmacology

authors： Baldwin RL,Chelonis JJ,Flake RA,Edwards MC,Feild CR,Meaux JB,Paule MG

更新日期：2004-02-01 00:00:00

abstract：:The nonmedical use of prescription drugs is a widely recognized public health issue, and young adults are particularly vulnerable to their use. Behavioral economic drug purchase tasks capture an individual's strength of desire and motivation for a particular drug. We examined young adult prescription drug purchase and...

journal_title：Experimental and clinical psychopharmacology

authors： Pickover AM,Messina BG,Correia CJ,Garza KB,Murphy JG

更新日期：2016-02-01 00:00:00

abstract：:Six features of the report are commented on. First, the Therapeutic Workplace intervention described in the report represents a creative and promising new approach to drug abuse treatment. Second, to the author's knowledge, it represents the first intervention that has been shown in a randomized clinical trial to sign...

journal_title：Experimental and clinical psychopharmacology

authors： Higgins ST

更新日期：2001-02-01 00:00:00

abstract：:This study examined the association between the heart rate (HR) response to alcohol intoxication, which is thought to reflect sensitivity to alcohol-induced reward and alcohol-induced behavioral disinhibition. High- and low-HR responders to alcohol participated in a go/no-go task, under sober and intoxicated condition...

journal_title：Experimental and clinical psychopharmacology

authors： Assaad JM,Pihl RO,Séguin JR,Nagin DS,Vitaro F,Tremblay RE

更新日期：2006-08-01 00:00:00

abstract：:This study shows that a moderate dose of alcohol (0.62 g/kg) can impair cognitive processes controlling behavioral inhibition and flexibility (i.e., inhibiting one response and making a different one). Two groups of male social drinkers (n = 8) received alcohol or a placebo and performed two change tasks that required...

journal_title：Experimental and clinical psychopharmacology

authors： Easdon CM,Vogel-Sprott M

更新日期：2000-08-01 00:00:00

abstract：:It is proposed that potential drug cues are evaluated preattentively, are prioritized, and subsequently trigger somatovisceral, behavioral, and cognitive responses. Throughout, this information processing is subjected to automatized attentional and interpretative biases. These processes can enhance subjective awarenes...

journal_title：Experimental and clinical psychopharmacology

authors： Ryan F

更新日期：2002-05-01 00:00:00

abstract：:Existing literature supports the five-factor model (FFM) of personality (i.e., Extraversion, Agreeableness, Conscientiousness, Emotional Stability, and Intellect or Openness) as a comprehensive representation of stable aspects of mood, affect, and behavior. This study evaluated the FFM as a framework for both self-per...

journal_title：Experimental and clinical psychopharmacology

authors： Winograd RP,Steinley DL,Sher KJ

更新日期：2014-06-01 00:00:00

abstract：:Delayed reward discounting (DRD) is a behavioral economic measure of impulsivity that has been consistently associated with addiction. It has also been identified as a promising addiction endophenotype, linking specific sources of genetic variation to individual risk. A challenge in the studies to date is that levels ...

journal_title：Experimental and clinical psychopharmacology

authors： MacKillop J,Gray JC,Weafer J,Sanchez-Roige S,Palmer AA,de Wit H

更新日期：2019-02-01 00:00:00

abstract：:Heavy drinking among college students is a public health concern in part due to the accessibility of alcohol and promotions such as "happy hours," which discount the price of alcohol. In addition, consuming alcohol at unregulated off-campus parties may result in greater alcohol consumption, higher blood alcohol concen...

journal_title：Experimental and clinical psychopharmacology

authors： Morrell MN,Reed DD,Martinetti MP

更新日期：2020-03-19 00:00:00

abstract：:Alcohol use and risky single occasion drinking are common among adolescents and are associated with a higher risk of various negative social, physical, academic, or sexual consequences. Studies have shown that among college students, willingness to experience negative consequences is associated with a higher likelihoo...

journal_title：Experimental and clinical psychopharmacology

authors： Wicki M,Mallett KA,Delgrande Jordan M,Reavy R,Turrisi R,Archimi A,Kuntsche E

更新日期：2018-04-01 00:00:00

abstract：:Nicotine addiction continues to be the main cause of preventable death in developed countries. Women and teen girls appear to be more vulnerable on certain aspects of nicotine addiction compared with men and boys. While the mechanism of gender differences in nicotine addiction is not yet clear, evidence suggests that ...

journal_title：Experimental and clinical psychopharmacology

authors： Lynch WJ,Sofuoglu M

更新日期：2010-12-01 00:00:00

abstract：:Oxytocin has been shown to decrease cocaine taking and seeking in male rats, suggesting potential treatment efficacy for drug addiction. In the present study, we extended these findings to the assessment of cocaine seeking and taking in female rats. Further, we made direct comparisons of oxytocin's impact on cocaine i...

journal_title：Experimental and clinical psychopharmacology

authors： Leong KC,Zhou L,Ghee SM,See RE,Reichel CM

更新日期：2016-02-01 00:00:00

abstract：:Smokers are highly reactive to smoking-related cues that are directly linked, or most proximal, to actual smoking behavior (e.g., lit cigarettes). However, over the course of smoking, proximal cues may not be the only stimuli to become strongly associated with smoking. Distal cues, such as the environments in which sm...

journal_title：Experimental and clinical psychopharmacology

authors： Conklin CA,Robin N,Perkins KA,Salkeld RP,McClernon FJ

更新日期：2008-06-01 00:00:00

abstract：:Increased discounting (devaluing) of delayed rewards is associated with nearly all types of substance use disorders (SUDs) and is also present in individuals with family histories of SUDs. Early life adversity (ELA) likely contributes to these findings as it is common in both individuals with SUDs and their children a...

journal_title：Experimental and clinical psychopharmacology

authors： Acheson A,Vincent AS,Cohoon A,Lovallo WR

更新日期：2019-04-01 00:00:00

abstract：:Despite considerable health risks due to lower levels of estrogen production and the compounding antiestrogenic effects of nicotine, postmenopausal females continue to smoke. These females face significant barriers to cessation, including negative affect, weight concerns, and menopausal symptom severity. The current p...

journal_title：Experimental and clinical psychopharmacology

authors： Peltier MR,Roys MR,Waters AF,Vinci C,Waldo KM,Stewart SA,Toups RC,Jones L,Copeland AL

更新日期：2018-04-01 00:00:00

abstract：:Habitual substance use is associated with attentional bias for stimuli related to the use. The current study tested whether individuals' substance use can be predicted from their attentional bias for concern-related and substance-related stimuli. Participants (N = 71; 54% male) were selected among university students ...

journal_title：Experimental and clinical psychopharmacology

authors： Fadardi JS,Ziaee S,Shamloo ZS

更新日期：2009-12-01 00:00:00

abstract：:The authors investigated several features of polydrug use in rats. Heroin and cocaine were self-administered following responses on different levers, with only 1 drug and 1 lever available on alternate days of training. Four doses of each drug (heroin: 25, 50, 100, and 200 microg/kg/infusion; cocaine: 0.25, 0.5, 1, an...

journal_title：Experimental and clinical psychopharmacology

authors： Leri F,Stewart J

更新日期：2001-08-01 00:00:00

abstract：:Two studies were conducted to determine the anger-attenuating effects of nicotine as a function of trait hostility. The 1st study examined the effects of nicotine on diary ratings of anger during a 24-hr period in a natural setting in 30 smokers and 30 nonsmokers. Participants took part in 2 monitoring sessions involv...

journal_title：Experimental and clinical psychopharmacology

authors： Jamner LD,Shapiro D,Jarvik ME

更新日期：1999-11-01 00:00:00

abstract：:Lapses within the first 2 weeks of a smoking cessation attempt are strongly associated with a return to regular smoking (S. L. Kenford et al., 1994). Unfortunately, little is known about how to prevent an initial lapse from progressing to a full relapse, and presently there are no validated lapse-responsive therapeuti...

journal_title：Experimental and clinical psychopharmacology

authors： Juliano LM,Houtsmuller EJ,Stitzer ML

更新日期：2006-11-01 00:00:00

abstract：:Some abused drugs have been reported to alter performance on naturalistic tasks such as driving and also on laboratory tasks. The performance effects of several drug classes were examined using a repeated measures design. Eight volunteers were administered 2 doses of ethanol, marijuana, amphetamine, hydromorphone, pen...

journal_title：Experimental and clinical psychopharmacology

authors： Pickworth WB,Rohrer MS,Fant RV

更新日期：1997-08-01 00:00:00

abstract：:Effects of different response requirements, response-independent cigarette puffs, and an alternative nondrug reinforcer on cigarette smoking were assessed in 2 experiments. The response requirement to obtain 2 puffs on a cigarette was manipulated while various numbers of response-independent puffs were provided (0, 6,...

journal_title：Experimental and clinical psychopharmacology

authors： Bickel WK,Madden GJ,DeGrandpre RJ

更新日期：1997-11-01 00:00:00

abstract：:Several studies examining both control and substance-dependent populations have found delay discounting to remain stable over time. In this report, we examine whether delay discounting changes in opioid-dependent individuals who complete a 12-week treatment. The 159 subjects who completed discounting assessments at ba...

journal_title：Experimental and clinical psychopharmacology

authors： Landes RD,Christensen DR,Bickel WK

更新日期：2012-08-01 00:00:00

abstract：:Cigarette smoking is highly prevalent among patients who are being treated for opioid-dependence, yet there have been limited scientific efforts to promote smoking cessation in this population. Contingency management (CM) is a behavioral treatment that provides monetary incentives contingent upon biochemical evidence ...

journal_title：Experimental and clinical psychopharmacology

authors： Dunn KE,Saulsgiver KA,Sigmon SC

更新日期：2011-02-01 00:00:00

abstract：:Drug abuse and obesity are serious public health problems. Dopamine plays a central role in mediating the reinforcing effects of drugs and food. Prolonged use of drugs is known to alter the function and/or sensitivity of many neurotransmitter systems, including dopamine; however, the impact of consuming foods high in ...

journal_title：Experimental and clinical psychopharmacology

authors： Collins GT,Chen Y,Tschumi C,Rush EL,Mensah A,Koek W,France CP

更新日期：2015-08-01 00:00:00

abstract：:In Experiment 1, the effect of repeated injections of 2.5, 5.0, or 10.0 mg/kg of chlordiazepoxide (CDP) on food intake and body weight was studied in rats on an activity anorexia (AA) regimen. For several days before CDP testing began, rats lived in activity wheels and had one 60-min meal per day. During CDP testing, ...

journal_title：Experimental and clinical psychopharmacology

authors： Lett BT,Grant VL,Koh MT,Parsons JF

更新日期：1998-11-01 00:00:00

abstract：:Female inner-city substance users evidence greater crack/cocaine use and are more likely to be dependent on this drug than on any other drug. Additionally, female inner-city substance users evidence greater crack/cocaine use and are more likely to be dependent on this drug than their male counterparts, despite no cons...

journal_title：Experimental and clinical psychopharmacology

authors： Lejuez CW,Bornovalova MA,Reynolds EK,Daughters SB,Curtin JJ

更新日期：2007-04-01 00:00:00