Abstract:
:A novel and highly efficient three-component reaction of 2-alkynylbenzaldoxime, carbodiimide, with electrophile (bromine or iodine monochloride) is disclosed, which generates 1-(4-haloisoquinolin-1-yl)ureas in good yields under mild conditions. Subsequent palladium-catalyzed Suzuki-Miyaura coupling reaction is introduced, leading to the diverse 1-(isoquinolin-1-yl)ureas.
journal_name
ACS Comb Scijournal_title
ACS combinatorial scienceauthors
Ye S,Wang H,Wu Jdoi
10.1021/co100026ysubject
Has Abstractpub_date
2011-03-14 00:00:00pages
120-5issue
2eissn
2156-8952issn
2156-8944journal_volume
13pub_type
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