Global daily dynamics of the pineal transcriptome.

Abstract:

:Transcriptome profiling of the pineal gland has revealed night/day differences in the expression of a major fraction of the genes active in this tissue, with two-thirds of these being nocturnal increases. A set of over 600 transcripts exhibit two-fold to >100-fold daily differences in abundance. These changes appear to be primarily attributable to adrenergic-cyclic-AMP-dependent mechanisms, which are controlled via a neural pathway that includes the suprachiasmatic nucleus, the master circadian oscillator. In addition to melatonin synthesis, night/day differences in gene expression impact genes associated with several specialized functions, including the immune/inflammation response, photo-transduction, and thyroid hormone/retinoic acid biology. The following nonspecialized cellular features are also affected: adhesion, cell cycle/cell death, cytoskeleton, DNA modification, endothelium, growth, RNA modification, small molecule biology, transcription factors, vesicle biology, signaling involving Ca(2+), cyclic nucleotides, phospholipids, mitogen-activated protein kinases, the Wnt signaling pathway, and protein phosphorylation.

journal_name

Cell Tissue Res

journal_title

Cell and tissue research

authors

Bustos DM,Bailey MJ,Sugden D,Carter DA,Rath MF,Møller M,Coon SL,Weller JL,Klein DC

doi

10.1007/s00441-010-1094-1

subject

Has Abstract

pub_date

2011-04-01 00:00:00

pages

1-11

issue

1

eissn

0302-766X

issn

1432-0878

journal_volume

344

pub_type

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