Abstract:
CONTEXT & OBJECTIVE:A recent paper by our group reported that regular aerobic exercise during pregnancy led to lower foetal IGF-I and IGF-II concentrations and a modest reduction in offspring birth weight when compared with the offspring of nontraining control participants. Maternal hormonal alterations in response to exercise training may be associated with the regulation of nutrient availability for foetal growth through placental regulation of maternal metabolism. OBJECTIVE:To determine whether the reduction in offspring size was associated with changes in the maternal IGF axis [including placental growth hormone (PGH)], leptin and/or free fatty acids (FFA) in response to aerobic exercise training in the second half of pregnancy. DESIGN AND SETTING:A randomized, controlled trial of exercise in pregnancy. PATIENTS:Eighty-four healthy nulliparous women (mean±SD age 30±4 year, BMI 25·5±4 kg/m(2) ). MEASUREMENTS:Serum samples were drawn at 19 and 35 weeks gestation to determine serum IGF-I, IGF-II, IGF-binding protein-1, IGF-binding protein-3, PGH, leptin and FFA. RESULTS:Exercise training in pregnancy had no impact on the pregnancy-related changes in the maternal IGF axis. Women in the exercise group experienced a 29% increase in leptin in late gestation (P=0·026 vs control) and a trend towards lower FFA (P=0·07 vs control). Late pregnancy changes in maternal leptin were inversely related to offspring birth weight (r= -0·24, P<0·05) and BMI (r= -0·25, P<0·05). CONCLUSIONS:An increase in leptin in exercising pregnant women may reflect subtle changes within the placenta in response to regular exercise and may contribute to the reduction in offspring size previously reported in this cohort.
journal_name
Clin Endocrinol (Oxf)journal_title
Clinical endocrinologyauthors
Hopkins SA,Baldi JC,Cutfield WS,McCowan L,Hofman PLdoi
10.1111/j.1365-2265.2010.03964.xsubject
Has Abstractpub_date
2011-04-01 00:00:00pages
495-500issue
4eissn
0300-0664issn
1365-2265journal_volume
74pub_type
杂志文章,随机对照试验abstract::We studied the acute effect of standard therapeutic doses of oral frusemide on indices of thyroid function in 34 hospital in-patients with congestive cardiac failure. A transient decrease in total T4, elevation in the T3 resin uptake and consequent increase in the free T4 index (FT4I) were seen 2-5 h after ingestion o...
journal_title:Clinical endocrinology
pub_type: 杂志文章
doi:10.1111/j.1365-2265.1987.tb00799.x
更新日期:1987-04-01 00:00:00
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pub_type: 杂志文章
doi:10.1111/j.1365-2265.2004.01985.x
更新日期:2004-03-01 00:00:00
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journal_title:Clinical endocrinology
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journal_title:Clinical endocrinology
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doi:10.1111/j.1365-2265.1992.tb02902.x
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journal_title:Clinical endocrinology
pub_type: 杂志文章
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journal_title:Clinical endocrinology
pub_type: 杂志文章
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journal_title:Clinical endocrinology
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更新日期:1988-01-01 00:00:00
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pub_type: 杂志文章
doi:10.1111/j.1365-2265.2011.03988.x
更新日期:2011-06-01 00:00:00
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doi:10.1046/j.1365-2265.2000.00934.x
更新日期:2000-02-01 00:00:00
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更新日期:1991-07-01 00:00:00
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doi:10.1111/cen.12265
更新日期:2014-04-01 00:00:00
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journal_title:Clinical endocrinology
pub_type: 杂志文章
doi:10.1111/j.1365-2265.2007.02816.x
更新日期:2007-06-01 00:00:00
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journal_title:Clinical endocrinology
pub_type: 杂志文章
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更新日期:1981-02-01 00:00:00
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pub_type: 杂志文章
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更新日期:2004-07-01 00:00:00
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journal_title:Clinical endocrinology
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pub_type: 杂志文章
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更新日期:1981-04-01 00:00:00
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journal_title:Clinical endocrinology
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pub_type: 杂志文章
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更新日期:2008-11-01 00:00:00
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journal_title:Clinical endocrinology
pub_type: 杂志文章,多中心研究
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更新日期:2019-08-01 00:00:00
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pub_type: 杂志文章
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更新日期:2012-09-01 00:00:00
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journal_title:Clinical endocrinology
pub_type: 临床试验,杂志文章,随机对照试验
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更新日期:1992-04-01 00:00:00
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更新日期:2008-04-01 00:00:00
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pub_type: 杂志文章
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更新日期:2006-10-01 00:00:00