当前位置： SCI文献检索 > CLINICAL AND EXPERIMENTAL RHEUMATOLOGY期刊下所有文献 > Pharmacological treatment of fibromyalgia.

Pharmacological treatment of fibromyalgia.

Abstract：

:Fibromyalgia (FM) is a common syndrome characterised by widespread pain and at least 11/18 painful tender points that requires multimodal pharmacological treatment also combined with non-pharmacological therapy. Various drugs currently are available to control the complex and different symptoms reported by patients. Only three drugs (duloxetine, milnacipram, pregabalin) are approved by the American Food and Drug Administration (FDA) and none by the European Medicines Agency (EMEA), consequently, off-label use is habitual in Europe. Most of the drugs improve only one or two symptoms; no drug capable of overall symptom control is yet available. Furthermore, different classes of drugs with different mechanisms of action are used off-label, including tricyclic antidepressants (TCAs), selective serotonin reuptake inhibitors (SSRIs), serotonin norepinephrine reuptake inhibitors (SNRIs), opioids, non-steroidal anti-inflammatory drugs (NSAIDs), growth hormone, corticosteroids and sedative hypnotics. As no single drug fully manages FM symptoms, multicomponent therapy should be used from the beginning. Various pharmacological treatments have been used to treat FM with inconclusive results, and gradually increasing low doses is suggested in order to maximise efficacy. The best treatment should be individualised and combined with patient education and non-pharmacological therapy.

journal_name

Clin Exp Rheumatol

journal_title

Clinical and experimental rheumatology

authors

Di Franco M,Iannuccelli C,Atzeni F,Cazzola M,Salaffi F,Valesini G,Sarzi-Puttini P

subject

Has Abstract

pub_date

2010-11-01 00:00:00

pages

S110-6

issue

6 Suppl 63

eissn

0392-856X

issn

1593-098X

pii

4528

journal_volume

28

pub_type

杂志文章,评审

相关文献

CLINICAL AND EXPERIMENTAL RHEUMATOLOGY文献大全
  • Coexistence of Behcet's disease and chronic myelomonocyte leukemia with trisomy 8: a case report and review of the literature.

    abstract：:Behçet's disease (BD) is a multisystem inflammatory vasculitis of unknown etiology and pathogenesis. Coexistence of BD along with hematological malignancies is extremely rare. We describe a patient diagnosed with BD and chronic myelomonocytic leukaemia (CMML) with trisomy 8. This case suggests that trisomy 8 may be in...

    journal_title：Clinical and experimental rheumatology

    pub_type： 杂志文章

    doi：

    authors： Mantzourani MG,Chantziara K,Thanopoulou I,Variami H,Vaiopoulos G,Pangalis GA

    更新日期：2009-03-01 00:00:00

  • Increased frequency of familial Mediterranean fever in Central Anatolia, Turkey.

    abstract：OBJECTIVE:It has been observed that familial Mediterranean fever is more prevalent among people coming from central Anatolia in Turkey. To test this observation the frequency of FMF was investigated by afield survey in Sivas, a city located in central of Turkey. METHODS:The survey was conducted in a cohort of 4809 per...

    journal_title：Clinical and experimental rheumatology

    pub_type： 杂志文章

    doi：

    authors： Onen F,Sumer H,Turkay S,Akyurek O,Tunca M,Ozdogan H

    更新日期：2004-07-01 00:00:00

  • One year in review 2017: systemic vasculitis.

    abstract：:Systemic vasculitis is a group of heterogeneous, disabling disorders. Great interest has recently arisen in pathophysiology, clinical phenotypes and therapy of large- and small-vessel vasculitis. The general work hypothesis has been to promote research focused on disease-related pathogenetic pathways, with the ultimat...

    journal_title：Clinical and experimental rheumatology

    pub_type： 杂志文章,评审

    doi：

    authors： Elefante E,Monti S,Bond M,Lepri G,Quartuccio L,Talarico R,Baldini C

    更新日期：2017-03-01 00:00:00

  • Tryptase enhances release of vascular endothelial growth factor from human osteoarthritic chondrocytes.

    abstract：OBJECTIVE:A contribution of mast cells and its mediators in the pathogenesis of arthritis has been postulated. We aimed to clarify the role of mast cell-derived serine protease tryptase and proteinase activated receptor (PAR)-2-mediated signaling in chondrocytes. METHODS:Human articular cartilage specimens were obtain...

    journal_title：Clinical and experimental rheumatology

    pub_type： 杂志文章

    doi：

    authors： Masuko K,Murata M,Xiang Y,Nakamura H,Yudoh K,Nishioka K,Beppu M,Kato T

    更新日期：2007-11-01 00:00:00

  • Inhibitory effects of leflunomide therapy on the activity of matrixmetalloproteinase-9 and the release of cartilage oligomeric matrix protein in patients with rheumatoid arthritis.

    abstract：OBJECTIVE:To determine the effects of the disease modifying antirheumatic drug (DMARD) leflunomide on the expression of the matrix metalloproteinase MMP-1 (collagenase) and the activity of MMP-9 that are believed to play a major role in cartilage destruction associated with inflammation in patients with rheumatoid arth...

    journal_title：Clinical and experimental rheumatology

    pub_type： 临床试验,杂志文章,多中心研究

    doi：

    authors： Kullich WC,Mur E,Aglas F,Niksic F,Czerwenka C

    更新日期：2006-03-01 00:00:00

  • Clinical inconsistency, benign course and normal employment rates in unselected systemic lupus erythematosus.

    abstract：:Of 65 unselected SLE patients from a defined population, 61 were sequentially followed for two years with an SLE supervision programme. The cumulative clinical manifestations included a relatively high frequency of pulmonary vascular disease and gastrointestinal involvement. Flares were more common during the summer s...

    journal_title：Clinical and experimental rheumatology

    pub_type： 杂志文章

    doi：

    authors： Sturfelt G,Nived O

    更新日期：1985-10-01 00:00:00

  • Factors associated with damage in patients with familial Mediterranean fever.

    abstract：OBJECTIVES:Defining predictors of damage would improve patient care. We applied damage indexes to patients with familial Mediterranean fever (FMF) and identified the predictors of damage. METHODS:This is a cross-sectional analysis of 926 FMF patients, who fulfilled the Tel-Hashomer criteria and had at least six months...

    journal_title：Clinical and experimental rheumatology

    pub_type： 杂志文章

    doi：

    authors： Babaoglu H,Armagan B,Bodakci E,Satis H,Atas N,Sari A,Yasar Bilge NS,Bilici Salman R,Yardimci GK,Avanoglu Guler A,Karadeniz H,Kilic L,Ozturk MA,Goker B,Haznedaroglu S,Kalyoncu U,Kasifoglu T,Tufan A

    更新日期：2020-09-01 00:00:00

  • Clinical features, scintiscan characteristics and X-ray progression of late onset rheumatoid arthritis.

    abstract：:The clinical features, serology behaviour, scintiscan characteristics and the degree of X-ray progression according to the disease duration were compared in two RA groups with a disease onset after 65 years of age (LORA) and before 65 (EORA) respectively. No differences emerged in either the clinical findings or in th...

    journal_title：Clinical and experimental rheumatology

    pub_type： 杂志文章

    doi：

    authors： Ferraccioli GF,Cavalieri F,Mercadanti M,Conti G,Viviano P,Ambanelli U

    更新日期：1984-04-01 00:00:00

  • Serum levels of tissue inhibitor of metalloproteinases in patients with mixed connective tissue disease.

    abstract：OBJECTIVE:To determine serum tissue inhibitor of metalloproteinase (TIMP)-1 and TIMP-2 levels in patients with mixed connective tissue disease (MCTD) and investigate whether these levels were correlated with the clinical or serological features of this disease. METHODS:Serum TIMP-1 and TIMP-2 levels were measured with...

    journal_title：Clinical and experimental rheumatology

    pub_type： 杂志文章

    doi：

    authors： Jinnin M,Ihn H,Yamane K,Asano Y,Yazawa N,Tamaki K

    更新日期：2002-07-01 00:00:00

  • Current management strategies for systemic sclerosis.

    abstract：:Systemic sclerosis remains a challenging disease despite progress that has taken place in the management of organ-based complications. Overall management strategies need to take into account the features of the disease that are common to almost all patients such as skin involvement, gastro-oesophageal manifestations a...

    journal_title：Clinical and experimental rheumatology

    pub_type： 杂志文章,评审

    doi：

    authors： Nihtyanova SI,Ong VH,Denton CP

    更新日期：2014-03-01 00:00:00

  • The most recent advances in pathophysiology and management of tumour necrosis factor receptor-associated periodic syndrome (TRAPS): personal experience and literature review.

    abstract：:Tumour necrosis factor-receptor associated periodic syndrome (TRAPS) is a rare autosomal dominant autoinflammatory disorder characterised by recurrent episodes of long-lasting fever and inflammation in different regions of the body, as musculo-skeletal system, skin, gastrointestinal tube, serosal membranes and eye. In...

    journal_title：Clinical and experimental rheumatology

    pub_type： 杂志文章,评审

    doi：

    authors： Magnotti F,Vitale A,Rigante D,Lucherini OM,Cimaz R,Muscari I,Granados Afonso de Faria A,Frediani B,Galeazzi M,Cantarini L

    更新日期：2013-05-01 00:00:00

  • Disability measured by the modified health assessment questionnaire in early rheumatoid arthritis: prognostic factors after two years of follow-up.

    abstract：OBJECTIVE:To analyze the rate and baseline prognostic factors of disability measured by the modified HAQ (MHAQ), in a series of patients with early rheumatoid arthritis (RA) after two years of therapy with a structured algorithm using disease-modifying anti-rheumatic drugs (DMARDs). METHODS:One hundred and five patien...

    journal_title：Clinical and experimental rheumatology

    pub_type： 杂志文章

    doi：

    authors： Graell E,Vazquez I,Larrosa M,Rodríguez-Cros JR,Hernández MV,Gratacós J,Gómez A,Cañete JD,Gómez-Puerta JA,Sanmartí R

    更新日期：2009-03-01 00:00:00

  • Growth reconstitution in juvenile idiopathic arthritis treated with etanercept.

    abstract：OBJECTIVE:Growth failure is a leading problem in uncontrolled juvenile idiopathic arthritis. It also affects 10% of patients who are not treated with corticosteroids. The influence of proinflammatory cytokines like interleukin-1 beta, interleukin-6 and tumour necrosis factor on the neuroendocrine axis as well as on the...

    journal_title：Clinical and experimental rheumatology

    pub_type： 杂志文章

    doi：

    authors： Schmeling H,Seliger E,Horneff G

    更新日期：2003-11-01 00:00:00

  • Economic burden of osteoporosis in women: data from the 2008 French hospital database (PMSI).

    abstract：OBJECTIVES:To estimate the number and costs of hospitalisations associated with osteoporosis in France. METHODS:Data for women aged 50 years and over were extracted from the 2008 French Hospital National Database. Criteria for acute care were established according to ICD-10 codes related to osteoporosis. As coding rul...

    journal_title：Clinical and experimental rheumatology

    pub_type： 杂志文章

    doi：

    authors： Maravic M,Jouaneton B,Vainchtock A,Tochon V

    更新日期：2012-03-01 00:00:00

  • Intravenous immunoglobulins in polyarteritis nodosa restricted to the limbs: case reports and review of the literature.

    abstract：:Polyarteritis nodosa (PAN) of the calf muscles is a rare form of vasculitis. We present two cases of PAN limited to the calf and a review of the literature, based on a MEDLINE (PubMed) search of the English literature from 1980 to 2005, using the key words "vasculitis restricted to limbs", "polyarteritis nodosa", and ...

    journal_title：Clinical and experimental rheumatology

    pub_type： 杂志文章

    doi：

    authors： Balbir-Gurman A,Nahir AM,Braun-Moscovici Y

    更新日期：2007-01-01 00:00:00

  • Measurement of interatrial dyssynchrony using tissue Doppler imaging predicts functional capacity and cardiac involvement in systemic sclerosis.

    abstract：OBJECTIVES:We aimed to assess the prevalence of interatrial electromechanical dyssynchrony in systemic sclerosis (SSc) patients, and to study the correlation between interatrial delay and standard follow-up parameters. METHODS:Forty consecutive patients with SSc were studied. Classical echocardiographic measurements w...

    journal_title：Clinical and experimental rheumatology

    pub_type： 杂志文章

    doi：

    authors： Eicher JC,Berthier S,Aho LS,Lorcerie B,Bonnotte B,Laurent G

    更新日期：2014-11-01 00:00:00

  • Interleukin-12 gene polymorphisim in patients with giant cell arteritis, polymyalgia rheumatica and elderly-onset rheumatoid arthritis.

    abstract：OBJECTIVE:The cytokine profile suggests that giant cell arteritis (GCA) is a Th1-driven disease, in which local IFN-gamma plays a critical role in the development of a systemic arteritis. IL-12 is a potent inducer of IFN-gamma and is critically involved in biasing an immune response towards a Th1 pathway. The purpose o...

    journal_title：Clinical and experimental rheumatology

    pub_type： 杂志文章

    doi：

    authors： Alvarez-Rodriguez L,Martínez-Taboada VM,López-Hoyos M,Mata C,Fernandez Prieto L,Agudo-Bilbao M,Calvo J,Ruiz Soto M,Rodriguez-Valverde V,Ruiz T,Blanco R,Corrales A,Carrasco-Marín E

    更新日期：2009-01-01 00:00:00

  • Hypergastrinemia in rheumatoid arthritis.

    abstract：:Fasting hypergastrinemia was noted in 13-41% of 82 of outpatients with definite or classical rheumatoid arthritis. No differences were noted between the normogastrinemic and the hypergastrinemic subjects in their age, sex, duration of rheumatoid disease, serological status, or medications. The food-stimulated gastrin ...

    journal_title：Clinical and experimental rheumatology

    pub_type： 杂志文章

    doi：

    authors： Yorke AJ,Davis P,Salkie M,Weinstein W,Thomson AB

    更新日期：1986-01-01 00:00:00

  • Short-term effect of cold provocation on single-breath carbon monoxide diffusing capacity in subjects with and without Raynaud's phenomenon.

    abstract：:The lung diffusing capacity for carbon monoxide was determined by the single breath method (DLCOsb) before, during, and after immersion of the left hand in cold water in four groups of subjects: (i) normal individuals; (ii) subjects with idiopathic Raynaud's disease; (iii) patients with progressive systemic sclerosis ...

    journal_title：Clinical and experimental rheumatology

    pub_type： 杂志文章

    doi：

    authors： Gastaud M,Dolisi C,Bermon S,Gaudin P,Defauw G,Ardisson JL

    更新日期：1995-09-01 00:00:00

  • Juvenile idiopathic arthritis. Subgroup characteristics and comparisons between rheumatoid arthritis-like subgroups and ankylosing spondylitis-like subgroups.

    abstract：:In terms of adult-onset definitions, rheumatoid arthritis (RA) and ankylosing spondylitis (AS) are rarely diagnosed in children. Adult RA is in most aspects similar to seropositive polyarticular arthritis in children, but AS differs in its clinical presentation according to age at onset. In general, the nomenclature a...

    journal_title：Clinical and experimental rheumatology

    pub_type： 杂志文章,评审

    doi：

    authors： Horneff G,Burgos-Vargas R

    更新日期：2009-07-01 00:00:00

  • Ultrasonographic measures of synovitis in an early phase clinical trial: a double-blind, randomised, placebo and comparator controlled phase IIa trial of GW274150 (a selective inducible nitric oxide synthase inhibitor) in rheumatoid arthritis.

    abstract：OBJECTIVES:To test the sensitivity to change of ultrasonographic endpoints in early phase clinical trials in subjects with active rheumatoid arthritis (RA). METHODS:A double-blind, placebo and comparator controlled, randomised, two-centre study investigated the effect on synovial thickness and vascularity of 28 days r...

    journal_title：Clinical and experimental rheumatology

    pub_type： 杂志文章,多中心研究,随机对照试验

    doi：

    authors： Seymour M,Pétavy F,Chiesa F,Perry H,Lukey PT,Binks M,Donatien PD,Freidin AJ,Eckersley RJ,McClinton C,Heath K,Prodanovic S,Radunovic G,Pilipovic N,Damjanov N,Taylor PC

    更新日期：2012-03-01 00:00:00

  • Ankylosing spondylitis--cardiac manifestations.

    abstract：:There is a definite association of heart disease with ankylosing spondylitis (AS). The magnitude of this relationship is less clear. Three types of inflammatory affections can be differentiated: 1. aortitis and aortic insufficiency with the possible necessity of cardiac surgery, 2. conduction disturbances of the atrio...

    journal_title：Clinical and experimental rheumatology

    pub_type： 杂志文章,评审

    doi：

    authors： Lautermann D,Braun J

    更新日期：2002-11-01 00:00:00

  • Patient-driven assessment of disease activity in Behçet's syndrome: cross-cultural adaptation, reliability and validity of the Turkish version of the Behçet's Syndrome Activity Score.

    abstract：OBJECTIVES:The Behçet's Syndrome Activity Score (BSAS) is the first patient reported outcome measure developed to assess the global disease activity in patients with Behçet's syndrome (BS). We aimed to evaluate the reliability and validity of the Turkish version of BSAS for measuring disease activity in BS. We further ...

    journal_title：Clinical and experimental rheumatology

    pub_type： 杂志文章

    doi：

    authors： Yilmaz S,Simsek I,Cinar M,Erdem H,Kose O,Yazici Y,Pay S

    更新日期：2013-05-01 00:00:00

  • Behçet's syndrome: a critical digest of the recent literature.

    abstract：:A similar disease severity among men and women in Brasil, a high frequency of gastrointestinal involvement in China, Japan and USA, a low frequency of pathergy positivity in Japan and USA underline the ethnic variations reported in recent studies. Polymorphisms pertaining both to innate and adaptive immunity in genome...

    journal_title：Clinical and experimental rheumatology

    pub_type： 杂志文章,评审

    doi：

    authors： Hatemi G,Seyahi E,Fresko I,Hamuryudan V

    更新日期：2012-05-01 00:00:00

  • Immune-mediated pathology following hepatitis B vaccination. Two cases of polyarteritis nodosa and one case of pityriasis rosea-like drug eruption.

    abstract：:The association of hepatitis B virus infection and vasculitis or other immune-mediated manifestations is well documented. Reports on such manifestations in relation to hepatitis B vaccination are scarce, however. We report 2 patients who developed polyarteritis nodosa following vaccination against hepatitis B. In one ...

    journal_title：Clinical and experimental rheumatology

    pub_type： 杂志文章

    doi：

    authors： De Keyser F,Naeyaert JM,Hindryckx P,Elewaut D,Verplancke P,Peene I,Praet M,Veys E

    更新日期：2000-01-01 00:00:00

  • Helicobacter pylori, gastric MALT and B-cell clonality.

    abstract：:MALT, or mucosa associated lymphoid tissue, is normally not present in gastric tissue. Its presence is often associated with persistent antigenic stimulation. MALT is a precursor of gastric MALT lymphoma, a low-grade lymphoma whose incidence recently appears to have increased. Although much epidemiologic and clinical ...

    journal_title：Clinical and experimental rheumatology

    pub_type： 杂志文章,评审

    doi：

    authors： Sorrentino D,Ferraccioli GF,Labombarda A,De Vita S,Avellini C,Beltrami CA,Bartoli E

    更新日期：1996-01-01 00:00:00

  • Expression of inflammasomes NLRP1, NLRP3 and AIM2 in different pathologic classification of lupus nephritis.

    abstract：OBJECTIVES:Lupus nephritis (LN) is an immune-complex mediated nephritis with complicated pathogenesis. The aims of the present study were to investigate whether inflammasomes are activated in the renal pathology of LN patients and analyse the association of inflammasome activation in different classes of LN renal tissu...

    journal_title：Clinical and experimental rheumatology

    pub_type： 杂志文章

    doi：

    authors： Huang T,Yin H,Ning W,Wang X,Chen C,Lin W,Li J,Zhou Y,Peng Y,Wang M,Ni X,Zhang W

    更新日期：2020-07-01 00:00:00

  • Gut mucosal T cell lines from ankylosing spondylitis patients are enriched with alphaEbeta7 integrin.

    abstract：OBJECTIVE:An intriguing link between gut and synovial inflammation exists in patients with spondyloarthropathy (SpA), illustrated by the high frequency of microscopically inflammatory gut lesions observed in these patients. We hypothesise that aberrant homing of mucosal T cells might play a role in the induction/perpet...

    journal_title：Clinical and experimental rheumatology

    pub_type： 杂志文章

    doi：

    authors： Van Damme N,Elewaut D,Baeten D,Demetter P,Cuvelier C,Verbruggen G,Mielants H,Veys EM,De Vos M,De Keyser F

    更新日期：2001-11-01 00:00:00

  • Autoimmune thyroiditis and primary Sjögren's syndrome: clinical and laboratory evidence of the coexistence of the two diseases.

    abstract：:The prevalence of primary Sjögren's syndrome (primary SS) among patients with autoimmune thyroiditis (AT), and that of AT among patients with primary SS were studied prospectively. Of 63 patients with AT, one had precipitating antibodies against SS-A/Ro antigen together with objectively verified primary SS, and none h...

    journal_title：Clinical and experimental rheumatology

    pub_type： 杂志文章

    doi：

    authors： Hansen BU,Ericsson UB,Henricsson V,Larsson A,Manthorpe R,Warfvinge G

    更新日期：1991-03-01 00:00:00

  • The initial predictors of death in 153 patients with ANCA-associated vasculitis in a single Korean centre.

    abstract：OBJECTIVES:We estimated the cumulative patient survival rates, the causes of death and the initial predictors of death in Korean patients with microscopic polyangiitis (MPA), granulomatosis with polyangiitis (GPA) and eosinophilic GPA (EGPA). METHODS:We reviewed the medical records of 153 patients with antineutrophil ...

    journal_title：Clinical and experimental rheumatology

    pub_type： 杂志文章

    doi：

    authors： Mun CH,Yoo J,Jung SM,Song JJ,Park YB,Lee SW

    更新日期：2018-03-01 00:00:00