Abstract：
:The lung diffusing capacity for carbon monoxide was determined by the single breath method (DLCOsb) before, during, and after immersion of the left hand in cold water in four groups of subjects: (i) normal individuals; (ii) subjects with idiopathic Raynaud's disease; (iii) patients with progressive systemic sclerosis without associated Raynaud's phenomenon; and (iv) patients with connective tissue disease associated with Raynaud's phenomenon. Our results showed significant differences in the evolution of DLCOsb after cold stimulation between the groups. Control subjects (group one) showed a transient but significant reduction in DLCOsb at the end of two minutes of cold stimulation, normalizing ten minutes later. Subjects with primary Raynaud's phenomenon (group two) showed on the contrary a transient but significant rise in DLCOsb after 2 minutes, while subjects with an isolated connective tissue disease without Raynaud's phenomenon (group three) showed a significant decrease in DLCOsb at both observation times. Patients with Raynaud's phenomenon associated with a connective tissue disease (group four) showed a delayed decrease in DLCOsb ten minutes after cold stimulation. This latter result appeared as an addition to the effects of cold stimulation observed in groups two and three.
journal_name
Clin Exp Rheumatoljournal_title
Clinical and experimental rheumatologyauthors
Gastaud M,Dolisi C,Bermon S,Gaudin P,Defauw G,Ardisson JLsubject
Has Abstractpub_date
1995-09-01 00:00:00pages
617-21issue
5eissn
0392-856Xissn
1593-098Xjournal_volume
13pub_type
杂志文章abstract：OBJECTIVES:The aim of the present study was to compare the clinical results and the quality of life in patients with symptomatic knee osteoarthritis randomised to either a new HA (HYADD 4) or corticosteroid (CS). A separate rationale was to evaluate the safety profile of HYADD 4. METHODS:All the patients presenting fo...
journal_title：Clinical and experimental rheumatology
pub_type： 杂志文章,随机对照试验
doi：
更新日期：2016-09-01 00:00:00
abstract：:It is recognised that the genetic profiles that give rise to chronic inflammatory diseases, under the influence of environmental agents, might have been implicated in the host defence mechanism against lethal infections in the past. Behçet's disease (BD) is an immune-mediated inflammatory disease, expressed as vasculi...
journal_title：Clinical and experimental rheumatology
pub_type： 杂志文章,评审
doi：
更新日期：2014-07-01 00:00:00
abstract：PURPOSE AND METHODS:In order to evaluate the prevalence of positive hepatitis C virus (HCV) serology and cryoglobulinemia in human immunodeficiency virus (HIV)-infected patients, the prevalence and the clinical significance of cryoglobulinemia were prospectively studied in a cohort of 86 HIV-infected subjects seen as o...
journal_title：Clinical and experimental rheumatology
pub_type： 杂志文章
doi：
更新日期：1997-09-01 00:00:00
abstract：OBJECTIVE:To investigate autoantibody induction in rheumatoid arthritis (RA) and ankylosing spondylitis (AS) in a cohort of French patients treated with TNF-alpha blockers. METHODS:We tested the serum of patients for antinuclear antibodies (ANA), anti-DNA antibodies and C4 complement at baseline, and for each infusion...
journal_title：Clinical and experimental rheumatology
pub_type： 临床试验,杂志文章
doi：
更新日期：2008-05-01 00:00:00
abstract：OBJECTIVES:Tocilizumab (TCZ) is an effective treatment in patients with rheumatoid arthritis (RA) refractory to anti-tumour necrosis factor-α. However, only few studies in real life have evaluated the efficacy of TCZ in long-standing rheumatoid arthritis (LSRA). Our aim was to evaluate the efficacy and safety of tocili...
journal_title：Clinical and experimental rheumatology
pub_type： 杂志文章
doi：
更新日期：2014-07-01 00:00:00
abstract：OBJECTIVE:Osteoporosis is infrequent in young premenopausal women and is often associated with secondary disorders. However, idiopathic osteoporosis may be found in this setting and few data are known on this condition. Therefore, the aim of this study was to analyse the clinical characteristics and bone remodelling ab...
journal_title：Clinical and experimental rheumatology
pub_type： 杂志文章
doi：
更新日期：2008-11-01 00:00:00
abstract：OBJECTIVES:To investigate the in-situ expression of acetylcholinesterase (AChE) in the inflamed vessel wall of patients with biopsy-positive giant cell arteritis (GCA) as compared to biopsy-negative non-GCA patients, and to evaluate the in-vivo expression of AChE in patients with large-vessel GCA (LVGCA) by 11C-donepez...
journal_title：Clinical and experimental rheumatology
pub_type： 杂志文章
doi：
更新日期：2019-03-01 00:00:00
abstract：:Musculoskeletal ultrasound is an evolving technique widely used in rheumatology thanks to the numerous advances and the improved work on standardisation. This article deals with the new developments in terms of technology and validation. ...
journal_title：Clinical and experimental rheumatology
pub_type： 历史文章,杂志文章,评审
doi：
更新日期：2014-01-01 00:00:00
abstract：:We report a patient with Behçet's syndrome who presented with upper gastrointestinal haemorrhage. Gastroduodenoscopy showed a gastroduodenal fistula which caused the appearance of double pylorus in the antrum. The possibility of peptic ulcer disease related to non-steroidal anti-inflammatory drug use or Behçet's syndr...
journal_title：Clinical and experimental rheumatology
pub_type： 杂志文章
doi：
更新日期：2015-11-01 00:00:00
abstract：OBJECTIVE:Crude preparations of Fun-boi (Stephania tetrandra), a traditional antirheumatic herb, have been reported to have immunomodulatory effects on both cell-mediated and humoral immunity in vitro, but little is known about the mode of action in vivo. The objective of this study was therefore to evaluate the effica...
journal_title：Clinical and experimental rheumatology
pub_type： 杂志文章
doi：
更新日期：2003-01-01 00:00:00
abstract：:****************************************************************************. ...
journal_title：Clinical and experimental rheumatology
pub_type： 信件
doi：
更新日期：2017-03-01 00:00:00
abstract：OBJECTIVE:To determine the effects of a glycinamide ribonucleotide formyltransferase (GARFT) inhibitor on macrophage inflammatory processes and in vivo in rat adjuvant arthritis. METHODS:GARFT inhibitors, LY309886 (6S-2',5'-thienyl-5, 10-dideazatetrahydrofolic acid) and LY329201 (R)-N-[[5-[2-(2-amino-1,4,5,6,7,8-hexah...
journal_title：Clinical and experimental rheumatology
pub_type： 杂志文章
doi：
更新日期：2005-07-01 00:00:00
abstract：OBJECTIVES:The effectiveness of anakinra (interleukin-1 receptor antagonist) in early rheumatoid arthritis (RA) is unknown. We evaluated the efficacy of anakinra (combined with methotrexate) in a randomised clinical trial of early active RA patients. METHODS:The Combination Anti-Rheumatic Drugs in Early RA-2 (CARDERA-...
journal_title：Clinical and experimental rheumatology
pub_type： 杂志文章,多中心研究,随机对照试验
doi：
更新日期：2016-01-01 00:00:00
abstract：OBJECTIVE:Gold sodium thiomalate (GST) is a drug commonly used for the treatment of rheumatoid arthritis (RA). To clarify the mechanism of therapeutic effects of GST on RA, we investigated if GST affects the differentiation of dendritic cells (DC), which are thought to play a pivotal role in RA pathogenesis. METHODS:W...
journal_title：Clinical and experimental rheumatology
pub_type： 杂志文章
doi：
更新日期：2002-09-01 00:00:00
abstract：OBJECTIVES:To analyse the correlation between the number of joint-contractures and other major clinical findings in a follow-up study of 131 patients with systemic sclerosis (SSc). METHODS:The range of motion of joints (ROM), HAQ-DI, and the major clinical characteristics were assessed. RESULTS:A high frequency of co...
journal_title：Clinical and experimental rheumatology
pub_type： 杂志文章
doi：
更新日期：2014-11-01 00:00:00
abstract：OBJECTIVES:Autoimmune thyroiditis (ATD) has been linked to various forms of arthritis. The relationship with spinal degenerative disc disease (DDD) is not known. We studied the association between ATD and spinal DDD. METHODS:We performed a cross-sectional analysis of patients who had data on both anti-thyroid peroxida...
journal_title：Clinical and experimental rheumatology
pub_type： 杂志文章
doi：
更新日期：2016-03-01 00:00:00
abstract：OBJECTIVE:To determine how frequently herbal remedies are employed as alternative therapies in rheumatic diseases, and the historical justification for their use. METHODS:We conducted a survey in 250 outpatients in the rheumatology clinic of a teaching hospital in México. We registered general demographic information ...
journal_title：Clinical and experimental rheumatology
pub_type： 杂志文章
doi：
更新日期：2001-03-01 00:00:00
abstract：:There is a definite association of heart disease with ankylosing spondylitis (AS). The magnitude of this relationship is less clear. Three types of inflammatory affections can be differentiated: 1. aortitis and aortic insufficiency with the possible necessity of cardiac surgery, 2. conduction disturbances of the atrio...
journal_title：Clinical and experimental rheumatology
pub_type： 杂志文章,评审
doi：
更新日期：2002-11-01 00:00:00
abstract：OBJECTIVES:To evaluate the effect of therapeutic and pharmacologic concentrations of two non-steroidal anti-inflammatory drugs (NSAIDs), nimesulide and naproxen, on the synthesis of urokinase (uPA), plasminogen activator inhibitor (PAI-1) and interleukin-6 (IL-6) in human synovial fibroblasts isolated from osteoarthrit...
journal_title：Clinical and experimental rheumatology
pub_type： 杂志文章
doi：
更新日期：1997-07-01 00:00:00
abstract：OBJECTIVES:The first aim was to make an inventory of available instruments and questionnaires for the assessment of disabilities in personal care in patients with rheumatic disorders. The second aim was to investigate which of these instruments have acceptable, methodological quality with regard to reliability, validit...
journal_title：Clinical and experimental rheumatology
pub_type： 杂志文章,评审
doi：
更新日期：2005-01-01 00:00:00
abstract：:A severe outbreak of coronavirus disease 2019 (COVID-19) emerged in China in December 2019, and spread so rapidly that more than 200,000 cases have so far been reported worldwide; on January 30, 2020, the WHO declared it the sixth public health emergency of international concern. The two previously reported coronaviru...
journal_title：Clinical and experimental rheumatology
pub_type： 杂志文章,评审
doi：
更新日期：2020-03-01 00:00:00
abstract：OBJECTIVES:To determine the types and to assess the role of auditory evoked potentials and otoacoustic emissions in early detection of hearing abnormalities in Behçet's disease (BD) patients. Their correlations with disease activity were also considered. METHODS:Thirty patients with BD and thirty apparently sex- and a...
journal_title：Clinical and experimental rheumatology
pub_type： 杂志文章
doi：
更新日期：2018-11-01 00:00:00
abstract：OBJECTIVES:To develop and test a new multidimensional questionnaire for assessment of children with auto-inflammatory disease (AID) such as FMF, PFAPA, HIDS, TRAPS in standard clinical care. METHODS:The juvenile auto-inflammatory disease multidimensional assessment report (JAIMAR) includes 16 parent or patient-centere...
journal_title：Clinical and experimental rheumatology
pub_type： 杂志文章
doi：
更新日期：2016-09-01 00:00:00
abstract：:Cytophagic histiocytic panniculitis (CHP) is a rare panniculitis characterized by systemic features, due to histiocytic infiltration along with haemophagocytosis, which may also appear in bone marrow, spleen, lymph nodes, and liver. Haemophagocytic lymphohistiocytosis (HLH) is a group of autoinflammatory disorders, wh...
journal_title：Clinical and experimental rheumatology
pub_type： 杂志文章
doi：
更新日期：2015-11-01 00:00:00
abstract：:Surgical treatment of rheumatoid arthritis dates back some fifty years to when rheumatology developed into a separate branch of medicine. An interdisciplinary approach to rheumatoid arthritis was then introduced at a few specialized centres. By refining the surgical techniques, increasing the number of surgical option...
journal_title：Clinical and experimental rheumatology
pub_type： 杂志文章,评审
doi：
更新日期：1989-09-01 00:00:00
abstract：OBJECTIVE:We investigated the presence of anti-GOR antibodies in patients with essential mixed cryoglobulinemia, since both autoimmune pathogenetic processes and a high prevalence of HCV infection are present in this syndrome. METHODS:We compared these cases to patients with HCV-related chronic active hepatitis or alc...
journal_title：Clinical and experimental rheumatology
pub_type： 杂志文章
doi：
更新日期：1995-11-01 00:00:00
abstract：OBJECTIVES:To compare measurement properties of the EQ-5D and SF-6D utility measures, to assess the association and agreement between these measures and to estimate minimal important differences (MID) in patients with systemic sclerosis (SSc). METHODS:Both measures were assessed twice in an observational prospective d...
journal_title：Clinical and experimental rheumatology
pub_type： 杂志文章
doi：
更新日期：2013-03-01 00:00:00
abstract：:Several cases of patients with concomitant SLE and HIV infection have been reported in the literature; however, the effect of immunosuppressive therapy on HIV replication has not been described. We present the case of a 46 y/o woman with a ten-year history of HIV infection who was treated with IV cyclophosphamide for ...
journal_title：Clinical and experimental rheumatology
pub_type： 杂志文章
doi：
更新日期：2000-07-01 00:00:00
abstract：:The randomized controlled clinical trial is the "gold standard" to evaluate therapeutic interventions, but is more effectively applied to studies of the short-term treatment of acute diseases than to the long-term treatment of chronic diseases. Clinical observations often provide more accurate outcome data in rheumato...
journal_title：Clinical and experimental rheumatology
pub_type： 杂志文章,评审
doi：
更新日期：1997-05-01 00:00:00
abstract：OBJECTIVES:This systematic literature review (SLR) and network meta-analysis (NMA) was aimed at comparing the relative efficacy and safety of abatacept (ABA) with other currently recommended therapies for patients with early RA. METHODS:An SLR (January 1998 to June 2018) was conducted including MEDLINE®, Embase, and C...
journal_title：Clinical and experimental rheumatology
pub_type： 杂志文章,meta分析
doi：
更新日期：2020-09-01 00:00:00
