Abstract:
OBJECTIVES:The anti-inflammatory effect of adenosine is partially mediated via the A3 adenosine receptor (A3AR), a Gi protein associated cell surface receptor. The highly selective A3AR agonist, IB-MECA was earlier shown to prevent the clinical and pathological manifestations of arthritis in experimental animal models of collagen and adjuvant induced arthritis (AIA). In this study we tested the effect of IB-MECA on the prevention of bone resorption in AIA rats and looked at the molecular mechanism of action. METHODS:Rats with AIA were treated orally twice daily with IB-MECA starting upon onset of disease and the clinical score was evaluated every other day. At study termination the foot, knee and hip region of both vehicle and IB-MECA treated animals were subjected to histomorphometric analysis. Western blot analysis was carried out on paw protein extracts. RESULTS:IB-MECA ameliorated the clinical manifestations of the disease and reduced pannus and fibrosis formation, attenuated cartilage and bone destruction and decreased the number of osteoclasts. In cell protein extracts derived from paw of AIA rats, A3AR was highly expressed in comparison to naïve animals. In paw extracts derived from IB-MECA treated AIA rats, down-regulation of the A3AR protein expression level was noted. PI3K, PKB/Akt, IKK, NF-kappaB, TNF-alpha and RANKL were down-regulated whereas caspase 3 was up-regulated. CONCLUSION:IB-MECA, a small highly bioavailable molecule, induces modulation of proteins which control survival and apoptosis resulting in the amelioration of the inflammatory process and the preservation of bone mass in AIA rats.
journal_name
Clin Exp Rheumatoljournal_title
Clinical and experimental rheumatologyauthors
Rath-Wolfson L,Bar-Yehuda S,Madi L,Ochaion A,Cohen S,Zabutti A,Fishman Psubject
Has Abstractpub_date
2006-07-01 00:00:00pages
400-6issue
4eissn
0392-856Xissn
1593-098Xpii
1869journal_volume
24pub_type
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journal_title:Clinical and experimental rheumatology
pub_type: 杂志文章
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更新日期:2009-09-01 00:00:00
abstract:OBJECTIVES:To more precisely determine whether there is a significant association of cytotoxic T-lymphocyte-associated antigen 4 (CTLA-4) gene polymorphisms with the susceptibility for Behçet's disease. METHODS:Eight studies that included data from 7 articles were identified using PubMed, Embase, Chinese Biomedical Li...
journal_title:Clinical and experimental rheumatology
pub_type: 杂志文章,meta分析,评审
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abstract::In terms of adult-onset definitions, rheumatoid arthritis (RA) and ankylosing spondylitis (AS) are rarely diagnosed in children. Adult RA is in most aspects similar to seropositive polyarticular arthritis in children, but AS differs in its clinical presentation according to age at onset. In general, the nomenclature a...
journal_title:Clinical and experimental rheumatology
pub_type: 杂志文章,评审
doi:
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journal_title:Clinical and experimental rheumatology
pub_type: 杂志文章
doi:
更新日期:1995-11-01 00:00:00
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journal_title:Clinical and experimental rheumatology
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doi:
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journal_title:Clinical and experimental rheumatology
pub_type: 杂志文章,meta分析
doi:
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journal_title:Clinical and experimental rheumatology
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doi:
更新日期:2008-09-01 00:00:00
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journal_title:Clinical and experimental rheumatology
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doi:
更新日期:2004-01-01 00:00:00
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journal_title:Clinical and experimental rheumatology
pub_type: 杂志文章,评审
doi:
更新日期:1989-09-01 00:00:00
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journal_title:Clinical and experimental rheumatology
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doi:
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journal_title:Clinical and experimental rheumatology
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doi:
更新日期:2005-09-01 00:00:00
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journal_title:Clinical and experimental rheumatology
pub_type: 杂志文章
doi:
更新日期:1991-01-01 00:00:00
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journal_title:Clinical and experimental rheumatology
pub_type: 杂志文章
doi:
更新日期:2005-05-01 00:00:00
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journal_title:Clinical and experimental rheumatology
pub_type: 杂志文章
doi:
更新日期:2014-03-01 00:00:00
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journal_title:Clinical and experimental rheumatology
pub_type: 杂志文章,评审
doi:
更新日期:2003-07-01 00:00:00
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journal_title:Clinical and experimental rheumatology
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doi:
更新日期:2014-09-01 00:00:00
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doi:
更新日期:2018-11-01 00:00:00
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journal_title:Clinical and experimental rheumatology
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doi:
更新日期:2015-07-01 00:00:00
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journal_title:Clinical and experimental rheumatology
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journal_title:Clinical and experimental rheumatology
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journal_title:Clinical and experimental rheumatology
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journal_title:Clinical and experimental rheumatology
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更新日期:2014-01-01 00:00:00
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journal_title:Clinical and experimental rheumatology
pub_type: 杂志文章
doi:
更新日期:1994-07-01 00:00:00
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journal_title:Clinical and experimental rheumatology
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doi:
更新日期:2012-11-01 00:00:00
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journal_title:Clinical and experimental rheumatology
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doi:
更新日期:2009-09-01 00:00:00
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journal_title:Clinical and experimental rheumatology
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doi:
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journal_title:Clinical and experimental rheumatology
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