Abstract：
OBJECTIVES:Ankylosing spondylitis (AS) is a chronic, progressive, and disabling disease, but the diagnosis is often missed and markedly delayed. An early diagnosis is important to establish a treatment to reduce disability and modify the natural course of disease. The aim of this study was to investigate the diagnostic (DD) and therapeutic (TD) delay according to the decade of diagnosis. The DD and TD correlation with radiological severity score and the new imaging techniques used in diagnosis (magnetic resonance [MRI], computerised tomography, scintigraphy for sacroiliac joints) were also investigated. METHODS:135 AS patients (45 female and 90 male, 36.5±10.2 years old at diagnosis) with disease onset between 1950 and 2008, were investigated; the time from onset to diagnosis (DD) and treatment (TD), the New York and ASAS criteria fulfilment, the New York sacroiliac radiological score, bamboo spine presence at first visit and the new imaging technique used at diagnosis were recorded and their correlations were analysed. RESULTS:The New York and ASAS criteria were met at the first visit, by 87% and 96%, respectively. The delay from onset of symptoms to diagnosis and treatment was 9±8 and 12±11 years, respectively, but decreased significantly between different decades (p<0.001). The severity of sacroiliitis (mean 2±1; 17/135, 12.5% - IV grade sacroiliitis at diagnosis) and bamboo spine (3.7% at diagnosis) correlated with DD and TD (p<0.001). Sacroiliac MRI use at diagnosis significantly decreased both DD and TD (p>0.001 and p<0.05, respectively). CONCLUSIONS:DD and TD were correlated to radiological severity; they progressively decreased over 6 decades.
journal_name
Clin Exp Rheumatoljournal_title
Clinical and experimental rheumatologyauthors
Salvadorini G,Bandinelli F,Delle Sedie A,Riente L,Candelieri A,Generini S,Possemato N,Bombardieri S,Matucci-Cerinic Msubject
Has Abstractpub_date
2012-07-01 00:00:00pages
561-5issue
4eissn
0392-856Xissn
1593-098Xpii
5444journal_volume
30pub_type
杂志文章abstract：OBJECTIVE:Skin disease can be one of the most refractory clinical manifestations of systemic lupus erythematosus (SLE). The standard therapy consists of sunscreens, topical corticosteroids and antimalarials. However in difficult cases a variety of other drugs have been tried. Here we describe our clinical experience wi...
journal_title：Clinical and experimental rheumatology
pub_type： 杂志文章
doi：
更新日期：2005-05-01 00:00:00
abstract：:The activity of dipeptidyl peptidase IV (DPP IV) was measured in the serum and peripheral blood mononuclear cells (MNC) of patients with systemic lupus erythematosus (SLE). The number of DPP IV positive (DPP IV+) lymphocytes in blood smears was determined cytochemically in groups of patients with active, moderate and ...
journal_title：Clinical and experimental rheumatology
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doi：
更新日期：1992-07-01 00:00:00
abstract：PURPOSE AND METHODS:In order to evaluate the prevalence of positive hepatitis C virus (HCV) serology and cryoglobulinemia in human immunodeficiency virus (HIV)-infected patients, the prevalence and the clinical significance of cryoglobulinemia were prospectively studied in a cohort of 86 HIV-infected subjects seen as o...
journal_title：Clinical and experimental rheumatology
pub_type： 杂志文章
doi：
更新日期：1997-09-01 00:00:00
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journal_title：Clinical and experimental rheumatology
pub_type： 杂志文章
doi：
更新日期：1992-09-01 00:00:00
abstract：OBJECTIVES:To assess the sleep quality in primary Sjögren's syndrome (pSS) patients and evaluate its relationship with the disease, quality of life and mood disorders. METHODS:The sleep quality of 29 pSS women and 29 matched controls was assessed by the Pittsburgh Sleep Quality Index (PSQI). Seven domains are grouped ...
journal_title：Clinical and experimental rheumatology
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doi：
更新日期：2016-05-01 00:00:00
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journal_title：Clinical and experimental rheumatology
pub_type： 杂志文章
doi：
更新日期：2019-05-01 00:00:00
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journal_title：Clinical and experimental rheumatology
pub_type： 杂志文章
doi：
更新日期：2003-09-01 00:00:00
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journal_title：Clinical and experimental rheumatology
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doi：
更新日期：1997-03-01 00:00:00
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journal_title：Clinical and experimental rheumatology
pub_type： 杂志文章
doi：
更新日期：2012-05-01 00:00:00
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journal_title：Clinical and experimental rheumatology
pub_type： 杂志文章,评审
doi：
更新日期：2014-07-01 00:00:00
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journal_title：Clinical and experimental rheumatology
pub_type： 杂志文章
doi：
更新日期：2008-09-01 00:00:00
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journal_title：Clinical and experimental rheumatology
pub_type： 杂志文章
doi：
更新日期：2017-03-01 00:00:00
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journal_title：Clinical and experimental rheumatology
pub_type： 杂志文章
doi：
更新日期：2017-01-01 00:00:00
abstract：OBJECTIVE:To investigate the incidence and clinical features in patients with cytomegalovirus (CMV)-positive antigenemia during high dose corticosteroid therapy for collagen vascular diseases, and risk factors associated with it. PATIENTS AND METHODS:We examined retrospectively 35 consecutive patients for the presence...
journal_title：Clinical and experimental rheumatology
pub_type： 杂志文章
doi：
更新日期：2006-11-01 00:00:00
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journal_title：Clinical and experimental rheumatology
pub_type： 杂志文章
doi：
更新日期：1995-07-01 00:00:00
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journal_title：Clinical and experimental rheumatology
pub_type： 杂志文章
doi：
更新日期：2017-09-01 00:00:00
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journal_title：Clinical and experimental rheumatology
pub_type： 杂志文章
doi：
更新日期：2004-03-01 00:00:00
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journal_title：Clinical and experimental rheumatology
pub_type： 杂志文章
doi：
更新日期：2006-03-01 00:00:00
abstract：OBJECTIVES:To compare the occurrence of non-infectious uveitis based on the type of tumour necrosis factor (TNF) inhibitor used to manage spondyloarthritis in ankylosing spondylitis (AS) patients. METHODS:The occurrence (new-onset and recurrence) of uveitis was reviewed retrospectively in AS patients receiving differe...
journal_title：Clinical and experimental rheumatology
pub_type： 杂志文章
doi：
更新日期：2020-11-01 00:00:00
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journal_title：Clinical and experimental rheumatology
pub_type： 共识发展会议,杂志文章
doi：
更新日期：2007-03-01 00:00:00
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journal_title：Clinical and experimental rheumatology
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doi：
更新日期：2005-07-01 00:00:00
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journal_title：Clinical and experimental rheumatology
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doi：
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journal_title：Clinical and experimental rheumatology
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更新日期：2015-09-01 00:00:00
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journal_title：Clinical and experimental rheumatology
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journal_title：Clinical and experimental rheumatology
pub_type： 杂志文章
doi：
更新日期：1989-01-01 00:00:00
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journal_title：Clinical and experimental rheumatology
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doi：
更新日期：2016-07-01 00:00:00
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doi：
更新日期：2018-11-01 00:00:00
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journal_title：Clinical and experimental rheumatology
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doi：
更新日期：2003-01-01 00:00:00
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journal_title：Clinical and experimental rheumatology
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