Abstract：
:It is recognised that the genetic profiles that give rise to chronic inflammatory diseases, under the influence of environmental agents, might have been implicated in the host defence mechanism against lethal infections in the past. Behçet's disease (BD) is an immune-mediated inflammatory disease, expressed as vasculitis, triggered by environmental factors in genetically susceptible individuals. We carried out a review of published data to draw up an evolutionary adaptation model, as Author's perspective, for genetic susceptibility factors and inflammatory immune response involved in BD pathogenesis. Two lethal infectious agents, Plasmodium Falciparum and Yersinia Pestis, are proposed as the putative driving forces that favoured the fixing of the major genetic susceptibility factors to BD, thus determining its geoepidemiology. Further studies are needed to confirm the validity of this evolutionary model which includes and integrates the key insights of previous hypotheses.
journal_name
Clin Exp Rheumatoljournal_title
Clinical and experimental rheumatologyauthors
Piga M,Mathieu Asubject
Has Abstractpub_date
2014-07-01 00:00:00pages
S123-9issue
4 Suppl 84eissn
0392-856Xissn
1593-098Xpii
7244journal_volume
32pub_type
杂志文章,评审abstract：OBJECTIVE:Osteoporosis is infrequent in young premenopausal women and is often associated with secondary disorders. However, idiopathic osteoporosis may be found in this setting and few data are known on this condition. Therefore, the aim of this study was to analyse the clinical characteristics and bone remodelling ab...
journal_title：Clinical and experimental rheumatology
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doi：
更新日期：2008-11-01 00:00:00
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journal_title：Clinical and experimental rheumatology
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更新日期：1990-01-01 00:00:00
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journal_title：Clinical and experimental rheumatology
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journal_title：Clinical and experimental rheumatology
pub_type： 杂志文章,评审
doi：
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journal_title：Clinical and experimental rheumatology
pub_type： 杂志文章
doi：
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journal_title：Clinical and experimental rheumatology
pub_type： 杂志文章,评审
doi：
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journal_title：Clinical and experimental rheumatology
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journal_title：Clinical and experimental rheumatology
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journal_title：Clinical and experimental rheumatology
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doi：
更新日期：2010-07-01 00:00:00
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journal_title：Clinical and experimental rheumatology
pub_type： 临床试验,杂志文章,多中心研究
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更新日期：2010-01-01 00:00:00
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journal_title：Clinical and experimental rheumatology
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更新日期：2007-11-01 00:00:00
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journal_title：Clinical and experimental rheumatology
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更新日期：2018-05-01 00:00:00
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journal_title：Clinical and experimental rheumatology
pub_type： 杂志文章,多中心研究
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更新日期：2016-03-01 00:00:00
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journal_title：Clinical and experimental rheumatology
pub_type： 杂志文章
doi：
更新日期：2012-05-01 00:00:00
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journal_title：Clinical and experimental rheumatology
pub_type： 杂志文章,评审
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更新日期：2003-09-01 00:00:00
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journal_title：Clinical and experimental rheumatology
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journal_title：Clinical and experimental rheumatology
pub_type： 杂志文章
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更新日期：2008-01-01 00:00:00
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journal_title：Clinical and experimental rheumatology
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journal_title：Clinical and experimental rheumatology
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journal_title：Clinical and experimental rheumatology
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journal_title：Clinical and experimental rheumatology
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doi：
更新日期：2016-11-01 00:00:00
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journal_title：Clinical and experimental rheumatology
pub_type： 杂志文章
doi：
更新日期：1999-03-01 00:00:00
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journal_title：Clinical and experimental rheumatology
pub_type： 杂志文章,评审
doi：
更新日期：1997-05-01 00:00:00
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journal_title：Clinical and experimental rheumatology
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更新日期：2003-03-01 00:00:00
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