Central compartment reoperation for recurrent/persistent differentiated thyroid cancer: patterns of recurrence, morbidity, and prediction of postoperative hypocalcemia.


BACKGROUND:Incidence rates of hypoparathyroidism and vocal cord paralysis are high following central compartment reoperation, but few prospective studies have assessed morbidities and factors predictive of hypocalcemia after reoperation. We investigated recurrence patterns, morbidity, and factors predictive of postoperative hypocalcemia in patients undergoing central compartment reoperation for recurrent/persistent differentiated thyroid cancer (DTC). METHODS:We prospectively evaluated 45 consecutive patients with recurrent/persistent DTC. Thyroid remnants or recurrent cancers were removed in 16 patients, the unilateral or bilateral central compartment was cleared in all patients, and the lateral compartment on the diseased side was comprehensively removed from 24 patients. Recurrence patterns were assessed histopathologically, morbidities were monitored, and serum concentrations of calcium and intact parathyroid hormone (iPTH) were measured in all patients. RESULTS:Eleven patients (24.4%) had tumor invasion into the recurrent laryngeal nerve and/or the tracheoesophagus. Central nodal involvement occurred frequently (86.7%), and the ipsilateral jugular nodes of the lateral compartment were frequently involved. Temporary and permanent vocal cord paralysis developed in 10 (22.2%) and 8 (17.8%) patients, respectively, due primarily to intentional nerve resection following tumor invasion. Of 41 patients without preoperative hypoparathyroidism, 21 (46.3%) had temporary and 2 (4.9%) had permanent hypocalcemia. Multivariate analysis showed that bilateral central compartment dissection and low iPTH levels (<12.0 pg/ml) were independent predictors of postoperative hypocalcemia. CONCLUSIONS:Most patients with recurrent/persistent DTC harbor lesions in the central compartment. Central compartment reoperation may lead to high rates of morbidity, including hypoparathyroidism, which can be predicted by surgical extent and low serum iPTH levels.


Ann Surg Oncol


Roh JL,Kim JM,Park CI




Has Abstract


2011-05-01 00:00:00












  • Tumor Involvement of the Nipple in Total Skin-Sparing Mastectomy: Strategies for Management.

    abstract:BACKGROUND:Despite a growing body of literature on oncologic and reconstructive outcomes after total skin-sparing mastectomy (TSSM), some questions related to this approach remain unanswered, including strategies for managing tumor involvement of the nipple while maintaining the aesthetic benefits of TSSM. METHODS:A p...

    journal_title:Annals of surgical oncology

    pub_type: 杂志文章


    authors: Amara D,Peled AW,Wang F,Ewing CA,Alvarado M,Esserman LJ

    更新日期:2015-11-01 00:00:00

  • Increasing mastectomy rates-the effect of environmental factors on the choice for mastectomy: a comparative analysis between Canada and the United States.

    abstract:PURPOSE:Unilateral mastectomy (UM) and contralateral prophylactic mastectomy (CPM) for early-stage breast cancer (ESBC) have been increasing. Numerous etiological factors for this rise have been suggested, including increasing use of magnetic resonance imaging (MRI) and reconstruction, surgeon's preference, and patient...

    journal_title:Annals of surgical oncology

    pub_type: 杂志文章


    authors: Covelli AM,Baxter NN,Fitch MI,Wright FC

    更新日期:2014-10-01 00:00:00

  • Simultaneous indocyanine green and (99m)Tc-antimony sulfur colloid-guided laparoscopic sentinel basin dissection for gastric cancer.

    abstract:BACKGROUND:There are few reports on a dual dye and isotope approach using laparoscopy in gastric cancer sentinel node mapping. The aim of this study is to evaluate the feasibility of laparoscopic sentinel basin dissection for gastric cancer using simultaneous indocyanine green (ICG) and (99m)Tc-antimony sulfur colloid ...

    journal_title:Annals of surgical oncology

    pub_type: 杂志文章


    authors: Park DJ,Kim HH,Park YS,Lee HS,Lee WW,Lee HJ,Yang HK

    更新日期:2011-01-01 00:00:00

  • Effect of body composition on outcomes after hepatic resection for hepatocellular carcinoma.

    abstract:PURPOSE:To evaluate the effect of body composition on outcomes after hepatic resection for patients with hepatocellular carcinoma (HCC). METHODS:We performed 190 hepatic resections for HCC and divided the patients into 2 groups on the basis of visceral fat area (VFA), assessed by computed tomographic measurement at th...

    journal_title:Annals of surgical oncology

    pub_type: 杂志文章


    authors: Itoh S,Shirabe K,Matsumoto Y,Yoshiya S,Muto J,Harimoto N,Yamashita Y,Ikegami T,Yoshizumi T,Nishie A,Maehara Y

    更新日期:2014-09-01 00:00:00

  • Practical Value of Molecular Pathology in Stage I-III Lung Cancer: Implications for the Clinical Surgeon.

    abstract::Over a decade since the discovery of EGFR mutation, and 6 years since prospective clinical trial data proved that routine molecular pathology tests improve survival in stage IV lung cancer, there is still debate whether to test patients with earlier stages of disease (stage I-III). As discoveries of targeted drugs for...

    journal_title:Annals of surgical oncology

    pub_type: 杂志文章,评审


    authors: Azzoli CG

    更新日期:2015-10-01 00:00:00

  • Results of a Phase Ib Trial of Combination Immunotherapy with a CD8+ T Cell Eliciting Vaccine and Trastuzumab in Breast Cancer Patients.

    abstract:BACKGROUND:CD8+ T cell-eliciting vaccines are being investigated in breast cancer patients. Preclinical data showed that trastuzumab increases the susceptibility of tumor cells to lysis by vaccine-generated CD8+ T cells, suggesting potential benefit of a combination immunotherapy strategy. The current trial was underta...

    journal_title:Annals of surgical oncology

    pub_type: 杂志文章


    authors: Clifton GT,Litton JK,Arrington K,Ponniah S,Ibrahim NK,Gall V,Alatrash G,Peoples GE,Mittendorf EA

    更新日期:2017-08-01 00:00:00

  • Benefit of adjuvant chemotherapy after resection of stage II (T1-2N1M0) non-small cell lung cancer in elderly patients.

    abstract:BACKGROUND:We evaluated the use and efficacy of adjuvant chemotherapy after resection of T1-2N1M0 non-small cell lung cancer (NSCLC) in elderly patients. METHODS:Factors associated with the use of adjuvant chemotherapy in patients older than 65 years of age who underwent surgical resection of T1-2N1M0 NSCLC without in...

    journal_title:Annals of surgical oncology

    pub_type: 杂志文章


    authors: Berry MF,Coleman BK,Curtis LH,Worni M,D'Amico TA,Akushevich I

    更新日期:2015-02-01 00:00:00

  • Cholangiocarcinoma Heterogeneity Revealed by Multigene Mutational Profiling: Clinical and Prognostic Relevance in Surgically Resected Patients.

    abstract:BACKGROUND:Cholangiocarcinoma can be classified in intrahepatic cholangiocarcinoma (ICC) and perihilar cholangiocarcinoma (PCC). Moreover, PCC includes two different forms: extrahepatic (EH) PCC, which arises from the perihilar EH large ducts, and intrahepatic (IH) PCC, in which a significant liver mass invades the per...

    journal_title:Annals of surgical oncology

    pub_type: 杂志文章


    authors: Ruzzenente A,Fassan M,Conci S,Simbolo M,Lawlor RT,Pedrazzani C,Capelli P,D'Onofrio M,Iacono C,Scarpa A,Guglielmi A

    更新日期:2016-05-01 00:00:00

  • Clinical and Radiologic Predictors of a Pathologic Complete Response to Neoadjuvant Chemotherapy (NACT) in Patients Undergoing Cytoreductive Surgery for Colorectal Peritoneal Metastases: Results of a Prospective Multi-center Study.

    abstract:BACKGROUND:Patients undergoing cytoreductive surgery for colorectal peritoneal metastases who have a pathologic complete response (pCR) to neoadjuvant chemotherapy experience a significantly longer survival than those with residual disease. This response is known only after surgery. This study aimed to examine clinical...

    journal_title:Annals of surgical oncology

    pub_type: 杂志文章


    authors: Bhatt A,Rousset P,Benzerdjeb N,Kammar P,Mehta S,Parikh L,Goswami G,Shaikh S,Kepenekian V,Passot G,Glehen O

    更新日期:2020-11-18 00:00:00

  • Lobe-Specific Lymph Node Dissection for Clinical Early-Stage (cIA) Peripheral Non-small Cell Lung Cancer Patients: What and How?

    abstract:OBJECTIVE:We investigated the possible lobe-specific lymph node (LN) metastasis pattern of early-stage peripheral non-small cell lung cancers (NSCLC) and define the extent of lobe-specific LN dissection for them. METHODS:We retrospectively collected clinical data of patients undergoing lobectomy or segmentectomy with ...

    journal_title:Annals of surgical oncology

    pub_type: 杂志文章


    authors: Deng HY,Zhou J,Wang RL,Jiang R,Zhu DX,Tang XJ,Zhou Q

    更新日期:2020-02-01 00:00:00

  • Intraoperative localization of insulinoma and normal pancreas using invisible near-infrared fluorescent light.

    abstract:BACKGROUND:Neuroendocrine tumors of the pancreas, such as insulinoma, are difficult to localize, and complete resection is essential for cure. Our hypothesis is that a near-infrared (NIR) fluorophore exhibiting uptake in insulinoma could provide high-sensitivity detection intraoperatively. MATERIALS AND METHODS:The op...

    journal_title:Annals of surgical oncology

    pub_type: 杂志文章


    authors: Winer JH,Choi HS,Gibbs-Strauss SL,Ashitate Y,Colson YL,Frangioni JV

    更新日期:2010-04-01 00:00:00

  • Gastrointestinal stromal tumors: current diagnosis, biologic behavior, and management.

    abstract::Gastrointestinal stromal tumors (GIST) are rare tumors of the gastrointestinal (GI) tract that arise from primitive mesenchymal cells. GISTs occur throughout the GI tract but are usually located in the stomach and small intestine. The majority of GISTs are immunohistochemically positive for c-kit protein (CD 117) and ...

    journal_title:Annals of surgical oncology

    pub_type: 杂志文章,评审


    authors: Pidhorecky I,Cheney RT,Kraybill WG,Gibbs JF

    更新日期:2000-10-01 00:00:00

  • The utility of frozen section evaluation for follicular thyroid lesions.

    abstract:BACKGROUND:Because fine-needle aspiration cannot reliably discriminate between benign and malignant follicular thyroid lesions, some surgeons use intraoperative frozen section (FS) to guide operative management. To determine the utility of FS for these lesions, we reviewed our institutional experience. METHODS:Between...

    journal_title:Annals of surgical oncology

    pub_type: 杂志文章


    authors: Callcut RA,Selvaggi SM,Mack E,Ozgul O,Warner T,Chen H

    更新日期:2004-01-01 00:00:00

  • Dialysis Increases the Risk of Bladder Recurrence in Patients with Upper Tract Urothelial Cancer: A Population-Based Study.

    abstract:BACKGROUND:The relation of dialysis to tumor recurrence in patients with upper tract urothelial cancer (UTUC) is unknown; however, a limited number of small-scale studies suggest that patients with renal diseases prior to UTUC are more likely to exhibit bladder recurrence. We performed a population-based analysis to de...

    journal_title:Annals of surgical oncology

    pub_type: 杂志文章


    authors: Lin MY,Li WM,Huang CN,Lee HL,Niu SW,Chen LT,Wu WJ,Hwang SJ

    更新日期:2018-04-01 00:00:00

  • Association Between Waiting Time from Diagnosis to Treatment and Survival in Patients with Curable Gastric Cancer: A Population-Based Study in the Netherlands.

    abstract:BACKGROUND:In the Netherlands, a maximum waiting time from diagnosis to treatment (WT) of 5 weeks is recommended for curative cancer treatment. This study aimed to evaluate the association between WT and overall survival (OS) in patients undergoing gastrectomy for cancer. METHODS:This nationwide study included data fr...

    journal_title:Annals of surgical oncology

    pub_type: 杂志文章


    authors: Brenkman HJF,Visser E,van Rossum PSN,Siesling S,van Hillegersberg R,Ruurda JP

    更新日期:2017-07-01 00:00:00

  • Short-term outcomes of ablation therapy for hepatic tumors: evidence from the 2006-2009 nationwide inpatient sample.

    abstract:BACKGROUND:Radiofrequency ablation (RFA) for the treatment of hepatic tumors has been increasingly used across the United States. Whether treatment-related morbidity has remained low with broader adoption is unclear. We conducted this study to describe in-hospital morbidity associated with RFA for hepatic tumors and to...

    journal_title:Annals of surgical oncology

    pub_type: 杂志文章


    authors: Fox JP,Gustafson J,Desai MM,Hellan M,Thambi-Pillai T,Ouellette J

    更新日期:2012-11-01 00:00:00

  • Severe duodenal involvement in familial adenomatous polyposis treated by pylorus-preserving pancreaticoduodenectomy.

    abstract:PURPOSE:Pancreaticoduodenectomy is an alternative to pancreas-sparing duodenectomy for radical treatment of duodenal lesions. The aims of this study were to assess the results of pylorus-preserving pancreaticoduodenectomy (PPPD) for severe duodenal polyposis in familial adenomatous polyposis in terms of morbidity, long...

    journal_title:Annals of surgical oncology

    pub_type: 杂志文章


    authors: Caillié F,Paye F,Desaint B,Bennis M,Lefèvre JH,Parc Y,Svrcek M,Balladur P,Tiret E

    更新日期:2012-09-01 00:00:00

  • Optical See-Through Cancer Vision Goggles Enable Direct Patient Visualization and Real-Time Fluorescence-Guided Oncologic Surgery.

    abstract:BACKGROUND:The inability to visualize the patient and surgical site directly, limits the use of current near infrared fluorescence-guided surgery systems for real-time sentinel lymph node biopsy and tumor margin assessment. METHODS:We evaluated an optical see-through goggle augmented imaging and navigation system (GAI...

    journal_title:Annals of surgical oncology

    pub_type: 杂志文章


    authors: Mondal SB,Gao S,Zhu N,Habimana-Griffin L,Akers WJ,Liang R,Gruev V,Margenthaler J,Achilefu S

    更新日期:2017-07-01 00:00:00

  • Total Laparoscopic Pancreaticoduodenectomy with Venous Reconstruction for Pancreatic Head Cancer with Involvement of the Superior Mesenteric Vein-Portal Vein Confluence.

    abstract:BACKGROUND:Laparoscopic pancreaticoduodenectomy with venous reconstruction is not commonly performed due to its technical challenges. In this video, we focus on the technical aspects for how to perform this procedure safely. METHODS:In a 69-year-old female with jaundice and diarrhea, a computed tomography scan showed ...

    journal_title:Annals of surgical oncology

    pub_type: 杂志文章


    authors: Garbarino GM,Fuks D,Cowan J,Ward M,Moisan F,Donatelli G,Beaussier M,Gayet B

    更新日期:2018-12-01 00:00:00

  • Laparoscopic abdominoperineal resection with open posterior cylindrical excision and primary transpelvic VRAM flap.

    abstract:BACKGROUND:In our own experience over the last 15 years, the primary transpelvic vertical rectus abdominis myocutaneous (VRAM) flap is a reliable tool to prevent perineal wound complications after cylindrical excision in radical anorectal tumor surgery. To minimize the operative trauma in such patients, we performed a ...

    journal_title:Annals of surgical oncology

    pub_type: 杂志文章


    authors: Horch RE,D'Hoore A,Holm T,Kneser U,Hohenberger W,Arkudas A

    更新日期:2012-02-01 00:00:00

  • Factors associated with variance in compliance with a sentinel lymph node dissection quality measure in early-stage breast cancer.

    abstract:BACKGROUND:Guidelines recommend sentinel lymph node dissection (SLND) for patients with clinical stage I/IIA/IIB breast cancer; however, a significant fraction of patients do not undergo this procedure. We sought to identify factors associated with noncompliance with the SLND benchmark in early-stage breast cancer. MA...

    journal_title:Annals of surgical oncology

    pub_type: 杂志文章


    authors: Olaya W,Wong J,Morgan JW,Truong C,Roy-Chowdhury S,Kazanjian K,Lum S

    更新日期:2010-10-01 00:00:00

  • High level of Notch1 protein is associated with poor overall survival in colorectal cancer.

    abstract:BACKGROUND:Notch1 regulates cell proliferation, development, and apoptosis. Aberrant expression of Notch1 has been discovered in many types of tumors. We examined Notch1 expression in colorectal cancer to assess its role as a prognostic indicator. METHODS:Notch1 protein expression was examined by immunohistochemistry ...

    journal_title:Annals of surgical oncology

    pub_type: 杂志文章


    authors: Chu D,Li Y,Wang W,Zhao Q,Li J,Lu Y,Li M,Dong G,Zhang H,Xie H,Ji G

    更新日期:2010-05-01 00:00:00

  • Morbidity of sentinel node biopsy: relationship between number of excised lymph nodes and patient perceptions of lymphedema.

    abstract:BACKGROUND:Sentinel lymph node biopsy (SLNB) is associated with reduced morbidity, although lymphedema remains a significant complication. Previously, we found no association between number of excised lymph nodes (LNs) and measured lymphedema in SLNB patients. In this analysis, we examined the relationship between numb...

    journal_title:Annals of surgical oncology

    pub_type: 杂志文章


    authors: Goldberg JI,Riedel ER,Morrow M,Van Zee KJ

    更新日期:2011-10-01 00:00:00

  • Laparoscopic detection of sentinel lymph nodes in gastrointestinal cancer: a novel and minimally invasive approach.

    abstract::Although the sentinel node (SN) concept has been validated in malignant melanoma and breast cancer, the application of this concept for other solid tumors, including gastrointestinal (GI) cancer, is still controversial. We have demonstrated the feasibility of radioguided SN mapping during laparotomy in patients with e...

    journal_title:Annals of surgical oncology

    pub_type: 杂志文章


    authors: Kitagawa Y,Ohgami M,Fujii H,Mukai M,Kubota T,Ando N,Watanabe M,Otani Y,Ozawa S,Hasegawa H,Furukawa T,Matsuda J,Kumai K,Ikeda T,Kubo A,Kitajima M

    更新日期:2001-10-01 00:00:00

  • Parenchyma-preserving resections for small nonfunctioning pancreatic endocrine tumors.

    abstract:BACKGROUND:Parenchyma-preserving resections (PPRs), including enucleation and middle pancreatectomy (MP), are accepted procedures for insulinomas, but their role in the treatment of nonfunctioning pancreatic endocrine tumors (NF-PETs) is debated. The aim of this study was to evaluate perioperative and long-term outcome...

    journal_title:Annals of surgical oncology

    pub_type: 杂志文章


    authors: Falconi M,Zerbi A,Crippa S,Balzano G,Boninsegna L,Capitanio V,Bassi C,Di Carlo V,Pederzoli P

    更新日期:2010-06-01 00:00:00

  • Metaplastic Breast Cancer Treatment and Outcomes in 2500 Patients: A Retrospective Analysis of a National Oncology Database.

    abstract:BACKGROUND:Metaplastic breast cancer (MBC) is characterized by chemoresistance and hematogenous spread. We sought to identify factors associated with improved MBC outcomes and increased likelihood of MBC diagnosis. METHODS:Women ≥ 18 years of age with stage I-III MBC and non-MBC diagnosed between 2010 and 2014 were id...

    journal_title:Annals of surgical oncology

    pub_type: 杂志文章


    authors: Ong CT,Campbell BM,Thomas SM,Greenup RA,Plichta JK,Rosenberger LH,Force J,Hall A,Hyslop T,Hwang ES,Fayanju OM

    更新日期:2018-08-01 00:00:00

  • Comparison of Detrusor Muscle Sampling Rate in Monopolar and Bipolar Transurethral Resection of Bladder Tumor: A Randomized Trial.

    abstract:PURPOSE:Our aim was to investigate the detrusor muscle sampling rate after monopolar versus bipolar transurethral resection of bladder tumor (TURBT). METHODS:This was a single-center, prospective, randomized, phase III trial on monopolar versus bipolar TURBT. Baseline patient characteristics, disease characteristics a...

    journal_title:Annals of surgical oncology

    pub_type: 杂志文章,随机对照试验


    authors: Teoh JY,Chan ES,Yip SY,Tam HM,Chiu PK,Yee CH,Wong HM,Chan CK,Hou SS,Ng CF

    更新日期:2017-05-01 00:00:00

  • Interval between neoadjuvant chemoradiotherapy and surgery for esophageal squamous cell carcinoma: does delayed surgery impact outcome?

    abstract:BACKGROUND:Although esophagectomy traditionally is recommended to perform within 8 weeks after neoadjuvant chemoradiotherapy (nCRT), data from neoadjuvantly treated rectal cancer patients demonstrate that delayed surgery ([8 weeks) can maximize the effect of CRT. Despite these promising data, investigators are concerne...

    journal_title:Annals of surgical oncology

    pub_type: 杂志文章


    authors: Chiu CH,Chao YK,Chang HK,Tseng CK,Chan SC,Liu YH,Chen WH

    更新日期:2013-12-01 00:00:00

  • Size and Location are the Most Important Risk Factors for Malignant Behavior in Resected Solitary Fibrous Tumors.

    abstract:PURPOSE:While previously thought to be clinically indolent, recent data suggest significant late metastatic capacity of solitary fibrous tumors (SFTs). We define prognostic factors for recurrence and disease-specific death (DSD) in resected primary SFTs. METHODS:Resected primary SFTs from 1982 to 2015 were identified ...

    journal_title:Annals of surgical oncology

    pub_type: 临床试验,杂志文章


    authors: Gholami S,Cassidy MR,Kirane A,Kuk D,Zanchelli B,Antonescu CR,Singer S,Brennan M

    更新日期:2017-12-01 00:00:00

  • Screening for psychological distress in surgical breast cancer patients.

    abstract:BACKGROUND:This pilot study assessed the levels of patient emotional distress and impact on clinic throughput time. METHODS:From April through August 2012, 149 breast cancer patients at the Penn State Hershey Breast Center were screened with the emotions thermometer (ET), a patient-rated visual 0-10 scale that measure...

    journal_title:Annals of surgical oncology

    pub_type: 杂志文章


    authors: Schubart JR,Emerich M,Farnan M,Stanley Smith J,Kauffman GL,Kass RB

    更新日期:2014-10-01 00:00:00