PI3KC2α, a class II PI3K, is required for dynamin-independent internalization pathways.

abstract：:The apical region of the Drosophila testis contains a niche with two stem cell populations: germline stem cells (GSCs) and cyst progenitor cells (CPCs). Asymmetrical division of these stem cells leads to gonioblast daughters (which undergo further mitoses) and cyst cell daughters (which withdraw from the cell cycle an...

journal_title：Journal of cell science

authors： Riparbelli MG,Colozza G,Callaini G

更新日期：2009-10-15 00:00:00

abstract：:Proper cellular functioning requires that cellular machinery behave in a spatiotemporally regulated manner in response to global changes in nutrient availability. Mounting evidence suggests that one way this is achieved is through the establishment of physically defined gradients of O-GlcNAcylation (O-linked addition ...

journal_title：Journal of cell science

authors： Harwood KR,Hanover JA

更新日期：2014-05-01 00:00:00

abstract：:The lipid phosphate phosphatase-related proteins (LPPRs), also known as plasticity-related genes (PRGs), are classified as a new brain-enriched subclass of the lipid phosphate phosphatase (LPP) superfamily. They induce membrane protrusions, neurite outgrowth or dendritic spine formation in cell lines and primary neuro...

journal_title：Journal of cell science

authors： Yu P,Agbaegbu C,Malide DA,Wu X,Katagiri Y,Hammer JA,Geller HM

更新日期：2015-09-01 00:00:00

abstract：:Effective cell-to-cell spreading of the facultative intracellular pathogen Listeria monocytogenes requires the interaction between bacteria and the microfilament system of the host cell. By recruiting actin filaments into a 'comet tail' localized at one pole of the bacterial cell wall, Listeria become mobile and prope...

journal_title：Journal of cell science

authors： Temm-Grove CJ,Jockusch BM,Rohde M,Niebuhr K,Chakraborty T,Wehland J

更新日期：1994-10-01 00:00:00

abstract：:The role of the haemolytic activity of Sendai virus in cell-cell fusion has been examined in monolayers of human erythrocytes and erythrocyte ghosts fused with either haemolytic or non-haemolytic virus. Morphological observations indicate that cell swelling and haemolysis is a distinct event in cell-cell fusion irresp...

journal_title：Journal of cell science

authors： Knutton S,Bächi T

更新日期：1980-04-01 00:00:00

abstract：:By differential screening of a Xenopus laevis egg cDNA library, we have isolated a 2,111 bp cDNA which corresponds to a maternal mRNA specifically deadenylated after fertilisation. This cDNA, called Eg2, encodes a 407 amino acid protein kinase. The pEg2 sequence shows significant identity with members of a new protein...

journal_title：Journal of cell science

authors： Roghi C,Giet R,Uzbekov R,Morin N,Chartrain I,Le Guellec R,Couturier A,Dorée M,Philippe M,Prigent C

更新日期：1998-03-01 00:00:00

abstract：:Thrombospondin-1 (TSP-1) and the highly related protein thrombospondin-2 (TSP-2) are trimeric extracellular molecules that have complex roles in wound healing, angiogenesis and matrix organisation. At the cellular level, TSP-1 supports cell adhesion and migration by the organisation of fascin spike cytoskeletal struct...

journal_title：Journal of cell science

authors： Anilkumar N,Annis DS,Mosher DF,Adams JC

更新日期：2002-06-01 00:00:00

abstract：:It is becoming clear that mechanical stimuli are crucial factors in regulating the biology of the cell, but the short-term structural response of a cell to mechanical forces remains relatively poorly understood. We mechanically stimulated cells transiently expressing actin-EGFP with controlled forces (0-20 nN) in orde...

journal_title：Journal of cell science

authors： Guolla L,Bertrand M,Haase K,Pelling AE

更新日期：2012-02-01 00:00:00

abstract：:Centrioles organise centrosomes and cilia, and these organelles have an important role in many cell processes. In flies, the centriole protein Ana1 is required for the assembly of functional centrosomes and cilia. It has recently been shown that Cep135 (also known as Bld10) initially recruits Ana1 to newly formed cent...

journal_title：Journal of cell science

authors： Saurya S,Roque H,Novak ZA,Wainman A,Aydogan MG,Volanakis A,Sieber B,Pinto DM,Raff JW

更新日期：2016-07-01 00:00:00

abstract：:Calcineurin-NFAT signaling has been shown to control activity-dependent muscle gene regulation and induce a program of gene expression typical of slow oxidative muscle fibers. Following Ca2+-calmodulin stimulation, calcineurin dephosphorylates NFAT proteins and induces their translocation into the nucleus. However, NF...

journal_title：Journal of cell science

authors： Tothova J,Blaauw B,Pallafacchina G,Rudolf R,Argentini C,Reggiani C,Schiaffino S

更新日期：2006-04-15 00:00:00

abstract：:Mutation of the LMNA gene, encoding nuclear lamin A and lamin C (hereafter lamin A/C), is a common cause of familial dilated cardiomyopathy (DCM). Among Finnish DCM patients, the founder mutation c.427T>C (p.S143P) is the most frequently reported genetic variant. Here, we show that p.S143P lamin A/C is more nucleoplas...

journal_title：Journal of cell science

authors： West G,Gullmets J,Virtanen L,Li SP,Keinänen A,Shimi T,Mauermann M,Heliö T,Kaartinen M,Ollila L,Kuusisto J,Eriksson JE,Goldman RD,Herrmann H,Taimen P

更新日期：2016-07-15 00:00:00

abstract：:Feedback mechanisms preventing M phase occurrence before S phase completion are assumed to depend on inhibition of cyclin B-cdc2 kinase activation by unreplicated DNA. In sea urchin, fertilization stimulates protein synthesis and releases eggs from G1 arrest. We found that in the one-cell sea urchin embryo cyclin B-cd...

journal_title：Journal of cell science

authors： Genevière-Garrigues AM,Barakat A,Dorée M,Moreau JL,Picard A

更新日期：1995-07-01 00:00:00

abstract：:Cytokinesis in many eukaryotes requires a contractile actomyosin ring that is placed at the division site. In fission yeast, which is an attractive organism for the study of cytokinesis, actomyosin ring assembly and contraction requires the myosin II heavy chain Myo2p. Although myo2-E1, a temperature-sensitive mutant ...

journal_title：Journal of cell science

authors： Palani S,Srinivasan R,Zambon P,Kamnev A,Gayathri P,Balasubramanian MK

更新日期：2018-01-04 00:00:00

abstract：:Megalin is a receptor expressed by embryonic epithelia that mediates endocytosis of numerous ligands, including sonic hedgehog (Shh) and retinol, the precursor to retinoic acid (RA). The importance of Shh and RA signaling in neurodevelopment, combined with the fact that megalin-deficient mice show profound neurodevelo...

journal_title：Journal of cell science

authors： McCarthy RA,Argraves WS

更新日期：2003-03-15 00:00:00

abstract：:Development of the nematocyst-taeniocyst complex in the four-zooid stage of a dinoflagellate, Polykrikos kofoidi, was studied by electron microscopy. We observed the following stages: formation of large spherical bodies in islets of cytoplasm containing extensive rough endoplasmic reticulum and Golgi complexes; differ...

journal_title：Journal of cell science

authors： Westfall JA,Bradbury PC,Townsend JW

更新日期：1983-09-01 00:00:00

abstract：:ADP-ribosylation factors (Arfs) and ADP-ribosylation factor-like proteins (Arls) are highly conserved small GTPases that function as main regulators of vesicular trafficking and cytoskeletal reorganization. Arl1, the first identified member of the large Arl family, is an important regulator of Golgi complex structure ...

journal_title：Journal of cell science

authors： Yu CJ,Lee FJ

更新日期：2017-05-15 00:00:00

abstract：:Recently, several 3D images of kinesin-family motor domains interacting with microtubules have been obtained by analysis of electron microscope images of frozen hydrated complexes at much higher resolutions (9-12 A) than in previous reports (15-30 A). The high-resolution maps show a complex interaction interface betwe...

journal_title：Journal of cell science

authors： Amos LA,Hirose K

更新日期：2007-11-15 00:00:00

abstract：:The events that accompany sporogenesis in the apogamous fern Dryopteris borreri parallel those seen in sexually reproducing ferns. Organelles dedifferentiate and redifferentiate, and form a discrete band across the equator of dyads; nuclear vacuoles and lipid spherosomes appear during prophase, and the major part of t...

journal_title：Journal of cell science

authors： Sheffield E,Laird S,Bell PR

更新日期：1983-09-01 00:00:00

abstract：:CDC14 was originally identified by L. Hartwell in his famous screen for genes that regulate the budding yeast cell cycle. Subsequent work showed that Cdc14 belongs to a family of highly conserved dual-specificity phosphatases that are present in a wide range of organisms from yeast to human. Human CDC14B is even able ...

journal_title：Journal of cell science

authors： Mocciaro A,Schiebel E

更新日期：2010-09-01 00:00:00

abstract：:The specific phosphatase inhibitor okadaic acid (OA) induced fragmentation of the Golgi apparatus in interphase HeLa cells. Immunoelectron microscopy for galactosyltransferase identified a major Golgi fragment composed of a cluster of vesicles and tubules that was morphologically indistinguishable from the 'Golgi clus...

journal_title：Journal of cell science

authors： Lucocq J,Warren G,Pryde J

更新日期：1991-12-01 00:00:00

abstract：:Paramecium tetraurelia is a unicellular organism that utilizes both axonemal and cytoplasmic dyneins. The highly conserved region containing the catalytic P-loop of the dynein heavy chain was amplified by RNA-directed polymerase chain reaction. Eight different P-loop-containing cDNA fragments were cloned. Southern hyb...

journal_title：Journal of cell science

authors： Asai DJ,Beckwith SM,Kandl KA,Keating HH,Tjandra H,Forney JD

更新日期：1994-04-01 00:00:00

abstract：:In fibroblasts, platelet-derived growth factor (PDGF) and epidermal growth factor (EGF) stimulate the formation of actin-rich, circular dorsal ruffles (CDRs) and phosphatidylinositol 3-kinase (PI3K)-dependent phosphorylation of Akt. To test the hypothesis that CDRs increase synthesis of phosphorylated Akt1 (pAkt), we ...

journal_title：Journal of cell science

authors： Yoshida S,Pacitto R,Sesi C,Kotula L,Swanson JA

更新日期：2018-11-16 00:00:00

abstract：:Embryonic stem (ES) cells are cells derived from the early embryo that can be propagated indefinitely in the primitive undifferentiated state while remaining pluripotent; they share these properties with embryonic germ (EG) cells. Candidate ES and EG cell lines from the human blastocyst and embryonic gonad can differe...

journal_title：Journal of cell science

authors： Pera MF,Reubinoff B,Trounson A

更新日期：2000-01-01 00:00:00

abstract：:The CHO1 antigen is a mitosis-specific kinesin-like motor located at the interzonal region of the spindle. The human cDNA coding for the antigen contains a domain with sequence similarity to the motor domain of kinesin-like protein (Nislow et al., Nature 359, 543, 1992). Here we cloned cDNAs encoding the CHO1 antigen ...

journal_title：Journal of cell science

authors： Kuriyama R,Dragas-Granoic S,Maekawa T,Vassilev A,Khodjakov A,Kobayashi H

更新日期：1994-12-01 00:00:00

abstract：:The mitotic spindle has long been recognized to play an essential role in determining the position of the cleavage furrow during cell division, however little is known about the mechanisms involved in this process. One attractive hypothesis is that signals from the spindle may function to induce reorganization of cort...

journal_title：Journal of cell science

authors： Fishkind DJ,Silverman JD,Wang YL

更新日期：1996-08-01 00:00:00

abstract：:We have characterised the functional regulation of the type-3 ryanodine receptor by the 12 kDa FK506-binding protein. Wild-type type-3 ryanodine receptor and mutant type-3 ryanodine receptor in which the critical valine at position 2322 in the central 12 kDa FK506-binding protein binding site was substituted by aspart...

journal_title：Journal of cell science

authors： Van Acker K,Bultynck G,Rossi D,Sorrentino V,Boens N,Missiaen L,De Smedt H,Parys JB,Callewaert G

更新日期：2004-03-01 00:00:00

abstract：:Cadherins and integrins are intrinsically linked through the actin cytoskeleton and share common signaling molecules. Although mechanosensing by the integrin-actin axis has long been appreciated, a growing body of literature now demonstrates that cadherins also transduce and respond to mechanical forces. Mounting evid...

journal_title：Journal of cell science

authors： Mui KL,Chen CS,Assoian RK

更新日期：2016-03-15 00:00:00

abstract：:Receptor protein tyrosine phosphatase beta (RPTP beta) mediates cell-cell and cell-matrix interactions. By searching for intracellular proteins that interact with the cytoplasmic region of this phosphatase using the two-hybrid method, we identified several proteins containing PDZ domains. One of these proteins, MAGI-3...

journal_title：Journal of cell science

authors： Adamsky K,Arnold K,Sabanay H,Peles E

更新日期：2003-04-01 00:00:00

abstract：:Meckel-Gruber syndrome (MKS) is a severe autosomal recessively inherited disorder caused by mutations in genes that encode components of the primary cilium and basal body. Here we show that two MKS proteins, MKS1 and meckelin, that are required for centrosome migration and ciliogenesis interact with actin-binding isof...

journal_title：Journal of cell science

authors： Dawe HR,Adams M,Wheway G,Szymanska K,Logan CV,Noegel AA,Gull K,Johnson CA

更新日期：2009-08-01 00:00:00

abstract：:Astrin is a mitotic-spindle-associated protein expressed in most human cell lines and tissues. However, its functions in spindle organization and mitosis have not yet been determined. Sequence analysis revealed that astrin has an N-terminal globular domain and an extended coiled-coil domain. Recombinant astrin was pur...

journal_title：Journal of cell science

authors： Gruber J,Harborth J,Schnabel J,Weber K,Hatzfeld M

更新日期：2002-11-01 00:00:00