Neuronal vulnerability of stroke-prone spontaneously hypertensive rats to ischemia and its prevention with antioxidants such as vitamin E.

abstract：:Physiological evidence has indicated that serotonin (5-hydroxytryptamine) could be a regulator of cerebral blood flow in various regions of the brain. In the present study, tryptophan hydroxylase immunocytochemistry was used to characterize, both at the light and electron microscopic levels, serotonergic nerve termina...

journal_title：Neuroscience

authors： Cohen Z,Ehret M,Maitre M,Hamel E

更新日期：1995-06-01 00:00:00

abstract：:In animal models of transients ischemia, selective vulnerability and delayed neuronal death in the hippocampus have been extensively described. However, little is known about selective damage in the neocortex and the thalamus, even though deficits in sensorimotor function are common in humans surviving hypoxic/ischemi...

journal_title：Neuroscience

authors： Lin CS,Polsky K,Nadler JV,Crain BJ

更新日期：1990-01-01 00:00:00

abstract：:In the present study we examined the effects of normal aging in the hippocampus and cerebellum, as well as behaviors associated with these substrates. A total of 67 CB6F1 hybrid mice were tested at one of five ages (4, 8, 12, 18 or 25 months) on the context pre-exposure facilitation effect (CPFE) modification of fear ...

journal_title：Neuroscience

authors： Kennard JA,Brown KL,Woodruff-Pak DS

更新日期：2013-09-05 00:00:00

abstract：:The antidromic activation of facial nucleus montoneurones has been studied in acute experiments on cats by means of extra- and intracellular recording techniques. Time and amplitude characteristics of separate components of the antidromic action potential and the after--potentials accompanying it have been analyzed. A...

journal_title：Neuroscience

authors： Fanardjian VV,Manvelyan LR,Kasabyan SA

更新日期：1983-08-01 00:00:00

abstract：:Sigma receptor (sigmaR), known as a unique nonopiate, nonphencyclidine brain receptor, can bind diverse classes of psychotropic drugs, neurosteroids and other synthetic compounds, such as (+)pentazocine, etc. Two types of sigmaRs have been identified: sigmaR1 and sigmaR2. In this work, we examined the expression of si...

journal_title：Neuroscience

authors： Liu LL,Wang L,Zhong YM,Yang XL

更新日期：2010-06-02 00:00:00

abstract：:The effects of excitatory amino acid antagonists on extracellular field potentials in the olfactory bulb produced by lateral olfactory tract stimulation were analysed in vivo. The compounds tested D-2-amino-5-phosphonovalerate, L-(+)2-amino-4-phosphonobutyrate, gamma-D-glutamylglycine, L-glutamic acid diethylester and...

journal_title：Neuroscience

authors： Jacobson I,Butcher S,Hamberger A

更新日期：1986-09-01 00:00:00

abstract：:Calcitonin gene-related peptide (CGRP) is a potent vasodilator and a neuromodulator implicated in the pathophysiology of migraine. It binds to the extracellular domains of calcitonin receptor-like receptor (CLR) and receptor activity-modifying protein (RAMP) 1 that together form the CGRP receptor. Antagonist antibodie...

journal_title：Neuroscience

authors： Miller S,Liu H,Warfvinge K,Shi L,Dovlatyan M,Xu C,Edvinsson L

更新日期：2016-07-22 00:00:00

abstract：:The vertebrate blood-brain barrier (BBB) creates an obstacle for central nervous system-related drug delivery. Claudin-5 (Cldn5), expressed in large quantities in BBB, plays a vital role in restricting BBB permeability. The C-terminal domain of Clostridium perfringens enterotoxin (cCPE) has been verified as binding to...

journal_title：Neuroscience

authors： Liao Z,Yang Z,Piontek A,Eichner M,Krause G,Li L,Piontek J,Zhang J

更新日期：2016-07-07 00:00:00

abstract：:The distribution of the enzyme protein-O-carboxylmethyltransferase (EC 2.1.1.24) has been investigated in the rat brain using both immunohistochemical and biochemical techniques. The enzyme, which carboxylmethylates free aspartic and glutamic acid residues of protein substrates, was localized in neurons, but not other...

journal_title：Neuroscience

authors： Billingsley ML,Kim S,Kuhn DM

更新日期：1985-05-01 00:00:00

abstract：:Microglia, the resident tissue macrophages of the central nervous system, have a highly differentiated morphology and do not express many of the antigens typically associated with other tissue macrophages. Activation of microglia is associated with a change in morphology and an increase in their repertoire of antigen ...

journal_title：Neuroscience

authors： Reid DM,Perry VH,Andersson PB,Gordon S

更新日期：1993-10-01 00:00:00

abstract：:It has been proposed that glutamatergic and dopaminergic systems are functionally opposed in their regulation of striatal output. The present study tested the effects of drugs that enhance AMPA-receptor-mediated glutamatergic transmission (ampakines) for their effects on dopamine-related alterations in cortical activi...

journal_title：Neuroscience

authors： Hess US,Whalen SP,Sandoval LM,Lynch G,Gall CM

更新日期：2003-01-01 00:00:00

abstract：:In mammals, the extraocular muscle fibers can be categorized in singly-innervated and multiply-innervated muscle fibers. In the monkey oculomotor, trochlear and abducens nucleus the motoneurons of multiply-innervated muscle fibers lie separated from those innervating singly-innervated muscle fibers and show different ...

journal_title：Neuroscience

authors： Eberhorn AC,Büttner-Ennever JA,Horn AK

更新日期：2006-02-01 00:00:00

abstract：:Dexamethasone (Dex) provides neuroprotection against subsequent hypoxia ischemia (HI) in newborn rats, but the mechanism of this neuroprotection is not well understood. It is known that vascular endothelial growth factor A (VEGF) has neuroprotective effects. The objective of this study was to evaluate the role of the ...

journal_title：Neuroscience

authors： Feng Y,Rhodes PG,Bhatt AJ

更新日期：2011-04-14 00:00:00

abstract：:The radioligands [3H]SCH 23390 and [3H]spiroperidol were used to label dopamine D1 and D2 receptors, respectively, in rat brain slices. Striatal sections were incubated in one of various concentrations of radioligand in the presence or absence of (+)-butaclamol and the resulting labeling was determined by liquid scint...

journal_title：Neuroscience

authors： Bardo MT,Hammer RP Jr

更新日期：1991-01-01 00:00:00

abstract：:The 5-HT(2A) serotonin receptor represents an important molecular target for atypical antipsychotic drugs and for most hallucinogens. In the mammalian cerebral cortex, 5-HT(2A) receptors are enriched in pyramidal neurons, within which 5-HT(2A) receptors are preferentially sorted to the apical dendrites. In primary cor...

journal_title：Neuroscience

authors： Xia Z,Hufeisen SJ,Gray JA,Roth BL

更新日期：2003-01-01 00:00:00

abstract：:Stress has long been associated with the development of neuropsychiatric and neurological disorders. The effects of stress vary depending upon the age during which the stress is incurred, the duration and severity of the stressor, and can further be influenced by levels of circulating gonadal hormones. To date, the ma...

journal_title：Neuroscience

authors： Bath KG,Schilit A,Lee FS

更新日期：2013-06-03 00:00:00

abstract：:Sensory neurons mediate diabetic peripheral neuropathy. Using a mouse model of diabetic peripheral neuropathy (BKS.Cg-m+/+Lepr(db)/J (db/db) mice) and cultured dorsal root ganglion (DRG) neurons, the present study showed that hyperglycemia downregulated miR-146a expression and elevated interleukin-1 receptor-activated...

journal_title：Neuroscience

authors： Wang L,Chopp M,Szalad A,Zhang Y,Wang X,Zhang RL,Liu XS,Jia L,Zhang ZG

更新日期：2014-02-14 00:00:00

abstract：:The results of a previous experiment suggest that the cell bodies of many jaw closing muscle spindle afferents in the trigeminal mesencephalic nucleus of the rabbit are phasically inhibited during fictive mastication. The aim of this study was to investigate one possible neurotransmitter system that could be involved ...

journal_title：Neuroscience

authors： Kolta A,Dubuc R,Lund JP

更新日期：1993-04-01 00:00:00

abstract：:Estradiol-induced plasticity involves changes in dendritic spine density and in the relative proportions of the different dendritic spine types that influence neurons and neural circuits. Such events affect brain structures that control the timing of neuroendocrine and behavioral processes, influencing both reproducti...

journal_title：Neuroscience

authors： González-Burgos I,Velázquez-Zamora DA,González-Tapia D,Cervantes M

更新日期：2015-07-09 00:00:00

abstract：:A new double-label autoradiographic glucose analog method for the sequential measurement of altered regional cerebral metabolic rates for glucose in the same animal is presented. This method is based on the sequential injection of two boluses of glucose tracer labeled with two different isotopes (short-lived 18F and l...

journal_title：Neuroscience

authors： Redies C,Diksic M,Evans AC,Gjedde A,Yamamoto YL

更新日期：1987-08-01 00:00:00

abstract：:Previous studies from our laboratory and others have shown that there are major age-related differences in brainstem neuronal function. Since GABAA receptors are major targets for GABA-mediated inhibitory modulation and play a key role in regulating cardiorespiratory function, especially during O2 deprivation, we exam...

journal_title：Neuroscience

authors： Xia Y,Haddad GG

更新日期：1992-08-01 00:00:00

abstract：:Vascular cognitive impairment and dementia (VCID) is the second leading cause of dementia behind Alzheimer's disease (AD) and is a frequent co-morbidity with AD. Despite its prevalence, little is known about the molecular mechanisms underlying the cognitive dysfunction resulting from cerebrovascular disease. Astrocyti...

journal_title：Neuroscience

authors： Sudduth TL,Weekman EM,Price BR,Gooch JL,Woolums A,Norris CM,Wilcock DM

更新日期：2017-01-26 00:00:00

abstract：:Organotypic cultures of fetal or early postnatal striatum were used to assess striatal patch formation and maintenance in the presence or absence of dopaminergic and glutamatergic influences. Vibratome-cut slices of the striatum prepared from embryonic day 19 to postnatal day 4 rat pups were maintained in static cultu...

journal_title：Neuroscience

authors： Snyder-Keller A,Costantini LC,Graber DJ

更新日期：2001-01-01 00:00:00

abstract：:Prolonged seizures (status epilepticus) induced by kainic acid activate programmed cell death mechanisms, and it is believed that kainic acid-induced status epilepticus induces neuronal apoptosis. In order to test this hypothesis, adult rats were subjected to 3-h kainic acid-induced seizures, with 24- or 72-h recovery...

journal_title：Neuroscience

authors： Fujikawa DG,Shinmei SS,Cai B

更新日期：2000-01-01 00:00:00

abstract：:The inhibitory neurotransmitter GABA is synthesized by glutamic acid decarboxylase (GAD), and two isoforms of this enzyme exist: GAD65 and GAD67. Immunocytochemical studies of the spinal cord have shown that whilst both are present in the dorsal horn, GAD67 is the predominant form in the ventral horn. The present stud...

journal_title：Neuroscience

authors： Mackie M,Hughes DI,Maxwell DJ,Tillakaratne NJ,Todd AJ

更新日期：2003-01-01 00:00:00

abstract：:The peculiar shape and disposition of Purkinje cell (PC) dendrites, planar and highly branched, offers an optimal model to analyze cellular and molecular regulators for the acquisition of neuronal dendritic trees. During the first 2 weeks after the end of the proliferation period, PCs undergo a 2-phase remodeling proc...

journal_title：Neuroscience

authors： Sotelo C,Dusart I

更新日期：2009-09-01 00:00:00

abstract：:Far from disproving the model of mind functioning proposed by psychoanalysis, the recent advances in neuropsychiatrical research confirmed the crucial ideas of Sigmund Freud. The hypothesis that the origin of mental illnesses lies in the impossibility for a subject to erase the long-term effects of a remote adverse ev...

journal_title：Neuroscience

authors： Centonze D,Siracusano A,Calabresi P,Bernardi G

更新日期：2005-01-01 00:00:00

abstract：:The beta-amyloid precursor protein is the precursor of the main component of senile plaques (the beta-amyloid peptide or beta/A4) found in the brain of aged humans and, in higher amounts, in the brain of Alzheimer's disease and Down's syndrome subjects. Four different forms of beta-amyloid precursor protein messenger ...

journal_title：Neuroscience

authors： Solà C,Mengod G,Probst A,Palacios JM

更新日期：1993-03-01 00:00:00

abstract：:Increases in plasma osmolality enhance nitric oxide (NO) levels in magnocellular neurosecretory cells (MNCs) of the supraoptic nucleus (SON) and modulate the secretion of both vasopressin (VP) and oxytocin (OT). In this paper, we describe the effects of hypertonicity on the electrical properties of MNCs by focusing on...

journal_title：Neuroscience

authors： da Silva MP,Ventura RR,Varanda WA

更新日期：2013-10-10 00:00:00

abstract：:Neurons in the hypothalamic arcuate nucleus (arcuate neurons) were traced on Golgi-impregnated sections. Dendrites of arcuate neurons showed characteristic orientation patterns. Dendrites along the lateral side follow the convex border of the nucleus by running parallel to the tanycyte processes. Neurons located in th...

journal_title：Neuroscience

authors： Réthelyi M

更新日期：1985-10-01 00:00:00