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Accounting for response misclassification and covariate measurement error improves power and reduces bias in epidemiologic studies.

Abstract：

PURPOSE:To quantify the impact of ignoring misclassification of a response variable and measurement error in a covariate on statistical power, and to develop software for sample size and power analysis that accounts for these flaws in epidemiologic data. METHODS:A Monte Carlo simulation-based procedure is developed to illustrate the differences in design requirements and inferences between analytic methods that properly account for misclassification and measurement error to those that do not in regression models for cross-sectional and cohort data. RESULTS:We found that failure to account for these flaws in epidemiologic data can lead to a substantial reduction in statistical power, over 25% in some cases. The proposed method substantially reduced bias by up to a ten-fold margin compared to naive estimates obtained by ignoring misclassification and mismeasurement. CONCLUSIONS:We recommend as routine practice that researchers account for errors in measurement of both response and covariate data when determining sample size, performing power calculations, or analyzing data from epidemiological studies.

journal_name

Ann Epidemiol

journal_title

Annals of epidemiology

authors

Cheng D,Branscum AJ,Stamey JD

doi

10.1016/j.annepidem.2010.03.012

subject

Has Abstract

pub_date

2010-07-01 00:00:00

pages

562-7

issue

7

eissn

1047-2797

issn

1873-2585

pii

S1047-2797(10)00058-X

journal_volume

20

pub_type

杂志文章

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