Abstract:
:Trimethylation of Lys36 in histone H3 (H3K36me3) coordinates events associated with the elongation phase of transcription and is also emerging as an important epigenetic regulator of cell growth and differentiation. We have identified the PWWP domain of bromo and plant homeodomain (PHD) finger-containing protein 1 (BRPF1) as a H3K36me3 binding module and have determined the structure of this domain in complex with an H3K36me3-derived peptide.
journal_name
Nat Struct Mol Bioljournal_title
Nature structural & molecular biologyauthors
Vezzoli A,Bonadies N,Allen MD,Freund SM,Santiveri CM,Kvinlaug BT,Huntly BJ,Göttgens B,Bycroft Mdoi
10.1038/nsmb.1797subject
Has Abstractpub_date
2010-05-01 00:00:00pages
617-9issue
5eissn
1545-9993issn
1545-9985pii
nsmb.1797journal_volume
17pub_type
杂志文章abstract:: ...
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