Abstract:
:A first attempt to attenuate the quorum sensing (QS) of a marine heterotroph microorganism, Vibrio fischeri , using signal molecule-sequestering polymers (SSPs) is presented. A set of rationally designed polymers with affinity toward a signal molecule of V. fischeri , N-(beta-ketocaproyl)-l-homoserine lactone (3-oxo-C6-AHL) was produced. It is reported that computationally designed polymers could sequester a signal molecule of V. fischeri and prevent QS-controlled phenotypes (in this case, bioluminescence) from being up-regulated. It was proven that the attenuation of bioluminescence of V. fischeri was due to sequestration of the signal molecule by specific polymers and not due to the toxicity of polymer or nonspecific depletion of nutrients. The ability to disrupt the bacterial communication using easy to synthesize and chemically inert polymers could provide a new concept for the development of pharmaceuticals and susceptible device coatings such as catheters.
journal_name
Biomacromoleculesjournal_title
Biomacromoleculesauthors
Piletska EV,Stavroulakis G,Karim K,Whitcombe MJ,Chianella I,Sharma A,Eboigbodin KE,Robinson GK,Piletsky SAdoi
10.1021/bm901451jsubject
Has Abstractpub_date
2010-04-12 00:00:00pages
975-80issue
4eissn
1525-7797issn
1526-4602journal_volume
11pub_type
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