Biodegradable stearylated peptide with internal disulfide bonds for efficient delivery of siRNA in vitro and in vivo.

abstract：:Steady state shear flow of different types of cellulose (microcrystalline, spruce sulfite and bacterial) dissolved in 1-ethyl-3-methylimidazolium acetate was studied in a large range of concentrations (0-15%) and temperatures (0-100 degrees C). Newtonian flow was recorded for all experimental conditions; these viscosi...

journal_title：Biomacromolecules

authors： Gericke M,Schlufter K,Liebert T,Heinze T,Budtova T

更新日期：2009-05-11 00:00:00

abstract：:A challenge in the development of multifunctional drug delivery systems is to establish a reasonable and effective synthetic route for multifunctional polymer preparation. Herein, we propose a unique protocol to prepare multifunctional micelles by a cross-assembly process using three different functional polyurethanes...

journal_title：Biomacromolecules

authors： Pan Z,Ren Y,Song N,Song Y,Li J,He X,Luo F,Tan H,Fu Q

更新日期：2016-06-13 00:00:00

abstract：:Light-harvesting antenna core (LH1-RC) complexes isolated from Rhodoseudomonas palustris were self-assembled on a gold electrode modified with self-assembled monolayers (SAMs) of the alkanethiols NH2(CH2)nSH, n = 2, 6, 8, 11; HOOC(CH2)7SH; and CH3(CH2)7SH, respectively. Adsorption of the LH1-RC complexes on the SAMs d...

journal_title：Biomacromolecules

authors： Kondo M,Nakamura Y,Fujii K,Nagata M,Suemori Y,Dewa T,Iida K,Gardiner AT,Cogdell RJ,Nango M

更新日期：2007-08-01 00:00:00

abstract：:Cross-linked homopolymers and copolymers of 2-hydroxyethyl methacrylate, HEMA, and ethylene glycol methacrylate phosphate, MOEP, have been synthesized, and the diffusion of water into these systems has been investigated. Only polymers with 0-20 mol % MOEP exhibited ideal swelling behavior as extensive fracturing occur...

journal_title：Biomacromolecules

authors： George KA,Wentrup-Byrne E,Hill DJ,Whittaker AK

更新日期：2004-07-01 00:00:00

abstract：:The currently used hemostatic agents are highly effective in stopping hemorrhages but have a limited role in the modulation of the wound-healing environment. Herein, we propose an intrinsically bioactive hemostatic cryogel based on platelet lysate (PL) and aldehyde-functionalized cellulose nanocrystals (a-CNCs). PL ha...

journal_title：Biomacromolecules

authors： Mendes BB,Gómez-Florit M,Araújo AC,Prada J,Babo PS,Domingues RMA,Reis RL,Gomes ME

更新日期：2020-09-14 00:00:00

abstract：:A new 320-member polymer library of end-modified poly(β-amino ester)s was synthesized. This library was chosen such that small differences to the structures of component backbone, side-chain, and end-group monomers could be systematically and simultaneously evaluated. The in vitro transfection efficacy and cytotoxicit...

journal_title：Biomacromolecules

authors： Sunshine JC,Akanda MI,Li D,Kozielski KL,Green JJ

更新日期：2011-10-10 00:00:00

abstract：:Tumorigenic cell behaviors can be suppressed or enhanced by their physicochemical environment. As a first step toward developing materials that allow tumorigenic behaviors to be observed and manipulated, we cultured related MCF10 breast cell lines on fibers composed of the Drosophila protein Ultrabithorax (Ubx). These...

journal_title：Biomacromolecules

authors： Hsiao HC,Santos A,Howell DW,Patterson JL,Fuchs-Young RS,Bondos SE

更新日期：2016-11-14 00:00:00

abstract：:Photoexcited TiO2 degrades biomolecules such as nucleic acids, cell membrane proteins, and enzymes. Stabilization of enzyme activity against the deactivation caused by the combination of TiO2-UV is essential if we are to develop novel hybrid materials exhibiting photocatalytic and biocatalytic activities useful for de...

journal_title：Biomacromolecules

authors： Lele BS,Russell AJ

更新日期：2004-09-01 00:00:00

abstract：:Despite recent advances in tumor treatment through cancer immunotherapy, the efficacy of this approach remains to be improved. Looking forward to high rates of objective clinical response, cancer immunotherapy combined with chemotherapy has gained increasing attention recently. Here, we constructed liposomes with matr...

journal_title：Biomacromolecules

authors： Liu Y,Chen XG,Yang PP,Qiao ZY,Wang H

更新日期：2019-02-11 00:00:00

abstract：:New aspects concerning the mechanism of formation of chitosan physical hydrogels without any cross-linking agent were studied. The gelation took place during the evaporation of a hydroalcoholic solution of chitosan. We first demonstrated that it was possible to form a physical hydrogel from a hydrochloride form of chi...

journal_title：Biomacromolecules

authors： Boucard N,Viton C,Domard A

更新日期：2005-11-01 00:00:00

abstract：:Highly fluorescent N-substituted 1-cyanobenz[f]isoindole chitosans (CBI-CSs) with various degrees of N-substitution (DS) were synthesized by reacting chitosan (CS) with naphthalene-2,3-dicarboxaldehyde (NDA) in the presence of cyanide under mild acidic conditions. Introduction of 1-cyanobenz[f]isoindole moieties into ...

journal_title：Biomacromolecules

authors： Gonil P,Sajomsang W,Ruktanonchai UR,Na Ubol P,Treetong A,Opanasopit P,Puttipipatkhachorn S

更新日期：2014-08-11 00:00:00

abstract：:The mechanical rigidity and degradation rate of hydrogels utilized as cell transplantation vehicles have been regarded as critical factors in new tissue formation. However, conventional approaches to accelerate the degradation rate of gels deteriorate their function as a mechanical support in parallel. We hypothesized...

journal_title：Biomacromolecules

authors： Kong HJ,Kaigler D,Kim K,Mooney DJ

更新日期：2004-09-01 00:00:00

abstract：:Nanofibrous biocomposite scaffolds of type I collagen and nanohydroxyapatite (nanoHA) of varying compositions (wt %) were prepared by electrostatic cospinning. The scaffolds were characterized for structure and morphology by Fourier transform infrared spectroscopy (FT-IR), scanning electron microscopy (SEM), atomic fo...

journal_title：Biomacromolecules

authors： Thomas V,Dean DR,Jose MV,Mathew B,Chowdhury S,Vohra YK

更新日期：2007-02-01 00:00:00

abstract：:A variety of important biological events are mediated by the multivalent interaction between relevant oligosaccharides and multiple saccharide receptors on lectins, toxins, and cell surfaces; a variety of glycopolymeric materials have therefore been investigated in studies aimed at manipulating these events. The synth...

journal_title：Biomacromolecules

authors： Polizzotti BD,Kiick KL

更新日期：2006-02-01 00:00:00

abstract：:A variety of natural polymers and proteins are considered to be 3D cell culture structures able to mimic the extracellular matrix (ECM) to promote bone tissue regeneration. Pectin, a natural polysaccharide extracted from the plant cell walls and having a chemical structure similar to alginate, provides interesting pro...

journal_title：Biomacromolecules

authors： Munarin F,Guerreiro SG,Grellier MA,Tanzi MC,Barbosa MA,Petrini P,Granja PL

更新日期：2011-03-14 00:00:00

abstract：:The clinical application of holmium-loaded poly(L-lactic acid) (PLLA) microspheres for the radionuclide treatment of liver malignancies requires in depth understanding of the degradation characteristics of the microspheres. To this end, an in-vitro degradation study was conducted. PLLA-microspheres with and without Ho...

journal_title：Biomacromolecules

authors： Zielhuis SW,Nijsen JF,Krijger GC,van het Schip AD,Hennink WE

更新日期：2006-07-01 00:00:00

abstract：:Ionic liquids (ILs) are composed only of ions. Of special interest to this review are those where at least one ion (the cation) is organic and whose melting points are below or not far above room temperature. ILs are designated as "green" solvents because they have extremely low vapor pressure, are non-inflammable, an...

journal_title：Biomacromolecules

authors： El Seoud OA,Koschella A,Fidale LC,Dorn S,Heinze T

更新日期：2007-09-01 00:00:00

abstract：:A poly[(R)-3-hydroxybutyrate] (P(3HB))-degrading marine bacterium (strain NK-1, JCM10458) was isolated from the Pacific Ocean deep-sea floor (1165 m in depth) in Japan. The organism was a motile and Gram negative, aerobic, and rod-shaped bacterium, and its DNA had a guanine-plus-cytosine content of 57.7 mol%. On the b...

journal_title：Biomacromolecules

authors： Kasuya K,Mitomo H,Nakahara M,Akiba A,Kudo T,Doi Y

更新日期：2000-07-01 00:00:00

abstract：:Heparins are widely used to prevent blood clotting during surgeries and for the treatment of thrombosis. However, bleeding associated with heparin therapy is a concern. Protamine, the only approved antidote for unfractionated heparin (UFH) could cause adverse cardiovascular events. Here, we describe a unique molecular...

journal_title：Biomacromolecules

authors： Kalathottukaren MT,Abbina S,Yu K,Shenoi RA,Creagh AL,Haynes C,Kizhakkedathu JN

更新日期：2017-10-09 00:00:00

abstract：:This study describes the first use of laccase-lipase enzymatic reaction for the synthesis of novel perfectly structured alternating copolymers. Initially, six types of complexing agents, linear(A)-linear(B), linear(A)-linear(B)-linear(A), linear-dendritic, dendritic-linear-dendritic, linear-hyperbranched, and hyperbra...

journal_title：Biomacromolecules

authors： Scheibel DM,Gitsov I

更新日期：2019-02-11 00:00:00

abstract：:We show that functionalizing polymer-coated colloidal nanoplatelets with guanosine groups allows synergistic increase of mechanical properties in nacre-mimetic lamellar self-assemblies. Anionic montmorillonite (MTM) was first coated using cationic poly(diallyldimethylammonium chloride) (PDADMAC) to prepare core-shell ...

journal_title：Biomacromolecules

authors： Martikainen L,Walther A,Seitsonen J,Berglund L,Ikkala O

更新日期：2013-08-12 00:00:00

abstract：:Minimally invasive implants and/or scaffolds integrated with multiple functionalities are of interest in the clinical settings. In this paper, chitosan (CTS) functionalized poly(lactic-co-glycolic acid) (PLGA) microspheres containing a model payload, lysozyme (Lyz), were prepared by a water-in-oil-in-water emulsion me...

journal_title：Biomacromolecules

authors： Bao M,Zhou Q,Dong W,Lou X,Zhang Y

更新日期：2013-06-10 00:00:00

abstract：:The elegant elasticity and toughness of muscles that are controlled by myofilament sliding, highly elastic springlike properties of titin, and Ca2+-induced conformational change of the troponin complex have been a source of inspiration to develop advanced materials for simulating elastic muscle motion. Herein, a highl...

journal_title：Biomacromolecules

authors： Zhao L,Zhang X,Luo Q,Hou C,Xu J,Liu J

更新日期：2020-10-12 00:00:00

abstract：:Poly(epsilon-caprolactone)/polylactide blend (PCL/PLA) is an interesting biomaterial because PCL and PLA present good complementarity in their physical properties and biodegradability. However, the thermodynamic incompatibility between two component polymers restricts further applications of their blend. In this work,...

journal_title：Biomacromolecules

authors： Wu D,Zhang Y,Zhang M,Yu W

更新日期：2009-02-09 00:00:00

abstract：:pH-dependent release from monoolein (MO) cubic phase was obtained by taking advantage of complex coacervation between hydrophobically modified alginate (HmAL) and hydrophobically modified silk fibroin (HmSF) in the water channels. The degree of coacervation was investigated at pH 3.0 by a light scattering method and t...

journal_title：Biomacromolecules

authors： Kwon TK,Kim JC

更新日期：2011-02-14 00:00:00

abstract：:Microbial biofilms are ubiquitous in nature, and they pose a serious threat to public health. Staphylococcus epidermidis is the most common clinical isolate from healthcare- and medical device-related biofilm infections. No antibiotic currently on the market can eradicate pathogenic biofilms, which contain complex def...

journal_title：Biomacromolecules

authors： Lam AK,Wouters CL,Moen EL,Pusavat J,Rice CV

更新日期：2019-10-14 00:00:00

abstract：:C13-dipeptides that did not gel on their own were found to form hydrogels when combined with mixtures (coassembly). At pH = 4.6, by mixing negatively charged C13-WD (C13-WD2- and/or C13-WD-) with C13-KW or C13-YK, where the side chain of K carried positive charge, two composite hydrogels with different mechanical prop...

journal_title：Biomacromolecules

authors： Hu T,Zhang Z,Euston SR,Geng M,Pan S

更新日期：2020-12-14 00:00:00

abstract：:Optimal curcumin delivery for medicinal applications requires a drug delivery system that both solubilizes curcumin and prevents degradation. To achieve this, curcumin has been encapsulated in submicrometer chitosan/Tween 20 particles via a benchtop spray-drying process. Spray-drying parameters have been optimized usi...

journal_title：Biomacromolecules

authors： O'Toole MG,Henderson RM,Soucy PA,Fasciotto BH,Hoblitzell PJ,Keynton RS,Ehringer WD,Gobin AS

更新日期：2012-08-13 00:00:00

abstract：:To devise a sensitive cellulase assay based on substrates having most of the physical characteristics of native cellulose, 5-(4,6-dichlorotriazinyl)aminofluorescein (DTAF) was used as a grafting agent to prepare suspensions of fluorescent microfibrils from bacterial cellulose. These suspensions were digested by a seri...

journal_title：Biomacromolecules

authors： Helbert W,Chanzy H,Husum TL,Schülein M,Ernst S

更新日期：2003-05-01 00:00:00

abstract：:We studied methoxy poly(ethylene glycol)-b-poly(ε-caprolactone)-b-poly(2-dimethylaminoethyl methacrylate) (mPEG-b-PCL-b-PDMAEMA) nanoparticles as the codelivery vector of hydrophobic drug and pDNA by employing dynamic light scattering (DLS), ζ potential, transmission electron microscopy (TEM), gel retardation assay, a...

journal_title：Biomacromolecules

authors： Yue X,Qiao Y,Qiao N,Guo S,Xing J,Deng L,Xu J,Dong A

更新日期：2010-09-13 00:00:00