Detecting larval export from marine reserves.

abstract：:Although the apoptotic role of caspases has been largely understood, accumulating evidence in Drosophila suggests that caspases also control other processes than apoptotic cell death. However, how caspases contribute to the development of the mammalian nervous system remains obscure. Here, we provide unique evidence t...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Ohsawa S,Hamada S,Kuida K,Yoshida H,Igaki T,Miura M

更新日期：2010-07-27 00:00:00

abstract：:The lactose permease of Escherichia coli catalyzes coupled translocation of galactosides and H(+) across the cell membrane. It is the best-characterized member of the Major Facilitator Superfamily, a related group of membrane proteins with 12 transmembrane domains that mediate transport of various substrates across ce...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Sorgen PL,Hu Y,Guan L,Kaback HR,Girvin ME

更新日期：2002-10-29 00:00:00

abstract：:China has experienced rapid urbanization and dramatic economic growth since its reform process started in late 1978. In this article, we present evidence for a significant urbanization effect on climate based on analysis of impacts of land-use changes on surface temperature in southeast China, where rapid urbanization...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Zhou L,Dickinson RE,Tian Y,Fang J,Li Q,Kaufmann RK,Tucker CJ,Myneni RB

更新日期：2004-06-29 00:00:00

abstract：:Inhibition of mitochondrial complex I is one of the leading hypotheses for dopaminergic neuron death associated with Parkinson's disease (PD). To test this hypothesis genetically, we used a mouse strain lacking functional Ndufs4, a gene encoding a subunit required for complete assembly and function of complex I. Delet...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Choi WS,Kruse SE,Palmiter RD,Xia Z

更新日期：2008-09-30 00:00:00

abstract：:MscS is a mechanosensitive channel that is ubiquitous among bacteria. Recent progress in the genome projects has revealed that homologs of MscS are also present in eukaryotes, but whether they operate as ion channels is unknown. In this study we cloned MSC1, a homolog of MscS in Chlamydomonas, and examined its functio...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Nakayama Y,Fujiu K,Sokabe M,Yoshimura K

更新日期：2007-04-03 00:00:00

abstract：:Extensive regeneration of the vertebrate body plan is found in salamander and fish species. In these organisms, regeneration takes place through reprogramming of differentiated cells, proliferation, and subsequent redifferentiation of adult tissues. Such plasticity is rarely found in adult mammalian tissues, and this ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Yun MH,Gates PB,Brockes JP

更新日期：2013-10-22 00:00:00

abstract：:BALB/c mice immunized with syngeneic methylcholanthrene-induced fibrosarcomas did not have antibodies against the unique tumor-specific transplantation antigens, even though they were capable of rejecting a lethal dose of tumor cells. Endogenous murine leukemia virus antigens expressed by certain of the tumors did, ho...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Brown JP,Klitzman JM,Hellström I,Nowinski RC,Hellström KE

更新日期：1978-02-01 00:00:00

abstract：:We established a pancreatic adenocarcinoma cell line (CFPAC-1) from a patient with cystic fibrosis (CF) and assessed some of its properties. The cells show epithelial morphology and express cytokeratin and oncofetal antigens characteristic of pancreatic duct cells. Basal and stimulated levels of cAMP and cAMP-dependen...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Schoumacher RA,Ram J,Iannuzzi MC,Bradbury NA,Wallace RW,Hon CT,Kelly DR,Schmid SM,Gelder FB,Rado TA

更新日期：1990-05-01 00:00:00

abstract：:The skeletal remains of a diminutive small-brained hominin found in Late Pleistocene cave deposits on the island of Flores, Indonesia were assigned to a new species, Homo floresiensis [Brown P, et al. (2004) A new small-bodied hominin from the Late Pleistocene of Flores, Indonesia. Nature 431: 1055-1061]. A dramatical...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Gordon AD,Nevell L,Wood B

更新日期：2008-03-25 00:00:00

abstract：:Light chain allotypic determinants were demonstrated on the surface of peripheral blood lymphocytes of rabbits. By means of a combined immunofluorescent and autoradiographic technique, a great majority of the individual lymphocytes of rabbits heteroxygous at the b locus were shown to have detectable quantities of only...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Davie JM,Paul WE,Mage RG,Goldman MB

更新日期：1971-02-01 00:00:00

abstract：:Protozoan parasites of the genus Leishmania undergo a complex life cycle involving transmission by biting sand flies and replication within mammalian macrophage phagolysosomes. A major component of the Leishmania surface coat is the glycosylphosphatidylinositol (GPI)-anchored polysaccharide called lipophosphoglycan (L...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Späth GF,Epstein L,Leader B,Singer SM,Avila HA,Turco SJ,Beverley SM

更新日期：2000-08-01 00:00:00

abstract：:Fusions of the lac operon to genes induced by treatment with sublethal levels of alkylating agents have been selected from random insertions of the Mu-dl(ApRlac) phage by screening for induction of beta-galactosidase activity in the presence of methyl methanesulfonate. Genetic analysis reveals that these fusions resul...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Volkert MR,Nguyen DC

更新日期：1984-07-01 00:00:00

abstract：:Expression of alphavbeta3- or alphavbeta5-integrins and selectins is widespread on blood cells and endothelial cells. Here we report that human tumor cells injected s.c. into mice lacking beta3- or beta3/beta5-integrins or various selectins show enhanced tumor growth compared with growth in control mice. There was inc...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Taverna D,Moher H,Crowley D,Borsig L,Varki A,Hynes RO

更新日期：2004-01-20 00:00:00

abstract：:Control over structural transformations in supramolecular entities by external stimuli is critical for the development of adaptable and functional soft materials. Herein, we have designed and synthesized a dipyridyl donor containing a central Z-configured stiff-stilbene unit that self-assembles in the presence of two ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Yan X,Xu JF,Cook TR,Huang F,Yang QZ,Tung CH,Stang PJ

更新日期：2014-06-17 00:00:00

abstract：:Cell-to-cell communication is essential for the development and patterning of multicellular organisms. In plants, plasmodesmata (PD) provide direct routes for intercellular signaling. However, the role that PD-mediated signaling plays in plant development has not been fully investigated. To gain a comprehensive view o...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Wu S,O'Lexy R,Xu M,Sang Y,Chen X,Yu Q,Gallagher KL

更新日期：2016-10-11 00:00:00

abstract：:Palmitoylation is a common lipid modification known to regulate the functional properties of various proteins and is a vital step in the biosynthesis of voltage-activated sodium (Nav) channels. We discovered a mutation in an intracellular loop of rNav1.2a (G1079C), which results in a higher apparent affinity for exter...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Bosmans F,Milescu M,Swartz KJ

更新日期：2011-12-13 00:00:00

abstract：:A three-step purification procedure for the isolation of heart muscle chalones is described. The method uses ultrafiltration followed by concanavalin A-Sepharose affinity chromatography and subsequent sucrose density gradient centrifugation. Analytical ultracentrifugation of the highly purified chalone fraction indica...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Kriek JA,van der Walt BJ,Bester AJ

更新日期：1981-07-01 00:00:00

abstract：:Molecules of keystone significance are relatively rare, yet mediate a variety of interactions between organisms. They influence the distribution and abundance of species, the transfer of energy across multiple trophic levels, and thus they play significant roles in structuring ecosystems. Despite their potential impor...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Kicklighter CE,Kamio M,Nguyen L,Germann MW,Derby CD

更新日期：2011-07-12 00:00:00

abstract：:The major late transcriptional unit of adenovirus type 2 has served as a model for studying transcription in eukaryotes. We report that pausing and premature termination are intrinsic to the transcription of this transcriptional unit by RNA polymerase II. In vivo and in isolated nuclei, transcription pauses at discret...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Maderious A,Chen-Kiang S

更新日期：1984-10-01 00:00:00

abstract：:Evidence is presented that suggests that GTP (or 5'-guanylylmethylene diphosphonate) is not essential for either formation of an AUG-directed, initiation factor IF-2-dependent initiation complex on the 30S subunit or for positioning of fMet-tRNA on the peptidyl site. However, recycling of limiting amounts of IF-2 requ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Mazumder R

更新日期：1972-10-01 00:00:00

abstract：:We have examined the use of our bis(sulfonamide) diol ligand (1) in the asymmetric addition of phenyl groups to cyclic alpha,beta-unsaturated ketones. Good to excellent enantioselectivities have been obtained with cyclic enones bearing alkyl substituents in the 2 position (71-97% enantiomeric excess). Furthermore, exc...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Li H,García C,Walsh PJ

更新日期：2004-04-13 00:00:00

abstract：:The rat W3/25 antigen was the first marker antigen of helper T lymphocytes to be identified. Subsequently, the human OKT4 antigen (now called CD4) was described, and cell distribution and functional data suggested that W3/25 and OKT4 antigens were homologous. This is now confirmed by the matching of peptide sequences ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Clark SJ,Jefferies WA,Barclay AN,Gagnon J,Williams AF

更新日期：1987-03-01 00:00:00

abstract：:Because synaptic vesicle exocytosis is a nano-mechanical process, it should be influenced by the mechanical properties of the cell membrane to which the vesicle fuses. By dissolving surfactants at various concentrations in the neuronal membrane, we have perturbed mechanical properties of the membrane and have found th...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Zhu Y,Stevens CF

更新日期：2008-11-18 00:00:00

abstract：:In animals, successful production of the visual chromophore (11-cis-retinal or derivatives thereof such as 11-cis-3-hydroxy-retinal) is essential for photoreceptor cell function and survival. These carotenoid-derived compounds must combine with a protein moiety (the opsin) to establish functional visual pigments. Evid...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Oberhauser V,Voolstra O,Bangert A,von Lintig J,Vogt K

更新日期：2008-12-02 00:00:00

abstract：:Mutations affecting mismatch repair result in elevated frequencies of microsatellite length alteration in prokaryotes and eukaryotes. However, the finding that microsatellite instability is found often in cells with a functional mismatch repair system prompted a search for other factors of tract alteration. In the pre...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Morel P,Reverdy C,Michel B,Ehrlich SD,Cassuto E

更新日期：1998-08-18 00:00:00

abstract：:When various wild strains of Penicillium lanosum and Aspergillus niger were placed in the same mild laboratory environment, their frequencies of new spontaneous mutations were clearly related to whether they had been isolated from a region of high or low microclimatic stress. In the mild environment, the total frequen...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Lamb BC,Mandaokar S,Bahsoun B,Grishkan I,Nevo E

更新日期：2008-04-15 00:00:00

abstract：:In nine patients with GM1 gangliosidosis, liver ganglioside GM1 beta-galactosidase (EC 3.2.1.23) activity ranged from less than 0.01% to 0.05% of normal. In a tenth patient's liver, much higher activity was found (0.5% of normal). In this patient the residual enzyme had the same molecular weight as beta-galactosidase ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Norden AG,O'Brien JS

更新日期：1975-01-01 00:00:00

abstract：:Using Drosophila pseudoobscura, we tested the hypothesis that social constraints on the free expression of mate preferences, by both females and males, decrease offspring viability and reproductive success of mating pairs. Mate preference arenas eliminated intrasexual combat and intersexual coercion. The time female a...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Anderson WW,Kim YK,Gowaty PA

更新日期：2007-03-13 00:00:00

abstract：:The proboscis is an important head appendage in insects that has primarily been thought to process gustatory information during food intake. Indeed, in Drosophila and other insects in which they have been identified, most gustatory receptors are expressed in proboscis neurons. Our previous characterization of the expr...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Kwon HW,Lu T,Rützler M,Zwiebel LJ

更新日期：2006-09-05 00:00:00

abstract：:Metal-inducible transcription of metallothionein (MT) genes involves the interaction of metal-responsive trans-acting factors with specific promoter DNA sequence elements. In this report, we present a genetic selection using the baker's yeast, Saccharomyces cerevisiae, to clone a gene from Candida glabrata encoding a ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Zhou PB,Thiele DJ

更新日期：1991-07-15 00:00:00