Abstract:
:Although the apoptotic role of caspases has been largely understood, accumulating evidence in Drosophila suggests that caspases also control other processes than apoptotic cell death. However, how caspases contribute to the development of the mammalian nervous system remains obscure. Here, we provide unique evidence that Apaf-1/caspase-9-mediated caspase signaling regulates the development of olfactory sensory neurons (OSNs), which includes axonal projection, synapse formation, and maturation of these neurons. This caspase signaling leads to a cleavage of Semaphorin 7A, a membrane-anchored semaphorin that is required for the proper axonal projection. Mutant mice deficient for apaf-1 or caspase-9 exhibit misrouted axons, impaired synaptic formation, and defects in the maturation of OSNs without affecting the number of these cells. Our findings suggest that Apaf-1/caspase-9-mediated nonapoptotic caspase signaling is required for the proper neural network formation during olfactory development.
journal_name
Proc Natl Acad Sci U S Aauthors
Ohsawa S,Hamada S,Kuida K,Yoshida H,Igaki T,Miura Mdoi
10.1073/pnas.0910488107subject
Has Abstractpub_date
2010-07-27 00:00:00pages
13366-71issue
30eissn
0027-8424issn
1091-6490pii
0910488107journal_volume
107pub_type
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