Exocytosis regulates urinary acidification in turtle bladder by rapid insertion of H+ pumps into the luminal membrane.

abstract：:The structure of the antigen-binding fragment (Fab) of an anti-phenylarsonate monoclonal antibody (36-71) bearing a major crossreacting idiotype of A/J mice has been solved and refined to an R factor of 19.3% at a resolution of 2.9 A. An initial electron density map was obtained with phase information from a total of ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Rose DR,Strong RK,Margolies MN,Gefter ML,Petsko GA

更新日期：1990-01-01 00:00:00

abstract：:Estimates of 21st Century global-mean surface temperature increase have generally been based on scenarios that do not include climate policies. Newly developed multigas mitigation scenarios, based on a wide range of modeling approaches and socioeconomic assumptions, now allow the assessment of possible impacts of clim...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Van Vuuren DP,Meinshausen M,Plattner GK,Joos F,Strassmann KM,Smith SJ,Wigley TM,Raper SC,Riahi K,de la Chesnaye F,den Elzen MG,Fujino J,Jiang K,Nakicenovic N,Paltsev S,Reilly JM

更新日期：2008-10-07 00:00:00

abstract：:Asn-linked glycans (N-glycans) play important roles in the quality control (QC) of glycoprotein folding in the endoplasmic reticulum (ER) lumen and in ER-associated degradation (ERAD) of proteins by cytosolic proteasomes. A UDP-Glc:glycoprotein glucosyltransferase glucosylates N-glycans of misfolded proteins, which ar...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Banerjee S,Vishwanath P,Cui J,Kelleher DJ,Gilmore R,Robbins PW,Samuelson J

更新日期：2007-07-10 00:00:00

abstract：:Commonly considered strategies for reducing the environmental impact of light-duty transportation include using alternative fuels and improving vehicle fuel economy. We evaluate the air quality-related human health impacts of 10 such options, including the use of liquid biofuels, diesel, and compressed natural gas (CN...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Tessum CW,Hill JD,Marshall JD

更新日期：2014-12-30 00:00:00

abstract：:The Alzheimer A beta amyloid peptide (A beta) is the principal proteinaceous component of amyloid associated with Alzheimer disease (AD). We have determined the relative abundance of A beta structural variants present in amyloid from brains of 10 individuals with sporadic AD, 2 individuals with familial AD carrying sp...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Näslund J,Schierhorn A,Hellman U,Lannfelt L,Roses AD,Tjernberg LO,Silberring J,Gandy SE,Winblad B,Greengard P

更新日期：1994-08-30 00:00:00

abstract：:Humans choose actions based on both habit and planning. Habitual control is computationally frugal but adapts slowly to novel circumstances, whereas planning is computationally expensive but can adapt swiftly. Current research emphasizes the competition between habits and plans for behavioral control, yet many complex...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Cushman F,Morris A

更新日期：2015-11-10 00:00:00

abstract：:Osteocalcin, a bone-specific protein and marker of the mature osteoblast, is expressed only in nonproliferating osteoblasts in a mineralizing extracellular matrix, while type I collagen is expressed in proliferating cells. The nuclear proteins encoded by the c-fos and c-jun protooncogenes are expressed during the prol...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Owen TA,Bortell R,Yocum SA,Smock SL,Zhang M,Abate C,Shalhoub V,Aronin N,Wright KL,van Wijnen AJ

更新日期：1990-12-01 00:00:00

abstract：:Distinct subsets of thymic epithelial cells (TECs) support T-cell development and selection. Isolated TECs contain multicellular complexes that enclose many viable thymocytes. However, the functions of those TECs, termed thymic nurse cells (TNCs), are unclear and the idea that TNCs are present in vivo is questioned. H...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Nakagawa Y,Ohigashi I,Nitta T,Sakata M,Tanaka K,Murata S,Kanagawa O,Takahama Y

更新日期：2012-12-11 00:00:00

abstract：:The F(1)F(0) ATP synthase is the smallest motor enzyme known. Previous studies had established that the central stalk, made of the gamma and epsilon subunits in the F(1) part and c subunit ring in the F(0) part, rotates relative to a stator composed of alpha(3)beta(3)deltaab(2) during ATP hydrolysis and synthesis. How...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Tsunoda SP,Rodgers AJ,Aggeler R,Wilce MC,Yoshida M,Capaldi RA

更新日期：2001-06-05 00:00:00

abstract：:The ability to analyze and isolate cells based on the expression of specific surface markers has increased our understanding of cell biology and produced numerous applications for biomedicine. However, established cell-sorting platforms rely on labels that are limited in number due to biophysical constraints, such as ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Dahotre SN,Chang YM,Wieland A,Stammen SR,Kwong GA

更新日期：2018-04-24 00:00:00

abstract：:Dimers of bacteriochlorophyll a (Bchla) with optical absorption maximum at 853 nm and a nonconservative circular dichroism spectrum are formed in a solution of formamide/water that contains micelles of Triton X-100. The apparent equilibrium constant and the corresponding Gibbs energy change for the Bchl self-organizat...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Scherz A,Rosenbach-Belkin V

更新日期：1989-03-01 00:00:00

abstract：:3T3 cells that have undergone adipose differentiation in vitro secrete into the culture medium a potent growth stimulatory activity for bovine aortic endothelial cells. When medium containing 2% fetal calf serum, which does not support significant endothelial cell growth, is conditioned by 3T3-F442A adipocytes, the en...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Castellot JJ Jr,Karnovsky MJ,Spiegelman BM

更新日期：1980-10-01 00:00:00

abstract：:Mesenteric fat is known to undergo inflammatory changes after 2,4,6,-trinitrobenzensulphonic acid (TNBS)-induced colitis. Neurotensin (NT) and neurotensin receptor 1 (NTR1) have been shown to play a major role in the pathogenesis of intestinal inflammation. This led us to explore whether NT and NTR1 are expressed in t...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Koon HW,Kim YS,Xu H,Kumar A,Zhao D,Karagiannides I,Dobner PR,Pothoulakis C

更新日期：2009-05-26 00:00:00

abstract：:Clinical data showing correlations between low thyroid-stimulating hormone (TSH) levels and high bone turnover markers, low bone mineral density, and an increased risk of osteoporosis-related fractures are buttressed by mouse genetic and pharmacological studies identifying a direct action of TSH on the skeleton. Here ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Sun L,Zhu LL,Lu P,Yuen T,Li J,Ma R,Baliram R,Moonga SS,Liu P,Zallone A,New MI,Davies TF,Zaidi M

更新日期：2013-06-11 00:00:00

abstract：:Neurons in the mammalian suprachiasmatic nuclei (SCN) generate daily rhythms in physiology and behavior, but it is unclear how they maintain and synchronize these rhythms in vivo. We hypothesized that parallel signaling pathways in the SCN are required to synchronize rhythms in these neurons for coherent output. We re...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Aton SJ,Huettner JE,Straume M,Herzog ED

更新日期：2006-12-12 00:00:00

abstract：:The ability to predictably control the coassembly of multiple nanoscale building blocks, especially those with disparate chemical and physical properties such as biomolecules and inorganic nanoparticles, has far-reaching implications in catalysis, sensing, and photonics, but a generalizable strategy for engineering sp...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Brodin JD,Auyeung E,Mirkin CA

更新日期：2015-04-14 00:00:00

abstract：:Actin-myosin subfragment-1 (SF-1) or actin-heavy meromyosin is dissociated by the binding of ADP and vanadate (Vi) under conditions such that ADP alone does not dissociate the complex. The association constant of the stable complex M.ADP.Vi, in which M indicates myosin [Goodno, C. C. (1979) Proc. Natl. Acad. Sci. USA ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Goodno CC,Taylor EW

更新日期：1982-01-01 00:00:00

abstract：:Remembering and discriminating objects based on their previously learned values are essential for goal-directed behaviors. While the cerebral cortex is known to contribute to object recognition, surprisingly little is known about its role in retaining long-term object-value associations. To address this question, we t...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Ghazizadeh A,Griggs W,Leopold DA,Hikosaka O

更新日期：2018-02-27 00:00:00

abstract：:A critical step in the induction of apoptosis is the activation of the apoptotic initiator caspase 9. We show that at its normal physiological concentration, caspase 9 is primarily an inactive monomer (zymogen), and that activity is associated with a dimeric species. At the high concentrations used for crystal formati...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Renatus M,Stennicke HR,Scott FL,Liddington RC,Salvesen GS

更新日期：2001-12-04 00:00:00

abstract：:The neuronal nucleus plays a vital role in information processing, but whether it supports computational functions such as paired-pulse facilitation, comparable to synapses, is unclear. Ca(2+)-dependent movement of calmodulin (CaM) to the nucleus is highly responsive to Ca(2+) entry through L-type channels and promote...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Mermelstein PG,Deisseroth K,Dasgupta N,Isaksen AL,Tsien RW

更新日期：2001-12-18 00:00:00

abstract：:Pre-mRNA splicing requires the bridging of the 5' and 3' ends of the intron. In yeast, this bridging involves interactions between the WW domains in the splicing factor PRP40 and a proline-rich domain in the branchpoint binding protein, BBP. Using a proline-rich domain derived from formin (a product of the murine limb...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Bedford MT,Reed R,Leder P

更新日期：1998-09-01 00:00:00

abstract：:Regulation of gene expression is usually separated into cis and trans components. The separation may become artificial if much of the variation in expression is under multigenic and epistatic (e.g., cis-by-trans) control. There is hence a need to quantify the relative contribution of cis, trans, and cis-by-trans effec...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Wang HY,Fu Y,McPeek MS,Lu X,Nuzhdin S,Xu A,Lu J,Wu ML,Wu CI

更新日期：2008-04-29 00:00:00

abstract：:The ability of long-term cultured and monoclonal T cell populations to provide antigen-specific help was assessed in a system of Ir gene-controlled in vitro antibody responses to soluble antigens. T-cell colonies and monoclonal T-cell lines were generated which proliferated specifically in response to poly(LTyr,Glu)-p...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Hodes RJ,Kimoto M,Hathcock KS,Fathman CG,Singer A

更新日期：1981-10-01 00:00:00

abstract：:The MLL (mixed-lineage leukemia) gene is involved in many chromosomal translocations associated with acute myeloid and lymphoid leukemia. We previously identified a transcriptional repression domain in MLL, which contains a region with homology to DNA methyltransferase. In chromosomal translocations, the MLL repressio...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Xia ZB,Anderson M,Diaz MO,Zeleznik-Le NJ

更新日期：2003-07-08 00:00:00

abstract：:We recognize, understand, and interact with objects through both vision and touch. Conceivably, these two sensory systems encode object shape in similar ways, which could facilitate cross-modal communication. To test this idea, we studied single neurons in macaque monkey intermediate visual (area V4) and somatosensory...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Yau JM,Pasupathy A,Fitzgerald PJ,Hsiao SS,Connor CE

更新日期：2009-09-22 00:00:00

abstract：:The peroxisome proliferator-activated receptor gamma coactivator 1-alpha (PGC-1α) is a transcriptional coactivator that controls expression of metabolic/energetic genes, programming cellular responses to nutrient and environmental adaptations such as fasting, cold, or exercise. Unlike other coactivators, PGC-1α contai...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Tavares CDJ,Aigner S,Sharabi K,Sathe S,Mutlu B,Yeo GW,Puigserver P

更新日期：2020-09-08 00:00:00

abstract：:Unlike other cation channels, each subunit of most transient receptor potential (TRP) channels has an additional TRP-domain helix with an invariant tryptophan immediately trailing the gate-bearing S6. Recent cryo-electron microscopy of TRP vanilloid subfamily, member 1 structures revealed that this domain is a five-tu...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Teng J,Loukin SH,Anishkin A,Kung C

更新日期：2015-03-17 00:00:00

abstract：:In vivo phage display identifies peptides that selectively home to the vasculature of individual organs, tissues, and tumors. Here we report the identification of a cyclic nonapeptide, CPGPEGAGC, which homes to normal breast tissue with a 100-fold selectivity over nontargeted phage. The homing of the phage is inhibite...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Essler M,Ruoslahti E

更新日期：2002-02-19 00:00:00

abstract：:A Down's syndrome associated gene, Single Minded 2 gene short form (SIM2-s), is specifically expressed in colon tumors but not in the normal colon. Antisense inhibition of SIM2-s in a RKO-derived colon carcinoma cell line causes growth inhibition, apoptosis, and inhibition of tumor growth in a nude mouse tumoriginicit...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Aleman MJ,DeYoung MP,Tress M,Keating P,Perry GW,Narayanan R

更新日期：2005-09-06 00:00:00

abstract：:The type of cytokines produced during T cell responses determines susceptibility or resistance to many pathogens and influences the development of autoimmunity and allergy. To define the role of individual accessory molecules in cytokine production during primary immune responses, Drosophila cell lines expressing muri...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Luksch CR,Winqvist O,Ozaki ME,Karlsson L,Jackson MR,Peterson PA,Webb SR

更新日期：1999-03-16 00:00:00