Abstract:
:Fragile sites are intriguing cytogenetic phenomena that have been extensively investigated in human and laboratory animal chromosomes over the past 40 years, but domestic animal species have been studied sporadically. Interest in the field has been recently renewed as increasing numbers of fragile site regions are cloned and characterized at the molecular level. Despite much effort, mechanisms by which specific DNA sequence confers fragility to a chromosome region remain unclear. Recent advancements in sequencing and mapping of domestic animal genomes provide tools for molecular characterization of fragile sites in animal chromosomes. Future comparative efforts may contribute insight into both the mechanisms that underlie chromosome fragility, and forces that drive rearrangements observed throughout evolution, and somatic changes that can result in disease or impair fertility.
journal_name
Cytogenet Genome Resjournal_title
Cytogenetic and genome researchauthors
Riggs PK,Rønne Mdoi
10.1159/000245910subject
Has Abstractpub_date
2009-01-01 00:00:00pages
97-109issue
1-2eissn
1424-8581issn
1424-859Xpii
000245910journal_volume
126pub_type
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