Fragile sites in domestic animal chromosomes: molecular insights and challenges.

Abstract:

:Fragile sites are intriguing cytogenetic phenomena that have been extensively investigated in human and laboratory animal chromosomes over the past 40 years, but domestic animal species have been studied sporadically. Interest in the field has been recently renewed as increasing numbers of fragile site regions are cloned and characterized at the molecular level. Despite much effort, mechanisms by which specific DNA sequence confers fragility to a chromosome region remain unclear. Recent advancements in sequencing and mapping of domestic animal genomes provide tools for molecular characterization of fragile sites in animal chromosomes. Future comparative efforts may contribute insight into both the mechanisms that underlie chromosome fragility, and forces that drive rearrangements observed throughout evolution, and somatic changes that can result in disease or impair fertility.

journal_name

Cytogenet Genome Res

authors

Riggs PK,Rønne M

doi

10.1159/000245910

subject

Has Abstract

pub_date

2009-01-01 00:00:00

pages

97-109

issue

1-2

eissn

1424-8581

issn

1424-859X

pii

000245910

journal_volume

126

pub_type

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