Controversy surrounding the role for routine central lymph node dissection for differentiated thyroid cancer.

abstract：PURPOSE OF REVIEW:Relapse has become the leading cause of death following allogeneic hematopoietic stem cell transplantation (HSCT). Despite improved understanding of the biology that underlies the graft-versus-leukemia/tumor effect the relapse rate did not decrease over the past 20 years. In general, prognosis is poor...

journal_title：Current opinion in oncology

authors： Kröger N

更新日期：2011-03-01 00:00:00

abstract：PURPOSE OF REVIEW:The purpose of this review is to highlight recent studies on mammalian sirtuins that coordinately regulate cellular metabolic homeostasis upon fasting and to summarize the beneficial effects of fasting on carcinogenesis and cancer therapy. RECENT FINDINGS:Recent studies have demonstrated that fasting...

journal_title：Current opinion in oncology

authors： Zhu Y,Yan Y,Gius DR,Vassilopoulos A

更新日期：2013-11-01 00:00:00

abstract：:The publication of the proceedings of Fourth Workshop on Carcinoma in situ was an impressive leap in our understanding of the interaction between prenatal and postpubertal factors in the development of germ cell cancer as well as increased insight into the molecular events that are involved in the development of these...

journal_title：Current opinion in oncology

authors： Oliver RT

更新日期：1999-05-01 00:00:00

abstract：PURPOSE OF REVIEW:Significant advances have been made in the treatment of younger patients with acute myeloid leukemia over the past 3 decades, but prognosis in the elderly has remained dismal, with median survival times of only a few months. Although a small percentage of older patients may be cured by standard chemot...

journal_title：Current opinion in oncology

authors： Amadori S,Del Principe MI,Venditti A

更新日期：2014-11-01 00:00:00

abstract：:The development of non-myeloablative and reduced-intensity conditioning regimens has enabled older or medically infirm patients with myeloid malignancies to be treated with allogeneic hematopoietic cell transplantation (HCT). The regimens are sufficiently immunosuppressive to allow engraftment of allogeneic cells and ...

journal_title：Current opinion in oncology

authors： Storb R

更新日期：2009-06-01 00:00:00

abstract：PURPOSE OF REVIEW:Early trials of high-dose therapy with autologous stem cell transplantation in mantle cell lymphoma were discouraging, with no clear survival advantage attributable to the procedure. Most early series were plagued by small numbers, retrospective designs, and short follow-up. Also, until recently, allo...

journal_title：Current opinion in oncology

authors： Jacobsen E,Freedman A

更新日期：2004-03-01 00:00:00

abstract：PURPOSE OF REVIEW:To evaluate the application of narrative within medical practice. Illness like cancer constitutes a biographical disruption that occurs several times during the disease, from diagnosis to complications and treatments. This review analyzes the interest of narrative ethics in medicine with a focus on ca...

journal_title：Current opinion in oncology

authors： Lossignol D

更新日期：2014-07-01 00:00:00

abstract：PURPOSE OF REVIEW:Advances in the health system and medical sciences are continuously pushing the barrier of life-expectancy. As a consequence, humans are being increasingly afflicted by age-associated diseases, such as cancer. The challenge now lies in understanding the mechanisms underlying ageing in order to reduce ...

journal_title：Current opinion in oncology

authors： Pereira B,Ferreira MG

更新日期：2013-01-01 00:00:00

abstract：PURPOSE OF REVIEW:Sarcomas are a diverse group of rare solid tumors with limited treatment options for patients with advanced, inoperable disease. Cabozantinib is a tyrosine kinase inhibitor currently approved for advanced renal cell, hepatocellular, and medullary thyroid carcinoma. Cabozantinib has potent activity aga...

journal_title：Current opinion in oncology

authors： Schöffski P,Blay JY,Ray-Coquard I

更新日期：2020-07-01 00:00:00

abstract：:Obstruction of the superior vena cava is seldom a true emergency and should not be treated without an adequate tissue diagnosis. For patients who are poor operative risks for invasive procedures, percutaneous biopsies of mediastinal masses under ultrasound guidance have resulted in a high diagnostic yield. Superior ve...

journal_title：Current opinion in oncology

authors： Shepherd FA

更新日期：1995-03-01 00:00:00

abstract：PURPOSE OF REVIEW:The purpose of this review is to highlight the most important developments in the diagnosis, prevention, and management of prostate cancer reported in the past year that have been published in the medical literature. RECENT FINDINGS:Recent research has yielded important insights into the effects of l...

journal_title：Current opinion in oncology

authors： Ryan CJ,Small EJ

更新日期：2004-05-01 00:00:00

abstract：PURPOSE OF REVIEW:Molecular genetic alterations characterize the development of human cancer. Recent advances in molecular genetic technology and the success of the human genome project have empowered investigators with new tools in dissecting the cancer genome for discovery of new cancer-associated genes. The purpose ...

journal_title：Current opinion in oncology

authors： Shih IeM,Wang TL

更新日期：2005-01-01 00:00:00

abstract：PURPOSE OF REVIEW:Gastroenteropancreatic neuroendocrine tumors (GEP-NETs) constitute a diverse group of neoplasms arising from the diffuse neuroendocrine cell system. During the last 2 years a new classification system, the WHO 2010, has come into clinical practice together with Tumor Nodes Metastases (TNM) staging and...

journal_title：Current opinion in oncology

authors： Oberg K

更新日期：2012-07-01 00:00:00

abstract：PURPOSE OF REVIEW:Atypical lipomatous tumors/well-differentiated liposarcomas (ALT/WDLs) are one of the more frequent mesenchymal neoplasms and are characterized by specific chromosome aberrations: supernumerary chromosome or giant marker chromosome or both. Extra copies of known oncogenes such as MDM2, CDK4, SAS, HMGA...

journal_title：Current opinion in oncology

authors： Arrigoni G,Doglioni C

更新日期：2004-07-01 00:00:00

abstract：:Over the past year, several research areas have been noteworthy. This article discusses decision making related to breast cancer treatment, the effects of treatment on measures of psychological distress, and studies related to quality-of-life among breast cancer patients. In addition, an area of continued interest inv...

journal_title：Current opinion in oncology

authors： Stefanek ME

更新日期：1993-11-01 00:00:00

abstract：:In 1996 progress has been made toward a better understanding of acute leukemias, their biology, the effects of different intensity or subtype-specific chemotherapy, and the contribution of bone marrow transplantation. In acute lymphoblastic leukemia, high-dose cytarabine in induction and in postremission treatment imp...

journal_title：Current opinion in oncology

authors： Büchner T

更新日期：1997-01-01 00:00:00

abstract：PURPOSE OF REVIEW:Recent Food and Drug Administration (FDA) approval of five new immune checkpoint inhibitors for the treatment of metastatic urothelial cancer represents the first major treatment breakthrough for this disease since the introduction of combination chemotherapy over 30 years ago. This review examines th...

journal_title：Current opinion in oncology

authors： Tabayoyong W,Gao J

更新日期：2018-05-01 00:00:00

abstract：:Many new modalities and increasing data have become available in the treatment of brain tumors. We will review the growing experience with newer treatment modalities such as brachytherapy, radiosurgery, hyperthermia, and photodynamic therapy. ...

journal_title：Current opinion in oncology

authors： Bahary JP,Larson DA

更新日期：1992-06-01 00:00:00

abstract：:The rapid development of computed tomography and magnetic resonance imaging has resulted in numerous applications of these modalities in head and neck oncology. In the past year further refinements in diagnostic capabilities have been obtained in magnetic resonance imaging. Computed tomography is rapidly being replace...

journal_title：Current opinion in oncology

authors： Castelijns JA

更新日期：1991-06-01 00:00:00

abstract：:Chronic myelogenous leukemia (CML) is a hematologic malignancy characterized by an initial chronic phase of expanded clonal myelopoiesis followed by inevitable progression to accelerated phase and finally to fatal blast crisis. Although interferon therapy results in hematologic control of disease in most patients and ...

journal_title：Current opinion in oncology

authors： Enright H,McGlave P

更新日期：1998-03-01 00:00:00

abstract：PURPOSE OF REVIEW:Prevention of infectious complications of chemotherapy-induced granulocytopenia is a major issue in preventive medicine, as febrile neutropenia is still associated with an overall 10% mortality and extensive morbidity and cost. RECENT FINDINGS:The prescription of granulocyte colony-stimulating factor...

journal_title：Current opinion in oncology

authors： Klastersky J,Awada A,Aoun M,Paesmans M

更新日期：2009-07-01 00:00:00

abstract：:Tyrosine kinase (type 1) growth factor receptors include the erbB family. These cell surface receptors were discovered in the context of cellular transformation and have subsequently been found to be overexpressed in many types of human cancer. Cumulative evidence suggests that upregulation of the most well-characteri...

journal_title：Current opinion in oncology

authors： Lango MN,Shin DM,Grandis JR

更新日期：2001-05-01 00:00:00

abstract：PURPOSE OF REVIEW:Small-cell carcinomas of the gynecologic tract are aggressive malignancies that can be misdiagnosed or inappropriately managed. This review provides a summary of current literature that will help the clinician to correctly diagnose and treat patients with small-cell carcinomas of the cervix, ovary, ut...

journal_title：Current opinion in oncology

authors： Cohen JG,Chan JK,Kapp DS

更新日期：2012-09-01 00:00:00

abstract：PURPOSE OF REVIEW:Crizotinib now is accepted as the standard first-line treatment of ALK-rearranged lung adenocarcinomas. To overcome the problem of crizotinib resistance, second-generation ALK inhibitors are in development. The aim of this review is to give an overview on the mechanisms behind crizotinib resistance an...

journal_title：Current opinion in oncology

authors： Pall G

更新日期：2015-03-01 00:00:00

abstract：:Recent work has shown that: 1) loss of transforming growth factor-beta response is associated with malignant progression, 2) maintenance of autocrine negative transforming growth factor-beta activity is a key impediment to malignant progression, and 3) the major mechanism for loss of RII expression in replication erro...

journal_title：Current opinion in oncology

authors： Brattain MG,Markowitz SD,Willson JK

更新日期：1996-01-01 00:00:00

abstract：PURPOSE OF REVIEW:The objective of the sentinel lymph node procedure in breast cancer is to perform an accurate axillary staging and provide good local control, while sparing the patients the morbidity of an axillary lymph node dissection. Since its routine clinical use, questions were raised concerning the implication...

journal_title：Current opinion in oncology

authors： Smeets A,Christiaens MR

更新日期：2005-11-01 00:00:00

abstract：:Work in the field of molecular neuro-oncology has evolved from a purely descriptive catalogue of regional mutations to the implication of specific genes in the malignant process. Reverse genetic strategies have resulted in the cloning of the neurofibromatosis-1 and neurofibromatosis-2 genes, the molecular physiology o...

journal_title：Current opinion in oncology

authors： Mikkelsen T

更新日期：1994-05-01 00:00:00

abstract：:The rising rate of germ cell cancer of the testis over the past decade has been demonstrated to be occurring predominantly in the younger age group (15 to 19 years) in association with earlier onset of puberty and earlier onset of regular sexual activity. Chemicals and viruses, with their atrophogenic effect, remain t...

journal_title：Current opinion in oncology

authors： Oliver RT

更新日期：1996-05-01 00:00:00

abstract：:Thyroid cancers are still the most common endocrine cancers. They are dominated by well-differentiated carcinomas, including papillary carcinoma, follicular carcinoma, and medullary thyroid carcinoma. Diagnosis is based on fine-needle aspiration cytologic examination. Recently, reverse transcription polymerase chain r...

journal_title：Current opinion in oncology

authors： Bi J,Lu B

更新日期：2000-01-01 00:00:00

abstract：PURPOSE OF REVIEW:Gastrointestinal stromal tumour patients with exon 9 KIT mutations have a worse outcome, but progression-free survival is improved by treatment with imatinib 800 mg daily. This review looks at the evidence and asks whether this should be standard treatment from diagnosis. RECENT FINDINGS:The phase II...

journal_title：Current opinion in oncology

authors： Judson I

更新日期：2008-07-01 00:00:00