Atypical lipomatous tumor: molecular characterization.

abstract：PURPOSE OF REVIEW:Multiple myeloma is a common hematological malignancy arising in the bone marrow. Bone lesions were initially depicted with conventional radiography, although recently F-FDG PET/CT and MRI are recognized as having a clear role in the initial workup and in the evaluation of therapy response. RECENT FI...

journal_title：Current opinion in oncology

authors： Martí-Bonmatí L,Ramirez-Fuentes C,Alberich-Bayarri Á,Ruiz-Llorca C

更新日期：2015-11-01 00:00:00

abstract：:The use of highly sensitive and specific assays to detect residual disease in patients with acute leukemia should provide a basis for optimizing therapy and maximizing each patient's chance of cure. Strategies for detecting residual disease are based on biologic properties that allow acute leukemia cells to be disting...

journal_title：Current opinion in oncology

authors： Baer MR

更新日期：1998-01-01 00:00:00

abstract：PURPOSE OF REVIEW:Research into the basic biology of telomeres continues to reveal details relevant to fundamental aspects of human cancer. The goal of this review is to highlight discoveries made within the last year, with emphasis on their relevance to cancer prevention, diagnosis, prognostics, and treatment. RECENT...

journal_title：Current opinion in oncology

authors： Meeker AK,De Marzo AM

更新日期：2004-01-01 00:00:00

abstract：PURPOSE OF REVIEW:In the 1990s, cancer patients were described as poor candidates for ICU admission on the basis of high mortality rates and management costs. Over the last decade, however, advances in the management of malignancies and organ failures have led to substantial increases in survival. This review discusses...

journal_title：Current opinion in oncology

authors： Darmon M,Azoulay E

更新日期：2009-07-01 00:00:00

abstract：:The development of non-myeloablative and reduced-intensity conditioning regimens has enabled older or medically infirm patients with myeloid malignancies to be treated with allogeneic hematopoietic cell transplantation (HCT). The regimens are sufficiently immunosuppressive to allow engraftment of allogeneic cells and ...

journal_title：Current opinion in oncology

authors： Storb R

更新日期：2009-06-01 00:00:00

abstract：:Platinum-based combination and single-agent chemotherapy have become accepted as treatments for locally advanced and metastatic nonsmall cell lung cancer as a consequence of improved survival, quality of life, and symptom control compared with best supportive care. However, it is clear that a therapeutic plateau has b...

journal_title：Current opinion in oncology

authors： Booton R,Thatcher N

更新日期：2002-03-01 00:00:00

abstract：PURPOSE OF REVIEW:This review presents an overview of recent developments in research examining coping with the effects of cancer treatment on sexuality. RECENT FINDINGS:A search was conducted using PubMed and Web of Knowledge to find papers published or in press in 2010. Papers examining coping efforts, effects of ca...

journal_title：Current opinion in oncology

authors： Reese JB

更新日期：2011-07-01 00:00:00

abstract：:Although early clinical gene therapy trials for recurrent central nervous system neoplasms showed the proof-of-principle, they did not fulfill the high expectations suggested by the preclinical experimental data. Insufficient distribution of vectors in human brain tumors and very low transduction efficiency require th...

journal_title：Current opinion in oncology

authors： Weyerbrock A,Oldfield EH

更新日期：1999-05-01 00:00:00

abstract：:The behavior of renal cell carcinoma remains one of the most unpredictable of the genitourinary neoplasms. Once this disease has spread beyond the confines of the kidney, it is extremely difficult to control. This year, emphasis has focused on the characteristic cytogenetic and chromosomal changes that are seen in thi...

journal_title：Current opinion in oncology

authors： Reese JH

更新日期：1992-06-01 00:00:00

abstract：PURPOSE OF REVIEW:To examine the most recent changes in published guidelines by various organizations for the treatment of patients with differentiated thyroid cancer. This document provides a comparison of recommendations for common topics currently found in available thyroid cancer care guidelines. RECENT FINDINGS:R...

journal_title：Current opinion in oncology

authors： Miller BS,Doherty GM

更新日期：2011-01-01 00:00:00

abstract：:The publication of the proceedings of Fourth Workshop on Carcinoma in situ was an impressive leap in our understanding of the interaction between prenatal and postpubertal factors in the development of germ cell cancer as well as increased insight into the molecular events that are involved in the development of these...

journal_title：Current opinion in oncology

authors： Oliver RT

更新日期：1999-05-01 00:00:00

abstract：PURPOSE OF REVIEW:Langerhans cell histiocytosis (LCH) is a rare disorder characterized by the infiltration of involved tissues by specialized dendritic cells. The demonstration of the constant activation of the mitogen-activated protein kinase (MAPK) pathway in LCH lesions has been a breakthrough in the understanding o...

journal_title：Current opinion in oncology

authors： Jouenne F,Benattia A,Tazi A

更新日期：2020-12-09 00:00:00

abstract：PURPOSE OF REVIEW:To highlight the most recent advances in the imaging of gliomas with a focus on high-grade gliomas. In the last several years, MRI and PET imaging of the brain have moved beyond anatomic imaging and are now capable of probing different aspects of tumor biology and response to treatment. These new tech...

journal_title：Current opinion in oncology

authors： Gerstner ER,Batchelor TT

更新日期：2010-11-01 00:00:00

abstract：PURPOSE OF REVIEW:The p53 tumor suppressor is a master regulator of antitumor defenses through its control of growth arrest, senescence and apoptosis. In recent years, p53 regulation was found to extend to a variety of biological processes including autophagy, fertility, metabolism and immune responses. Here, we focus ...

journal_title：Current opinion in oncology

authors： Menendez D,Shatz M,Resnick MA

更新日期：2013-01-01 00:00:00

abstract：:Although variation in diet may account for approximately one third of the variation in cancer incidence worldwide, epidemiologic studies have proven to be a blunt instrument for identifying causal relationships between intakes of specific food constituents and cancer risk at specific sites. Diets rich in fruits and ve...

journal_title：Current opinion in oncology

authors： Mathers JC,Burn J

更新日期：1999-09-01 00:00:00

abstract：PURPOSE OF REVIEW:Temsirolimus (Torisel) is a mammalian target of rapamycin (mTOR) inhibitor approved for the treatment of relapsed/refractory mantle cell lymphoma (MCL). The recommended dosage in this indication (175 mg once weekly for 3 weeks and then 75 mg once weekly as maintenance) is higher than that for renal ce...

journal_title：Current opinion in oncology

authors： Bouabdallah K,Ribrag V,Terriou L,Soria JC,Delarue R

更新日期：2013-03-01 00:00:00

abstract：PURPOSE OF REVIEW:This article reviews the potential benefit of maintenance therapy for patients with follicular lymphoma. RECENT FINDINGS:Follicular lymphoma, despite substantial improvements in survival, is usually incurable. Several randomized studies have shown that the combination of anti-CD20 and chemotherapy ca...

journal_title：Current opinion in oncology

authors： Michallet AS,Coiffier B,Salles G

更新日期：2011-09-01 00:00:00

abstract：PURPOSE OF REVIEW:Primary thyroid lymphoma (PTL) is a rare but clinically important malignancy of the thyroid. This article reviews the diagnosis, histologic subtypes, pathogenesis, and treatment of PTL, with the objective of optimizing diagnosis and management of the disease. RECENT FINDINGS:Recent studies have shed ...

journal_title：Current opinion in oncology

authors： Graff-Baker A,Sosa JA,Roman SA

更新日期：2010-01-01 00:00:00

abstract：PURPOSE OF REVIEW:Recent discoveries have demonstrated that ovarian cancer is actually composed of multiple separate diseases. Clear cell cancer is an important example. This review will describe the unique biology of clear cell carcinoma, its novel molecular features, and the recent translation of this into new therap...

journal_title：Current opinion in oncology

authors： Penson RT,Dizon DS,Birrer MJ

更新日期：2013-09-01 00:00:00

abstract：:Despite continuing advances in the molecular characterization of the events promoting metastasis, no significant impact has been made on therapy or survival rates for patients with advanced tumors. Over the past 12 months there has been a general consolidation of the emerging evidence indicating that tumor spread is r...

journal_title：Current opinion in oncology

authors： Dorudi S,Hart IR

更新日期：1993-01-01 00:00:00

abstract：:The vast majority of adults with acute lymphoblastic leukemia (ALL) now achieve remission with current intensive chemotherapy regimens. Nevertheless, most adults with ALL will eventually relapse and die of their disease. Specific clinical and molecular-cytogenetic prognostic factors have been identified that are begin...

journal_title：Current opinion in oncology

authors： Verma A,Stock W

更新日期：2001-01-01 00:00:00

abstract：PURPOSE OF REVIEW:The rising incidence of oropharyngeal squamous cell carcinoma (OPSCC), in large part as a result of the human papillomavirus (HPV), has driven a movement for the change in the management strategies. Renewed interest in minimally invasive approaches of endoscopic head and neck surgery led to introducti...

journal_title：Current opinion in oncology

authors： Dias FL,Walder F,Leonhardt FD

更新日期：2017-05-01 00:00:00

abstract：:The bcr-abl fusion protein is present in the vast majority of cases of chronic myelogenous leukemia, and the deregulated tyrosine kinase activity of this protein is essential for leukemic transformation. Thus, bcr-abl is an ideal target for pharmacologic inhibition. In preclinical studies, ST1571 (formerly CGP57148B),...

journal_title：Current opinion in oncology

authors： O'Dwyer ME,Druker BJ

更新日期：2000-11-01 00:00:00

abstract：:Recent papers dealing with the effect of biologic response modifiers on the therapeutic activity of anticancer drugs are reviewed. Preclinical findings indicate that both interferons and tumor necrosis factor-alpha are able to synergize with different cytotoxic drugs in increasing both tumor cytotoxicity or cytostasis...

journal_title：Current opinion in oncology

authors： Parmiani G,Rivoltini L

更新日期：1991-12-01 00:00:00

abstract：PURPOSE OF REVIEW:The psychosocial needs of adolescent and young adult (AYA) siblings of cancer patients are easily overlooked. Accordingly, the evidence base informing short and long-term outcomes for these young people is sparse. This review provides an overview of recent research highlighting the experiences, unmet ...

journal_title：Current opinion in oncology

authors： Patterson P,Medlow S,McDonald FE

更新日期：2015-07-01 00:00:00

abstract：:Many new modalities and increasing data have become available in the treatment of brain tumors. We will review the growing experience with newer treatment modalities such as brachytherapy, radiosurgery, hyperthermia, and photodynamic therapy. ...

journal_title：Current opinion in oncology

authors： Bahary JP,Larson DA

更新日期：1992-06-01 00:00:00

abstract：:Chemopreventive strategies hold substantial promise for reducing the incidence of colorectal cancer, the second leading cause of cancer-related mortality in the United States. This review focuses on recent advances in the identification of molecular targets and novel strategies for chemopreventive intervention. Many c...

journal_title：Current opinion in oncology

authors： Clapper ML,Chang WC,Meropol NJ

更新日期：2001-07-01 00:00:00

abstract：PURPOSE OF REVIEW:This review presents the analysis of recently published studies about the benefit from granulocyte-colony stimulating factors (G-CSF) in older cancer patients receiving chemotherapy. RECENT FINDINGS:During the last years, no major study aiming to confirm the clinical benefit of G-CSF prophylaxis in o...

journal_title：Current opinion in oncology

authors： Klastersky JA,Dal Lago L,Lalami Y

更新日期：2020-07-01 00:00:00

abstract：:The management of tumors arising from or, by extension, involving the skull base is complex due to the density and sensitivity of nearby neurovascular structures, the proximity of these structures to the relatively contaminated spaces of the paranasal sinuses or ear and mastoid, the varied pathologic entities encounte...

journal_title：Current opinion in oncology

authors： DeMonte F

更新日期：1995-05-01 00:00:00

abstract：PURPOSE OF REVIEW:To review the 2008-2009 literature on pediatric genitourinary tumors and highlight the most significant publications. RECENT FINDINGS:New techniques such as gene expression profiling, PET, nephron-sparing surgery, and stem cell transplantation are being incorporated into contemporary treatments for p...

journal_title：Current opinion in oncology

authors： McLean TW,Buckley KS

更新日期：2010-05-01 00:00:00