Biologic agents as modifiers of chemotherapeutic effects.

abstract：:Despite continuing advances in the molecular characterization of the events promoting metastasis, no significant impact has been made on therapy or survival rates for patients with advanced tumors. Over the past 12 months there has been a general consolidation of the emerging evidence indicating that tumor spread is r...

journal_title：Current opinion in oncology

authors： Dorudi S,Hart IR

更新日期：1993-01-01 00:00:00

abstract：PURPOSE OF REVIEW:As the number and uses for targeted therapies such as epidermal growth factor receptor inhibitors (EGFRIs) increase, so does the need to recognize and treat the dermatologic side-effects of these agents. Although agents such as gefitinib, erlotinib, cetuximab, lapatinib, and panitumumab have less syst...

journal_title：Current opinion in oncology

authors： Wu PA,Balagula Y,Lacouture ME,Anadkat MJ

更新日期：2011-07-01 00:00:00

abstract：PURPOSE OF REVIEW:Melanoma is the third most common metastatic brain tumor in the United States and is a major cause of morbidity and mortality. The development of more effective therapies for melanoma brain metastases is a major unmet clinical need and is summarized in this review. RECENT FINDINGS:Management strategi...

journal_title：Current opinion in oncology

authors： Tarhini AA,Agarwala SS

更新日期：2004-03-01 00:00:00

abstract：PURPOSE OF REVIEW:Ovarian germ cell tumours are rare, but curable at all stages of disease. This review gives an outline of the main controversies regarding the management of this disease. RECENT FINDINGS:Pelvic malignancies are very rare during pregnancy, which should avoid the need for radical surgery or termination...

journal_title：Current opinion in oncology

authors： Patterson DM,Rustin GJ

更新日期：2006-09-01 00:00:00

abstract：:Palliative (terminal) care is now recognized worldwide as an important, multidisciplinary aspect of the continuing care of patients with incurable cancer. Symptom control and quality-of-life are of the essence. Various treatment methods are available, and radiotherapy and chemotherapy (used appropriately) are importan...

journal_title：Current opinion in oncology

authors： Hancock BW,Ahmedzai S,Clark D

更新日期：1993-07-01 00:00:00

abstract：PURPOSE OF REVIEW:Evaluate the recent literature about the relation of clinical infection and colorectal cancer in terms of diagnosis of an occult infection and possible impact on oncological outcome and review the possible role of the gut microbiota in the role of colorectal cancer oncogenesis. RECENT FINDINGS:Data p...

journal_title：Current opinion in oncology

authors： Massaut E,Hendlisz B,Klastersky JA

更新日期：2019-07-01 00:00:00

abstract：:The rapid development of computed tomography and magnetic resonance imaging has resulted in numerous applications of these modalities in head and neck oncology. In the past year further refinements in diagnostic capabilities have been obtained in magnetic resonance imaging. Computed tomography is rapidly being replace...

journal_title：Current opinion in oncology

authors： Castelijns JA

更新日期：1991-06-01 00:00:00

abstract：PURPOSE OF REVIEW:Mycosis fungoides and Sézary syndrome arise from malignant T cells that reside in skin, and subsequently are capable of circulating between skin, lymph nodes, and blood. The pathophysiologic mechanisms that cause and result in different behaviors of the skin-homing-malignant T cells in different stage...

journal_title：Current opinion in oncology

authors： Rubio Gonzalez B,Zain J,Rosen ST,Querfeld C

更新日期：2016-01-01 00:00:00

abstract：:The behavior of renal cell carcinoma remains one of the most unpredictable of the genitourinary neoplasms. Once this disease has spread beyond the confines of the kidney, it is extremely difficult to control. This year, emphasis has focused on the characteristic cytogenetic and chromosomal changes that are seen in thi...

journal_title：Current opinion in oncology

authors： Reese JH

更新日期：1992-06-01 00:00:00

abstract：:The use of highly sensitive and specific assays to detect residual disease in patients with acute leukemia should provide a basis for optimizing therapy and maximizing each patient's chance of cure. Strategies for detecting residual disease are based on biologic properties that allow acute leukemia cells to be disting...

journal_title：Current opinion in oncology

authors： Baer MR

更新日期：1998-01-01 00:00:00

abstract：:Mantle cell lymphoma is a distinct subtype and accounts for approximately 5 to 10% of non-Hodgkin lymphomas. The malignant cells express pan B-cell markers, including CD19, CD20 and CD22, and the T-cell marker CD5, whereas CD10 and CD23 expression are usually absent. By cytogenetic analysis, the t(11;14)(q13;q32) tran...

journal_title：Current opinion in oncology

authors： Leonard JP,Schattner EJ,Coleman M

更新日期：2001-09-01 00:00:00

abstract：:The cancer patient often presents with fever and pulmonary infiltrates, in particular during the course of chemotherapy or after bone marrow transplantation. In these conditions, specific diagnoses are mainly related to an infective cause, but noninfectious processes, malignant or not, are also found alone or in combi...

journal_title：Current opinion in oncology

authors： Ninane V

更新日期：2001-07-01 00:00:00

abstract：PURPOSE OF REVIEW:This paper reviews the advances in surgery in head and neck cancer patients. RECENT FINDINGS:Sentinel node biopsy is a promising diagnostic technique to detect occult lymph node metastases, especially in oral carcinomas. Fludeoxyglucose-PET seems to be useful in detecting recurrent (laryngeal) carcin...

journal_title：Current opinion in oncology

authors： de Bree R,Leemans CR

更新日期：2010-05-01 00:00:00

abstract：:The past decade has been marked by an explosion of knowledge regarding the dysregulation of cancer at the molecular level. It has become apparent that oncogenes, tumor suppressor genes, and other ancillary molecules interact in complex pathways that govern cellular homeostasis. We review three molecular events that ha...

journal_title：Current opinion in oncology

authors： Dome JS,Look AT

更新日期：1999-01-01 00:00:00

abstract：:Bladder cancer is a common and chemotherapy-responsive tumor, related to tobacco smoking, environmental arsenic exposure, industrial dye exposure, and parasitic schistosomiasis exposure. Both reduction of carcinogen exposure and chemoprevention, possibly with cyclooxygenase 2 inhibitors, should reduce the incidence. T...

journal_title：Current opinion in oncology

authors： Patton SE,Hall MC,Ozen H

更新日期：2002-05-01 00:00:00

abstract：:Malignant melanoma is a tumor that offers unique possibilities for approaches to targeted therapy by virtue of the pigment biosynthesis pathway. Such approaches may seek to use the incorporation of toxic intermediates or to use the natural transcriptional control of genes coding for enzymes involved in melanin formati...

journal_title：Current opinion in oncology

authors： Hart IR,Vile RG

更新日期：1994-03-01 00:00:00

abstract：PURPOSE OF REVIEW:To discuss the recent developments of multimodal treatment for patients with local advanced rectal cancer, including incorporation of new chemotherapeutic and targeted agents, and the optimal sequence and timing of treatment components. RECENT FINDINGS:Five randomized trials have been completed to de...

journal_title：Current opinion in oncology

authors： Rödel C,Hofheinz R,Liersch T

更新日期：2012-07-01 00:00:00

abstract：PURPOSE OF REVIEW:The worldwide incidence of melanoma and nonmelanoma skin cancers is increasing alarmingly. The development of new techniques such as dermoscopy leads to a consequent progress in skin cancers screening. The purpose of this review is to highlight recent advances in dermoscopy, reviewing primary research...

journal_title：Current opinion in oncology

authors： Massone C,Di Stefani A,Soyer HP

更新日期：2005-03-01 00:00:00

abstract：PURPOSE OF REVIEW:Sarcomas are a diverse group of rare solid tumors with limited treatment options for patients with advanced, inoperable disease. Cabozantinib is a tyrosine kinase inhibitor currently approved for advanced renal cell, hepatocellular, and medullary thyroid carcinoma. Cabozantinib has potent activity aga...

journal_title：Current opinion in oncology

authors： Schöffski P,Blay JY,Ray-Coquard I

更新日期：2020-07-01 00:00:00

abstract：:Over the past year, several research areas have been noteworthy. This article discusses decision making related to breast cancer treatment, the effects of treatment on measures of psychological distress, and studies related to quality-of-life among breast cancer patients. In addition, an area of continued interest inv...

journal_title：Current opinion in oncology

authors： Stefanek ME

更新日期：1993-11-01 00:00:00

abstract：:Carcinoma of the uterine corpus is the most common malignancy in the female pelvis. Surgical resection and staging are now the accepted approach to therapy, with excellent survival compared with other gynecologic malignancies. Several controversies exist, however, regarding optimal surgical management. Some of these c...

journal_title：Current opinion in oncology

authors： McAlpine JN,Spirtos NM,Chen MD

更新日期：2002-09-01 00:00:00

abstract：PURPOSE OF REVIEW:This article reviews the most recent developments and implications in regard to isocitrate dehydrogenase mutations in chondrosarcoma, a disease in which currently available systemic therapies have proven inefficacious, with an emphasis on how disruption in normal cellular metabolism plays a role in on...

journal_title：Current opinion in oncology

authors： Azzi G,Velez M,Mathias-Machado MC

更新日期：2014-07-01 00:00:00

abstract：KEY POINTS:(1) Surgery is the standard primary treatment for early stage endometrial cancer, with local adjuvant therapies such as pelvic radiotherapy and vaginal brachytherapy most often used in patients with high risk of recurrence. (2) There are currently very few well designed studies evaluating local therapies in ...

journal_title：Current opinion in oncology

authors： Deeks E

更新日期：2007-09-01 00:00:00

abstract：:Recent efforts have been directed at identifying and characterizing candidate tumor suppressor genes and the activities of oncogenes in primary brain tumors. The p53 gene mapping to region p13 of chromosome 17 has several characteristics as a tumor suppressor gene. The wild-type p53 protein, which is a transcriptional...

journal_title：Current opinion in oncology

authors： Steck PA,Saya H

更新日期：1991-06-01 00:00:00

abstract：PURPOSE OF REVIEW:This review will discuss the most recent literature regarding frontline therapy, treatment of patients not eligible for intensive chemotherapy, and novel agents for relapsed/refractory patients with mantle cell lymphoma (MCL). RECENT FINDINGS:Longer follow-up of previously studied intensive regimens ...

journal_title：Current opinion in oncology

authors： Rivera-Rodriguez N,Cabanillas F

更新日期：2013-11-01 00:00:00

abstract：:Family history plays an important role in breast, ovarian, and colorectal cancers. The increasing availability of genetic testing has forced women with these malignancies and their physicians to confront new questions regarding screening and prevention. This review highlights the screening for and prevention of breast...

journal_title：Current opinion in oncology

authors： Basil JB,Rader JS

更新日期：2000-09-01 00:00:00

abstract：PURPOSE OF REVIEW:Retroperitoneal sarcoma (RPS) is a rare disease, and until recently, its natural history and outcome were poorly understood. Recently, collaborations between individual centers have led to an unprecedented collection of retrospective and prospective data and successful recruitment to the first randomi...

journal_title：Current opinion in oncology

authors： van Houdt WJ,Raut CP,Bonvalot S,Swallow CJ,Haas R,Gronchi A

更新日期：2019-07-01 00:00:00

abstract：PURPOSE OF REVIEW:Advances in the health system and medical sciences are continuously pushing the barrier of life-expectancy. As a consequence, humans are being increasingly afflicted by age-associated diseases, such as cancer. The challenge now lies in understanding the mechanisms underlying ageing in order to reduce ...

journal_title：Current opinion in oncology

authors： Pereira B,Ferreira MG

更新日期：2013-01-01 00:00:00

abstract：PURPOSE OF REVIEW:Preclinical and clinical developments in germ cell tumors over the past year are summarized. RECENT FINDINGS:Attenuations in the rising incidence of testicular germ cell tumors are beginning to be observed in certain European populations. Additional data on predisposing factors related to race, estro...

journal_title：Current opinion in oncology

authors： Bridges B,Hussain A

更新日期：2007-05-01 00:00:00

abstract：:The biologic and clinical heterogeneity of lymphomas represents the major obstacle to their diagnosis. Because histologic analysis, which is the initial diagnostic approach, has been demonstrated to be insufficient in the definition of certain types of lymphomas, molecular and immunologic techniques have been increasi...

journal_title：Current opinion in oncology

authors： Veronese ML,Schichman SA,Croce CM

更新日期：1996-09-01 00:00:00