Local therapy in endometrial cancer: evidence based review.

abstract：PURPOSE OF REVIEW:Langerhans cell histiocytosis (LCH) is a rare disorder characterized by the infiltration of involved tissues by specialized dendritic cells. The demonstration of the constant activation of the mitogen-activated protein kinase (MAPK) pathway in LCH lesions has been a breakthrough in the understanding o...

journal_title：Current opinion in oncology

authors： Jouenne F,Benattia A,Tazi A

更新日期：2020-12-09 00:00:00

abstract：:The bcr-abl fusion protein is present in the vast majority of cases of chronic myelogenous leukemia, and the deregulated tyrosine kinase activity of this protein is essential for leukemic transformation. Thus, bcr-abl is an ideal target for pharmacologic inhibition. In preclinical studies, ST1571 (formerly CGP57148B),...

journal_title：Current opinion in oncology

authors： O'Dwyer ME,Druker BJ

更新日期：2000-11-01 00:00:00

abstract：:With the widespread diffusion of stereotactic radiosurgical procedures, GKR treatments have gained considerable momentum as a major therapeutic option for patients harboring primary or metastatic brain tumors. Present results in high grade gliomas indicate a potential palliative role of this technique. The overall low...

journal_title：Current opinion in oncology

authors： Gerosa M,Nicolato A,Foroni R

更新日期：2003-05-01 00:00:00

abstract：PURPOSE OF REVIEW:Atypical lipomatous tumors/well-differentiated liposarcomas (ALT/WDLs) are one of the more frequent mesenchymal neoplasms and are characterized by specific chromosome aberrations: supernumerary chromosome or giant marker chromosome or both. Extra copies of known oncogenes such as MDM2, CDK4, SAS, HMGA...

journal_title：Current opinion in oncology

authors： Arrigoni G,Doglioni C

更新日期：2004-07-01 00:00:00

abstract：PURPOSE OF REVIEW:To present the model of the Supportive Care in Cancer Unit (SCCU) of the National Cancer Institute (NCI) of Milan. RECENT FINDINGS:In the last few years, there has been a debate on different models of integration of palliative care in oncology, on early palliative care, supportive care, supportive an...

journal_title：Current opinion in oncology

authors： Ida RC,Adelaide PM,Stefania B

更新日期：2012-07-01 00:00:00

abstract：PURPOSE OF REVIEW:Despite remarkable advances in the treatment of non-Hodgkin's lymphoma of all histologic subtypes, nervous system involvement remains a dire complication associated with a rapid decline in quality of life, few good treatment options, and a short overall survival. In fact, these advances in treatment m...

journal_title：Current opinion in oncology

authors： Lim HY,Thiel E,Glantz MJ

更新日期：2008-09-01 00:00:00

abstract：PURPOSE OF REVIEW:The objective of the sentinel lymph node procedure in breast cancer is to perform an accurate axillary staging and provide good local control, while sparing the patients the morbidity of an axillary lymph node dissection. Since its routine clinical use, questions were raised concerning the implication...

journal_title：Current opinion in oncology

authors： Smeets A,Christiaens MR

更新日期：2005-11-01 00:00:00

abstract：:Enormous progress has been made in the last several years in delineating signal transduction pathways associated with cell proliferation and apoptosis. The components of these pathways, which include both oncogenes and tumor suppressors, may provide viable targets for therapeutic intervention for the treatment of canc...

journal_title：Current opinion in oncology

authors： Huang PS,Heimbrook DC

更新日期：1997-01-01 00:00:00

abstract：PURPOSE OF REVIEW:Research into the basic biology of telomeres continues to reveal details relevant to fundamental aspects of human cancer. The goal of this review is to highlight discoveries made within the last year, with emphasis on their relevance to cancer prevention, diagnosis, prognostics, and treatment. RECENT...

journal_title：Current opinion in oncology

authors： Meeker AK,De Marzo AM

更新日期：2004-01-01 00:00:00

abstract：PURPOSE OF REVIEW:Preclinical and clinical developments in germ cell tumors over the past year are summarized. RECENT FINDINGS:Attenuations in the rising incidence of testicular germ cell tumors are beginning to be observed in certain European populations. Additional data on predisposing factors related to race, estro...

journal_title：Current opinion in oncology

authors： Bridges B,Hussain A

更新日期：2007-05-01 00:00:00

abstract：:Mucosal injury due to ionizing radiation or cytotoxic agents begins with damage to stem cells in the basal epithelium, progresses as these cells are depleted, and is complicated by inflammation and superimposed infection. Suppression of oral and pharyngeal infection, cytokine stimulation of neutrophils, and protection...

journal_title：Current opinion in oncology

authors： Marks JE

更新日期：1997-05-01 00:00:00

abstract：PURPOSE OF REVIEW:Oral mucositis remains a frequent debilitating toxicity associated with drug and radiation regimens used to treat cancer. This review highlights the recent understanding of the biological basis, risk factors for, and management for oral mucositis. RECENT FINDINGS:Prevalence and incidence data for muc...

journal_title：Current opinion in oncology

authors： Villa A,Sonis ST

更新日期：2015-05-01 00:00:00

abstract：:The treatment options for patients with recurrent head and neck malignancies arising in a previously irradiated field are limited. Surgical salvage is feasible in a minority of patients. The majority are referred for palliative chemotherapy with no realistic chance for cure. Data are accumulating to support reirradiat...

journal_title：Current opinion in oncology

authors： Garofalo MC,Haraf DJ

更新日期：2002-05-01 00:00:00

abstract：PURPOSE OF REVIEW:Recent Food and Drug Administration (FDA) approval of five new immune checkpoint inhibitors for the treatment of metastatic urothelial cancer represents the first major treatment breakthrough for this disease since the introduction of combination chemotherapy over 30 years ago. This review examines th...

journal_title：Current opinion in oncology

authors： Tabayoyong W,Gao J

更新日期：2018-05-01 00:00:00

abstract：PURPOSE OF REVIEW:We summarize the concept of a locally advanced basal cell carcinoma (laBCC) and present the current consensus definition. We also review the key pieces of primary research undertaken in the past year and how these affect the use of smoothened inhibitors in a clinical setting. RECENT FINDINGS:Medium t...

journal_title：Current opinion in oncology

authors： Khoo AB,Ali FR,Lear JT

更新日期：2016-03-01 00:00:00

abstract：PURPOSE OF REVIEW:The review aims at comprehensively discussing our current knowledge on bone metastases incidence in non-small cell lung cancer (NSCLC), their related complications as well as clinical impact in patients suffering from advanced disease. RECENT FINDINGS:After evoking the use of zoledronic acid as the e...

journal_title：Current opinion in oncology

authors： Peters S,Meylan E

更新日期：2013-03-01 00:00:00

abstract：PURPOSE OF REVIEW:In the present review, we discuss the possible role of the unfolded protein response (UPR) in the acquisition of tumor cell characteristics and in the prognosis of cancer outcome, which could assist and contribute to the development of more promising therapeutic strategies. RECENT FINDINGS:Accumulati...

journal_title：Current opinion in oncology

authors： Galmiche A,Sauzay C,Chevet E,Pluquet O

更新日期：2017-01-01 00:00:00

abstract：PURPOSE OF REVIEW:The possibility of complete recovery for a lung cancer patient depends on very early diagnosis, as it allows total surgical resection. Screening for this cancer in a high-risk population can be performed using a radiological approach, but this holds a certain number of limitations. Liquid biopsy could...

journal_title：Current opinion in oncology

authors： Hofman P

更新日期：2017-01-01 00:00:00

abstract：:Transforming growth factor-beta is believed to play a dual role in carcinogenesis. Through its ability to inhibit cellular proliferation it suppresses tumor development in its early stages, but in the course of tumor progression malignant cells often acquire resistance to growth inhibition by transforming growth facto...

journal_title：Current opinion in oncology

authors： Wieser R

更新日期：2001-01-01 00:00:00

abstract：PURPOSE OF REVIEW:Immunotherapy of HPV-induced premalignant anogenital lesions and cervical cancer has made impressive progress. HPV as causative agent is targeted by prophylactic and therapeutic vaccination strategies. Preclinical and clinical studies have shown induction of natural and/or vaccine-induced immune respo...

journal_title：Current opinion in oncology

authors： Schreckenberger C,Kaufmann AM

更新日期：2004-09-01 00:00:00

abstract：:Approximately 1 in 10 US women will be diagnosed with breast cancer in her lifetime. With such a high incidence, breast cancer is a serious health concern for all American women. Within the past year, clues about the function of genes associated with breast cancer have been garnered, and novel genes that may contribut...

journal_title：Current opinion in oncology

authors： Unger MA,Weber BL

更新日期：2000-11-01 00:00:00

abstract：:Disease-free survival for patients with small sarcomas of bone has been impressively improved with the use of intensive combination chemotherapy and safe local control with surgery or radiation. The ability of monoclonal antibodies to recognize different antigens has allowed new insights into the histogenesis and has ...

journal_title：Current opinion in oncology

authors： Jürgens HF

更新日期：1994-07-01 00:00:00

abstract：PURPOSE OF REVIEW:Several epidemiologic studies have enhanced our understanding of the impact of respiratory viruses on bone marrow transplant recipients. RECENT FINDINGS:Respiratory viral infections occur frequently following stem cell transplantation but present atypically. Many patients have asymptomatic infections...

journal_title：Current opinion in oncology

authors： Ison MG

更新日期：2009-03-01 00:00:00

abstract：PURPOSE OF REVIEW:To provide examples of mitochondria-specific metabolic events that influence tumor cell biology, and of metabolism-related mitochondrial biomarkers and therapeutic targets in cancer cells. RECENT FINDINGS:Cancer cell mitochondria are rewired to optimally serve the cancer cell under various conditions...

journal_title：Current opinion in oncology

authors： Shoshan M

更新日期：2017-01-01 00:00:00

abstract：PURPOSE OF REVIEW:Mycosis fungoides and Sézary syndrome arise from malignant T cells that reside in skin, and subsequently are capable of circulating between skin, lymph nodes, and blood. The pathophysiologic mechanisms that cause and result in different behaviors of the skin-homing-malignant T cells in different stage...

journal_title：Current opinion in oncology

authors： Rubio Gonzalez B,Zain J,Rosen ST,Querfeld C

更新日期：2016-01-01 00:00:00

abstract：PURPOSE OF REVIEW:To summarize recent developments and controversies in the diagnosis and management of nonmuscle invasive bladder cancer (NMIBC). RECENT FINDINGS:The majority of incident bladder cancer diagnoses are noninvasive. The mainstay of diagnosis remains cystoscopy and transurethral resection, with enhanced o...

journal_title：Current opinion in oncology

authors： Bassett JC,Eifler JB,Resnick MJ,Clark PE

更新日期：2014-05-01 00:00:00

abstract：:Diarrhea is a common event in the clinical history of cancer patients. It can be caused by the presence of tumor or it can be a side effect of treatment. The latter problem is occurring more often because new drugs (CPT-11) or drug combinations (fluorouracil plus interferon or leucovorin) have diarrhea as the dose-lim...

journal_title：Current opinion in oncology

authors： Cascinu S

更新日期：1995-07-01 00:00:00

abstract：PURPOSE OF REVIEW:Although outcomes for patients with follicular lymphoma have improved with chemoimmunotherapy, the disease remains incurable. There is a wide variation in survival, and although the Follicular Lymphoma International Prognostic Index helps to risk-stratify patients, there is a need for robust biomarker...

journal_title：Current opinion in oncology

authors： Gribben JG

更新日期：2010-09-01 00:00:00

abstract：PURPOSE OF REVIEW:In the 1990s, cancer patients were described as poor candidates for ICU admission on the basis of high mortality rates and management costs. Over the last decade, however, advances in the management of malignancies and organ failures have led to substantial increases in survival. This review discusses...

journal_title：Current opinion in oncology

authors： Darmon M,Azoulay E

更新日期：2009-07-01 00:00:00

abstract：:Pleural effusions are a common development in patients with cancer. The optimal means of control are not defined, but systemic treatment is often effective in patients with drug-sensitive tumors. Local treatments advocated in the management of malignant pleural effusions differ in the means of drainage, the length of ...

journal_title：Current opinion in oncology

authors： Tattersall M

更新日期：1992-08-01 00:00:00