Respiratory syncytial virus and other respiratory viruses in the setting of bone marrow transplantation.

abstract：PURPOSE OF REVIEW:(18)F-fluoro-2-deoxy-D-glucose PET-computed tomography (CT) has a major clinical impact in oncology not only for diagnostics but also for staging, response assessment, and relapse detection. However, several other PET tracers are needed for a more complete molecular characterization of cancers which h...

journal_title：Current opinion in oncology

authors： Garcia C,Gebhart G,Flamen P

更新日期：2012-11-01 00:00:00

abstract：:Chemopreventive strategies hold substantial promise for reducing the incidence of colorectal cancer, the second leading cause of cancer-related mortality in the United States. This review focuses on recent advances in the identification of molecular targets and novel strategies for chemopreventive intervention. Many c...

journal_title：Current opinion in oncology

authors： Clapper ML,Chang WC,Meropol NJ

更新日期：2001-07-01 00:00:00

abstract：:Mucosal injury due to ionizing radiation or cytotoxic agents begins with damage to stem cells in the basal epithelium, progresses as these cells are depleted, and is complicated by inflammation and superimposed infection. Suppression of oral and pharyngeal infection, cytokine stimulation of neutrophils, and protection...

journal_title：Current opinion in oncology

authors： Marks JE

更新日期：1997-05-01 00:00:00

abstract：:Despite continuing advances in the molecular characterization of the events promoting metastasis, no significant impact has been made on therapy or survival rates for patients with advanced tumors. Over the past 12 months there has been a general consolidation of the emerging evidence indicating that tumor spread is r...

journal_title：Current opinion in oncology

authors： Dorudi S,Hart IR

更新日期：1993-01-01 00:00:00

abstract：:Enormous progress has been made in the last several years in delineating signal transduction pathways associated with cell proliferation and apoptosis. The components of these pathways, which include both oncogenes and tumor suppressors, may provide viable targets for therapeutic intervention for the treatment of canc...

journal_title：Current opinion in oncology

authors： Huang PS,Heimbrook DC

更新日期：1997-01-01 00:00:00

abstract：PURPOSE OF REVIEW:The most common mechanism of resistance to epidermal growth factor receptor (EGFR) tyrosine kinase inhibitors (TKIs) is acquisition of the T790M gatekeeper mutation. Third-generation EGFR TKIs irreversibly inhibit EGFR mutants (EGFRm), especially T790M, while sparing wild-type EGFR. There are several ...

journal_title：Current opinion in oncology

authors： Sun JM,Park K

更新日期：2017-03-01 00:00:00

abstract：PURPOSE OF REVIEW:Melanoma has proven resistant to most available chemotherapy and immunotherapy. Despite a range of different biochemical targets, most agents kill cancer cells by induction of apoptosis. RECENT FINDINGS:Investigation of this process has provided insights into the resistance mechanisms in cancer cells...

journal_title：Current opinion in oncology

authors： Hersey P

更新日期：2006-03-01 00:00:00

abstract：PURPOSE OF REVIEW:The current status of postoperative adjuvant therapy for nonsmall cell lung cancer (NSCLC) is reviewed. RECENT FINDINGS:Cisplatin-based postoperative chemotherapy is a current standard of care for patients with stage II-III NSCLC who underwent complete resection. However, its benefit is limited. In t...

journal_title：Current opinion in oncology

authors： Mitsudomi T,Soh J

更新日期：2021-01-01 00:00:00

abstract：PURPOSE OF REVIEW:To describe how to better identify frail multiple myeloma patients and to treat them appropriately. RECENT FINDINGS:Proteasome inhibitors, such as bortezomib, carfilzomib, and ixazomib, and immunomodulatory agents (IMiDs), such as thalidomide, lenalidomide, and pomalidomide, have significantly improv...

journal_title：Current opinion in oncology

authors： Zweegman S,Engelhardt M,Larocca A,EHA SWG on ‘Aging and Hematology’.

更新日期：2017-09-01 00:00:00

abstract：PURPOSE OF REVIEW:Sarcomas are a diverse group of rare solid tumors with limited treatment options for patients with advanced, inoperable disease. Cabozantinib is a tyrosine kinase inhibitor currently approved for advanced renal cell, hepatocellular, and medullary thyroid carcinoma. Cabozantinib has potent activity aga...

journal_title：Current opinion in oncology

authors： Schöffski P,Blay JY,Ray-Coquard I

更新日期：2020-07-01 00:00:00

abstract：:Breast cancer is a leading women's health issue. Continued advances in understanding the temporal sequencing of relevant exposures promises to shed light on the continuum of breast carcinogenesis. Oral contraceptive use and the transient increase in risk following childbirth are exposures that affect the near-term ris...

journal_title：Current opinion in oncology

authors： Alberg AJ,Helzlsouer KJ

更新日期：1997-11-01 00:00:00

abstract：:Recent studies are refining the treatment approaches of radiation therapy and combination chemotherapy in Hodgkin's disease. In early-stage disease, attempts are being made to lessen the toxicity of treatment while maintaining excellent results. Optimal results are achieved in advanced disease with combined radiation ...

journal_title：Current opinion in oncology

authors： Straus DJ

更新日期：1993-09-01 00:00:00

abstract：:Collaborative study groups have invested considerable effort in the last decade in defining the role of allogeneic and autologous bone marrow transplantation as consolidation treatment for first remission of acute myeloid leukemia in younger patients. These efforts have been able, more precisely, to quantitate the deg...

journal_title：Current opinion in oncology

authors： Burnett AK,Kell J

更新日期：2000-03-01 00:00:00

abstract：PURPOSE OF REVIEW:Recent Food and Drug Administration (FDA) approval of five new immune checkpoint inhibitors for the treatment of metastatic urothelial cancer represents the first major treatment breakthrough for this disease since the introduction of combination chemotherapy over 30 years ago. This review examines th...

journal_title：Current opinion in oncology

authors： Tabayoyong W,Gao J

更新日期：2018-05-01 00:00:00

abstract：:Both paclitaxel and docetaxel have shown activity when used as a single agent in patients with squamous cell carcinoma of the head and neck (SCCHN). Combinations of both drugs with platinum derivatives and antimetabolites have been tested in patient populations with encouraging results, but some have exhibited conside...

journal_title：Current opinion in oncology

authors： Schrijvers D,Vermorken JB

更新日期：1998-05-01 00:00:00

abstract：:This review highlights recent advances in understanding the mode of action of retinoids at the level of molecular and cellular biology in relation to the new clinical results achieved with retinoids in various malignancies. All-trans-retinoic acid has been established in the clinic as a first-line differentiation ther...

journal_title：Current opinion in oncology

authors： Holdener EE,Bollag W

更新日期：1993-11-01 00:00:00

abstract：PURPOSE OF REVIEW:This article reviews the potential benefit of maintenance therapy for patients with follicular lymphoma. RECENT FINDINGS:Follicular lymphoma, despite substantial improvements in survival, is usually incurable. Several randomized studies have shown that the combination of anti-CD20 and chemotherapy ca...

journal_title：Current opinion in oncology

authors： Michallet AS,Coiffier B,Salles G

更新日期：2011-09-01 00:00:00

abstract：:A better understanding of the immunobiology after transplantation and of the available recombinant cytokines that enhance hematopoietic reconstitution following autologous and allogeneic bone marrow transplantation is likely to result in safer application of bone marrow transplantation. Residual tumor cells escaping c...

journal_title：Current opinion in oncology

authors： Slavin S,Nagler A

更新日期：1991-04-01 00:00:00

abstract：:There is an emerging consensus on the importance of identifying non-Hodgkin's lymphoma patients with different prognoses so that these patients can be optimally treated and the relative benefits of different therapeutic approaches can be adequately assessed. This review of recent publications on prognostic factors in ...

journal_title：Current opinion in oncology

authors： Shipp M

更新日期：1992-10-01 00:00:00

abstract：:Over the past decade, high-dose chemotherapy followed by autologous bone marrow support (ABMS) has been employed with increasing frequency to treat patients with a variety of solid tumors. This paper explores the rationale and relevant clinical data for the use of this approach to treat patients with breast and ovaria...

journal_title：Current opinion in oncology

authors： Shpall EJ,Jones RB,Bearman S

更新日期：1994-03-01 00:00:00

abstract：PURPOSE OF REVIEW:Vandetanib is a small molecule tyrosine kinase inhibitor that has been recently approved as an 'orphan drug' for the treatment of patients with unresectable, locally advanced, or metastatic medullary thyroid cancer (MTC). RECENT FINDINGS:MTC is a neuroendocrine malignancy frequently associated with m...

journal_title：Current opinion in oncology

authors： Campbell MJ,Seib CD,Gosnell J

更新日期：2013-01-01 00:00:00

abstract：PURPOSE OF REVIEW:Mycosis fungoides and Sézary syndrome arise from malignant T cells that reside in skin, and subsequently are capable of circulating between skin, lymph nodes, and blood. The pathophysiologic mechanisms that cause and result in different behaviors of the skin-homing-malignant T cells in different stage...

journal_title：Current opinion in oncology

authors： Rubio Gonzalez B,Zain J,Rosen ST,Querfeld C

更新日期：2016-01-01 00:00:00

abstract：PURPOSE OF REVIEW:In the past few years, the advent of PARP inhibitors has been a revolution in the management of ovarian cancer. Patients harboring somatic or germ line BRCA1/2 mutations exhibit different clinical and treatment response behavior. The BRCA gene is involved in repairing DNA repair via homologous recombi...

journal_title：Current opinion in oncology

authors： Vanacker H,Romeo C,Ray-Coquard I

更新日期：2019-09-01 00:00:00

abstract：PURPOSE OF REVIEW:Chemotherapy is a cornerstone treatment in patients with early breast cancer. Although some cancer cell-related predictors are emerging, the indications of chemotherapy and the choice of chemotherapy regimen are not individualized enough, emphasizing the need for new predictors. This review will summa...

journal_title：Current opinion in oncology

authors： Andre F,Berrada N,Desmedt C

更新日期：2010-11-01 00:00:00

abstract：:Human immunodeficiency virus (HIV)-1 infection is associated with increased frequency of Kaposi's sarcoma and high-grade B-cell lymphoma. Several other cancers in HIV-1-infected individuals have been reported, although without statistically significant increase in their respective occurrences. Although HIV-1 does not ...

journal_title：Current opinion in oncology

authors： Gill PS

更新日期：1991-10-01 00:00:00

abstract：PURPOSE OF REVIEW:The concept of palliative care is becoming increasingly important in the management of glioma patients. However, the right time for implementation, as well as the individual degree of integration of palliative care aspects, are still a matter of debate. This review updates recent evidence of palliativ...

journal_title：Current opinion in oncology

authors： Oberndorfer S,Hutterer M

更新日期：2019-11-01 00:00:00

abstract：:Recent efforts have been directed at identifying and characterizing candidate tumor suppressor genes and the activities of oncogenes in primary brain tumors. The p53 gene mapping to region p13 of chromosome 17 has several characteristics as a tumor suppressor gene. The wild-type p53 protein, which is a transcriptional...

journal_title：Current opinion in oncology

authors： Steck PA,Saya H

更新日期：1991-06-01 00:00:00

abstract：:The development of non-myeloablative and reduced-intensity conditioning regimens has enabled older or medically infirm patients with myeloid malignancies to be treated with allogeneic hematopoietic cell transplantation (HCT). The regimens are sufficiently immunosuppressive to allow engraftment of allogeneic cells and ...

journal_title：Current opinion in oncology

authors： Storb R

更新日期：2009-06-01 00:00:00

abstract：:The treatment options for patients with recurrent head and neck malignancies arising in a previously irradiated field are limited. Surgical salvage is feasible in a minority of patients. The majority are referred for palliative chemotherapy with no realistic chance for cure. Data are accumulating to support reirradiat...

journal_title：Current opinion in oncology

authors： Garofalo MC,Haraf DJ

更新日期：2002-05-01 00:00:00

abstract：:Chronotherapy consists in the administration of medicines according to biological rhythms. Further insight into the mechanisms of the circadian system has led to adapting the delivery of cancer chemotherapy to rhythms in drug metabolism or cell proliferation. The pharmacology of anticancer agents has long been known t...

journal_title：Current opinion in oncology

authors： Lévi F

更新日期：1996-07-01 00:00:00