Update on the taxoids and other new agents in head and neck cancer therapy.

abstract：PURPOSE OF REVIEW:The growing awareness that the immune system is a key player in the antitumoral response and the excellent clinical results achieved in some settings with anti-programmed cell death 1 (PD1)/programmed death ligand 1 (PDL1) and anti-cytotoxic T-lymphocyte-associated protein 4 (CTLA4) drugs has led to t...

journal_title：Current opinion in oncology

authors： Anciaux M,Vandeputte C,Hendlisz A

更新日期：2017-07-01 00:00:00

abstract：PURPOSE OF REVIEW:The possibility of complete recovery for a lung cancer patient depends on very early diagnosis, as it allows total surgical resection. Screening for this cancer in a high-risk population can be performed using a radiological approach, but this holds a certain number of limitations. Liquid biopsy could...

journal_title：Current opinion in oncology

authors： Hofman P

更新日期：2017-01-01 00:00:00

abstract：:The treatment options for patients with recurrent head and neck malignancies arising in a previously irradiated field are limited. Surgical salvage is feasible in a minority of patients. The majority are referred for palliative chemotherapy with no realistic chance for cure. Data are accumulating to support reirradiat...

journal_title：Current opinion in oncology

authors： Garofalo MC,Haraf DJ

更新日期：2002-05-01 00:00:00

abstract：PURPOSE OF REVIEW:This review provides an overview of recent updates in understanding the mechanisms by which glioblastoma cells interact with their cellular and molecular partners within the microenvironment. RECENT FINDINGS:We have now a better knowledge of the cell populations involved in Glioblastoma (GBM) invasio...

journal_title：Current opinion in oncology

authors： Chouleur T,Tremblay ML,Bikfalvi A

更新日期：2020-11-01 00:00:00

abstract：:The search for effective adjuvant therapy for melanoma has resulted in the testing of a remarkably broad spectrum of therapeutic agents. Until recently, there was little evidence to suggest a benefit for any adjuvant therapy. The demonstration of activity for adjuvant high-dose interferon alfa in a cooperative group t...

journal_title：Current opinion in oncology

authors： Sondak VK,Wolfe JA

更新日期：1997-03-01 00:00:00

abstract：:The pathogenesis of prostate cancer reflects complex interactions among environmental and genetic factors. Recent advances suggest molecular mechanisms that may explain geographic and ethnic variations in prostate cancer incidence, and understanding of molecular disease progression is advancing rapidly. Clinically, th...

journal_title：Current opinion in oncology

authors： Small EJ,Reese DM

更新日期：2000-05-01 00:00:00

abstract：PURPOSE OF REVIEW:Concept of refractory coeliac disease (RCD) emerged in the past decade and refers to persistence of malnutrition and intestinal villous atrophy for more than 1 year strict gluten-free diet in coeliac patients. Diagnosis of this condition remains difficult and conditions treatment and follow-up. RECEN...

journal_title：Current opinion in oncology

authors： Malamut G,Cellier C

更新日期：2013-09-01 00:00:00

abstract：PURPOSE OF REVIEW:Immunotherapy of HPV-induced premalignant anogenital lesions and cervical cancer has made impressive progress. HPV as causative agent is targeted by prophylactic and therapeutic vaccination strategies. Preclinical and clinical studies have shown induction of natural and/or vaccine-induced immune respo...

journal_title：Current opinion in oncology

authors： Schreckenberger C,Kaufmann AM

更新日期：2004-09-01 00:00:00

abstract：PURPOSE OF REVIEW:Advances in the health system and medical sciences are continuously pushing the barrier of life-expectancy. As a consequence, humans are being increasingly afflicted by age-associated diseases, such as cancer. The challenge now lies in understanding the mechanisms underlying ageing in order to reduce ...

journal_title：Current opinion in oncology

authors： Pereira B,Ferreira MG

更新日期：2013-01-01 00:00:00

abstract：PURPOSE OF REVIEW:This review presents the analysis of recently published studies about the benefit from granulocyte-colony stimulating factors (G-CSF) in older cancer patients receiving chemotherapy. RECENT FINDINGS:During the last years, no major study aiming to confirm the clinical benefit of G-CSF prophylaxis in o...

journal_title：Current opinion in oncology

authors： Klastersky JA,Dal Lago L,Lalami Y

更新日期：2020-07-01 00:00:00

abstract：PURPOSE OF REVIEW:The review focuses on the most recent advances in the diagnostic and prognostic work-up of adult acute lymphoblastic leukemia (ALL) and its implications in the clinical management of the disease. RECENT FINDINGS:ALL can be identified on the basis of morphologic, cytochemical and immunophenotypic crit...

journal_title：Current opinion in oncology

authors： Vitale A,Guarini A,Chiaretti S,Foà R

更新日期：2006-11-01 00:00:00

abstract：PURPOSE OF REVIEW:Small-cell carcinomas of the gynecologic tract are aggressive malignancies that can be misdiagnosed or inappropriately managed. This review provides a summary of current literature that will help the clinician to correctly diagnose and treat patients with small-cell carcinomas of the cervix, ovary, ut...

journal_title：Current opinion in oncology

authors： Cohen JG,Chan JK,Kapp DS

更新日期：2012-09-01 00:00:00

abstract：:Approximately 1 in 10 US women will be diagnosed with breast cancer in her lifetime. With such a high incidence, breast cancer is a serious health concern for all American women. Within the past year, clues about the function of genes associated with breast cancer have been garnered, and novel genes that may contribut...

journal_title：Current opinion in oncology

authors： Unger MA,Weber BL

更新日期：2000-11-01 00:00:00

abstract：:The currently used staging system in melanoma has not been significantly modified since 1988. While this four-stage system effectively stratifies patients into prognostic groups, additional discriminating criteria have been reported that is not presently incorporated in the staging system. The following additions and ...

journal_title：Current opinion in oncology

authors： Ross M

更新日期：1998-03-01 00:00:00

abstract：PURPOSE OF REVIEW:Management of the epithelial ovarian cancer (EOC) remains a therapeutic challenge, with continued poor overall survival (OS). Given low chemotherapy response rates for recurrent disease and short survival times, new treatment options with improved therapeutic indices for targeting cancer's vulnerabili...

journal_title：Current opinion in oncology

authors： Ratner ES,Sartorelli AC,Lin ZP

更新日期：2012-09-01 00:00:00

abstract：PURPOSE OF REVIEW:Gastroenteropancreatic neuroendocrine tumors (GEP-NETs) constitute a diverse group of neoplasms arising from the diffuse neuroendocrine cell system. During the last 2 years a new classification system, the WHO 2010, has come into clinical practice together with Tumor Nodes Metastases (TNM) staging and...

journal_title：Current opinion in oncology

authors： Oberg K

更新日期：2012-07-01 00:00:00

abstract：PURPOSE OF REVIEW:(18)F-fluoro-2-deoxy-D-glucose PET-computed tomography (CT) has a major clinical impact in oncology not only for diagnostics but also for staging, response assessment, and relapse detection. However, several other PET tracers are needed for a more complete molecular characterization of cancers which h...

journal_title：Current opinion in oncology

authors： Garcia C,Gebhart G,Flamen P

更新日期：2012-11-01 00:00:00

abstract：PURPOSE OF REVIEW:The mutational landscape in lung adenocarcinoma (LADC) is broadly recognized, particularly regarding the presence of the epidermal growth factor receptor (EGFR) mutation in non-smokers. However, even in the EGFR canonical-mutant LADC, other accompanying alterations surface which may have a major impac...

journal_title：Current opinion in oncology

authors： Rosell R,Karachaliou N,Arrieta O

更新日期：2020-01-01 00:00:00

abstract：:Mantle cell lymphoma is a distinct subtype and accounts for approximately 5 to 10% of non-Hodgkin lymphomas. The malignant cells express pan B-cell markers, including CD19, CD20 and CD22, and the T-cell marker CD5, whereas CD10 and CD23 expression are usually absent. By cytogenetic analysis, the t(11;14)(q13;q32) tran...

journal_title：Current opinion in oncology

authors： Leonard JP,Schattner EJ,Coleman M

更新日期：2001-09-01 00:00:00

abstract：:Prophylactic platelet transfusion can prevent spontaneous hemorrhage in thrombocytopenic cancer patients undergoing intensive treatment, but it is limited by the development of platelet alloimmunization. Exclusive use of leukocyte-depleted blood products delays or prevents the development of platelet alloimmunization ...

journal_title：Current opinion in oncology

authors： Wallerstein R Jr,Deisseroth AB

更新日期：1991-08-01 00:00:00

abstract：:Our understanding of the pathogenesis and management of squamous cell carcinoma of the anal canal has undergone profound change over the last 30 years. Epidemiologic studies have demonstrated that infection with human papillomavirus is most likely responsible for the majority of cases. Primary treatment with concomita...

journal_title：Current opinion in oncology

authors： Ryan DP,Mayer RJ

更新日期：2000-07-01 00:00:00

abstract：PURPOSE OF REVIEW:Ovarian germ cell tumours are rare, but curable at all stages of disease. This review gives an outline of the main controversies regarding the management of this disease. RECENT FINDINGS:Pelvic malignancies are very rare during pregnancy, which should avoid the need for radical surgery or termination...

journal_title：Current opinion in oncology

authors： Patterson DM,Rustin GJ

更新日期：2006-09-01 00:00:00

abstract：PURPOSE OF REVIEW:Gene expression profiling has highlighted the biologic heterogeneity of breast cancer and has begun to influence the ability of the medical community to individualize patient therapy. The review is intended to highlight the most important advances in the field over recent years with an emphasis on tho...

journal_title：Current opinion in oncology

authors： Morris SR,Carey LA

更新日期：2007-11-01 00:00:00

abstract：PURPOSE OF REVIEW:Chronic graft-versus-host disease is an important cause of late morbidity and mortality after allogeneic stem cell transplantation. With the renewed interest in its pathophysiology and treatment, this review discusses recent clinical and laboratory advances in this disease. Advances in pathophysiology...

journal_title：Current opinion in oncology

authors： Cutler C,Antin JH

更新日期：2006-03-01 00:00:00

abstract：PURPOSE OF REVIEW:Prevention of infectious complications of chemotherapy-induced granulocytopenia is a major issue in preventive medicine, as febrile neutropenia is still associated with an overall 10% mortality and extensive morbidity and cost. RECENT FINDINGS:The prescription of granulocyte colony-stimulating factor...

journal_title：Current opinion in oncology

authors： Klastersky J,Awada A,Aoun M,Paesmans M

更新日期：2009-07-01 00:00:00

abstract：:In 1996 progress has been made toward a better understanding of acute leukemias, their biology, the effects of different intensity or subtype-specific chemotherapy, and the contribution of bone marrow transplantation. In acute lymphoblastic leukemia, high-dose cytarabine in induction and in postremission treatment imp...

journal_title：Current opinion in oncology

authors： Büchner T

更新日期：1997-01-01 00:00:00

abstract：PURPOSE OF REVIEW:To review the 2008-2009 literature on pediatric genitourinary tumors and highlight the most significant publications. RECENT FINDINGS:New techniques such as gene expression profiling, PET, nephron-sparing surgery, and stem cell transplantation are being incorporated into contemporary treatments for p...

journal_title：Current opinion in oncology

authors： McLean TW,Buckley KS

更新日期：2010-05-01 00:00:00

abstract：PURPOSE OF REVIEW:Over the past 20 years, tremendous strides have been made to decrease treatment-related morbidity and mortality following allogeneic transplant, including management of acute and chronic lung injury. Within this context, three distinct entities are recognized, idiopathic pneumonia syndrome (IPS), bron...

journal_title：Current opinion in oncology

authors： Yanik G,Kitko C

更新日期：2013-03-01 00:00:00

abstract：:The clinical staging of bone tumors, even rare ones, has been much improved with the availability of better imaging techniques. Once diagnosis of a rare bone tumor has been made, close consultation between clinician, radiologist, and pathologist is essential for optimal treatment. Recent advances in the staging proced...

journal_title：Current opinion in oncology

authors： Dirix LY,Van Oosterom AT

更新日期：1991-08-01 00:00:00

abstract：:There is an emerging consensus on the importance of identifying non-Hodgkin's lymphoma patients with different prognoses so that these patients can be optimally treated and the relative benefits of different therapeutic approaches can be adequately assessed. This review of recent publications on prognostic factors in ...

journal_title：Current opinion in oncology

authors： Shipp M

更新日期：1992-10-01 00:00:00