Abstract:
PURPOSE OF REVIEW:Chemotherapy is a cornerstone treatment in patients with early breast cancer. Although some cancer cell-related predictors are emerging, the indications of chemotherapy and the choice of chemotherapy regimen are not individualized enough, emphasizing the need for new predictors. This review will summarize recent advances concerning the implication of tumor microenvironment in the response to chemotherapy. RECENT FINDINGS:In recent years, some data have emerged suggesting that microenvironment could be involved in chemotherapy efficacy. The infiltration of tumor by lymphocytes has been highly correlated with the sensitivity to chemotherapy. These data are consistent with the discovery that anthracyclines could induce immune activation through immunogenic cell death. At the opposite, gene expression analyses have suggested that a stroma signature could predict resistance to neoadjuvant chemotherapy. Finally, chemotherapy has been shown to induce a spike of progenitors for endothelial cells, a mechanism that in turns mediates angiogenesis repopulation. SUMMARY:Preliminary data from pioneer studies suggest that tumor microenvironment could be involved in chemotherapy sensitivity and resistance. Such knowledge could generate two advances: simple predictors for chemotherapy efficacy based on pathology could be generated and strategies that aim at reversing drug resistance could be developed.
journal_name
Curr Opin Oncoljournal_title
Current opinion in oncologyauthors
Andre F,Berrada N,Desmedt Cdoi
10.1097/CCO.0b013e32833fb384subject
Has Abstractpub_date
2010-11-01 00:00:00pages
547-51issue
6eissn
1040-8746issn
1531-703Xjournal_volume
22pub_type
杂志文章,评审abstract:PURPOSE OF REVIEW:Management of the epithelial ovarian cancer (EOC) remains a therapeutic challenge, with continued poor overall survival (OS). Given low chemotherapy response rates for recurrent disease and short survival times, new treatment options with improved therapeutic indices for targeting cancer's vulnerabili...
journal_title:Current opinion in oncology
pub_type: 杂志文章,评审
doi:10.1097/CCO.0b013e3283564230
更新日期:2012-09-01 00:00:00
abstract:PURPOSE OF REVIEW:Noninvasive encapsulated follicular variant of papillary thyroid carcinoma (PTC) has been established in the literature as a clinically indolent tumor. Despite this, it was traditionally treated like all other PTCs. In an attempt to reduce overtreatment of this entity, a panel of experts reclassified ...
journal_title:Current opinion in oncology
pub_type: 杂志文章,评审
doi:10.1097/CCO.0000000000000416
更新日期:2018-01-01 00:00:00
abstract:PURPOSE OF REVIEW:The most common mechanism of resistance to epidermal growth factor receptor (EGFR) tyrosine kinase inhibitors (TKIs) is acquisition of the T790M gatekeeper mutation. Third-generation EGFR TKIs irreversibly inhibit EGFR mutants (EGFRm), especially T790M, while sparing wild-type EGFR. There are several ...
journal_title:Current opinion in oncology
pub_type: 杂志文章,评审
doi:10.1097/CCO.0000000000000350
更新日期:2017-03-01 00:00:00
abstract:PURPOSE OF REVIEW:AIDS-related malignancies are an ongoing cause of mortality in individuals with HIV infection. In the HIV-negative setting, high-dose chemotherapy or stem cell transplantation is an option for patients with hematologic malignancies. Prior to the advent of effective HIV therapy, stem cell transplantati...
journal_title:Current opinion in oncology
pub_type: 杂志文章,评审
doi:10.1097/CCO.0b013e32833d2cf0
更新日期:2010-09-01 00:00:00
abstract:PURPOSE OF REVIEW:Gallbladder carcinoma (GBC), classified as a biliary tract cancer (BTC) along with intrahepatic and extrahepatic cholangiocarcinomas, is a rare disease in Western countries, but a highly prevalent disease in Chile, other countries in Latin America, India and Japan. It commonly presents at an advanced ...
journal_title:Current opinion in oncology
pub_type: 杂志文章,评审
doi:10.1097/CCO.0b013e3283620fd8
更新日期:2013-07-01 00:00:00
abstract::Platinum-based combination and single-agent chemotherapy have become accepted as treatments for locally advanced and metastatic nonsmall cell lung cancer as a consequence of improved survival, quality of life, and symptom control compared with best supportive care. However, it is clear that a therapeutic plateau has b...
journal_title:Current opinion in oncology
pub_type: 杂志文章,评审
doi:10.1097/00001622-200203000-00009
更新日期:2002-03-01 00:00:00
abstract:PURPOSE OF REVIEW:Small-cell carcinomas of the gynecologic tract are aggressive malignancies that can be misdiagnosed or inappropriately managed. This review provides a summary of current literature that will help the clinician to correctly diagnose and treat patients with small-cell carcinomas of the cervix, ovary, ut...
journal_title:Current opinion in oncology
pub_type: 杂志文章,评审
doi:10.1097/CCO.0b013e3283565ed6
更新日期:2012-09-01 00:00:00
abstract:PURPOSE OF REVIEW:The possibility of complete recovery for a lung cancer patient depends on very early diagnosis, as it allows total surgical resection. Screening for this cancer in a high-risk population can be performed using a radiological approach, but this holds a certain number of limitations. Liquid biopsy could...
journal_title:Current opinion in oncology
pub_type: 杂志文章,评审
doi:10.1097/CCO.0000000000000343
更新日期:2017-01-01 00:00:00
abstract:PURPOSE OF REVIEW:The rising incidence of oropharyngeal squamous cell carcinoma (OPSCC), in large part as a result of the human papillomavirus (HPV), has driven a movement for the change in the management strategies. Renewed interest in minimally invasive approaches of endoscopic head and neck surgery led to introducti...
journal_title:Current opinion in oncology
pub_type: 杂志文章
doi:10.1097/CCO.0000000000000365
更新日期:2017-05-01 00:00:00
abstract:PURPOSE OF REVIEW:In the present review, we discuss the possible role of the unfolded protein response (UPR) in the acquisition of tumor cell characteristics and in the prognosis of cancer outcome, which could assist and contribute to the development of more promising therapeutic strategies. RECENT FINDINGS:Accumulati...
journal_title:Current opinion in oncology
pub_type: 杂志文章,评审
doi:10.1097/CCO.0000000000000339
更新日期:2017-01-01 00:00:00
abstract::In the past decade, the discovery of tumor antigens recognized by T cells has revolutionized the tumor vaccine field. The appreciation that peptides are bound to and restricted by major histocompatibility class I and II molecules for immune recognition has encouraged a number of early-phase clinical trials of peptide ...
journal_title:Current opinion in oncology
pub_type: 杂志文章,评审
doi:10.1097/00001622-200103000-00007
更新日期:2001-03-01 00:00:00
abstract:PURPOSE OF REVIEW:Malignant brain tumors have a very poor prognosis and the natural history of disease is very short, usually less than 1 year. Brain tumor patients often present peculiar symptoms of disease that require appropriate supportive treatment, namely, peritumoral brain edema, venous thromboembolism, seizures...
journal_title:Current opinion in oncology
pub_type: 杂志文章,评审
doi:10.1097/CCO.0b013e32833e078c
更新日期:2010-11-01 00:00:00
abstract:PURPOSE OF REVIEW:Sub-Saharan Africa has the largest population of people living with AIDS in the world, with Nigeria having the third largest after South Africa and India. With the advent of treatment programs, more people in Nigeria are now living with the virus but are at increased risk of cancer similar to the expe...
journal_title:Current opinion in oncology
pub_type: 杂志文章,评审
doi:10.1097/CCO.0b013e32832e6385
更新日期:2009-09-01 00:00:00
abstract:PURPOSE OF REVIEW:This review focuses on the surgical management of soft tissue sarcomas of the hands and the feet. With recent advances in limb salvage surgery and radiotherapy delivery, local control of soft tissue sarcoma in the extremity has become optimized, and the associated functional results of this treatment ...
journal_title:Current opinion in oncology
pub_type: 杂志文章,评审
doi:10.1097/01.cco.0000166651.38417.c8
更新日期:2005-07-01 00:00:00
abstract:PURPOSE OF REVIEW:To discuss the recent developments of multimodal treatment for patients with local advanced rectal cancer, including incorporation of new chemotherapeutic and targeted agents, and the optimal sequence and timing of treatment components. RECENT FINDINGS:Five randomized trials have been completed to de...
journal_title:Current opinion in oncology
pub_type: 杂志文章,评审
doi:10.1097/CCO.0b013e328352ea02
更新日期:2012-07-01 00:00:00
abstract:PURPOSE OF REVIEW:Primary central nervous system lymphoma (PCNSL) is a rare tumor, and its optimal management is a matter of controversy. Recent developments of collaborative groups devoted to PCNSL have allowed to conduct randomized trials addressing important issues. In addition, genome wide analysis provided new ins...
journal_title:Current opinion in oncology
pub_type: 杂志文章,评审
doi:10.1097/CCO.0000000000000233
更新日期:2015-11-01 00:00:00
abstract:PURPOSE OF REVIEW:Despite remarkable advances in the treatment of non-Hodgkin's lymphoma of all histologic subtypes, nervous system involvement remains a dire complication associated with a rapid decline in quality of life, few good treatment options, and a short overall survival. In fact, these advances in treatment m...
journal_title:Current opinion in oncology
pub_type: 杂志文章,评审
doi:10.1097/CCO.0b013e32830b829e
更新日期:2008-09-01 00:00:00
abstract:PURPOSE OF REVIEW:Sarcomas are a diverse group of rare solid tumors with limited treatment options for patients with advanced, inoperable disease. Cabozantinib is a tyrosine kinase inhibitor currently approved for advanced renal cell, hepatocellular, and medullary thyroid carcinoma. Cabozantinib has potent activity aga...
journal_title:Current opinion in oncology
pub_type: 杂志文章,评审
doi:10.1097/CCO.0000000000000644
更新日期:2020-07-01 00:00:00
abstract::Thyroid cancers are still the most common endocrine cancers. They are dominated by well-differentiated carcinomas, including papillary carcinoma, follicular carcinoma, and medullary thyroid carcinoma. Diagnosis is based on fine-needle aspiration cytologic examination. Recently, reverse transcription polymerase chain r...
journal_title:Current opinion in oncology
pub_type: 杂志文章,评审
doi:10.1097/00001622-200001000-00009
更新日期:2000-01-01 00:00:00
abstract::Controversy exists over the role that environmental estrogens, such as pesticides or polychlorinated biphenyls (PCBs), might play as risk factors for breast cancer. Several laboratory studies have suggested that these chemicals function as weak estrogens, binding to the estrogen receptor and inducing various measures ...
journal_title:Current opinion in oncology
pub_type: 杂志文章,评审
doi:10.1097/00001622-199809000-00018
更新日期:1998-09-01 00:00:00
abstract:PURPOSE OF REVIEW:Primary thyroid lymphoma (PTL) is a rare but clinically important malignancy of the thyroid. This article reviews the diagnosis, histologic subtypes, pathogenesis, and treatment of PTL, with the objective of optimizing diagnosis and management of the disease. RECENT FINDINGS:Recent studies have shed ...
journal_title:Current opinion in oncology
pub_type: 杂志文章,评审
doi:10.1097/CCO.0b013e3283330848
更新日期:2010-01-01 00:00:00
abstract:PURPOSE OF REVIEW:Evaluate the recent literature about the relation of clinical infection and colorectal cancer in terms of diagnosis of an occult infection and possible impact on oncological outcome and review the possible role of the gut microbiota in the role of colorectal cancer oncogenesis. RECENT FINDINGS:Data p...
journal_title:Current opinion in oncology
pub_type: 杂志文章,评审
doi:10.1097/CCO.0000000000000543
更新日期:2019-07-01 00:00:00
abstract::Perioperative brachytherapy results in a better local control rate than surgery alone for extremity soft tissue sarcoma. Brachytherapy enables the delivery of a high radiation dose to a limited volume of tissue, allows the reduction of radiation treatment time, enables direct visualization of the tumor bed and surroun...
journal_title:Current opinion in oncology
pub_type: 杂志文章,评审
doi:10.1097/00001622-200307000-00006
更新日期:2003-07-01 00:00:00
abstract::The appearance of skin lesions in patients with occult or obvious malignancy may be of extreme value in the detection and management of cancer because the skin is readily accessible to examination and biopsy. Examination of the skin of our patients can provide important insights into underlying malignant processes or ...
journal_title:Current opinion in oncology
pub_type: 杂志文章,评审
doi:10.1097/00001622-199903000-00011
更新日期:1999-03-01 00:00:00
abstract:PURPOSE OF REVIEW:To summarize the current knowledge about the biology and clinical management of adult desmoid tumors. RECENT FINDINGS:In the past decade, we have learned that desmoid tumors are driven by alterations of the Wnt/APC/β-catenin pathway, sporadic desmoid tumors are associated with somatic mutations of CT...
journal_title:Current opinion in oncology
pub_type: 杂志文章,评审
doi:10.1097/CCO.0000000000000374
更新日期:2017-07-01 00:00:00
abstract:PURPOSE OF REVIEW:Despite significant improvements in the treatment of Burkitt lymphoma, outcomes of adults are generally inferior to those of children. This review summarizes the most recent developments in the management of Burkitt lymphoma and leukemia in adults. RECENT FINDINGS:Current regimens have largely been d...
journal_title:Current opinion in oncology
pub_type: 杂志文章,评审
doi:10.1097/00001622-200409000-00003
更新日期:2004-09-01 00:00:00
abstract::Contrary to the case with bacterial infections, progress in the diagnosis and treatment of invasive mycoses in cancer patients has been unsatisfactory. Amphotericin B deoxycholate has remained the drug of choice for severe invasive fungal infections for nearly 40 years. However, its infusion-related side effects, as w...
journal_title:Current opinion in oncology
pub_type: 杂志文章,评审
doi:10.1097/00001622-199709040-00002
更新日期:1997-07-01 00:00:00
abstract::Recent publications dealing with the pathology of squamous carcinomas of the head and neck have been critically reviewed with particular reference to potential prognostic factors and improved methods for identifying nodal metastases. The topics covered include cytophotometry and proliferative patterns, molecular biolo...
journal_title:Current opinion in oncology
pub_type: 杂志文章,评审
doi:10.1097/00001622-199305000-00009
更新日期:1993-05-01 00:00:00
abstract:PURPOSE OF REVIEW:(18)F-fluoro-2-deoxy-D-glucose PET-computed tomography (CT) has a major clinical impact in oncology not only for diagnostics but also for staging, response assessment, and relapse detection. However, several other PET tracers are needed for a more complete molecular characterization of cancers which h...
journal_title:Current opinion in oncology
pub_type: 杂志文章,评审
doi:10.1097/CCO.0b013e32835766f7
更新日期:2012-11-01 00:00:00
abstract:PURPOSE OF REVIEW:To describe how to better identify frail multiple myeloma patients and to treat them appropriately. RECENT FINDINGS:Proteasome inhibitors, such as bortezomib, carfilzomib, and ixazomib, and immunomodulatory agents (IMiDs), such as thalidomide, lenalidomide, and pomalidomide, have significantly improv...
journal_title:Current opinion in oncology
pub_type: 杂志文章,评审
doi:10.1097/CCO.0000000000000395
更新日期:2017-09-01 00:00:00